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Search Results: 1 - 10 of 6861 matches for " Milton;Gil "
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Topical anti-inflammatory activity of Calea prunifolia HBK (Asteraceae) in the TPA model of mouse ear inflammation
Gómez, Milton;Gil, Juan F.;
Journal of the Brazilian Chemical Society , 2011, DOI: 10.1590/S0103-50532011001200021
Abstract: phytochemical study of calea prunifolia hbk identified two compounds derived from p-hydroxyacetophenone, the 1-(2-hydroxy-5-(1-methoxyethyl)phenyl)-3-methylbut-2 -en-1-one showed a satisfactory anti-inflammatory activity (58.33%), when considering that this is a natural product. although the two derived compounds are structurally similar, the anti-inflammatory activity of 1-(2-hydroxy-5-methoxyphenyl)-3-methylbut-2-en-1-one was not significant (2.08%). the test was conducted in a model of inflammation induced by topical application of 12-o-tetradecanoylphorbol-13-acetate (tpa) in the ear of mice. the positive control was tested with indomethacin and the negative control was done only with vehicle. these results allow the identification of a pharmacophore group that through molecular modeling studies and organic synthesis can result in compounds with improved anti-inflammatory activity.
Training Needs of International Medical Graduates [IMGs] in Psychiatry  [PDF]
Milton Kramer
Open Journal of Psychiatry (OJPsych) , 2014, DOI: 10.4236/ojpsych.2014.44036
Abstract: The potential shortage of psychiatrists over the next 5 - 10 years has focused attention on the need to recruit more IMGs to fill the needs rather than use nurse practitioners or physician assistants. IMGs make up about 1/3 of first year psychiatry residents. These individuals have been found to provide services to the poor, the elderly and the psychotic. The quality of their medical work has been found to be satisfactory. The training needs of these physicians require an understanding on the part of their teachers that they come from cultures with different values that we have. The extended families of these primarily Asian residents clash with our strong commitment to individualism. It leads to a We-self rather than our I-Self. This difference coupled with the stress of leaving to come to a new culture is a great stress. Their exposure to psychiatry has been limited. They request and need more interview demonstration and practice, ore feedback and examinations. They should have help in accent reduction. They should be exposed to the working of the hospital by sitting on departmental and hospital committees. The faculty should extend their social opportunities and work as mentors on joint projects. Courses on the history of American culture should be taught. Psychotherapy for them should be encouraged as well as teaching medical ethics. They must become the major educational concern for the department that they are in.
Citotoxicidad y actividad anticancerígena de dos flavonoides aislados y purificados de Brownea ariza Brenth
GIL R,Juan F; Milton,GóMEZ B; TREJOS S,Juanita;
Vitae , 2009,
Abstract: the growing resistance to anticancer agents has turned medical science and pharmacology towards finding new compounds with these characteristics; in this area the natural products have great relevance, since many of these have anticancer activity. flavonoids as secondary metabolites have reported anti-tumor activity and can become important source for cancer treatment; why search isolate flavonoids brownea ariza brenth to evaluate their anticancer activity. the phytochemical analysis of leaves of brownea ariza brenth. (caesalpiniaceae) let isolate a flavonol identified as (1), and a glycoside flavonol described as quercitrin (2). the structures are determined by spectroscopic techniques: uv-vis with shift reagents; 1d and 2d nmr (1h, 13c, cosy, dept, hmbc; hmqc), and mass spectrometry. it evaluates the cytotoxic activity in vero cell (atcc: ccl-81) and anticancer activity in myeloma murino sp2/0-ag14 (atcc: crl-1581), doing count the number of viable cells by graduation with tripan blue, obtaining a concentration cytotoxic average (1) of 300 μg/ml and not determined to (2) in concentrations of work; anticancer activity for (1) has a median effective concentration of 150 μg /ml and not given to (2) in concentrations of work.
Citotoxicidad y actividad anticancerígena de dos flavonoides aislados y purificados de Brownea ariza Brenth Cytotoxicity and anticarcinogenic activity of two flavonoids isolated and purified from Brownea ariza Brenth
Juan F GIL R,GóMEZ B Milton,Juanita TREJOS S
Vitae , 2009,
Abstract: La creciente resistencia a agentes anticancerígenos ha volcado la ciencia médica y farmacológica hacia la búsqueda de nuevos compuestos con estas características, en este campo los productos naturales tienen gran relevancia por la actividad antitumoral mostrada por muchos de ellos. Los flavonoides son metabolitos secundarios que tienen reportada actividad anticancerígena y pueden convertirse en fuente importante para tratar el cáncer; por esto se pretende aislar flavonoides de Brownea ariza Brenth, determinar su estructura y evaluar su actividad antitumoral. Los análisis fitoquímicos de las hojas de Brownea ariza Brenth (Caesalpiniaceae) permiten aislar un flavonol identificado como (1), y un glicósido de flavonol, Quercitrina (2). Las estructuras se determinan por técnicas espectroscópicas: UV-Vis con reactivos de desplazamiento; RMN 1D y 2D (1H, 13C, COSY, DEPT, HMBC; HMQC), y espectrometría de masas. Se evalúa la actividad citotóxica en línea celular VERO (ATCC:CCL-81) y la actividad anticancerígena en Mieloma Murino SP2/0-Ag14 (ATCC:CRL-1581), realizando conteo de células viables por exclusión con azul Tripan, obteniéndose una concentración citotóxica media para (1) de 300 μg/mL y no determinada para (2) en las concentraciones trabajadas; la actividad anticancerígena para (1) tiene una concentración efectiva media de 150 μg/mLy no determinada para (2) en las concentraciones trabajadas. The growing resistance to anticancer agents has turned medical science and pharmacology towards finding new compounds with these characteristics; in this area the natural products have great relevance, since many of these have anticancer activity. Flavonoids as secondary metabolites have reported anti-tumor activity and can become important source for cancer treatment; why search isolate flavonoids Brownea ariza Brenth to evaluate their anticancer activity. The Phytochemical analysis of leaves of Brownea ariza Brenth. (Caesalpiniaceae) let isolate a flavonol identified as (1), and a glycoside flavonol described as Quercitrin (2). The structures are determined by spectroscopic techniques: UV-Vis with shift reagents; 1D and 2D NMR (1H, 13C, COSY, DEPT, HMBC; HMQC), and mass spectrometry. It evaluates the cytotoxic activity in VERO cell (ATCC: CCL-81) and anticancer activity in Myeloma Murino SP2/0-Ag14 (ATCC: CRL-1581), doing count the number of viable cells by graduation with tripan blue, obtaining a concentration cytotoxic average (1) of 300 μg/mL and not determined to (2) in concentrations of work; anticancer activity for (1) has a median effective concentration of 1
Estado da arte do procedimento percutaneo: paciente octogenário submetido com sucesso, em apenas uma sess?o, a valvotomia pulmonar, implante de stent coronário e implante de marcapasso definitivo
Pimentel Filho, Wilson Albino;Soares Neto, Milton de Macedo;Cividanis, Gil Vicente;Feijó Júnior, Rubens Vaz;
Arquivos Brasileiros de Cardiologia , 2005, DOI: 10.1590/S0066-782X2005001700007
Abstract: this report describes a case involving an 82 year old patient with mild renal insufficiency, severe pulmonary valve stenosis (pvs), severe anterior descending artery stenosis and complete atrioventricular block, who successfully underwent, in a single session, coronary angioplasty and a stent implant, pulmonary valvotomy and a permanent pacemaker implant.
On Infrasound Standards, Part 1 Time, Frequency, and Energy Scaling  [PDF]
Milton A. Garces
InfraMatics (InfraMatics) , 2013, DOI: 10.4236/inframatics.2013.22002
Abstract: A standardized, self-similar, multiresolution algorithm is developed for scaling infrasonic signal time, frequency, and power within the framework of fractional octave bands. This work extends accepted fractional octave band schemas to 0.001 Hz (1000 s periods) to facilitate the analysis of broadband signals as well as the deep acoustic-gravity and Lamb waves captured by the global infrasound network. The Infrasonic Energy, Nth Octave (INFERNO) multiresolutionEnergy Estimator is applied to computing the total acoustic energy of the Russian meteor signature recorded in the 45mHz-9 Hz frequency band by IMS array 131KZ, Kazakhstan.

Estratégia de detec??o precoce e redu??o de mortalidade na sepse grave
Westphal, Glauco Adrieno;Feijó, Janaína;Andrade, Patrícia Silva de;Trindade, Louise;Suchard, Cezar;Monteiro, Márcio Andrei Gil;Martins, Sheila Fonseca;Nunes, Fernanda;Caldeira Filho, Milton;
Revista Brasileira de Terapia Intensiva , 2009, DOI: 10.1590/S0103-507X2009000200001
Abstract: objective: to evaluate the impact of implementing an institutional policy for detection of severe sepsis and septic shock. methods: study before (stage i), after (stage ii) with prospective data collection in a 195 bed public hospital.. stage i: patients with severe sepsis or septic shock were included consecutively over 15 months and treated according to the surviving sepsis campaign guidelines. stage ii: in the 10 subsequent months, patients with severe sepsis or septic shock were enrolled based on an active search for signs suggesting infection (ssi) in hospitalized patients. the two stages were compared for demographic variables, time needed for recognition of at least two signs suggesting infection (ssi-δt), compliance to the bundles of 6 and 24 hours and mortality. results: we identified 124 patients with severe sepsis or septic shock, 68 in stage i and 56 in stage ii. the demographic variables were similar in both stages. the δt-ssi was 34 ± 54 hours in stage i and 7 ± 8.4 hours in stage ii (p <0.001). there was no difference in compliance to the bundles. in parallel there was significant reduction of mortality rates at 28 days (54.4% versus 30%, p <0.02) and hospital (67.6% versus 41%, p <0.003). conclusion: the strategy used helped to identify early risk of sepsis and resulted in decreased mortality associated with severe sepsis and septic shock.
Building Capacity for Intercultural Citizenship  [PDF]
Ida Castiglioni, Milton J. Bennett
Open Journal of Social Sciences (JSS) , 2018, DOI: 10.4236/jss.2018.63016
Abstract:
Changing national boundaries, migration and mobility, multinational residence, and the cross-border flow of refugees are challenging traditional views of citizenship. The term “intercultural citizenship” is coined to refer to a definition based more on affiliation with a cultural group than on legal ascription to a nation state. The implications of citizenship based on belonging carry some of the same rights and responsibilities as legal citizenship, but in addition they include 1) conscious identification with chosen groups; 2) acceptance of responsibility for sustaining the commonweal in a variety of ways; 3) development of flexible perceptual boundaries that allow for multiple group identifications; and 4) participation in the group coordination of meaning and action that constitutes the maintenance of a living culture. Three major factors in building capacity for intercultural citizenship are explored: 1) capacity for empathy, which involves overcoming the golden rule and its assumption of similarity to embrace the platinum rule and the assumption of difference; 2) capacity for mutual adaptation, which generates virtual third cultures, or forms of communicative intersectionality; and 3) capacity for intercultural ethicality, which demands that judgments be made among viable alternatives revealed by empathic perspective-taking.
Correction for false statement
Milton Diamond
International Journal of Pediatric Endocrinology , 2012, DOI: 10.1186/1687-9856-2012-1
Abstract: A false statement has been published in your journal in an article by P. A. Lee and C. P. Houk. (2010) Article ID 563640. "The Role of Support Groups, Advocacy Groups, and Other Interested Parties in Improving the Care of Patients with Congenital Adrenal Hyperplasia: Pleas and Warnings [1]."These authors say "Confrontational tactics used by "advocacy" groups have included pressuring the medical community to adopt narrow mandates, such as a moratorium on all reproductive system surgery (six), that cannot apply to the broad range of situations encountered in practice or the use of accusations regarding therapy received by patients in the past."In support of their argument they cite our paper (M. Diamond & H. K. Sigmundson, Management of intersexuality. Guidelines for dealing with persons with ambiguous genitalia. Archives of Pediatrics & Adolescent Medicine. 1997;151(10):1046-1050 [2]. We have been wrongly quoted and cited.Here is exactly what we say:"Perform no major surgery for cosmetic reasons alone; only for conditions related to physical/medical health. This will entail a great deal of explanation needed for the parents who will want their children to "look normal." Explain to them that appearances during childhood, while not typical of other children, may be of less importance than functionality and post pubertal erotic sensitivity of the genitalia. Surgery can potentially impair sexual/erotic function. Therefore such surgery, which includes all clitoral surgery and any sex reassignment, should typically wait until puberty or after when the patient is able to give truly informed consent." [emphasis added].Our emphasis was on cosmetic surgery and since our statement no evidence has shown any surgery had been of benefit. Many unneeded surgeries have been devastating.Significantly damaging were those surgeries imposed on males that were sex reassigned for different reasons. Often these were instances where the penis was considered too small for appropriate male sta
MMBB arquitectos
Braga,Milton;
ARQ (Santiago) , 2002, DOI: 10.4067/S0717-69962002005100009
Abstract: they emerge from a country whose 20th century architectural project was charged with a certain modernity, marked by the presence of le corbusier, niemeyer and the creation of brasilia. today, the neutral nature of the works of mmbb architects marks a transition, offering silence as a possible route to the new brazil
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