oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Search Results: 1 - 10 of 393 matches for " Mitsuru Sasako "
All listed articles are free for downloading (OA Articles)
Page 1 /393
Display every page Item
Operative Benefits of Artificial Pneumothorax in Thoracoscopic Esophagectomy in the Left Lateral Decubitus Position for Esophageal Cancer  [PDF]
Masashi Takemura, Nobuaki Kaibe, Mamiko Takii, Mitsuru Sasako
International Journal of Clinical Medicine (IJCM) , 2015, DOI: 10.4236/ijcm.2015.612127
Abstract: Objectives: This study aimed to evaluate operative benefits of artificial pnuemothorax in thoracoscopic esophagectomy in the left lateral decubitus position. Methods: We retrospectively analyzed short-term surgical outcomes including learning curve of 60 consecutive patients who underwent thoracoscopic esophagectomy with artificial pnuemothorax in the left lateral decubitus position between April 2010 and November 2012 in our department. Results: The median operation time and intraoperative blood loss were 443 min and 220 ml, respectively, and these values were 174 min and 95 ml, respectively, in the thoracic phase of surgery. The median number of harvested lymph node was 37. Only 1 patient required conversion to open esophagectomy. The postoperative 30-day mortality rate was 1.7%. The thoracic operation time significantly decreased after an experience of 10 cases and intraoperative blood loss during thoracic phasesignificantly decreased after an experience of 20 cases (p < 0.05), and operation time remained constant for the following cases. The number of harvested lymph nodes did not exhibit significant changes with an increase in the number of case experienced. Conclusions: Artificial pneumothorax provided the shorting of learning curve at the thoracoscopic esophagectomy in the left lateral decubitus position.
Short Term Operative Outcomes of Laparoscopic Gastric Mobilization in Esophagectomy for Esophageal Cancer: Comparison with Hand Assisted Technique  [PDF]
Masashi Takemura, Mamiko Takii, Nobuaki Kaibe, Tsutomu Oshima, Mitsuru Sasako
Surgical Science (SS) , 2016, DOI: 10.4236/ss.2016.77039
Abstract: Objective: This study evaluated the safety and operative utilities of the laparoscopic gastric mobilization compared with hand-assisted laparoscopic gastric mobilization. Patients and Methods: From April 2010 to November 2015, 125 patients with esophageal cancer have been performed laparoscopic mobilization; 33 under hand-assisted laparoscopic gastric mobilization (HLG group) and 92 under laparoscopic gastric mobilization without hand-assisted technique (LG group). Preoperative data and surgical outcomes of 2 groups were compared. Results: Preoperative data were not significantly different except for BMI. Operation time in abdominal procedure of LG group is significantly longer than HLG group (P < 0.0001). Otherwise, the blood loss and number of dissected nodes of abdominal procedure was not significantly different in two groups. The perioperative blood transfusions were needed in 7 cases (21.2%) in HLG group and 25 (27.1%) in LG group. The postoperative complications and mortality within 30 days after surgery were not significantly different in two groups. The length of hospital stay was 29 days in HLG group and 31 days in HG group, respectively. Conclusions: Our results suggested that laparoscopic gastric mobilization was safe technique and the short-term operative outcomes were comparable with that of hand-assisted laparoscopic mobilization.
Implications of double-stranded DNA structure for development, cancer and evolution  [PDF]
Mitsuru Furusawa
Open Journal of Genetics (OJGen) , 2011, DOI: 10.4236/ojgen.2011.13014
Abstract: Genomes consist of DNA and the genetic information is encoded in a linear form of DNA. According to the central dogma of molecular biology, the genetic information is transcribed into mRNA, and mRNA translated into a polypeptide. Gene expression should be precisely regulated in order to create progeny. Unlike RNA, DNA has double-stranded structure. Is there any specific biological reason why DNA has evolved to possess double-stranded structure? In this presentation, biological implications of the double-stranded structure of the DNA molecule will be reviewed. In eukaryotes, it has been reported that cells might have the machinery that distinguishes one DNA-strand from the other, and that the strand-recognition mechanism might control development, cancer and evolution. Three prominent models concerning biological implications of replication of double-stranded DNA will be discussed: 1) Klar’s “somatic strand-specific imprinting and selective chromatid segregation model” for differential gene regulation, 2) Cairns’ “immortal strand inheritance model” for cancer prohibition, and 3) the “disparity mutagenesis model” for the acceleration of evolution proposed by the present author.
Animal Model of Lung Metastasis of Hepatocellular Carcinoma: A Tool for the Development of Anti-Metastatic Therapeutics  [PDF]
Mitsuru Futakuchi
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.42A051
Abstract:

We observed that N-nitrosomorpholine (NMOR) given after a multi-carcinogenic treatment induces liver carcinomas with 56% lung metastasis. An additional treatment with diethylnitrosamine (DEN) with NMOR further enhanced the incidence of hepatocellular carcinoma (HCC) with lung metastasis. We have further revised the duration of NMOR treatment to establish an animal model with a simple experimental protocol and an appropriate experimental duration to facilitate investigation exploring the mechanisms of HCC metastasis and development of anti-metastatic therapeutics. We observed that DEN exposure followed by a 16-week treatment with NMOR to be a most efficient protocol for the induction of HCC metastasizing to the lung. In this review, we will discuss about the usefulness of animal models for induction of highly metastatic HCC and the assessment of the efficacy of anti-metastatic therapeutics. Additionally, we will also discuss use of these models in analysis of individual steps in the metastatic process by using non-steroidal anti-inflammatory drugs, aspirin and indomethacin, two nuclear factor kappa B (NF-κB) inhibitors, pentoxifylline and N-acetyl-L-cysteine.

Effects of Calcium Ion, Calpains, and Calcium Channel Blockers on Retinitis Pigmentosa
Mitsuru Nakazawa
Journal of Ophthalmology , 2011, DOI: 10.1155/2011/292040
Abstract: Recent advances in molecular genetic studies have revealed many of the causative genes of retinitis pigmentosa (RP). These achievements have provided clues to the mechanisms of photoreceptor degeneration in RP. Apoptosis is known to be a final common pathway in RP and, therefore, a possible therapeutic target for photoreceptor rescue. However, apoptosis is not a single molecular cascade, but consists of many different reactions such as caspase-dependent and caspase-independent pathways commonly leading to DNA fractionation and cell death. The intracellular concentration of calcium ions is also known to increase in apoptosis. These findings suggest that calpains, one of the calcium-dependent proteinases, play some roles in the process of photoreceptor apoptosis and that calcium channel antagonists may potentially inhibit photoreceptor apoptosis. Herein, the effects of calpains and calcium channel antagonists on photoreceptor degeneration are reviewed.
A Review of Fusion and Tokamak Research Towards Steady-State Operation: A JAEA Contribution
Mitsuru Kikuchi
Energies , 2010, DOI: 10.3390/en3111741
Abstract: Providing a historical overview of 50 years of fusion research, a review of the fundamentals and concepts of fusion and research efforts towards the implementation of a steady state tokamak reactor is presented. In 1990, a steady-state tokamak reactor (SSTR) best utilizing the bootstrap current was developed. Since then, significant efforts have been made in major tokamaks, including JT-60U, exploring advanced regimes relevant to the steady state operation of tokamaks. In this paper, the fundamentals of fusion and plasma confinement, and the concepts and research on current drive and MHD stability of advanced tokamaks towards realization of a steady-state tokamak reactor are reviewed, with an emphasis on the contributions of the JAEA. Finally, a view of fusion energy utilization in the 21st century is introduced.
Development of Fabrication Methods of Filler/Polymer Nanocomposites: With Focus on Simple Melt-Compounding-Based Approach without Surface Modification of Nanofillers
Mitsuru Tanahashi
Materials , 2010, DOI: 10.3390/ma3031593
Abstract: Many attempts have been made to fabricate various types of inorganic nanoparticle-filled polymers (filler/polymer nanocomposites) by a mechanical or chemical approach. However, these approaches require modification of the nanofiller surfaces and/or complicated polymerization reactions, making them unsuitable for industrial-scale production of the nanocomposites. The author and coworkers have proposed a simple melt-compounding method for the fabrication of silica/polymer nanocomposites, wherein silica nanoparticles without surface modification were dispersed through the breakdown of loose agglomerates of colloidal nano-silica spheres in a kneaded polymer melt. This review aims to discuss experimental techniques of the proposed method and its advantages over other developed methods.
A Grande Eleva o Eustática do Mioceno e Sua Influência na Origem do Grupo Barreiras
Mitsuru Arai
Geologia USP : Série Científica , 2006,
Abstract: O Grupo Barreiras é uma unidade que ocorre ao longo da faixa costeira do Brasil, desde o Estado do Amapá até o Rio deJaneiro, caracterizando-se pela ocorrência quase contínua e pela regularidade geomorfológica. Sua origem tem sido motivo demuitas discuss es. Tradicionalmente, a unidade vinha sendo considerada como de origem continental, mas trabalhos recentesvêm mostrando evidências irrefutáveis de influência marinha, tanto de natureza paleontológica, como sedimentológica. Adata o palinológica e sua correla o com as unidades litoestratigráficas coevas das partes submersas das bacias da margemcontinental brasileira e das outras partes do planeta permitiram um estudo integrado sob a luz da Estratigrafia de Seqüências.Essa análise estratigráfica integrada permitiu relacionar a origem do Grupo Barreiras com a eleva o eustática global que teveseu máximo na parte média do Mioceno, mais precisamente no intervalo do Burdigaliano ao Serravaliano (12 – 20 Ma). Asedimenta o do Barreiras lato sensu sofreu uma interrup o no Tortoniano (início do Neomioceno), quando houve umrebaixamento eustático global que ocasionou um extenso evento erosivo nas áreas emersas e a forma o de cunhas fortementeprogradantes na por o submersa das bacias submersas (offshore). Com a retomada da subida eustática no Plioceno (Zancleano,4 – 5 Ma), depositou-se o segundo ciclo (Barreiras Superior). A eros o e o retrabalhamento do Grupo Barreiras no Quaternáriodevem ter sido responsáveis, em parte, pela atual configura o da plataforma continental.
Middle Cretaceous palynological assemblages rich in copepod eggs: their paleoecological significance
ARAI MITSURU
Anais da Academia Brasileira de Ciências , 2002,
Abstract:
Effects of Calcium Ion, Calpains, and Calcium Channel Blockers on Retinitis Pigmentosa
Mitsuru Nakazawa
Journal of Ophthalmology , 2011, DOI: 10.1155/2011/292040
Abstract: Recent advances in molecular genetic studies have revealed many of the causative genes of retinitis pigmentosa (RP). These achievements have provided clues to the mechanisms of photoreceptor degeneration in RP. Apoptosis is known to be a final common pathway in RP and, therefore, a possible therapeutic target for photoreceptor rescue. However, apoptosis is not a single molecular cascade, but consists of many different reactions such as caspase-dependent and caspase-independent pathways commonly leading to DNA fractionation and cell death. The intracellular concentration of calcium ions is also known to increase in apoptosis. These findings suggest that calpains, one of the calcium-dependent proteinases, play some roles in the process of photoreceptor apoptosis and that calcium channel antagonists may potentially inhibit photoreceptor apoptosis. Herein, the effects of calpains and calcium channel antagonists on photoreceptor degeneration are reviewed. 1. Introduction Retinitis pigmentosa (RP) represents a group of hereditary retinal degenerations principally characterized by progressive rod-dominant photoreceptor degeneration in the initial stage and eventual cone photoreceptor degeneration in later stages. Patients with RP mainly complain of night blindness and photophobia in the early stage, followed by gradual constriction of the visual field, decreased visual acuity, and color blindness in later stages. The prevalence of RP is roughly 1 in 4,000-5,000 people, and the condition is common in both Asian and Western countries. Significant features of RP include heterogeneity in both clinical and genetic characteristics. For instance, the severity and progression of RP vary from patient to patient even in the same family, despite affected members presumably sharing the same causative gene mutation. Heredities are also heterogeneous, characterized by at least 3 different modes of inheritance, such as autosomal-dominant, autosomal-recessive, and X-linked patterns. Since a mutation in the rhodopsin gene was first identified as causing one type of autosomal-dominant RP [1], at least 48 different causative genes have been identified (RetNet: http://www.sph.uth.tmc.edu/retnet/disease.htm); however, many other putative causative genes and mutations have yet to be identified. Molecular genetic studies have also demonstrated that a primary lesion in RP involves photoreceptor and/or retinal pigment epithelial cells in which many causative genes are specifically expressed under physiological conditions. Photoreceptor or retinal pigment epithelial cells are known to
Page 1 /393
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.