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Search Results: 1 - 10 of 3016 matches for " Mika Yoshida "
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Allocation of Mobile Chippers for a Concentrated Bioenergy Demand  [PDF]
Mika Yoshida
Open Journal of Forestry (OJF) , 2019, DOI: 10.4236/ojf.2019.94016
Abstract: Allocation of mobile chippers is a tactical problem of management in a bioenergy supply chain. It influences the entire supply cost of the wood chip since the transportation distance and the chipping productivity decide the transportation cost. Great and concentrated demands of woody biomass require multiple suppliers, and there should be the best allocation of mobile chippers which minimize the entire supply cost. This study aims to clarify better management of the supply chain consisting of multiple players for a great and concentrated demand for wood chip. The model was a supply chain for a typical biomass power plant with 5.8 MW capacity. Suppliers were assumed to select mobile chippers from two sizes, 140-kW and 353-kW. By the model simulation, it was clarified that the well-considered allocation of two different mobile chippers could reduce the entire supply cost less than the conventional system using a fixed chipper at the power plant. The best management was to use only the 353-kW chippers, and secondly to allocate the less productive chippers closer to the demand to prevent the incline of the transportation cost. However, the possible conflict was also specified as the increased cost of the suppliers using more productive chippers in the second best allocation strategy. This result emphasizes the necessity of resolving such conflict by making the collaborative relationship among stakeholders which has been pointed out by other researches as well to sustain the better condition of the supply chain.
Thermodinamic Interpretaion of the Morphology Individuality of Natural and Synthesized Apatite Single Crystals  [PDF]
Takaomi Suzuki, Haruka Takemae, Mika Yoshida
Journal of Crystallization Process and Technology (JCPT) , 2013, DOI: 10.4236/jcpt.2013.34019
Abstract:

Specific surface free energy (SSFE) of natural calcium fluorapatite from the same mother rock and synthesized barium chlorapatite from the same lot was determined using contact angle of water and formamide droplets, compared with grown length of crystal face (h). The experimentally obtained SSFEs have different values even for the same index faces of the different crystals. The SSFEs also have wide distribution for each face of crystals. Observed SSFE is considered to be not only the SSFE of ideally flat terrace face, but also includes the contribution of strep free energy. Though the crystals we experimentally obtained were growth form, the relationship between SSFE and h was almost proportional, which looks like satisfying Wulff’s relationship qualitatively. The slope of SSFE versus h line shows the driving force of crystal growth, and the line for larger crystal has less steep slope. The driving force of crystal growth for larger crystal is smaller, which also means that the chemical potential is larger for larger crystal. The individuality of crystals for the same lot can be explained by the difference of the chemical potential of each crystal.

Realization of features of immune response by dynamical system models and a possible mechanism of memory of antigen invasion
Mika Yoshida,Kinji Fuchikami,Tatsuya Uezu
Quantitative Biology , 2006,
Abstract: Among features of real immune responses which occur when antigens invade a body,there are two remarkable features. One is that the amount of antibodies produced in the secondary invasion by the same antigens is more than 10 times larger than that in the primary invasion. The other is that more effective antibodies which can neutralize the antigens more quickly are produced by somatic hypermutation during the immune response. This phenomenon is named as 'affinity maturation'. In this paper, we try to reproduce these features by dynamical system models and present possible factors to realize them. Further, we present a model in which the memory of the invasion by antigens is realized without immune memory cells.
Expression and Epigenetic Change of the AR and FSHR Genes in the Granulosa Cells of Endometriosis Patients
Mika Hayashi,Yoshiki Yamashita,Atsushi Hayashi,Yoko Yoshida
Genetics & Epigenetics , 2012,
Abstract:
Astrocytic Ca2+ signals are required for the functional integrity of tripartite synapses
Tanaka Mika,Shih Pei-Yu,Gomi Hiroshi,Yoshida Takamasa
Molecular Brain , 2013, DOI: 10.1186/1756-6606-6-6
Abstract: Background Neuronal activity alters calcium ion (Ca2+) dynamics in astrocytes, but the physiologic relevance of these changes is controversial. To examine this issue further, we generated an inducible transgenic mouse model in which the expression of an inositol 1,4,5-trisphosphate absorbent, “IP3 sponge”, attenuates astrocytic Ca2+ signaling. Results Attenuated Ca2+ activity correlated with reduced astrocytic coverage of asymmetric synapses in the hippocampal CA1 region in these animals. The decreased astrocytic ‘protection’ of the synapses facilitated glutamate ‘spillover’, which was reflected by prolonged glutamate transporter currents in stratum radiatum astrocytes and enhanced N-methyl-D-aspartate receptor currents in CA1 pyramidal neurons in response to burst stimulation. These mice also exhibited behavioral impairments in spatial reference memory and remote contextual fear memory, in which hippocampal circuits are involved. Conclusions Our findings suggest that IP3-mediated astrocytic Ca2+ signaling correlates with the formation of functional tripartite synapses in the hippocampus.
Resistance coefficient during ice slurry flow through pipe sudden constriction
?. Mika
Archives of Foundry Engineering , 2010,
Abstract: Due to the adverse environmental effects of some commonly-used refrigerants, efforts are still underway to find new cooling mediumsthat would be safer to the ozone layer and would not increase the greenhouse effect. Ice slurry as a new ecological coolant suits theprocesses requiring the preservation of constant and equal temperature in the cooling process of the full section of the cooled solid. Thanks to that, ice slurry can find a wide potential application in such branches of industry, as heat treatment, materials engineering, or foundry. In this paper, flow systems which are commonly used in fittings elements such as diameter’s reductions in ice slurry pipelines, are experimentally investigated. In the study reported in this paper, the consideration was given to the specific features of the slurry flow in which the flow qualities depend mainly on the volume fraction of solid particles. The results of the experimental studies on the flow resistance, presented herein, enabled to determine the resistance coefficient during the ice slurry flow through the pipe sudden constriction. The volume fraction of solid particles in the slurry ranged from 5 to 30%. The recommended and non-recommended range of the Reynolds number for the ice slurry flow through the pipe sudden constriction were presented in this paper. The experimental studies were conducted on a few variants of the most common reductions of copper pipes. Further studies on the determination of the resistance coefficient in the remaining fittings elements of the pipeline were recommended in the paper as well as the further theoretical studies intended to determine the theoretical relations to calculate the resistance coefficient in all the fittings elements in the pipeline (on the basis of the experimental studies) and to elaborate the calculation pattern of the entire ice slurry system.
Electrophoretic characterization of species of fibronectin bearing sequences from the N-terminal heparin-binding domain in synovial fluid samples from patients with osteoarthritis and rheumatoid arthritis
John H Peters, Steven Carsons, Mika Yoshida, Fred Ko, Skye McDougall, Grace A Loredo, Theodore J Hahn
Arthritis Research & Therapy , 2003, DOI: 10.1186/ar1001
Abstract: Fibronectins (FNs), a family of multifunctional adhesion proteins that differ from one another through alternative splicing of a pre-mRNA derived from a single gene, are found as soluble dimeric molecules in the blood and as insoluble multimers within the extracellular matrix of tissues, where they are concentrated in basement membranes and blood vessel walls [1-3]. They bind to cell-surface integrin receptors and participate in a variety of cellular processes, including adhesion, migration, transformation, and apoptosis, as well as wound healing, fibrosis, and hemostasis [1-5]. FN is deposited in cartilage from osteoarthritis (OA) [3,6-9], and fragmented forms of FN have been detected in synovial fluid (SF) and articular cartilage from patients with OA and patients with rheumatoid arthritis (RA) [10-17]. On the basis of such findings, plasma-derived FN (pFN) and specific purified pFN fragments have been tested for their capacity to regulate the function of chondrocytes in vitro. Whereas intact, soluble pFN has been observed to exert little or no effect, several purified, proteolytically derived pFN fragments have proved to be active [18-26]. Additionally, mixtures of fragments derived from OA cartilage have been observed to promote chondrolysis in vitro [17].Although fragments corresponding to the 29-kDa (also referred to as 30-kDa) amino-terminal (N-terminal) heparin-binding domain (HBD) have been studied most extensively, species derived from sites spanning most of the FN molecule have been observed to trigger catabolic gene expression in chondrocytes [18-26]. For example, purified fragments of pFN corresponding to the 120- to 140-kDa central cell-binding domain (CBD), the 50-kDa gelatin-binding domain (GBD), and the 40-kDa C-terminal HBD have each been observed to trigger release of proteoglycans from cartilage slices in vitro, as has a recombinant version of the alternatively spliced EIIIA segment (Fig. 1) [18,22,25-27]. In addition, the 29-kDa N-terminal HBD h
Expression and Epigenetic Change of the AR and FSHR Genes in the Granulosa Cells of Endometriosis Patients
Mika Hayashi, Yoshiki Yamashita, Atsushi Hayashi, Yoko Yoshida, Sachiko Kawabe, Masami Hayashi, Yoshito Terai, Hideki Kamegai and Masahide Ohmichi
Genetics & Epigenetics , 2012, DOI: 10.4137/GEG.S9877
Abstract: Background: Endometriosis is one of the most common gynecological diseases associated with infertility. Endometriosis may affect the androgen receptor (AR) mRNA expression in human granulosa cells and the methylation of the promoter region of AR. We investigated 28 patients with endometriosis and 47 subjects without endometriosis undertaking IVF treatment. Methods: Granulosa cells were obtained from 28 patients with endometriosis and 47 subjects without endometriosis as a control. Expressions of AR and FSHR mRNA were then evaluated by OneStep real-time PCR analysis, and the level of methylation of the promoter region was qualified by methylation-specified PCR (MSP). Results: The expression of AR mRNA in the endometriosis group was statistically lower than that in the control group. As well, FSHR mRNA expression in the control group showed a positive correlation with AR mRNA expression; however, there was no such correlation in endometriosis patients. In the control group, AR mRNA expression was statistically higher in pregnant subjects compared with non-pregnant subjects; however, in the endometriosis group, no significant difference was identified. The promoter of AR was heavily methylated in all endometriosis cases; however, only 5 (45.4%) were methylated in the control group. Conclusion: Lower AR mRNA expression and methylation of the AR promoter region might affect the expression of AR and FSHR in the presence of endometriosis, thus leading to a disturbance in the regulation of AR and FSHR.
Inverse Associations between Obesity Indicators and Thymic T-Cell Production Levels in Aging Atomic-Bomb Survivors
Kengo Yoshida, Eiji Nakashima, Yoshiko Kubo, Mika Yamaoka, Junko Kajimura, Seishi Kyoizumi, Tomonori Hayashi, Waka Ohishi, Yoichiro Kusunoki
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0091985
Abstract: Reduction of the naive T-cell population represents a deteriorating state in the immune system that occurs with advancing age. In animal model studies, obesity compromises the T-cell immune system as a result of enhanced adipogenesis in primary lymphoid organs and systemic inflammation. In this study, to test the hypothesis that obesity may contribute to the aging of human T-cell immunity, a thousand atomic-bomb survivors were examined for obesity status and ability to produce naive T cells, i.e., T-cell receptor excision circle (TREC) numbers in CD4 and CD8 T cells. The number of TRECs showed a strong positive correlation with naive T cell numbers, and lower TREC numbers were associated with higher age. We found that the TREC number was inversely associated with levels of obesity indicators (BMI, hemoglobin A1c) and serum CRP levels. Development of type-2 diabetes and fatty liver was also associated with lower TREC numbers. This population study suggests that obesity with enhanced inflammation is involved in aging of the human T-cell immune system. Given the fact that obesity increases the risk of numerous age-related diseases, attenuated immune competence is a possible mechanistic link between obesity and disease development among the elderly.
Pitfalls and Remedies in DEA Applications: How to Handle an Occurrence of Zero in Multipliers by Strong Complementary Slackness Conditions  [PDF]
Toshiyuki Sueyoshi, Mika Goto
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.55A005
Abstract: This study discusses a guideline on a proper use of Data Envelopment Analysis (DEA) that has been widely used for performance analysis in public and private sectors. The use of DEA is equipped with Strong Complementary Slackness Conditions (SCSCs) in this study, but an application of DEA/SCSCs depends upon its careful use, as summarized in the guideline. The guideline consists of the five suggestions. First, a data set used in the DEA applications should not have a ratio variable (e.g., financial ratios) in an input(s) and/or an output(s). Second, radial DEA models under variable and constant Returns to Scale (RTS) need a special treatment on zero in a data set. Third, the DEA evaluation needs to drop an outlier. Fourth, an imprecise number (e.g., 1/3) may suffer from a round-off error because DEA needs to specify it in a precise expression to operate a computer code. Finally, when a large input or output variable may dominate other variables in DEA computation, it is necessary to normalize the data set or simply to divide each observation by its average. Such a simple treatment produces more reliable DEA results than the one without any data adjustment. This study also discusses how to handle an occurrence of zero in DEA multipliers by applying SCSCs. The DEA/SCSCs can serve for a multiplier restriction approach without any prior information. Thus, the propesed DEA/SCSCs can provide more reliable results than a straight use of DEA.
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