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Search Results: 1 - 10 of 27866 matches for " Min Cui "
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Research on Video on Demand Based on P2P Network  [PDF]
Min Cui
Intelligent Information Management (IIM) , 2010, DOI: 10.4236/iim.2010.25041
Abstract: A P2P approaches to extend the ability of Video on Demand systems to serve more users. In the proposed system users share with each other the media data obtained and the media server is no longer the only source to get data from, thereby, the load on the media server could be greatly alleviated and the overall system capacity increases and more users could be served. The P2P streaming system introduces efficient searching; data transfer dynamically monitoring and initial buffering to maintain a high quality of playback. Its provider selection policy helps to reduce the load of the underlying network by avoiding remote data transfer.
Literature Review on Product Distinctiveness Evaluation and Consumer Choice Based on Need for Uniqueness  [PDF]
Min Gao, Bingqun Cui
American Journal of Industrial and Business Management (AJIBM) , 2016, DOI: 10.4236/ajibm.2016.67079
Abstract: Product distinctiveness evaluation based on need for uniqueness is a fundamental psychological process in consumer choice, and researchers have found some results about it. From product feature comparison perspective, this article arranges these influence factors and establishes the structural system of consumer evaluation for product distinctiveness, and summarizes the researches achievements in this field.
Possible Metformin-Induced Toe Nails Disorder  [PDF]
Min Lu, Ying Zhou, Yimin Cui
Pharmacology & Pharmacy (PP) , 2013, DOI: 10.4236/pp.2013.43039
Abstract:

The aim of this article was to report a case of toe nails disorder associated with metformin use in an elderly patient with type2diabetes. Two years ago, after receiving metformin 0.5 g three times daily for 6 months, a 60-year-old Chinese man found his ten toe nails gradually thickened and yellowed (especially two thumbs). The symptoms improved and recovered after metformin discontinuance. Half year ago, metformin 0.5 g three times daily adopted again and toe nails disorder occurred again. Physician modified the therapy plan and replaced metformin with acarbose to control blood glucose level of this patient. According to the follow up 3 months after his discharge, ten toe nails recovered significantly and new parts of the nails were normal. Nail disorder was rarely reported in the worldwide, but the physicians should keep awareness of this adverse drug reaction (ADR), proper actions should be taken once it occurred to avoid unnecessary suffering of the patient.

Diverse Chromatin Remodeling Genes Antagonize the Rb-Involved SynMuv Pathways in C. elegans
Mingxue Cui,E. Bridget Kim,Min Han
PLOS Genetics , 2006, DOI: 10.1371/journal.pgen.0020074
Abstract: In Caenorhabditis elegans, vulval cell-fate specification involves the activities of multiple signal transduction and regulatory pathways that include a receptor tyrosine kinase/Ras/mitogen-activated protein kinase pathway and synthetic multivulva (SynMuv) pathways. Many genes in the SynMuv pathways encode transcription factors including the homologs of mammalian Rb, E2F, and components of the nucleosome-remodeling deacetylase complex. To further elucidate the functions of the SynMuv genes, we performed a genome-wide RNA interference (RNAi) screen to search for genes that antagonize the SynMuv gene activities. Among those that displayed a varying degree of suppression of the SynMuv phenotype, 32 genes are potentially involved in chromatin remodeling (called SynMuv suppressor genes herein). Genetic mutations of two representative genes (zfp-1 and mes-4) were used to further characterize their positive roles in vulval induction and relationships with Ras function. Our analysis revealed antagonistic roles of the SynMuv suppressor genes and the SynMuv B genes in germline-soma distinction, RNAi, somatic transgene silencing, and tissue specific expression of pgl-1 and the lag-2/Delta genes. The opposite roles of these SynMuv B and SynMuv suppressor genes on transcriptional regulation were confirmed in somatic transgene silencing. We also report the identifications of ten new genes in the RNAi pathway and six new genes in germline silencing. Among the ten new RNAi genes, three encode homologs of proteins involved in both protein degradation and chromatin remodeling. Our findings suggest that multiple chromatin remodeling complexes are involved in regulating the expression of specific genes that play critical roles in developmental decisions.
Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegans.
Cui Mingxue,Kim E Bridget,Han Min
PLOS Genetics , 2006,
Abstract: In Caenorhabditis elegans, vulval cell-fate specification involves the activities of multiple signal transduction and regulatory pathways that include a receptor tyrosine kinase/Ras/mitogen-activated protein kinase pathway and synthetic multivulva (SynMuv) pathways. Many genes in the SynMuv pathways encode transcription factors including the homologs of mammalian Rb, E2F, and components of the nucleosome-remodeling deacetylase complex. To further elucidate the functions of the SynMuv genes, we performed a genome-wide RNA interference (RNAi) screen to search for genes that antagonize the SynMuv gene activities. Among those that displayed a varying degree of suppression of the SynMuv phenotype, 32 genes are potentially involved in chromatin remodeling (called SynMuv suppressor genes herein). Genetic mutations of two representative genes (zfp-1 and mes-4) were used to further characterize their positive roles in vulval induction and relationships with Ras function. Our analysis revealed antagonistic roles of the SynMuv suppressor genes and the SynMuv B genes in germline-soma distinction, RNAi, somatic transgene silencing, and tissue specific expression of pgl-1 and the lag-2/Delta genes. The opposite roles of these SynMuv B and SynMuv suppressor genes on transcriptional regulation were confirmed in somatic transgene silencing. We also report the identifications of ten new genes in the RNAi pathway and six new genes in germline silencing. Among the ten new RNAi genes, three encode homologs of proteins involved in both protein degradation and chromatin remodeling. Our findings suggest that multiple chromatin remodeling complexes are involved in regulating the expression of specific genes that play critical roles in developmental decisions.
Missile Fault Detection Based on Linear Parameter Varying Fault Detection Filter
Cui Yu,Huang Xin Han,Wang Min
Information Technology Journal , 2009,
Abstract: Focusing on the problem of fault detection and isolation (FDI) for a missile in the cruise phase, a solution based on Linear Parameter Varying (LPV) Fault Detection Filter (FDF) is proposed. The missile LPV model incorporating faults is established and converted to a suitable form for the appliance of LPV, FDI via simplifying and other tools. Based on that, a fault detection system of missile is proposed for fault detection and isolation, of which the LPV filter bank can be designed using standard geometrical approach. Simulation results demonstrate that the designed fault detection system will alarm in a short time once faults happen and then locate the fault part correctly. Since the designed fault detection system is suitable for the high maneuverability of the missile and the on-line calculation load is small, the solution is of great practical value.
Preliminary assay of β-amyloid binding elements in heart-beneficial recipe
Min CHENG,Cui-qing ZHU
Zhong Xi Yi Jie He Xue Bao , 2008,
Abstract: Objective: To explore whether there are β-amyloid protein (Aβ) binding elements in heart-beneficial recipe (HBR, a compound traditional Chinese herbal medicine), which can ameliorate the cytotoxicity of Aβ.Methods: The extract of HBR and Aβ1-40 were co-precipitated, and the Aβ1-40 in pellets was detected by immunoblotting. Affi-gel-Aβ1-40 was constructed, and Affi-gel-Aβ1-40 affinity elements from the extract of HBR were analyzed by high-performance liquid chromatography (HPLC). The assay of lactic dehydrogenase (LDH) release from the primary cultured rat cortex neurons was used to evaluate the cytotoxicity of Aβ1-42, and the protection effects of the HBR serum and the Affi-gel-Aβ1-40 treated HBR serum. Results: Immunoblotting examination showed Aβ1-40 could be co-precipitated with components of HBR following co-incubation, and the amount of Aβ1-40 within pellets decreased when the HBR extract was diluted. Aβ1-40 affinity elements from the extract of HBR, eluted from Affi-gel-Aβ1-40 by glycine solution (pH=2.5), could be detected by HPLC-fluorescent detector system. The analysis of LDH release showed that exposure of neurons to 5 μmol/L Aβ1-42 for 48 h caused a significant increase of LDH release in either a serum free or 10% serum contained culture condition (P<0.01). The rat HBR serum was able to suppress Aβ1-42 induced LDH release (P<0.05), whereas Affi-gel-Aβ1-40 treated HBR serum still maintained the ability to attenuate Aβ1-42 induced LDH release although the effect was somewhat decreased compared with Affi-gel treated HBR serum. Conclusion: There are Aβ affinity components in HBR, which could not increase the Aβ cytotoxicity, but might be able to inhibit the cytotoxicity of Aβ. The results implied that the exploration of Aβ affinity elements from Chinese medicinal recipe which is effective for Alzheimer disease, might be an important direction in Alzheimer disease therapeutic research area.
The Safety and Tolerance of Herbal Anti-Angina Drug Compound Danshen Droplet Pill in Healthy Volunteers  [PDF]
Ying Zhou, Yimin Cui, Xia Zhao, Yong Huo, Zhaohong Nie, Min Zhao, Zhixin Guo, He Sun
Pharmacology & Pharmacy (PP) , 2013, DOI: 10.4236/pp.2013.46071
Abstract: Background: Compound Salvia Pellet (T89), consisting of Danshen (salvia miltiorrhiza), Sanqi (panax notoginseng), and Borneol (Cinnamomum camphora), has been used worldwide for 14 years for chronic angina treatment. Purpose: A dose escalation study to determine the maximum tolerance dose (MTD) in Chinese population to support a proposed dose regimen change. Methods: Forty-six participants (age 18 to 45 yrs, male to female ratio = 1:1) were divided into a series of 6 patients cohorts, and sequentially assigned into one of the escalating dose groups, starting from 540 mg, the clinical doses, until 4 out of 6 subjects experience clinical Adverse Events (AEs) or when the pre-defined 3510 mg dose level is reached and completed. All doses were given orally as a single dose 2 hours after breakfast. Adverse events, vital signs, 12-lead ECG, clinical and laboratory parameters and medical evaluation were conducted as outcome measures. Results: Study completed at the highest pre-defined dose level of 3510 mg dose as never had 4/6 of subject experience AEs in any dose levels studied. All participants completed the study and data were included in the safety analysis. The only moderate AE observation (muscle damage) was observed at 2970 mg dose and was recovered without any medical treatment, and all other AEs (ECG, dizziness, muscle damage) were mild and may (5 cases) or may not (9 cases) be related to testing drug and were all self-resolved within 30 min after dose. Conclusion: Given as single oral dose, Compound Salvia Pellet is safe and well-tolerated up to the 3510 mg studied. The MTD value of Compound Salvia Pellet is unknown from this trial and must be higher than 3510 mg, 13 times higher than its current clinical dose.
Ordering-sensitive and Semantic-aware Topic Modeling
Min Yang,Tianyi Cui,Wenting Tu
Computer Science , 2015,
Abstract: Topic modeling of textual corpora is an important and challenging problem. In most previous work, the "bag-of-words" assumption is usually made which ignores the ordering of words. This assumption simplifies the computation, but it unrealistically loses the ordering information and the semantic of words in the context. In this paper, we present a Gaussian Mixture Neural Topic Model (GMNTM) which incorporates both the ordering of words and the semantic meaning of sentences into topic modeling. Specifically, we represent each topic as a cluster of multi-dimensional vectors and embed the corpus into a collection of vectors generated by the Gaussian mixture model. Each word is affected not only by its topic, but also by the embedding vector of its surrounding words and the context. The Gaussian mixture components and the topic of documents, sentences and words can be learnt jointly. Extensive experiments show that our model can learn better topics and more accurate word distributions for each topic. Quantitatively, comparing to state-of-the-art topic modeling approaches, GMNTM obtains significantly better performance in terms of perplexity, retrieval accuracy and classification accuracy.
High Body Mass Has No Effect on Cellular and Innate Immunity in Siberian Hamsters (Phodopus sungorus)  [PDF]
Yufen Tian, Mengmeng Chen, Xiangdi Cui, Min Du, Qiuli Yu, Xiaokai Hu, Deli Xu
Natural Science (NS) , 2017, DOI: 10.4236/ns.2017.97023
Abstract: Body mass is considered to be related with immune function in animals. Our aim was to test the hypothesis that cellular and innate immunity would be suppressed in high body mass of Siberian hamsters (Phodopus sungorus). Six heavier (high body mass, HBM) and six lighter (low body mass, LBM) hamsters were selected from 28 male hamsters. Body mass, body fat mass, wet spleen mass and blood glucose levels were significantly higher in the HBM group than in the LBM group. However, phytohaemagglutinin response, serum bacteria killing capacity and white blood cells did not differ between the two groups, suggesting cellular and innate immunity was?not impaired in high body mass of hamsters. There was no correlation between cellular, innate immunity and body mass, body fat mass and glucose levels, suggesting cellular and innate immunity was?not suppressed by higher body mass, body fat mass and glucose levels. In summary, cellular and innate immunity was not impaired in the HBM hamsters compared with the LBM hamsters.
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