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Search Results: 1 - 10 of 22432 matches for " Min Seong Jang "
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Modeling and Simulation of Fiber Orientation in Injection Molding of Polymer Composites
Jang Min Park,Seong Jin Park
Mathematical Problems in Engineering , 2011, DOI: 10.1155/2011/105637
Abstract: We review the fundamental modeling and numerical simulation for a prediction of fiber orientation during injection molding process of polymer composite. In general, the simulation of fiber orientation involves coupled analysis of flow, temperature, moving free surface, and fiber kinematics. For the governing equation of the flow, Hele-Shaw flow model along with the generalized Newtonian constitutive model has been widely used. The kinematics of a group of fibers is described in terms of the second-order fiber orientation tensor. Folgar-Tucker model and recent fiber kinematics models such as a slow orientation model are discussed. Also various closure approximations are reviewed. Therefore, the coupled numerical methods are needed due to the above complex problems. We review several well-established methods such as a finite-element/finite-different hybrid scheme for Hele-Shaw flow model and a finite element method for a general three-dimensional flow model. 1. Introduction Short fiber reinforced polymer composites are widely used in manufacturing industries due to their light weight and enhanced mechanical properties. The short fiber composite products are commonly manufactured by injection molding, compression molding, and extrusion processes. During those processes, the fibers orient themselves due to the flow and interactions between neighboring fibers and/or cavity wall. This orientation is anisotropic in general, which results in an anisotropic property of final products. Thus, the prediction of the fiber orientation during the process has been the subject of considerable amount of research during past decades. The injection molding process is a well-established mass-production method for polymeric materials. In this process, the molten polymer or polymer composite is injected into a mold cavity, which is namely a filling stage. After cooling the polymer material inside the mold, the final product is ejected from the mold. The overall processing time is usually less than one minute, and a complex three-dimensional shape can be produced quite easily. In the injection molding of short fiber polymer composites, the fiber orientation develops during the filling stage of the process. In this paper, we review the modeling and simulation of fiber orientation during injection molding filling stage. The prediction of fiber orientation in injection molding involves two subjects of fiber orientation simulation and injection molding simulation. In this paper, we give more attentions in the first subject of the fiber orientation while the later one is rather
Parasitic Nematode-Induced CD4+Foxp3+T Cells Can Ameliorate Allergic Airway Inflammation
Shin Ae Kang,Mi-Kyung Park,Min Kyoung Cho,Sang Kyun Park,Min Seong Jang,Bo-Gie Yang,Myoung Ho Jang,Dong-Hee Kim,Hak Sun Yu
PLOS Neglected Tropical Diseases , 2014, DOI: 10.1371/journal.pntd.0003410
Abstract: Background The recruitment of CD4+CD25+Foxp3+T (Treg) cells is one of the most important mechanisms by which parasites down-regulate the immune system. Methodology/Principal Findings We compared the effects of Treg cells from Trichinella spiralis-infected mice and uninfected mice on experimental allergic airway inflammation in order to understand the functions of parasite-induced Treg cells. After four weeks of T. spiralis infection, we isolated Foxp3-GFP-expressing cells from transgenic mice using a cell sorter. We injected CD4+Foxp3+ cells from T. spiralis-infected [Inf(+)Foxp3+] or uninfected [Inf(-)Foxp3+] mice into the tail veins of C57BL/6 mice before the induction of inflammation or during inflammation. Inflammation was induced by ovalbumin (OVA)-alum sensitization and OVA challenge. The concentrations of the Th2-related cytokines IL-4, IL-5, and IL-13 in the bronchial alveolar lavage fluid and the levels of OVA-specific IgE and IgG1 in the serum were lower in mice that received intravenous application of Inf(+)Foxp3+ cells [IV(inf):+(+) group] than in control mice. Some features of allergic airway inflammation were ameliorated by the intravenous application of Inf(-)Foxp3+ cells [IV(inf):+(-) group], but the effects were less distinct than those observed in the IV(inf):+(+) group. We found that Inf(+)Foxp3+ cells migrated to inflammation sites in the lung and expressed higher levels of Treg-cell homing receptors (CCR5 and CCR9) and activation markers (Klrg1, Capg, GARP, Gzmb, OX40) than did Inf(-)Foxp3+ cells. Conclusion/Significance T. spiralis infection promotes the proliferation and functional activation of Treg cells. Parasite-induced Treg cells migrate to the inflammation site and suppress immune responses more effectively than non-parasite-induced Treg cells. The adoptive transfer of Inf(+)Foxp3+ cells is an effective method for the treatment and prevention of allergic airway diseases in mice and is a promising therapeutic approach for the treatment of allergic airway diseases.
The association of 18F-deoxyglucose (FDG) uptake of PET with polymorphisms in the glucose transporter gene (SLC2A1) and hypoxia-related genes (HIF1A, VEGFA, APEX1) in non-small cell lung cancer. SLC2A1 polymorphisms and FDG-PET in NSCLC patients
Seong-Jang Kim, Sang-Hyun Hwang, In Joo Kim, Min Ki Lee, Chang Hun Lee, Sang-Yull Lee, Eun Yup Lee
Journal of Experimental & Clinical Cancer Research , 2010, DOI: 10.1186/1756-9966-29-69
Abstract: We investigated the association between solute carrier family 2 (facilitated glucose transporter), member 1 -2841A>T, hypoxia-inducible factor 1 alpha Pro582Ser, Ala588Thr, apurinic/apyimidinic endonuclease Asp148Glu, or vascular endothelial growth factor A +936C>T and 2-[fluorine-18]-fluoro-2-deoxy-D-glucose-uptake among 154 patients with non-small-cell lung cancer.The solute carrier family 2 (facilitated glucose transporter), member 1 -2841A>T polymorphism was significantly associated with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose-uptake in combination with the apurinic/apyimidinic endonuclease Asp148Glu (T>G) polymorphism in the squamous cell type of non-small-cell lung cancer. The solute carrier family 2 (facilitated glucose transporter), member 1 TT genotype had a higher maximum standardized uptake values than the AA + AT genotype when the apurinic/apyimidinic endonuclease genotype was TT (mean maximum standardized uptake values, 12.47 ± 1.33 versus 8.46 ± 2.90, respectively; P = 0.028). The mean maximum standardized uptake values were not statistically different with respect to vascular endothelial growth factor A and hypoxia-inducible factor 1 alpha polymorphisms.A glucose transporter gene polymorphism was shown to be statistically associated with glucose-uptake when the apurinic/apyimidinic endonuclease genotype is TT in patients with the squamous cell type of non-small-cell lung cancer. Our findings suggest that a newly developed tracer for positron emission tomography could be affected by genetic polymorphisms.Positron emission tomography (PET) imaging of malignant tumors with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) as a tracer (FDG uptake depends on glucose uptake) is a non-invasive diagnostic, and prognostic tool that measures tumor metabolism. FDG-PET has been shown to have the ability to diagnose disease. Moreover, FDG-PET is used for treatment planning and is used to evaluate the response to therapy [1]. The SLC2A1 (also called glucose transport
Ulmus davidiana var. japonica Nakai Upregulates Eosinophils and Suppresses Th1 and Th17 Cells in the Small Intestine
Han-Sung Lee, Min Seong Jang, Jung-Hwan Kim, Chun-Pyo Hong, Eun-Jung Lee, Eun Ji Jeun, Chan Kim, Eun-Kyung Kim, Kwang-Seong Ahn, Bo-Gie Yang, Kwang Seok Ahn, Young Pyo Jang, Kyoo-Seok Ahn, You-Me Kim, Myoung Ho Jang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0076716
Abstract: The bark of Ulmus davidiana var. japonica Nakai (Ulmaceae) has been used in traditional Korean medicine for chronic inflammation in the gastrointestinal tract. Here we investigated the frequency and cytokine profile of the major immune cells in the small intestinal lamina propria (SI LP), spleen, and mesenteric lymph nodes (MLNs) of mice treated orally with Ulmus davidiana var. japonica Nakai bark water extract (UDE) to address the immunomodulatory role of this herb in intestinal homeostasis. B6 mice were given 5g/kg UDE once daily for 14 days. They were then sacrificed, and cells were isolated from the spleen, MLNs, and SI LP. The proportion of B versus T lymphocytes, CD4+ versus CD8+ T lymphocytes, Th1 and Th17 cells, and Foxp3+ regulatory T cells in the spleen, MLNs, and SI LP were analyzed. The frequency of antigen-presenting cells (APCs), including dendritic cells, macrophages, and eosinophils in the SI LP and the expression of costimulatory molecules on APCs were also evaluated. The numbers and frequencies of Th1 and Th17 cells in the SI LP were significantly reduced in the UDE-treated mice compared with PBS controls. In addition, the proportion of IL-4-producing eosinophils in the SI LP was significantly elevated in the UDE-treated mice compared with controls. Taken together, these data indicate that UDE up-regulates the number and frequency of SI LP eosinophils, which can down-regulate the Th1 and Th17 responses via IL-4 secretion and contribute to intestinal homeostasis.
Clinical significances of preoperative serum interleukin-6 and C-reactive protein level in operable gastric cancer
Do-Kyong Kim, Sung Oh, Hyuk-Chan Kwon, Suee Lee, Kyung A Kwon, Byung Kim, Seong-Geun Kim, Sung-Hyun Kim, Jin Jang, Min Kim, Kyeong Kim, Jin-Yeong Han, Hyo-Jin Kim
BMC Cancer , 2009, DOI: 10.1186/1471-2407-9-155
Abstract: A total of 115 patients who underwent gastrectomy were enrolled in this study. Serum levels of IL-6 were assessed via Enzyme-Linked Immuno-Sorbent Assay (ELISA), and CRP was measured via immunoturbidimetry. Histological findings included tumor size, depth of tumor invasion, lymph node (LN) metastasis, and TNM stage (6th AJCC Stage Groupings: The staging systems; Primary tumor, regional LN, metastasis).Increases in cancer invasion and staging are generally associated with increases in preoperative serum IL-6 levels. IL-6 and CRP levels were correlated with invasion depth (P < 0.001, P = 0.001), LN metastasis (P < 0.001, P = 0.024) and TNM stage (P < 0.001, P < 0.001). The presence of peritoneal seeding metastasis is associated with IL-6 levels (P = 0.012). When we established the cutoff value for IL-6 level (6.77 pg/dL) by ROC curve, we noted significant differences in time to progression (TTP; P < 0.001) and overall survival (OS; P = 0.010). However, CRP evidenced no significance with regard to patients' TTP and OS levels. Serum IL-6 levels were correlated positively with CRP levels (r2 = 0.049, P = 0.018).Preoperative serum IL-6 and CRP levels might be markers of tumor invasion, LN metastasis, and TNM stage. Preoperative high IL-6 levels were proposed as a poor prognostic factor for disease recurrence and overall survival in patients with gastric cancers.Interleukin-6 (IL-6) is a multi-poietic cytokine that induces the growth and differentiation of immune cells, the production and expression of other cytokines, and acute-phase protein synthesis. IL-6 also exerts several effects on cancer cells [1,2].In cancer, IL-6 is generally known to be involved in host defense mechanisms. IL-6 binds to the IL-6 receptor, activates the Janus kinase (JAK), and subsequently phosphorylates the signal transducers and activators of transcription (STAT). The phosphorylated STAT gene translocates into the nucleus and activates the target gene (JAK/STAT) pathway. Suppressor of cytokine
Prevalence of human papillomavirus infection and genotype distribution among high-risk Korean women for prospecting the strategy of vaccine development
Jee Eun Rhee, Mi Yeong Shin, Choong Mo Kim, Hye Young Kee, Jae Keun Chung, Sang-Kee Min, Seong-Joon Kim, Dai-Ho Jang, Sung Soon Kim, Byeong-Sun Choi
Virology Journal , 2010, DOI: 10.1186/1743-422x-7-201
Abstract: Infection with certain types of human papillomavirus (HPV) is recognized as a causal and necessary factor for developing cervical cancer [1,2], which is the fourth of the most common cancer in South Korean women [3]. More than 140 different HPV genotypes have been characterized and approximately 50 of these genotypes are known to infect the genital tract and be oncogenic or high-risk (HR) types (HPV-16, -18, -31, -33, -35, -39, -45, -51, -52, -56, -58, -59, -66 and -68). HR genotypes are significantly associated with progression to invasive cervical cancer [2,4]. Therefore, assessment of the HPV genotypic spectrum among sexually active women is important for predicting public health problems such as the risks of developing cervical intraepithelial neoplasia and cervical cancer [5,6].HPV-16, the most common HR type, is detected in 50 - 60% of high-grade squamous intraepithelial lesions and invasive cervical cancers and HPV-18 is followed by an incidence of 10 - 20% [4,7]. Thus, HPV-16 and -18 are considered as the types responsible for causing most cervical cancers in many countries [4,7]. Clinical trials have reported that these vaccines can protect many uninfected women from developing precancerous cervical lesions caused by HPV-16 and -18 [8,9]. In spite of their high effectiveness to reduce the incidence of cervical cancer, the usefulness of these vaccines is still being debated because of the differences in the geographical distribution of HPV genotypes [10].Vaccines against HPV-16 and -18 have been developed to help the prevention of cervical cancer and the use of Merck's Gardasil (the quadrivalent vaccine for HPV-6, -11, -16 and -18) and GSK's Cervarix (the bivalent vaccine for HPV-16 and -18) have been licensed by the Korea Food and Drug Administration. Population-based study for the distribution of HPV genotype is needed to predict how much these vaccines might influence to the prevention of cervical cancer.In the present study, the prevalence and distributi
Porous Polyimide Membranes Prepared by Wet Phase Inversion for Use in Low Dielectric Applications
Soohyun Kim,Keon-Soo Jang,Hee-Dok Choi,Seung-Hoon Choi,Seong-Ji Kwon,Il-Doo Kim,Jung Ah Lim,Jae-Min Hong
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms14058698
Abstract: A wet phase inversion process of polyamic acid (PAA) allowed fabrication of a porous membrane of polyimide (PI) with the combination of a low dielectric constant (1.7) and reasonable mechanical properties (Tensile strain: 8.04%, toughness: 3.4 MJ/m 3, tensile stress: 39.17 MPa, and young modulus: 1.13 GPa), with further thermal imidization process of PAA. PAA was simply synthesized from purified pyromellitic dianhydride (PMDA) and 4,4-oxydianiline (ODA) in two different reaction solvents such as γ-butyrolactone (GBL) and N-methyl-2-pyrrolidinone (NMP), which produce M w/PDI of 630,000/1.45 and 280,000/2.0, respectively. The porous PAA membrane was fabricated by the wet phase inversion process based on a solvent/non-solvent system via tailored composition between GBL and NMP. The porosity of PI, indicative of a low electric constant, decreased with increasing concentration of GBL, which was caused by sponge-like formation. However, due to interplay between the low electric constant (structural formation) and the mechanical properties, GBL was employed for further exploration, using toluene and acetone vs. DI-water as a coagulation media. Non-solvents influenced determination of the PAA membrane size and porosity. With this approach, insight into the interplay between dielectric properties and mechanical properties will inform a wide range of potential low-k material applications.
Phylogenetic Analysis of a Swine Influenza A(H3N2) Virus Isolated in Korea in 2012
Jin Il Kim, Ilseob Lee, Sehee Park, Sangmoo Lee, Min-Woong Hwang, Joon-Yong Bae, Jun Heo, Donghwan Kim, Seok-Il Jang, Kabsu Kim, Man-Seong Park
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0088782
Abstract: Influenza A virus (IAV) can infect avian and mammalian species, including humans. The genome nature of IAVs may contribute to viral adaptation in different animal hosts, resulting in gene reassortment and the reproduction of variants with optimal fitness. As seen again in the 2009 swine-origin influenza A H1N1 pandemic, pigs are known to be susceptible to swine, avian, and human IAVs and can serve as a ‘mixing vessel’ for the generation of novel IAV variants. To this end, the emergence of swine influenza viruses must be kept under close surveillance. Herein, we report the isolation and phylogenetic study of a swine IAV, A/swine/Korea/PL01/2012 (swPL01, H3N2 subtype). After screening nasopharyngeal samples from pigs in the Gyeongsangnam-do region of Korea from December 2011 to May 2012, we isolated the swPL01 virus and sequenced its all of 8 genome segments (polymerase basic 2, PB2; polymerase basic 1, PB1; polymerase acidic, PA; hemagglutinin, HA; nucleocapsid protein, NP; neuraminidase, NA; matrix protein, M; and nonstructural protein, NS). The phylogenetic study, analyzed with reference strains registered in the National Center for Biotechnology Information (NCBI) database, indicated that the swPL01 virus was similar to the North American triple-reassortant swine strains and that the HA gene of the swPL01 virus was categorized into swine H3 cluster IV. The swPL01 virus had the M gene of the triple-reassortant swine H3N2 viruses, whereas that of other contemporary strains in Korea was transferred from the 2009 pandemic H1N1 virus. These data suggest the possibility that various swine H3N2 viruses may co-circulate in Korea, which underlines the importance of a sustained surveillance system against swine IAVs.
Motor-Evoked Potential Confirmation of Functional Improvement by Transplanted Bone Marrow Mesenchymal Stem Cell in the Ischemic Rat Brain
Dong-Kyu Jang,Sang-In Park,Young-Min Han,Kyung-Sool Jang,Moon-Seo Park,Young-An Chung,Min-Wook Kim,Lee-So Maeng,Pil-Woo Huh,Do-Sung Yoo,Seong-Whan Jung
Journal of Biomedicine and Biotechnology , 2011, DOI: 10.1155/2011/238409
Abstract: This study investigated the effect of bone marrow mesenchymal stem cells (BMSCs) on the motor pathway in the transient ischemic rat brain that were transplanted through the carotid artery, measuring motor-evoked potential (MEP) in the four limbs muscle and the atlantooccipital membrane, which was elicited after monopolar and bipolar transcortical stimulation. After monopolar stimulation, the latency of MEP was significantly prolonged, and the amplitude was less reduced in the BMSC group in comparison with the control group (<.05). MEPs induced by bipolar stimulation in the left forelimb could be measured in 40% of the BMSC group and the I wave that was not detected in the control group was also detected in 40% of the BMSC group. Our preliminary results imply that BMSCs transplanted to the ischemic rat brain mediate effects on the functional recovery of the cerebral motor cortex and the motor pathway.
AM-FM Interference Excision in Spread Spectrum Communications via Projection Filtering
Patrick J. Loughlin,Seong-Cheol Jang
EURASIP Journal on Advances in Signal Processing , 2001, DOI: 10.1155/s1687617201000257
Abstract: Recently, Amin et al. introduced a projection filtering method for excising constant amplitude FM jammers from DSSS communications, with minimal distortion to the PN sequence. In this paper, we show that this approach can be applied to AM-FM jammers as well, with a simple modification. Theoretical performance measures (correlator SNR) of the AM-FM projection method are derived, and demonstrate that near ideal performance is achieved for unbiased estimates of the jammer parameters. Results showing the effects of estimation errors in the AM and FM of the jammer on SNR are also provided. In general, FM errors cause greater performance degradation than the same level of error in estimating the AM.
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