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Search Results: 1 - 10 of 464007 matches for " Milton A.;Greco "
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Fator de impacto: importancia e influência no meio editorial, acadêmico e científico
Ruiz, Milton A.;Greco, Oswaldo T.;Braile, Domingo M.;
Revista Brasileira de Hematologia e Hemoterapia , 2009, DOI: 10.1590/S1516-84842009005000080
Abstract: in this report, the authors present information on bibliometric instruments and their importance in measuring the quality of scientific journals and researchers. they present the history and deployment of the impact factor by the institute for scientific information that exists since 1955. criticism regarding the inadequacy of the impact factor in the evaluation of scientific publications, its misuse and editorial handling strategies of this bibliometric index are presented and discussed. the new capes classification for journals, based on various criteria and in particular the impact factor, is presented as is its influence on national scientific and academic life. the authors conclude that, despite all obstacles and discussions, the impact factor of the institute for scientific information is still a useful tool and is the only one available to assess, in isolation, scientific and intellectual productivity.
Transplante de Células-tronco marcadas para o miocárdio de paciente com doen?a de chagas
Jacob, José Luiz Balthazar;Salis, Fernando Vilela;Ruiz, Milton A.;Greco, Oswaldo Tadeu;
Arquivos Brasileiros de Cardiologia , 2007, DOI: 10.1590/S0066-782X2007001400014
Abstract: stem cell transplantation is a new therapy applied to produce cardiac regeneration through differentiation or increase of heart myocytes or neovascular proliferation in patients in the end stage of congestive heart failure secondary to dilated cardiomyopathy1, but the results are still unknown2,3.
O transplante de células-tronco hematopoéticas como op??o no tratamento de doen?as n?o hematológicas
Ruiz, Milton A.;Piron-Ruiz, Lilian;Lago, Mario R.;Maset, Angelo;Santos, Adriana B.;Greco, Oswaldo T.;
Revista Brasileira de Hematologia e Hemoterapia , 2009, DOI: 10.1590/S1516-84842009000700011
Abstract: in this report we discuss data and perspectives of hematopoietic stem cell transplantation in non-hematologic diseases. aspects related to the conditioning regimen and its relationship with toxicity and mortality are also presented. specific autoimmune diseases are discussed, in particular systemic lupus erythematosus, systemic sclerosis, multiple sclerosis and type 1 diabetes mellitus. the aim of the procedure in autoimmune diseases is immune reprogramming. apparently this procedure has indications for diseases in which conventional treatments have failed when organ damage is not definitive, but likely to occur if transplantation is not performed. the most promising method appears to be autologous stem cell transplantation with non-myeloablative conditioning regimens to obtain survival that is estimated at more than 50% for all autoimmune diseases, with low toxicity and no mortality related to transplantation. the controversial results of solid tumor treatment and particularities of breast cancer are also presented. hematopoietic stem cell transplantation is the apparent indication for solid tumors based on intensive treatment with myeloablative doses in order to induce the graft versus tumor effect. the myeloablative conditioning regimens are introduced with the purpose of reducing the toxicity and inducing immunosuppression but the data are insufficient and questionable requiring the introduction of new therapeutic strategies based on cellular and immune therapy.
Células-tronco de medula óssea em isquemia crítica de membros
Araujo, José Dalmo;Araujo Filho, José Dalmo;Ciorlin, Emerson;Ruiz, Milton A.;Greco, Oswaldo T.;Ardito, Roberto V.;Lago, Mario;
Revista Brasileira de Hematologia e Hemoterapia , 2009, DOI: 10.1590/S1516-84842009005000031
Abstract: the authors discuss clinical aspects and conventional treatment of lower limb critical ischemia and the alternative of therapy with autogenous bone marrow stem cells in patients who have exhausted, without success, all the current means of treatment. they comment on the historical aspects, the sources, animal experiments, clinical research and, finally, their initial experience with six patients, all of whom had previous indication of major or minor amputation. for only one patient amputation could not be avoided. in addition to excellent results in pain relief and healing of ischemic ulcers, no deleterious side effects were noted suggesting that this type of cell therapy is safe and efficient although further research and randomized studies are needed to make this a standard therapy.
O G-CSF na terapia do acidente vascular cerebral
Maset, Angelo L.;Piron-Ruiz, Lilian;Greco, Oswaldo T.;Lago, Mario;Poloni, Alana F. C.;Ruiz, Milton A.;
Revista Brasileira de Hematologia e Hemoterapia , 2009, DOI: 10.1590/S1516-84842009005000022
Abstract: the granulocyte colony-stimulating-factor (g-csf) is a glycoproteina which has been described for decades, and it is commonly utilized in the treatment of neutropenic states and bone marrow transplants. g-csf stimulates hematopoietic stem-cels e crucially regulates the survival of mature neutrophils through a mechanism of apoptosis inhibition. beyond its systemic effect, recently it has been shown its surprising activity in the central nervous system (cns). g-csf administration mobilizes bone marrow stem cells para systemic blood, and those cells cross the blood-brain-barrier e target brain's damaged area. g-csf's activity in the cns has been defined as multimodal, because additionally it has been demonstrated a direct neuroprotective action through different mechanisms such as antiapoptotic activity, angiogenesis, anti-inflamatory effect, and stimulation of endogenous neurogenesis. this paper sumarizes g-csf action in the cns and approaches its potential para use in stroke.
Terapia celular em doen?as pulmonares: existem perspectivas?
Ribeiro-Paes, Jo?o T.;Bilaqui, Aldemir;Greco, Oswaldo T.;Ruiz, Milton A.;Alves-de-Moraes, Luis B. C.;Faria, Carolina A.;Stessuk, Talita;
Revista Brasileira de Hematologia e Hemoterapia , 2009, DOI: 10.1590/S1516-84842009005000034
Abstract: cell therapy can be briefly described as the use of cells in the treatment of diseases. although the number of scientific reports involving lung and cell therapy in humans is not expressive, there are consistent data, both in humans and animal models. experiments show the migration of bone marrow stem cells to the lung, in different situations. these results provide the experimental basis for the use of stem cells in the regeneration of the lung tissue in animal models. in our laboratory, several projects have been conducted aiming to evaluate the pulmonary response (morphological and functional) to treatment with adult stem cells in mice with experimentally induced chronic obstructive pulmonary disease. the results obtained, together with those from other research groups, allow us to consider the possibility of application, in the near future, of cell therapy in chronic obstructive pulmonary disease patients. for another disease, cystic fibrosis, cell therapy shows particular aspects in relation to other chronic degenerative pulmonary diseases. in this pathology, there are interesting and promising advances, however, the results are incipient and, thus, it must be said that the association between genetic and cell therapy appears to be a possibility, but still far from being consolidated and incorporated as a safe and effective therapeutic alternative in cystic fibrosis. on the other hand, based on the results obtained in experimental models, it is possible to postulate that cell therapy with hematopoietic stem cells (or from other sources) brings consistent application perspectives in several other human pulmonary diseases, especially in chronic obstructive pulmonary disease.
Ressincroniza??o cardíaca e terapia celular: existe terapia associativa?
Greco, Oswaldo T.;Greco, Rafael L.;Abreu, Ana C.;Jacob, José Luiz B.;Ardito, Roberto V.;Takeda, Roberto T.;Parro Junior, Adelino;Sallis, Fernando V.;Lago, Mario R.;Ruiz, Milton A.;
Revista Brasileira de Hematologia e Hemoterapia , 2009, DOI: 10.1590/S1516-84842009005000025
Abstract: in recent years cardiac resynchronization therapy has been a well defined approach for patients with functional class iii or iv heart failure (hf) who do not respond to optimized therapy. studies have shown efficacy, but one well defined group of dilated heart diseases with large areas of fibrosis has not had the same success rates (30-40%). hence, we decided to associate stem cell transplant in these patients. since april 2005 we started to transplant stem cells in 25 patients (16 men) with nyha iii/iv hf with ejection fraction < 35% and ventricle dyssynchrony. their ages varied between 30 and 80, (mean age 58) and 44% (11 patients) had a chagasic etiology. resynchronization and stem cell therapy were performed via epicardial (12) or endocardial (13) approaches. cell selection was by ficoll filtration with a mean number of 3.0 x 108 cells infused: cd 34+ (5.0 x 106) and cd 133+ (2.5 x 106). in 24 months of evolution we noticed that 84.8% of these patients survived and mortality (15.2%) was not related to the procedure. the survival of pacemaker recipients (52.4%) was higher than another similar group that did not receive pacemaker implants and chagasic patients survived less than the ischemic and the idiopathic patients (42.4%, 55.6% and 77.2%, respectively). in spite of these initial differences, there was no statistical difference between these groups (log-rank test of p=0.218 and p= 0.626, respectively). in cases that resynchronization was performed in isolation, the results do not seem to be satisfactory so we chose to associate stem cell therapy as a safe and adequate alternative for patients with hf and dilated myocardiopathy.
On Infrasound Standards, Part 1 Time, Frequency, and Energy Scaling  [PDF]
Milton A. Garces
InfraMatics (InfraMatics) , 2013, DOI: 10.4236/inframatics.2013.22002
Abstract: A standardized, self-similar, multiresolution algorithm is developed for scaling infrasonic signal time, frequency, and power within the framework of fractional octave bands. This work extends accepted fractional octave band schemas to 0.001 Hz (1000 s periods) to facilitate the analysis of broadband signals as well as the deep acoustic-gravity and Lamb waves captured by the global infrasound network. The Infrasonic Energy, Nth Octave (INFERNO) multiresolutionEnergy Estimator is applied to computing the total acoustic energy of the Russian meteor signature recorded in the 45mHz-9 Hz frequency band by IMS array 131KZ, Kazakhstan.

Stability of correlated electronic systems under the influence of the electron-phonon interaction
A. Greco,A. Dobry
Physics , 1996, DOI: 10.1016/0038-1098(96)00307-9
Abstract: We have used an exact diagonalization technique to study the stability of the $t-J$-Holstein and Hubbard-Holstein models under the influence of the electron-phonon interaction. Previous results have been obtained using frozen-phonon technique or introducing only a few dynamical phonon modes due to the large Hilbert space. To check these results we have done exact diagonalization in a small cluster (four sites) including all the phonon modes allowed by symmetry. We compare our results with those obtained by using the adiabatic approximation.
Manifestation of marginal Fermi liquid and phonon excitations in photoemision experiments of cuprate superconductors
A. Greco,A. Dobry
Physics , 2001, DOI: 10.1016/S0038-1098(02)00071-6
Abstract: Recent ARPES experiments in cuprates superconductors show a kink in the electron dispersion near the Fermi energy. This kink coexists with a linear frequency dependence of the imaginary part of the electron self-energy. In this paper we show that both features could be accounted for if an electron-phonon interaction is included in a model where the electrons are described by a marginal Fermi liquid theory. Phonons provide the energy scale seen in the experiments but the quasiparticle weight at the Fermi level is zero. At high binding energy, in agreement with the experiment, the electron dispersion does not go to the one-electron band. We analyze the compatibility between the electron scattering rate extracted from ARPES experiment and the one extracted from transport properties. We conclude that the electron-phonon interaction relevant for transport properties is strongly screened respect to the one extracted from ARPES. This is in agreement with recent studies in the context of 1/N expansion on t-J model.
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