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Search Results: 1 - 10 of 208656 matches for " Minna Kytt?l? "
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Diversity in Family Structure—Diversity in Communication between Family Members?  [PDF]
Piia M. Bj?rn, Minna Kyttl
Psychology (PSYCH) , 2013, DOI: 10.4236/psych.2013.43A035
Abstract:

This study aims at investigating the parent-adolescent communication of Finnish families from a multi informant perspective. Thirteen- and fourteen-year-old adolescents (n = 171) and their parents were asked to complete a questionnaire examining positive and problematic communication between the two parties. Information about their family structure was collected. The results indicated an interrelationship between parental and adolescent assessments, particularly regarding negative aspects of communication. The boys assessed their communication with parents as more positive than did the girls. The results showed that the mothers still are the synchronizing hearts of communication in modern families, whereas the fathers’ roles in family communication were more modest suggesting that the stereotypical roles in Finnish families persist even today.

Novel interactions of CLN5 support molecular networking between Neuronal Ceroid Lipofuscinosis proteins
Annina Lyly, Carina von Schantz, Claudia Heine, Mia-Lisa Schmiedt, Tessa Sipil?, Anu Jalanko, Aija Kyttl
BMC Cell Biology , 2009, DOI: 10.1186/1471-2121-10-83
Abstract: We found that CLN5 interacts with several other NCL proteins namely, CLN1/PPT1, CLN2/TPP1, CLN3, CLN6 and CLN8. Furthermore, analysis of the intracellular targeting of CLN5 together with the interacting NCL proteins revealed that over-expression of PPT1 can facilitate the lysosomal transport of mutated CLN5FinMajor, normally residing in the ER and in the Golgi complex. The significance of the novel interaction between CLN5 and PPT1 was further supported by the finding that CLN5 was also able to bind the F1-ATPase, earlier shown to interact with PPT1.We have described novel interactions between CLN5 and several NCL proteins, suggesting a modifying role for these proteins in the pathogenesis of individual NCL disorders. Among these novel interactions, binding of CLN5 to CLN1/PPT1 is suggested to be the most significant one, since over-expression of PPT1 was shown to influence on the intracellular trafficking of mutated CLN5, and they were shown to share a binding partner outside the NCL protein spectrum.Neuronal ceroid lipofuscinoses (NCLs) are the most common group of children's progressive neurodegenerative disorders with an estimated incidence of 1:12500 in the USA and Nordic countries and approximately 1:100 000 worldwide [reviewed in [1,2]]. NCL disorders are mostly recessively inherited, and to date, eight different genes have been characterized to underlie these diseases [3-5]. Despite having genetic heterogeneity, NCL diseases resemble each other both clinically and neuropathologically. The clinical course varies from severe congenital disease to milder adult-onset forms. NCLs are phenotypically expressed by progressive mental deterioration, blindness, epileptic seizures and premature death. The pathological findings of these lysosomal storage disorders include intracellular accumulation of autofluorescent lipopigment with variable ultrastructural appearance as well as progressive loss of neocortical neurons. The major component of the intracellular storage ma
Glycosylation, transport, and complex formation of palmitoyl protein thioesterase 1 (PPT1) – distinct characteristics in neurons
Annina Lyly, Carina von Schantz, Tarja Salonen, Outi Kopra, Jani Saarela, Matti Jauhiainen, Aija Kyttl, Anu Jalanko
BMC Cell Biology , 2007, DOI: 10.1186/1471-2121-8-22
Abstract: Our study shows that the N-glycosylation of N197 and N232, but not N212, is essential for PPT1's activity and intracellular transport. Deglycosylation of overexpressed PPT1 produced in neurons and fibroblasts demonstrates differentially modified PPT1 in different cell types. Furthermore, antibody internalization assays showed differences in PPT1 transport when compared with a thoroughly characterized lysosomal enzyme aspartylglucosaminidase (AGA), an important observation potentially influencing therapeutic strategies. PPT1 was also demonstrated to form oligomers by size-exclusion chromatography and co-immunoprecipitation assays. Finally, the consequences of disease mutations were analyzed in the perspective of our new results, suggesting that the mutations increase both the degree of glycosylation of PPT1 and its ability to form complexes.Our current study describes novel properties for PPT1. We observe differences in PPT1 processing and trafficking in neuronal and non-neuronal cells, and describe for the first time the ability of PPT1 to form complexes. Understanding the basic characteristics of PPT1 is fundamental in order to clarify the molecular pathogenesis behind neurodegeneration in INCL.Neuronal ceroid lipofuscinoses (NCLs) comprise a group of recessively inherited neurodegenerative disorders of which the infantile form, INCL, is the most severe [1]. Clinical symptoms include motor and cognitive deterioration, visual failure, and seizures, leading to death in the first or second decade of life. Pathological findings include autofluorescent lysosomal storage material, harbouring an ultrastructure of granular osmiophilic deposits (GRODs) in all tissues of the patients [2]. While most cell types remain unaffected despite the presence of storage material, cortical neurons are lost during the disease process. However, the mechanism of cell death has remained elusive.The defective gene behind the INCL disease, CLN1, encodes for palmitoyl protein thioesterase 1 (P
Clinic Pathological Study of Aneurysmal Fibrous Histiocytoma  [PDF]
Minna Gao, Xiao Lin
Journal of Biosciences and Medicines (JBM) , 2019, DOI: 10.4236/jbm.2019.75001
Abstract:
Aneurysmal fibrous histiocytoma (AFH) is a rare variant of benign fibrous histiocytoma (FH), Characterized by blood-filled spaces within the fibrohistiocytic tumor. AFH has a higher recurrence rate than FH. The diagnosis of AFH is often problematic due to its overlapping morphological features with other skin tumors. The diagnosis of AFH depends on histological features and immunohistochemistry. The aim of this study is to understand the clinical and histopathological diagnostic criteria for AFH.
Resolving the Human Remains Crisis in British Archaeology: A Reply with Insight into Related Issues in Finland
Minna Lapinoja
Papers from the Institute of Archaeology , 2011, DOI: 10.5334/pia.371
Abstract:
Auditory-Visual Matching and Language-Based Learning Disorders: Two Studies of Specific Language Impairment and Developmental Dyslexia
Minna Tormanen
International Journal of Education , 2009, DOI: 10.5296/ije.v1i1.202
Abstract:
Displaying knowledge in journalistic texts: A contrastive analysis of an evidential particle in Estonian and Finnish
Minna Jaakola
L?hiv?rdlusi. L?hivertailuja , 2012, DOI: 10.5128/lv22.02
Abstract: This paper examines the semantics of the Estonian and Finnish epistemic-evidential particles teatavasti and tiett v sti (‘as is generally known’ and ‘as far as is known’). Based on newspaper data and focusing on textual and intersubjective meanings, this analysis adopts the Cognitive Grammar description of relational predicates. The comparison is based on the properties of the fact that is within the scope of the particle (knowledge that is specific or generic, conventionalised or non-conventionalised, and more or less irrefutable). Whereas the Finnish particle conveys a strong implication of reported knowledge, which often causes a message of slight hedging, the Estonian particle is used to mark the issue at hand as being certain. In addition, the information in Estonian is displayed as being accessible and shared to interlocutors. On a textual level, the characteristic feature of this Estonian particle is to mark a fact as the background information for a more topical element of the text. In contrast, the Finnish particle is often used for organising the different reported voices in a text.DOI: http://dx.doi.org/10.5128/LV22.02
The impact of Finno-Ugric languages in second language research: Looking back and setting goals
Minna Suni
L?hiv?rdlusi. L?hivertailuja , 2012, DOI: 10.5128/lv22.14
Abstract: This state of the art review aims at discussing the potential relevance of Finno-Ugric languages in the larger context of second language research. Key results received in the studies conducted in the field of Finno-Ugric languages as second languages are introduced, and some interim conclusions based on them are made. The main areas in focus are cross-linguistic influence, forms and constructions, second language interaction, and motivation, identities and integration. Furthermore, some future lines of investigation are suggested for the researchers of the field. The research activities are recommended to get more closely bound to the internationally established or emerging paradigms, and research activities involving several Finno-Ugric languages are strongly encouraged. To promote international co-operation, some existing gaps or obvious needs for research are pointed out, and preliminary research initiatives are made. DOI: http://dx.doi.org/10.5128/LV22.14
Aider et être aidé : l’importance de la notion d’aide dans les dispositifs d’apprentissage en ligne
Minna Puustinen
Revue Internationale des Technologies en Pédagogie Universitaire , 2012,
Abstract: [Fran ais] Cet article est une introduction au numéro spécial sur la notion d’aide dans les dispositifs d’apprentissage en ligne. Il met l’accent sur le r le essentiel que joue la notion d’aide dans ces dispositifs, mais aussi sur le fait qu’à l’heure actuelle, relativement peu de chercheurs travaillent sur cette thématique. Il propose également quelques réflexions soulevées par les articles publiés dans ce numéro spécial (par exemple, sur les concepts clés, sur des questions méthodologiques et sur des perspectives de réflexion). [English] This paper is an introduction to the special issue on the notion of help in online learning environments. It emphasizes the essential role played by the notion of help in these environments but also the fact that relatively few researchers work on this topic. It further provides some reflections on the articles published in the special issue (e.g., on the key notions, on methodological questions, and on perspectives for further reflection).
EFFECT OF XYLANASE TREATMENT ON DEWATERING PROPERTIES OF BIRCH KRAFT PULP
Minna Marianne Blomstedt,Jaakko Asikainen,Annina L?hdeniemi,Timo Yl?nen
BioResources , 2010,
Abstract: In this study it was shown that the enzymatic removal of xylan from ECF-bleached birch kraft pulp enhances the water removal from the pulp, especially in the late stages of pulp drying. The effect of xylanase treatments on dewatering was clarified by using a moving belt former (MBF), a press simulator (MTS), and an IR-drying equipment, to simulate and to measure dewatering properties on wire, press and drying sections of a paper machine. The xylanase treatment slightly increased the pulp freeness indicating improved pulp drainage properties. At the moving belt former, however, no significant changes that would indicate enhanced dewatering in forming were observed. The xylanase treatments slightly enhanced the dewatering in wet pressing and furthermore, at the thermal drying the xylanase treatment had a positive effect on the dry solid content (DSC) development, and time to reach the 95% dry solids content was reduced by up to 15%. This was also confirmed by the decrease in the fiber saturation point (FSP) values and the amount of bulk water. Our results indicate that the xylanase treatment affected the water-binding xylan in the fiber cell wall, yielding enhanced dewatering properties, without deteriorating the pulp and paper properties.
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