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Search Results: 1 - 10 of 286 matches for " Miho Asahara "
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Soluble Isoform of the Receptor for Advanced Glycation End Products as a Biomarker for Postoperative Respiratory Failure after Cardiac Surgery
Tokujiro Uchida, Nagara Ohno, Miho Asahara, Yoshitsugu Yamada, Osamu Yamaguchi, Makoto Tomita, Koshi Makita
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0070200
Abstract: Purpose Postoperative respiratory failure is a major problem which can prolong the stay in the intensive care unit in patients undergoing cardiac surgery. We measured the serum levels of the soluble isoform of the receptor for advanced glycation end products (sRAGE), and we studied its association with postoperative respiratory failure. Methods Eighty-seven patients undergoing elective cardiac surgery were enrolled in this multicenter observational study in three university hospitals. Serum biomarker levels were measured perioperatively, and clinical data were collected for 7 days postoperatively. The duration of mechanical ventilation was studied for 28 days. Results Serum levels of sRAGE elevated immediately after surgery (median, 1751 pg/mL; interquartile range (IQR) 1080–3034 pg/mL) compared with the level after anesthetic induction (median, 884 pg/mL; IQR, 568–1462 pg/mL). Postoperative sRAGE levels in patients undergoing off-pump coronary artery bypass grafting (median, 1193 pg/mL; IQR 737–1869 pg/mL) were significantly lower than in patients undergoing aortic surgery (median, 1883 pg/mL; IQR, 1406–4456 pg/mL; p = 0.0024) and valve surgery (median, 2302 pg/mL; IQR, 1447–3585 pg/mL; p = 0.0005), and postoperative sRAGE correlated moderately with duration of cardiopulmonary bypass (rs = 0.44, p<0.0001). Receiver operating characteristic curve analysis demonstrated that postoperative sRAGE had a predictive performance with area under the curve of 0.81 (95% confidence interval 0.71–0.88) for postoperative respiratory failure, defined as prolonged mechanical ventilation >3 days. The optimum cutoff value for prediction of respiratory failure was 3656 pg/mL, with sensitivity and specificity of 62% and 91%, respectively. Conclusions Serum sRAGE levels elevated immediately after cardiac surgery, and the range of elevation was associated with the morbidity of postoperative respiratory failure. Early postoperative sRAGE levels appear to be linked to cardiopulmonary bypass, and may have predictive performance for postoperative respiratory failure; however, large-scale validation studies are needed.
A Questionnaire Analysis of the Asch Experiment without Using Confederates  [PDF]
Miho Arai, Kazuo Mori
Psychology (PSYCH) , 2013, DOI: 10.4236/psych.2013.411127
Abstract:

Without using confederates, Mori and Arai (2010) replicated the Asch results with 40 male and 64 female Japanese undergraduates in same-sex groups of four. One from each foursome wore a different type of polarizing sunglasses so that he/she observed the standard lines differently form the other three participants, who played the same role as the majority in the Asch experiments. As expected, the minority participants tended to conform to the majority. There was a gender difference: the female minority participants conformed, but the males did not. The present study reported the qualitative findings from analysis of the responses on a questionnaire administered in the Mori and Arai experiments. It revealed that female participants who conformed more than the males were less confident and felt more isolated and anxious than the males.

Histone Acetylation Influences the Activity of Sox9-related Transcriptional Complex
Furumatsu,Takayuki,Asahara,Hiroshi
Acta Medica Okayama , 2010,
Abstract: Chondrocyte differentiation is the fundamental process in skeletal development. From the mesenchymal condensation of chondroprogenitors to the hypertrophic maturation of chondrocytes, chondrogenesis is sequentially regulated by cross-talk among transcription factors, growth factors, and chromatin structure. The master transcription factor Sry-type HMG box (Sox) 9 has an essential role in the expression of chondrogenic genes through the association with Sox9-binding sites on its target genes. Several transcription factors and coactivators, such as Scleraxis/E47 and p300, cooperatively modulate the Sox9-dependent transcription by interacting with Sox9. The Sox9-related transcriptional apparatus activates its target gene expression through p300-mediated histone acetylation on chromatin. The transforming growth factor (TGF)-β superfamily also plays a key role in chondrocyte differentiation. The TGF-β-regulated Smad3/4 complex activates Sox9-dependent transcription on chromatin by associating with Sox9 itself, and by recruiting p300 onto Sox9. These findings suggest that the epigenetic status including histone modification and chromatin structure, directly influences Sox9-regulated chondrocyte differentiation. In this article, we review the regulators of Sox9 expression itself, modulators of posttranslational Sox9 function, and Sox9-associating factors in the Sox9-dependent epigenetic regulation during chondrogenesis.
Chinese Associations and the Making of Chinese Identities in Singapore (1819-1959)
Miho Goda
Kasarinlan : Philippine Journal of Third World Studies , 1998,
Abstract: The identity of the Chinese in Singapore took more than a century and half to develop. During British rule it began with one's place of origin and dialect or bang. The Chinese identity remained ethnically fragmented until the mainland became a republic. The emergence of communism was the next turning point as dissatisfied Chinese began identifying themselves as Singaporeans. These stages in the evolution and development of Chinese identities took place under the guidance of Chinese associations and the schools they established and managed in the Crown colony.
Optimization of Lattice QCD codes for the AMD Opteron processor
Miho Koma
Physics , 2005, DOI: 10.1016/j.nima.2005.11.108
Abstract: We report our experience of the optimization of the lattice QCD codes for the new Opteron cluster at DESY Hamburg, including benchmarks. Details of the optimization using SSE/SSE2 instructions and the effective use of prefetch instructions are discussed.
Uniqueness of the direct decomposition of toric manifolds
Miho Hatanaka
Mathematics , 2013,
Abstract: In this paper, we study the uniqueness of the direct decomposition of a toric manifold. We first observe that the direct decomposition of a toric manifold as \emph{algebraic varieties} is unique up to order of the factors. An algebraically indecomposable toric manifold happens to decompose as smooth manifold and no criterion is known for two toric manifolds to be diffeomorphic, so the unique decomposition problem for toric manifolds as \emph{smooth manifolds} is highly nontrivial and nothing seems known for the problem so far. We prove that this problem is affirmative if the complex dimension of each factor in the decomposition is less than or equal to two. A similar argument shows that the direct decomposition of a smooth manifold into copies of $\mathbb{C}P^1$ and simply connected closed smooth 4-manifolds with smooth actions of $(S^1)^2$ is unique up to order of the factors.
Lipopolysaccharide-Deficient Mutants of Salmonella enterica Have Increased Sensitivity to Catechins  [PDF]
Miho Yoshii, Akira Okamoto, Michio Ohta
Advances in Microbiology (AiM) , 2013, DOI: 10.4236/aim.2013.35054
Abstract:

Antimicrobial activity is one of the well-known biological characteristics of catechins, the main extract of green tea leaves. It is thought that catechins intercalate into the bacterial cell membrane and damage the lipid bilayer. However, the association between catechins and lipopolysaccharides, which consist of an O side chain, core oligosaccharide, and lipid A, has not been previously investigated. In this study, we evaluated the catechin sensitivity of Salmonella enterica mutants that lack the O side chain and have core oligosaccharides of different lengths. These rough mutants were more sensitive to catechins than a bacterial strain with intact lipopolysaccharide. We conclude that the O side chain and core oligosaccharide play an important role in protecting Gram-negative bacteria against the antimicrobial activity of catechins.

Changes in Attitudes toward Lumbar Spinal Stenosis Treatment  [PDF]
Shin-ichi Konno, Miho Sekiguchi
Open Journal of Orthopedics (OJO) , 2014, DOI: 10.4236/ojo.2014.46027
Abstract: As the environment surrounding healthcare continues to evolve, there is a need to revise outcome assessment criteria. A shift is being demanded in diagnosis and treatment outcome assessment practices from objective to subjective assessment and from evaluation by doctors to assessment that is based on the patient’s own perspective. Therefore, lumbar diseases must now be assessed from multiple perspectives. Some major indices for evaluation are pain and numbness, functional status, general health status, disability, and patient satisfaction. An effective assessment method for lumbar spinal stenos is that examines symptoms, quality of life, and healthcare economics as key assessment factor is reviewed.
Mast Cell Infiltration and Leukotriene Receptor Expression in Various Tumors: Possible Clinical Application of Common Pathological Findings Concerned with Tumor Development  [PDF]
Masao Sugamata, Tomomi Ihara, Miho Sugamata
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.67066
Abstract: Since the mechanisms of the developmental processes of tumors remain unclear, early detection and early treatment of the tumors is necessary to save patients with malignant tumors. Therapies currently available to patients are surgery, chemotherapy, and radiotherapy. However, there are many patients who cannot be saved by such therapies. In this study, we found the common features of various tumor tissues, and we demonstrated the effect of therapeutics that target them by using experimental rats with spontaneous tumors. 26 kinds of human tumors (epithelial or mesenchymal origin, and malignant or benign) and Sprague-Dawley rats with spontaneous mammary gland tumors were examined by light and electron microscope. To detect of mast cells and leukotriene receptor, toluidine blue stain and immunohistochemical stain were performed. The rats were orally administered one of leukotriene receptor antagonists. We found that the presence of numerous mast cells and expression of leukotriene receptors in various tumor (human tumors and rat spontaneous tumors). And the therapeutic effects, which suppressed not only tumor progress but also angiogenesis and nerve formation, for rat tumors by administration of leukotriene receptor antagonist could obtain. Our data suggest the possibility that allergic reactions, in which leukotriene and leukotriene receptors in particular appear to play an important role, are involved in the development and progression of tumors and that it may be possible to control tumor progression by regulating such reactions. Our results might be useful for clinical applications of oncotherapy.
Relationship between Reflective Practice Skills and Volume of Writing in a Reflective Journal  [PDF]
Miho Tanaka, Reiko Okamoto, Keiko Koide
Health (Health) , 2018, DOI: 10.4236/health.2018.103022
Abstract: Background: According to the diversification of the health needs and the expansion of health disparities, public health nurses need to improve their practical capabilities, starting from basic education in graduate and undergraduate courses. And Reflective Practice with using reflective journal is one way of improving practical capabilities. The purpose of this study was to investigate the relationship between the volume of reflective journal and the quality of progress in the reflective cycle. Methods: The participants in this study were 20 junior students majoring in public health nursing (hereinafter “PHN students”) at a university in the Chugoku area, Japan. We asked the participants to answer the questions on Reflective Practice Skills (RPS) composed of six criteria corresponding to the six questions of Gibbs on the reflective cycle before and after they started writing RJ. The volume of reflective writing was measured by the number of characters written by the PHN students in RJ of the reflective practice for three months. The study plan was approved by the Ethics Committee for Nursing Study, Okayama University. Results: Although the average total RPS score showed a change of about 3 points as a result of the 3-month RJ writing exercise, no correlation was observed between the RPS score and the RJ writing volume (r = 0.175). However, we did observe a moderately positive correlation between the RPS score and the RJ writing volume with regard to Items 5 and 6 (r = 0.475 and r = 0.444, respectively). Conclusion: This study indicated that detailed RJ writing helps to complete the reflective cycle all the way to theorization and action planning, and that the volume of writing may serve as a criterion for qualitative evaluation.
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