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Search Results: 1 - 10 of 1491 matches for " Minhee Jang "
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Korean Red Ginseng Extract Attenuates 3-Nitropropionic Acid-Induced Huntington’s-Like Symptoms
Minhee Jang,Min Jung Lee,Cheon Suk Kim,Ik-Hyun Cho
Evidence-Based Complementary and Alternative Medicine , 2013, DOI: 10.1155/2013/237207
Ethyl pyruvate attenuates formalin-induced inflammatory nociception by inhibiting neuronal ERK phosphorylation
Min Jung Lee, Minhee Jang, Hyuk-Sang Jung, Sung-Hoon Kim, Ik-Hyun Cho
Molecular Pain , 2012, DOI: 10.1186/1744-8069-8-40
Abstract: EP significantly decreased formalin-induced nociceptive behavior during phase II, the magnitude of paw edema, and the activation of c-Fos in L4-L5 spinal dorsal horn. EP also attenuated the phosphorylation of extracellular signal-regulated kinase (ERK) in the neurons of L4-L5 spinal dorsal horn after formalin injection. Interestingly, the i.t. administration of PD98059, an ERK upstream kinase (MEK) inhibitor, completely blocked the formalin-induced inflammatory nociceptive responses.These results demonstrate that EP may effectively inhibit formalin-induced inflammatory nociception via the inhibition of neuronal ERK phosphorylation in the spinal dorsal horn, indicating its therapeutic potential in suppressing acute inflammatory pain.
Minocycline markedly reduces acute visceral nociception via inhibiting neuronal ERK phosphorylation
Ik-Hyun Cho, Min Jung Lee, Minhee Jang, Nam Gil Gwak, Ka Yeon Lee, Hyuk-Sang Jung
Molecular Pain , 2012, DOI: 10.1186/1744-8069-8-13
Abstract: Minocycline (4, 10, or 40 mg/kg) significantly decreased acetic acid-induced nociception (0-60 minutes post-injection) and the enhancement in the number of c-Fos positive cells in the T5-L2 spinal cord induced by acetic acid injection. Also, the expression of spinal phosphorylated extracellular signal-regulated kinase (p-ERK) induced by acetic acid was reduced by minocycline pre-administration. Interestingly, intrathecal introduction of PD98059, an ERK upstream kinase inhibitor, markedly blocked the acetic acid-stimulated pain responses.These results demonstrate that minocycline effectively inhibits acetic acid-induced acute abdominal nociception via the inhibition of neuronal p-ERK expression in the spinal cord, and that minocycline may have therapeutic potential in suppressing acute abdominal pain.Minocycline is a second-generation tetracycline antibiotic derivative that effectively crosses the blood-brain barrier [1], and which has a proven safety record in humans [2]. Minocycline has anti-inflammatory and neuroprotective effects in animal models of cerebral ischaemia [3,4], traumatic injury [5], glutamate-induced neurotoxicity [6], experimental autoimmune encephalonmyelitis [7], Huntington's disease [8] and Parkinson's disease [2,9,10]. Minocycline's efficacy has been bolstered by studies showing decreased secondary neuronal damage via the inhibition of microglial activation. Recently, it has been demonstrated that this minocycline-mediated microglial inhibition attenuates the development of pain hypersensitivity by inhibiting proinflammatory cytokine expression in rat models of both neuropathic pain and spinal immune activation by intrathecal human immunodeficiency virus-1 (HIV-1) gp120 [11,12]. Also, minocycline completely reverses mechanical hyperalgesia in diabetic rats through microglia-induced changes in the expression of the potassium chloride co-transporter 2 (KCC2) in the spinal cord [13]. In addition, we confirmed that minocycline attenuates tactile hy
Oriental Medicine Kyung-Ok-Ko Prevents and Alleviates Dehydroepiandrosterone-Induced Polycystic Ovarian Syndrome in Rats
Minhee Jang, Min Jung Lee, Jin Moo Lee, Chun-Sik Bae, Sung-Hoon Kim, Jong Hoon Ryu, Ik-Hyun Cho
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0087623
Abstract: Kyung-Ok-Ko (KOK), a traditional herbal prescription composed of Rehmannia glutinosa Liboschitz var. purpurae, Lycium chinense, Aquillaria agallocha, Poria cocos, Panax ginseng, and honey, has been widely used in traditional Oriental medicine as a vitalizing medicine or as the prescription for patients with age-associated disorders such as amnesia and stroke. However, the potential protective value of KOK for the treatment of polycystic ovarian syndrome (PCOS) is largely unknown. We investigated whether pre-administration (daily from 2 hours before PCOS induction) and post-administration (daily after induction of PCOS) of KOK (0.5, 1.0, and 2.0 g/kg/day, p.o.) could have a protective effect in a dehydroepiandrosterone (DHEA, s.c.)-induced PCOS rat model. Pre-administration of KOK significantly decreased the elevated body weight and ovary weight, elevated size and number of follicular cysts, elevated level of serum glucose, and estradiol after DHEA injection. KOK reduced the elevated percentage of CD8 (+) T lymphocytes in lymph nodes, the elevated mRNA expression of CD11b and CD3 in ovaries, and infiltration of macrophages in ovarian tissue with PCOS. KOK diminished the increased mRNA expression of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), chemokines (IL-8, MCP-1), and iNOS in the ovaries, and increased the reduced mRNA expression of growth factors (EGF, TGF-β) by DHEA injection. Post-administration of KOK also improved the DHEA-induced PCOS-like symptoms, generally similar to those evident from pre-administration of KOK. KOK may effectively prevent and improve DHEA-induced PCOS via anti-inflammatory action, indicating its preventive and therapeutic potential for suppressing PCOS.
The Distribution of Multiple Shot Noise Process and Its Integral  [PDF]
Jiwook Jang
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.53047

In this paper, we study multiple shot noise process and its integral. We analyse these two processes systematically for their theoretical distributions, based on the piecewise deterministic Markov process theory developed by Davis [1] and the martingale methodology used by Dassios and Jang [2]. The analytic expressions of the Laplace transforms of these two processes are presented. We also obtain the multivariate probability generating function for the number of jumps, for which we use a multivariate Cox process. To derive these, we assume that the Cox processes jumps, intensity jumps and primary event jumps are independent of each other. Using the Laplace transform of the integral of multiple shot noise process, we obtain the tail of multivariate distributions of the first jump times of the Cox processes, i.e. the multivariate survival functions. Their numerical calculations and other relevant joint distributions numerical values are also presented.

Electrophysiologic Biomarkers for Assessing Disease Progression and the Effect of Riluzole in SOD1 G93A ALS Mice
Jia Li, Minhee Sung, Seward B. Rutkove
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0065976
Abstract: Objective To compare electrical impedance myography (EIM) 50 kHz phase to weight, motor score, paw grip endurance (PGE), CMAP amplitude, and MUNE for the identification of disease progression and the effect of riluzole in the SOD1 G93A mouse. Methods Twenty-three animals received 8 mg/kg/day riluzole in the drinking water starting at 6 weeks of age; 22 animals served as controls. Weight, motor score, PGE, CMAP, MUNE, and EIM were performed weekly to evaluate disease progression. Results No difference in clinical disease onset or survival was found between treated and untreated groups. In addition, all methods failed to identify any beneficial effect of riluzole. Thus, data from all animals were combined for additional analyses. Of the 4 parameters, EIM phase showed the earliest change from baseline and the most linear decline throughout the entire measurement period. In addition, EIM phase correlated with PGE, CMAP amplitude, and MUNE (Spearman r = 0.92, 0.90, and 0.72, respectively, p<0.01 for all). The rate of EIM phase decline also correlated with individual animal survival (Spearman r = ?0.31, p<0.05). Conclusions At this dose, riluzole is ineffective in slowing progression of ALS. However, EIM phase shows early linear declines, supporting its potential as a useful new biomarker for preclinical drug testing.
Fluid Flower : Microliquid Patterning via Drop Impact
Minhee Lee,Ho-Young Kim
Physics , 2008,
Abstract: In microfluidic technologies, direct patterning of liquid without resorting to micromachined solid structures has various advantages including reduction of the frictional dissipation and the fabrication cost. This fluid dynamics video illustrates the method to micropattern a liquid on a solid surface with drop impact. We experimentally show that a water drop impacting with the wettability-patterned solid retracts fast on the hydrophobic regions while being arrested on the hydrophilic areas.
Solvent-Induced Phase-Inversion and Electrical Actuation of Dielectric Copolymer Films  [PDF]
Yeonju Jang, Toshihiro Hirai
Materials Sciences and Applications (MSA) , 2011, DOI: 10.4236/msa.2011.23023
Abstract: Block copolymers posses inherently the ability of form a variety of phase-separated microdomain structures. The lengths of block segments and the selectivity of the solvent are primary factors affecting the resultant morphology. This paper investigated the effect of casting solvents on the morphologies and electrical actuation of poly(methyl methacrylate)-poly(n-butyl acrylate)-poly(methyl methacrylate) (PMMA-PnBA-PMMA) triblock copolymer films comprising PMMA hard segment and PnBA soft segment. Transmission electron microscopy and confocal laser scanning microscopy observation revealed that PMMA and PnBA segments were assembled into various micro- and nano-sized phase structures where either of them formed continuous phase. This implies that continous phase could be inversed by used casting solvents. Solvent-dependent phase morphologies had a significant effect on the electrical actuation results. Increase of the PnBA contents and the continuous phases of PnBA soft segments improved both of electrical actuation and dielectric constant, indicating that solvent-induced phase separation modulates the electrical actuation of dielectric films. The significance of the role of solvent selectivity and the major continuous phase of the polymer in defining the morphology and electrical actuation of the self-assembled block copolymer structure are discussed.
Predictive formulas expressing relationship among dose rate, duration of exposure and mortality probability in total body irradiation in humans  [PDF]
Sung Jang Chung
Journal of Biomedical Science and Engineering (JBiSE) , 2011, DOI: 10.4236/jbise.2011.47063
Abstract: A clear and exact quantitative relationship between dose of radiation and mortality in humans is still not known because of lack of human data that would enable to determine LD50 for humans in total body irradiation. Analysis of human data has been primarily from radiation accidents, radiotherapy and the atomic bomb victims.The death rate equation derived from the 'probacent'-probability model of survival probability is employed in this study to construct the general formula of mortality probability as a function of dose rate and duration of exposure in total body irradiation in humans. There is a remarkable agreement between formula-predicted and published estimated LD50 and also between both mortality probabilities. The formulas of LD50 ans mortality probability in lethal radiation exposure for humans might be helpful in preventing radiation hazard and injury, and further for safety in radiotherapy.
Computer program of nonlinear, curved regression for ‘probacent’-probability equation in biomedicine  [PDF]
Sung Jang Chung
Journal of Biomedical Science and Engineering (JBiSE) , 2011, DOI: 10.4236/jbise.2011.49078
Abstract: On the basis of experimental observations on animals, applications to clinical data on patients and theoretical statistical reasoning, the author developed a com-puter-assisted general mathematical model of the ‘probacent’-probability equation, Equation (1) and death rate (mortality probability) equation, Equation (2) derivable from Equation (1) that may be applica-ble as a general approximation method to make use-ful predictions of probable outcomes in a variety of biomedical phenomena [1-4]. Equations (1) and (2) contain a constant, γ and c, respectively. In the pre-vious studies, the author used the least maximum- difference principle to determine these constants that were expected to best fit reported data, minimizing the deviation. In this study, the author uses the method of computer-assisted least sum of squares to determine the constants, γ and c in constructing the ‘probacent’-related formulas best fitting the NCHS- reported data on survival probabilities and death rates in the US total adult population for 2001. The results of this study reveal that the method of com-puter-assisted mathematical analysis with the least sum of squares seems to be simple, more accurate, convenient and preferable than the previously used least maximum-difference principle, and better fit-ting the NCHS-reported data on survival probabili-ties and death rates in the US total adult population. The computer program of curved regression for the ‘probacent’-probability and death rate equations may be helpful in research in biomedicine.
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