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Search Results: 1 - 10 of 29446 matches for " Min Young Oh "
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Association between FGFR1OP2/wit3.0 Polymorphisms and Residual Ridge Resorption of Mandible in Korean Population
Jee Hwan Kim, Min Young Oh, Janghyun Paek, Jaehoon Lee
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0042734
Abstract: Background A previous study on the genetic association between single nucleotide polymorphisms in FGFR1OP2/wit3.0 and the long term atrophy of edentulous mandible hypothesized that the excessive jawbone atrophy after dental extraction may be associated with abnormal oral mucosa contraction induced by the FGFR1OP2/wit 3.0 gene. It was reported that the minor allele of rs840869 or rs859024 in FGFR1OP2/wit3.0 was associated with the excessive atrophy of edentulous mandible. The present study represents an attempt to replicate the results of this previous study and to examine the genetic association between polymorphisms in FGFR1OP2 and residual ridge resorption of mandible in a Korean population. Methodology/Principal Findings 134 subjects (70.46±9.02 years) with partially or completely edentulous mandible were recruited. The mandibular bone height was measured following the protocol of the American College of Prosthodontists (ACP). From 24 subjects, seven variants in FGFR1OP2 were discovered and four of them were novel. Selected SNPs that are not in high LD at r2 threshold of 0.8 were genotyped for the remaining population. There was no frequency of the minor allele of SNP rs859024 in Korean population. SNP rs840869 was not associated with residual ridge resorption (p = 0.479). The bone height of the subject with the ss518063493 minor allele (8.52 mm) was shorter than that of those subjects with major alleles (18.96±5.33 mm, p = 0.053). Conclusions/Significance The patient with minor allele of ss518063493 may be associated with excessive atrophy of edentulous mandible whereas the patients with that of rs840869 are not associated in Korean population. The result from this study may assist in developing a novel genetic diagnostic test and be useful in identifying Koreans susceptible to developing excessive jawbone atrophy after dental extraction.
Effects of Chemosignals from Sad Tears and Postprandial Plasma on Appetite and Food Intake in Humans
Tae Jung Oh, Min Young Kim, Kyong Soo Park, Young Min Cho
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0042352
Abstract: Chemosignals from human body fluids may modulate biological functions in humans. The objective of this study was to examine whether chemosignals from human sad tears and postprandial plasma modulate appetite. We obtained fasting and postprandial plasma from male participants and sad tears and saline, which was trickled below the eyelids, from female volunteers. These samples were then randomly distributed to male participants to sniff with a band-aid containing 100 μl of each fluid on four consecutive days in a double-blind fashion. We checked appetite by a visual analogue scale (VAS) and food intake by measuring the consumption of a test meal. In addition, the serum levels of total testosterone and LH were measured. Twenty men (mean age 26.3±4.6 years) were enrolled in this study. They could not discriminate between the smell of fasting and postprandial plasma and the smell of sad tears and trickled saline. Appetite and the amount of food intake were not different between the groups. Although the VAS ratings of appetite correlated with the food intake upon sniffing fasting plasma, postprandial plasma, and trickled saline, there was no such correlation upon sniffing sad tears. In addition, the decrease in serum testosterone levels from the baseline was greater with sad tears than with the trickled saline (?28.6±3.3% vs. ?14.0±5.2%; P = 0.019). These data suggest that chemosignals from human sad tears and postprandial plasma do not appear to reduce appetite and food intake. However, further studies are necessary to examine whether sad tears may alter the appetite-eating behavior relation.
Dietary preference, physical activity, and cancer risk in men: national health insurance corporation study
Young Yun, Min Lim, Young-Joo Won, Sang Park, Yoon Chang, Sang Oh, Soon Shin
BMC Cancer , 2008, DOI: 10.1186/1471-2407-8-366
Abstract: This prospective cohort study included 444,963 men, older than 40 years, who participated in a national health examination program begun in 1996. Based on the answer to the question "What kind of dietary preference do you have?" we categorized dietary preference as (1) vegetables, (2) mixture of vegetables and meat, and (3) meats. We categorized LPA as low (< 4 times/wk, < 30 min/session), moderate (2–4 times/wk, ≥ 30 min/session or ≥ 5 times/wk, < 30 min/session), or high (≥ 5 times/wk, ≥ 30 min/session). We obtained cancer incidence data for 1996 through 2002 from the Korean Central Cancer Registry. We used a standard Poisson regression model with a log link function and person-time offset to estimate incidence and relative risk..During the 6-year follow-up period, we identified 14,109 cancer cases. Multivariate analysis revealed that a preference for vegetables or a mixture of vegetables and meat as opposed to a preference for meat played a significant protective role against lung cancer incidence (aRR, 0.81; 95% confidence interval [CI], 0.68–0.98). Compared with the low LPA group, subjects with moderate-high LPA had a significantly lower risk for stomach (aRR, 0.91; 95%CI, 0.86–0.98), lung (aRR, 0.83; 95%CI, 0.75–0.92), and liver (aRR, 0.88; 95%CI, 0.81–0.95) cancer. Among current smokers, the combined moderate-high LPA and vegetable or mixture of vegetables and meat preference group showed a 40% reduced risk of lung cancer (aRR, 0.60; 95%CI, 0.47–0.76) compared with the combined low LPA and meat preference group. Among never/former smokers, subjects with moderate-high LPA and a preference for vegetables or a mixture of vegetables and meat showed reduced stomach cancer risk (aRR, 0.72; 95%CI, 0.54–0.95).Our findings add to the evidence of the beneficial effects of vegetable preference on lung cancer risk and of physical activity on lung, stomach, and liver cancer risk. Additionally, vegetable preference combined with LPA might significantly reduce lung and stom
Molecular characterization of partial-open reading frames 1a and 2 of the human astroviruses in South Korea
Jae Lee, Gyu-Cheol Lee, Young Oh, Young Lee, Min Kim, Chan Lee
Virology Journal , 2010, DOI: 10.1186/1743-422x-7-221
Abstract: Astroviruses (AstVs), belong to the Astroviridae family, are non-enveloped, single-stranded, and positive-sense RNA viruses [1]. Their genomes have both 5' and 3' non-translated regions, and contain three open reading frames (ORFs), denoted as ORF1a, ORF1b, and ORF2, which encode a serine protease, an RNA-dependent RNA polymerase, and a structural protein, respectively [1,2]. AstVs are known to infect humans as well as a variety of mammalian and avian species [3-5]. In humans, eight serotypes have been described, which have been associated with up to ~10% sporadic cases of nonbacterial diarrhea in children [6-10] and 0.5-15% outbreaks [11-13].Walter et al. (2001) analyzed the gene of AstVs and found that the ORF2 region belonged to human AstV (HAstv)-5 whereas the ORF1b region belonged to HAstV-3, and that recombination occurred between the HAstV types [14]. Besides, in some other studies, recombination was found to occur between mamastroviruses and HAstV [15]. Such recombination may result in a new epidemic HAstV because it is similar to antigen drift of influenza viruses [16-19]. Therefore, characterization of HAstVs genome is important to understand the recombination between human and mammalian AstVs, the origin of the viruses, and their molecular evolution, as well as the phylogenetic relationship among the HAstV genotypes. For this purpose, there is a need to obtain more complete genome sequences of HAstV. The complete genome sequences of seven genotypes (HAstV-1, 2, 3, 4, 5, 6, and 8) and the HAstV-7 ORF2 sequence are available [18,20-23]. In this study, the partial nucleotide sequences of ORF1a and ORF2 of HAstVs, responsible for sporadic gastroenteritis in South Korea, were obtained, and their molecular characteristics were investigated.From 2004 to 2005, stool specimens of patients suspected to have acute gastroenteritis were provided by nine hospitals located in the Seoul metropolitan area. 1 g of a stool specimen was added into 9 mL phosphate-buffered sal
Development of Three Dimensional Automatic Body Fat Measurement Software from CT, and Its Validation and Evaluation  [PDF]
Young Jae Kim, Jun Yong Jeong, Su Youn Nam, Min Ju Kim, Jae Hwan Oh, Kwang Gi Kim, Dae Kyung Sohn
Journal of Biomedical Science and Engineering (JBiSE) , 2015, DOI: 10.4236/jbise.2015.810063
Abstract: Abdominal obesity describes the accumulation of excessive fat in the abdomen. It is known that depending on its distribution, visceral obesity presents a greater danger to health than subcutaneous obesity. To properly prevent and treat visceral obesity, accurate evaluation methods are necessary, and hence quantitative VAT estimation is extremely important. CT scans are the most accurate method for estimating VAT, but it requires a great deal of time and effort, limiting its use in studying or evaluating obesity in patients. This paper proposed automatic measurement software that could quickly differentiate between and measure VAT and SAT. The method was verified using a total of 100 abdominal CT data values; this paper measured the SAT and VAT in the entire abdomen using the automatic measurement software. Additionally, through a comparative evaluation between the automated measurements and manual measurements such as BMI and waist circumference, clinical reliability and viability were validated and evaluated. Between automated measurements and manual measurements, the TAT (r = 0.995, p = 0.01), SAT (r = 0.987, p = 0.01) and VAT (r = 0.993, p = 0.01) showed high correlation. Using BMI as the main metric, the TAT for automated measurements (r = 0.674, p = 0.01) and the TAT for manual measurements (r = 0.703, p = 0.01) showed the strongest correlation. When using waist circumference, the VAT for automated measurements (r = 0.826, p = 0.01) and the VAT for manual measurements (r = 0.822, p = 0.01) showed the strongest correlation. With these results, the reliability and viability of the automatic measurement software were confirmed. The software is expected to help greatly in reducing the time and in providing objective data of VAT measurements from CT scans for clinical research.
Prediction and Experimental Validation of Novel STAT3 Target Genes in Human Cancer Cells
Young Min Oh, Jong Kyoung Kim, Yongwook Choi, Seungjin Choi, Joo-Yeon Yoo
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0006911
Abstract: The comprehensive identification of functional transcription factor binding sites (TFBSs) is an important step in understanding complex transcriptional regulatory networks. This study presents a motif-based comparative approach, STAT-Finder, for identifying functional DNA binding sites of STAT3 transcription factor. STAT-Finder combines STAT-Scanner, which was designed to predict functional STAT TFBSs with improved sensitivity, and a motif-based alignment to minimize false positive prediction rates. Using two reference sets containing promoter sequences of known STAT3 target genes, STAT-Finder identified functional STAT3 TFBSs with enhanced prediction efficiency and sensitivity relative to other conventional TFBS prediction tools. In addition, STAT-Finder identified novel STAT3 target genes among a group of genes that are over-expressed in human cancer cells. The binding of STAT3 to the predicted TFBSs was also experimentally confirmed through chromatin immunoprecipitation. Our proposed method provides a systematic approach to the prediction of functional TFBSs that can be applied to other TFs.
Production of 2,3-butanediol in Saccharomyces cerevisiae by in silico aided metabolic engineering
Chiam Yu Ng, Moo-Young Jung, Jinwon Lee, Min-Kyu Oh
Microbial Cell Factories , 2012, DOI: 10.1186/1475-2859-11-68
Abstract: We first identified gene deletion strategy by performing in silico genome-scale metabolic analysis. Based on the best in silico strategy, in which disruption of alcohol dehydrogenase (ADH) pathway is required, we then constructed gene deletion mutant strains and performed batch cultivation of the strains. Deletion of three ADH genes, ADH1, ADH3 and ADH5, increased 2,3-butanediol production by 55-fold under microaerobic condition. However, overproduction of glycerol was observed in this triple deletion strain. Additional rational design to reduce glycerol production by GPD2 deletion altered the carbon fluxes back to ethanol and significantly reduced 2,3-butanediol production. Deletion of ALD6 reduced acetate production in strains lacking major ADH isozymes, but it did not favor 2,3-butanediol production. Finally, we introduced 2,3-butanediol biosynthetic pathway from Bacillus subtilis and E. aerogenes to the engineered strain and successfully increased titer and yield. Highest 2,3-butanediol titer (2.29?g·l-1) and yield (0.113?g·g-1) were achieved by Δadh1 Δadh3 Δadh5 strain under anaerobic condition.With the aid of in silico metabolic engineering, we have successfully designed and constructed S. cerevisiae strains with improved 2,3-butanediol production.
The Functional Role of Prion Protein (PrPC) on Autophagy
Hae-Young Shin,Jae-Min Oh,Yong-Sun Kim
Pathogens , 2013, DOI: 10.3390/pathogens2030436
Abstract: Cellular prion protein (PrP C) plays an important role in the cellular defense against oxidative stress. However, the exact protective mechanism of PrP C is unclear. Autophagy is essential for survival, differentiation, development, and homeostasis in several organisms. Although the role that autophagy plays in neurodegenerative disease has yet to be established, it is clear that autophagy-induced cell death is observed in neurodegenerative disorders that exhibit protein aggregations. Moreover, autophagy can promote cell survival and cell death under various conditions. In this review, we describe the involvement of autophagy in prion disease and the effects of PrP C.
Fermentation by Lactobacillus enhances anti-inflammatory effect of Oyaksungisan on LPS-stimulated RAW 264.7 mouse macrophage cells
You-Chang Oh, Won-Kyung Cho, Jin Hui Oh, Ga Young Im, Yun Hee Jeong, Min Cheol Yang, Jin Yeul Ma
BMC Complementary and Alternative Medicine , 2012, DOI: 10.1186/1472-6882-12-17
Abstract: The investigation was focused on whether OY and fermented OYs could inhibit the production of pro-inflammatory mediators such as nitric oxide (NO) and prostaglandin (PG) E2 as well as the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, tumor necrosis factor (TNF)-α, interleukin (IL)-6, nuclear factor (NF)-κB and mitogen-activated protein kinases (MAPKs) in LPS-stimulated RAW 264.7 cells.We found that OY inhibits a little LPS-induced NO, PGE2, TNF-α and IL-6 productions as well as the expressions of iNOS and COX-2. Interestingly, the fermentation significantly increased its inhibitory effect on the expression of all pro-inflammatory mediators. Furthermore, the fermented OYs exhibited elevated inhibition on the translocation of NF-κB p65 through reduced IκBα degradation as well as the phosphorylations of extracellular signal-regulated kinase (ERK), p38 and c-Jun NH2-terminal kinase (JNK) MAPKs than untreated control or original OY.Finally, the fermentation by Lactobacillus potentiates the anti-inflammatory effect of OY by inhibiting NF-κB and MAPK activity in the macrophage cells.Oyaksungisan (OY) is a traditional herbal medication that consists of twelve herbs and is known to have anti-arthralgia, anti-paralysis and anti-dizziness effects. Since ancient times, OY has been widely used as a traditional medication in Asian countries. More specifically, it has been prescribed for the treatment of beriberi, vomiting, diarrhea and circulatory disturbance.Recent studies have demonstrated that OY inhibits the adjuvant arthritis in rat [1] and OY has neuroprotective activity [2]. It was also reported that OY exerts the protective effect against H2O2-induced apoptosis [3] and other studies have revealed the anti-inflammatory effect in peripheral blood mononuclear cells from cerebral infarction patients [4]. However, the effect and mechanism of OY or fermented OYs on macrophage-mediated inflammation still remain unknown.The fermented plant products
SHP-1 Regulation of Mast Cell Function in Allergic Inflammation and Anaphylaxis
Li Zhou, Sun Young Oh, Yuqi Zhou, Baojun Yuan, Fan Wu, Min Hee Oh, Yefu Wang, Cliff Takemoto, Nico Van Rooijen, Tao Zheng, Zhou Zhu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0055763
Abstract: Allergic inflammation and severe allergic reactions (anaphylaxis) are important in allergen induced diseases. Bacterial products such as lipopolysaccharide (LPS) are ubiquitous and can facilitate allergen induced Th2 immune responses. Phosphatase SHP-1 is critical in regulating immunological homeostasis and in allergen induced Th2 immune responses in the lung. However, the mechanisms underlying the initiation of allergic inflammation and allergen induced anaphylaxis are still not completely elucidated and it is unclear whether SHP-1 plays any role in LPS-induced airway inflammation and in allergen-induced anaphylaxis. In this study we tested the hypothesis that phosphatase SHP-1 plays an important role in allergic inflammation and anaphylaxis and determined whether its effects are through regulation of mast cell functions. SHP-1 deficient (mev/+ and mev/mev) and mast cell deficient (KitW-sh) mice were examined in their responses to LPS airway stimulation and to ovalbumin (OVA) allergen induced systemic anaphylaxis. Compared to wild type mice, mev/+ mice had significantly enhanced LPS induced airway inflammation and OVA induced anaphylactic responses, including hypothermia and clinical symptoms. These changes were mast cell dependent as KitW-sh mice had reduced responses whereas adoptive transfer of mast cells restored the responses. However, T and B cells were not involved and macrophages did not play a significant role in LPS induced airway inflammation. Interestingly, basophil differentiation from SHP-1 deficient bone marrow cells was significantly reduced. These findings provided evidence that through regulation of mast cell functions SHP-1 plays a critical role as a negative regulator in allergic inflammation and in allergen induced anaphylaxis. In addition, SHP-1 seems to be required for normal basophil development.
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