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Search Results: 1 - 10 of 137941 matches for " Min-Chuan Wang "
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A Flexible Quasi-Solid-State Electrochromic Device with Polymeric Electrolyte and WO3/NiO Complementary System  [PDF]
Jen-Yuan Wang, Min-Chuan Wang, Der-Jun Jan
Journal of Materials Science and Chemical Engineering (MSCE) , 2015, DOI: 10.4236/msce.2015.37018
Abstract:

A flexible quasi-solid-state electrochromic device (ECD), assembled with a polymeric crystal composite electrolyte and tungsten oxide/nickel oxide (WO3/NiO) complementary system, is demonstrated in this study. The polymer composite, which is composed of a UV-cured ethoxylated trimethylolpropane triacrylate (ETPTA), propylene carbonate (PC) and ferrocene (Fc), is used as the electrolyte in the flexible quasi-solid-state ECD. The optimal composition ration of this composite is at the weight ratio of 15/85 for ETPTA/PC with 1 M LiClO4. For the cathodic electrochromic electrode, a flexible polyethylene terephthalate (PET) is used as the substrate, and indium-tin- oxide (ITO) and WO3 are deposited sequentially on the PET by sputtering. A NiO/ITO/PET electrode prepared by sputtering is used as the anodic coloring electrode. The thickness of ITO, WO3 and NiO film is 110, 70 and 60 nm, respectively. This flexible all-solid-state ECD fabricated with the polymeric crystal composite electrolyte shows an optical contrast of ca. 37.5% at 550 nm. The optical transmittance of the ECD at 550 nm can be reversibly modulated from 47.5% (bleached) to 10.0% (darkened), by applying potentials of 2.5 and 2.5 V, respectively.

Retrovirus vector transfection of rat insulin gene into pancreas decrease blood glucose of diabetic rat  [PDF]
Min-Chuan Lai, Chi Yang
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.47100
Abstract:

Human and animal diabetes mellitus were controlled by a dietary treatment supplemented with either a sulfonylurea drug or insulin injection. Insulin injections were inconvenient and the hypoglycemia induced by insulin-overdose could be fatal. Sulfonylurea drugs were administered orally, however, do not typically provide satisfactory control of blood glucose as a starting treatment in 25% - 30% patients. Therefore, it was imperative to develop a method for the control of human and animal diabetes mellitus. Recently, insulin gene transferred and expressed in non-pancreatic cells as a means for the treatment of diabetes was developed rapidly in the expanding gene therapy. Retrovirus, lentivirus, adenovirus, adenoassociated virus and herpes simplex had been used as viral vectors, and the constructed viral-insulin gene was successfully transferred into diabetic rat cells. A gene, containing promoter, enhancer and rat type I insulin gene (a-chain, b-chain and signal peptide), was constructed into a retrovirus vector in the study. The constructed viral-insulin gene was transferred into mouse fibroblast cell. The insulin concentration in 3-day cultured mouse fibroblast cells was 4806.35 ± 53.72 pg/ml. The insulin concentration for the viral vector containing enhancer and promoter of rat insulin gene was higher than the vector containing only insulin gene by a 61% increase in the cultured mouse fibroblast cells. The enhancer and promoter activity of rat insulin gene would be an important determinant for the expression of insulin gene. The secreted amount of insulin by retrovirus vector contained enhancer/promoter gene in this study could achieve as high concentrations (4806.35 ± 53.72 pg/ml) as the insulin injection therapy. Blood glouse decreased sig-

nificantly for at last 10 days demonstrated that transfection, direction injection of viral-insulin gene into pancreas of diabetic rat, was successful. These studies suggest that the retrovirus vector might be used to transfer the insulin gene in vitro and in vivo.

Methylcobalamin Facilitates Collateral Sprouting of Donor Axons and Innervation of Recipient Muscle in End-to-Side Neurorrhaphy in Rats
Wen-Chieh Liao, Yueh-Jan Wang, Min-Chuan Huang, Guo-Fang Tseng
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0076302
Abstract: Using ulnar nerve as donor and musculocutaneous nerve as recipient we found earlier that end-to-side neurorrhaphy resulted in weak functional reinnervation after lengthy survival. End-to-side neurorrhaphy however is the sole choice of nerve repair at times and has the advantage of conserving donor nerve function. Here, we investigated whether myelination-enhancing agent methylcobalamin and motoneuron trophic factor pleiotrophin enhances the recovery after end-to-side neurorrhaphy. Methylcobalamin significantly increased the expression of growth associated protein 43 and S100 protein and βIII tubulin in musculocutaneous nerve 1 month after neurorrhaphy suggesting the ingrowth of ulnar axonal sprouts in reactive Schwann cell environment. Upper limb functional test, compound muscle action potential measurements, motor end plate counts, and axon and myelin analyses showed that methylcobalamin treatment alone or with pleiotrophin improved the recovery significantly, 3 and 6 months post-surgery. There were fewer axons, closer in number to that of the intact recipient nerve, found in the distal repaired nerve of the methylcobalamin-treated than that of the vehicle control, suggesting that methylcobalamin facilitates axonal maturation and eliminates supernumerary sprouts. In conclusion, our results showed that methylcobalamin does indeed enhance the recovery of peripheral nerve repaired in end-to-side configuration.
The effect of demethylasterriquinone B-1 on insulin secretion in rat pancreas  [PDF]
Min-Chuan Lai, Yu-Shan Lo, Chi Yang
Journal of Diabetes Mellitus (JDM) , 2013, DOI: 10.4236/jdm.2013.33017
Abstract:

A small nonpeptidyl compoud extracted from Pseudomassaria sp. was found to induce the activity of human insulin receptor tyrosine kinase in vitro. The compound was identified as demethylasterriquinone B-1 (DMAQ-B1). DMAQ- B1 also induced an increase in [Ca2+]i and insulin secretion in mice pancreatic beta-cells at low glucose (3 mM) concentration via insulin receptor substrate-1/phosphatidylinositol-3-kinase (PI3 kinase) pathway. By using rat pancreatic perfusion technique, we found that 10 μM DMAQ-B1 directly stimulated insulin secretion up to 240% in normal rat pancreas. In the dosage from 1 to 20 μM, DMAQ-B1 stimulated insulin secretion in a dose dependent manner. Furthermore, DMAQ-B1 enhanced glucose-induced insulin secretion by 17.6% (first stage) and 19.0% (second stage), respectively. The PI3 kinase inhibitors, LY 294002 (3.9 μM) or wortmannin (100 nM), inhibited DMAQ-B1-induced insulin secretion by 46.3% and 57.4%, respectively. LY 294002 or wortmannin also inhibited DMAQ-B1 with10 mMglucose-induced insulin secretion by 70.3% and 79.0%, respectively. All the results suggested that DMAQ-B1 directly stimulated insulin secretion and enhanced glucose-induced insulin secretion. The effect of DMAQ-B1 may mediate through the activation of PI3 kinase pathway to stimulate insulin secretion in normal rat pancreas.

FPGA-Based Reconfigurable Measurement Instruments with Functionality Defined by User
Tsai Guo-Ruey,Lin Min-Chuan
EURASIP Journal on Advances in Signal Processing , 2006,
Abstract: Using the field-programmable gate array (FPGA) with embedded software-core processor and/or digital signal processor cores, we are able to construct a hardware kernel for measurement instruments, which can fit common electronic measurement and test requirements. We call this approach the software-defined instrumentation (SDI). By properly configuring, we have used the hardware kernel to implement an -channel arbitrary waveform generator with various add-on functions, a wideband and precise network analyzer, a high-speed signal digitizer, and a real-time sweep spectrum analyzer. With adaptively reconfiguring the hardware kernel, SDI concept can easily respond to the rapidly changing user-application-specified needs in measurement and test markets.
COSMC Is Overexpressed in Proliferating Infantile Hemangioma and Enhances Endothelial Cell Growth via VEGFR2
Jian-Jr Lee, Chia-Hua Chen, Ya-Hsin Chen, Miao-Juei Huang, John Huang, Ji-Shiang Hung, Ming-Ting Chen, Min-Chuan Huang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0056211
Abstract: Infantile hemangiomas are localized lesions comprised primarily of aberrant endothelial cells. COSMC plays a crucial role in blood vessel formation and is characterized as a molecular chaperone of T-synthase which catalyzes the synthesis of T antigen (Galβ1,3GalNAc). T antigen expression is associated with tumor malignancy in many cancers. However, roles of COSMC in infantile hemangioma are still unclear. In this study, immunohistochemistry showed that COSMC was upregulated in proliferating hemangiomas compared with involuted hemangiomas. Higher levels of T antigen expression were also observed in the proliferating hemangioma. Overexpression of COSMC significantly enhanced cell growth and phosphorylation of AKT and ERK in human umbilical vein endothelial cells (HUVECs). Conversely, knockdown of COSMC with siRNA inhibited endothelial cell growth. Mechanistic investigation showed that O-glycans were present on VEGFR2 and these structures were modulated by COSMC. Furthermore, VEGFR2 degradation was delayed by COSMC overexpression and facilitated by COSMC knockdown. We also showed that COSMC was able to regulate VEGF-triggered phosphorylation of VEGFR2. Our results suggest that COSMC is a novel regulator for VEGFR2 signaling in endothelial cells and dysregulation of COSMC expression may contribute to the pathogenesis of hemangioma.
Design of occlusion pressure testing system for infusion pump  [PDF]
Peng Zhang, Shu-Yi Wang, Chuan-Yi Yu, Min-Yan Zhang
Journal of Biomedical Science and Engineering (JBiSE) , 2009, DOI: 10.4236/jbise.2009.26062
Abstract: Reliability of medical devices such as infusion pumps is extremely important because these devices are being used in patients who are in critical condition. Occlusion pressure, as an important parameter of infusion pumps, should be detected when an occlusion occurred. How-ever, infusion pumps’ occlusion pressure could not be tested and the performance of these pumps is not known to us. In order to test the occlusion pressure of infusion pump, a testing system has been put forward according to standards of IEC 60601-2-24:1998/ GB 9706.27- 2005. The system is comprised of sensor, acquisition card, three-way tap and so on; this system is controlled by a PC. At the same time, sampling rate could be changed if necessary and test time could be recorded. And then the characteristics of this system were studied, such as linear, effects of pump rates and different pumps. The system remained linear in a given environment. The higher is the pump rate, the faster is the time to reach occlusion condi-tion. The testing system has been proved to be effective in testing the occlusion pressure of infusion pumps and the accuracy error of pressure is content the demand of ±1% of range.
Quantum strategy in moving frames
Jian-Chuan Tan,An Min Wang
Physics , 2008, DOI: 10.1016/j.physleta.2008.12.032
Abstract: We investigate quantum strategy in moving frames by considering Prisoner's Dilemma and propose four thresholds of $\gamma$ for two players to determine their \textit{Nash Equilibria}. Specially, an interesting phenomenon appears in relativistic situation that the quantum feature of the game would be enhanced and diminished for different players whose particle's initial spin direction are respectively parallel and antiparallel to his/her movement direction, that is, for the former the quantum feature of the game is enhanced while for the latter the quantum feature would be diminished. Thus a classical latter could still maintain his/her strictly dominant strategy (classical strategy) even if the game itself is highly entangled.
The security of Ping-Pong protocol
Jian-Chuan Tan,An Min Wang
Physics , 2008,
Abstract: Ping-Pong protocol is a type of quantum key distribution which makes use of two entangled photons in the EPR state. Its security is based on the randomization of the operations that Alice performs on the travel photon (qubit), and on the anti-correlation between the two photons in the EPR state. In this paper, we study the security of this protocol against some known quantum attacks, and present a scheme that may enhance its security to some degree.
Combination of the Kinect with Virtual Reality in Balance Training for the Elderly  [PDF]
Wei-Min Hsieh, Chih-Chen Chen, Shih-Chuan Wang, Yu-Luen Chen, Yuh-Shyan Hwang, Jin-Shin Lai
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.510B037
Abstract:

Daily life movements such as standing, walking, and jumping need balance ability to achieve. Good balance control is closely related to the body stability and its development. According to medical research, people showing dizziness after taking drugs may have their balance ability substantially affected, and are more likely to fall, especially true to the elderly. This study proposes the combination of Kinect with virtual reality to build an information platform of interactive scenarios, for practices and evaluation on balance ability. Based on the indicators of balance ability, this platform sets out various training activities to improve the balance ability, making the supposedly boring process fun and vivid for a much better training purposes. Also, according to literatures, training with gaming patterns results in 30% reduction of falls. What’s more, this type of training can have the data, like time of use, scores, and joint postures, recorded and sent through network to databases on remote computer servers. The data collected from this platform can be sorted and analyzed, and the results can then be used to evaluate the performance of the balance training, and referenced for follow-up planning in the future.


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