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Search Results: 1 - 10 of 35185 matches for " Mick van der Wegen "
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河口海岸中长时间尺度动力地貌系统模拟研究与进展
郭磊城,何青,Dano,ROELVINK,Zhengbing,WANG,Mick,VAN,DER,WEGEN
地理学报 , 2013, DOI: 10.11821/dlxb201309003
Abstract: 我国河口海岸动力沉积和动力地貌研究以沉积学和地貌学的方法侧重静态描述,动力地貌相互作用的定量研究不多,与缺少动力地貌模型技术有关。本文介绍了中长时间尺度的河口海岸动力地貌模型技术及其发展和应用,讨论了决定动力地貌演变的泥沙余输运及引起泥沙余输运的主要动力因子,介绍了动力地貌模型的应用进展,进而分析了河口海岸地貌过程的机制和地貌平衡系统。本文指出对淤泥质及复杂动力条件下的河口海岸动力地貌过程还有待进一步研究。
Projected Evolution of California's San Francisco Bay-Delta-River System in a Century of Climate Change
James E. Cloern, Noah Knowles, Larry R. Brown, Daniel Cayan, Michael D. Dettinger, Tara L. Morgan, David H. Schoellhamer, Mark T. Stacey, Mick van der Wegen, R. Wayne Wagner, Alan D. Jassby
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0024465
Abstract: Background Accumulating evidence shows that the planet is warming as a response to human emissions of greenhouse gases. Strategies of adaptation to climate change will require quantitative projections of how altered regional patterns of temperature, precipitation and sea level could cascade to provoke local impacts such as modified water supplies, increasing risks of coastal flooding, and growing challenges to sustainability of native species. Methodology/Principal Findings We linked a series of models to investigate responses of California's San Francisco Estuary-Watershed (SFEW) system to two contrasting scenarios of climate change. Model outputs for scenarios of fast and moderate warming are presented as 2010–2099 projections of nine indicators of changing climate, hydrology and habitat quality. Trends of these indicators measure rates of: increasing air and water temperatures, salinity and sea level; decreasing precipitation, runoff, snowmelt contribution to runoff, and suspended sediment concentrations; and increasing frequency of extreme environmental conditions such as water temperatures and sea level beyond the ranges of historical observations. Conclusions/Significance Most of these environmental indicators change substantially over the 21st century, and many would present challenges to natural and managed systems. Adaptations to these changes will require flexible planning to cope with growing risks to humans and the challenges of meeting demands for fresh water and sustaining native biota. Programs of ecosystem rehabilitation and biodiversity conservation in coastal landscapes will be most likely to meet their objectives if they are designed from considerations that include: (1) an integrated perspective that river-estuary systems are influenced by effects of climate change operating on both watersheds and oceans; (2) varying sensitivity among environmental indicators to the uncertainty of future climates; (3) inevitability of biological community changes as responses to cumulative effects of climate change and other drivers of habitat transformations; and (4) anticipation and adaptation to the growing probability of ecosystem regime shifts.
In Vivo Detection of Amyloid-β Deposits Using Heavy Chain Antibody Fragments in a Transgenic Mouse Model for Alzheimer's Disease
Rob J. A. Nabuurs, Kim S. Rutgers, Mick M. Welling, Athanasios Metaxas, Maaike E. de Backer, Maarten Rotman, Brian J. Bacskai, Mark A. van Buchem, Silvère M. van der Maarel, Louise van der Weerd
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0038284
Abstract: This study investigated the in vivo properties of two heavy chain antibody fragments (VHH), ni3A and pa2H, to differentially detect vascular or parenchymal amyloid-β deposits characteristic for Alzheimer's disease and cerebral amyloid angiopathy. Blood clearance and biodistribution including brain uptake were assessed by bolus injection of radiolabeled VHH in APP/PS1 mice or wildtype littermates. In addition, in vivo specificity for Aβ was examined in more detail with fluorescently labeled VHH by circumventing the blood-brain barrier via direct application or intracarotid co-injection with mannitol. All VHH showed rapid renal clearance (10–20 min). Twenty-four hours post-injection 99mTc-pa2H resulted in a small yet significant higher cerebral uptake in the APP/PS1 animals. No difference in brain uptake were observed for 99mTc-ni3A or DTPA(111In)-pa2H, which lacked additional peptide tags to investigate further clinical applicability. In vivo specificity for Aβ was confirmed for both fluorescently labeled VHH, where pa2H remained readily detectable for 24 hours or more after injection. Furthermore, both VHH showed affinity for parenchymal and vascular deposits, this in contrast to human tissue, where ni3A specifically targeted only vascular Aβ. Despite a brain uptake that is as yet too low for in vivo imaging, this study provides evidence that VHH detect Aβ deposits in vivo, with high selectivity and favorable in vivo characteristics, making them promising tools for further development as diagnostic agents for the distinctive detection of different Aβ deposits.
Revision Rates after Primary Hip and Knee Replacement in England between 2003 and 2006
Nokuthaba Sibanda,Lynn P Copley,Jim D Lewsey,Mick Borroff,Paul Gregg,Alex J MacGregor,Martin Pickford,Martyn Porter,Keith Tucker,Jan H van der Meulen ,on behalf of the Steering Committee of the National Joint Registry (NJR) for England and Wales
PLOS Medicine , 2008, DOI: 10.1371/journal.pmed.0050179
Abstract: Background Hip and knee replacement are some of the most frequently performed surgical procedures in the world. Resurfacing of the hip and unicondylar knee replacement are increasingly being used. There is relatively little evidence on their performance. To study performance of joint replacement in England, we investigated revision rates in the first 3 y after hip or knee replacement according to prosthesis type. Methods and Findings We linked records of the National Joint Registry for England and Wales and the Hospital Episode Statistics for patients with a primary hip or knee replacement in the National Health Service in England between April 2003 and September 2006. Hospital Episode Statistics records of succeeding admissions were used to identify revisions for any reason. 76,576 patients with a primary hip replacement and 80,697 with a primary knee replacement were included (51% of all primary hip and knee replacements done in the English National Health Service). In hip patients, 3-y revision rates were 0.9% (95% confidence interval [CI] 0.8%–1.1%) with cemented, 2.0% (1.7%–2.3%) with cementless, 1.5% (1.1%–2.0% CI) with “hybrid” prostheses, and 2.6% (2.1%–3.1%) with hip resurfacing (p < 0.0001). Revision rates after hip resurfacing were increased especially in women. In knee patients, 3-y revision rates were 1.4% (1.2%–1.5% CI) with cemented, 1.5% (1.1%–2.1% CI) with cementless, and 2.8% (1.8%–4.5% CI) with unicondylar prostheses (p < 0.0001). Revision rates after knee replacement strongly decreased with age. Interpretation Overall, about one in 75 patients needed a revision of their prosthesis within 3 y. On the basis of our data, consideration should be given to using hip resurfacing only in male patients and unicondylar knee replacement only in elderly patients.
Additional Arguments for a Correction of the Debye-Hückel, Maxwell-Boltzmann Equations for Dilute Electrolyte Equilibria  [PDF]
Peter van der Weg
American Journal of Analytical Chemistry (AJAC) , 2018, DOI: 10.4236/ajac.2018.99032
Abstract: Peter Debye and Erich Hückel had developed a theory for the ionic activity coefficients in dilute solutions of strong electrolytes some 95 years ago [1]. Their limiting law still stands and is confirmed as close to reality in many experiments. In a previous article [2], it is shown that these limiting activity coefficients arise because the electrical contribution in the electrochemical potential of ionic species is overestimated traditionally with a factor 2. The smaller value removes inconsistencies in the models and complies better with the basic electrostatic principles. In this article further evidence is given in support of this alternative description. As consequence the dilute activity coefficients become unity, e.g. are removed, which means that the electrochemical potential of ions in dilute solutions is expressed directly in concentration, instead of activity, which simplifies modelling in such dilute solutions.
Chest Wall Reconstruction with Precontoured Locking Plate Proof of Concept  [PDF]
Elmer Lodder, Maarten van der Elst
Journal of Cancer Therapy (JCT) , 2010, DOI: 10.4236/jct.2010.13021
Abstract: Complications after chest wall resection are common and are reported to occur in approximately 40% of patients. The most frequent complications are respiratory or wound complications. Restoring rib continuity after a resection is likely to prevent respiratory complications. However many patients remain painful after a reconstruction. This article describes a new technique using a titanium alloy precontoured locking plate and locking screws to reconstruct the chest wall after resection of the 7th rib on the left.
Diminishing demandingness of parents; children with recurrent infections  [PDF]
Ellen van der Gaag, Miriam Münow
Health (Health) , 2012, DOI: 10.4236/health.2012.48077
Abstract: Background and Method: Parenting and parenting styles are in favor of authoritative parents compared with non-authoritative parents. These parents display higher levels of both responsiveness and demandingness. We studied the aspect of demandingness using a questionnaire aimed at children aged between 1 and 4 years. 82 Children with recurrent respiratory infections (RRI) and 399 control children were included. Results: Parents of RRI children regulated the quantitative dietary intake of their child less; likewise they gave less stimulation to their children to eat. They also taught their children less on what they can or cannot touch and they argued more with their children (all p < 0.05). However, when it comes to simple rules like watching television or not, the parents of RRI children were very clear. There were however no differences in rules about television watching, computer time or bedtimes. Conclusions: Our study shows that parents of children with RRI are less demanding in complex pedagogic situations that ask for creativity from the parents. However, they are demanding with respect to simple rules. We found no child factors that could explain why children give their parents a hard time. We hypothesize that the parents of RRI children could be less capable of handling complex pedagogic situations (even more complicated by the infections) instead of being unwilling.
Classification of Toxic Cyanobacterial Blooms by Fourier-Transform Infrared Technology (FTIR)  [PDF]
Gabriel Kenne, Deon van der Merwe
Advances in Microbiology (AiM) , 2013, DOI: 10.4236/aim.2013.36A001
Abstract: Cyanobacteria are gram-negative photosynthetic bacteria capable of producing toxins responsible for morbidity and mortality in humans and domestic animals. They are capable of forming concentrated blooms, referred to as harmful algal blooms (HABs). Characterization of HABs is necessary to reduce risks from human and animal exposures to toxins. Current methods used to classify cyanobacteria and cyanotoxins have limitations related to time, analyst skills, and cost. Fourier-Transform Infrared Spectroscopy (FTIR) is a potential tool for rapid, robust cyanobacterial classification that is not limited by these factors. To examine the practicality of this method, library screening with default software algorithms was performed on HAB samples, followed by principle component cluster analyses and dendrogram analysis of samples meeting minimum quality requirements. Two tested spectrometers and software packages were successful at distinguishing cyanobacteria from green algae. Principle component cluster analysis and dendrogram analysis also resulted in clear differentiation between cyanobacteria and green algae. While these methods cannot be used independently to fully characterize HABs, they show the potential and practicality of FTIR as a screening tool.
Tortuguero National Park, Costa Rica: Baseline CO2 Emissions from Boat Tours into the Channels System  [PDF]
Irene Alvarado-Van der Laat
Low Carbon Economy (LCE) , 2014, DOI: 10.4236/lce.2014.51003
Abstract:

Tortuguero National Park located on the Caribbean coast of Costa Rica is only accessible by boat or air and attracts an average of 130,000 visitors yearly. The main activity of the park is the turtle nesting and hatching along the beaches as well as the observation of wildlife in the channel sys- tem. This makes it important to study the CO2 emitted by the tours operating in the park. To cal- culate these emissions researchers gathered data on engine type, horsepower and duration of idle while boats waited to buy tickets at the park entrance. The study found that tour operators emit- ted a minimum of 5.5 tons of CO2 per year into the atmosphere and water. It is likely that the park is more polluted than immediately evident.

Hospitalization Can Correct Behavioral Feeding Disorders in Children by Resetting the Pedagogic Climate  [PDF]
Ellen van der Gaag, Miriam Münow
Open Journal of Pediatrics (OJPed) , 2014, DOI: 10.4236/ojped.2014.42019
Abstract:

Background: Behavioral feeding disorders are common among children, which sometimes become progressive, and consequently, children may refuse to eat anything. Parents have lots of difficulties to reset such a disturbed eating pattern. The aim of this study was to perform an analysis of clinical intervention in behavioral feeding disorders in young children. Methods: We conducted a retrospective analysis of data of 28 children aged 1 - 9 years with behavioral feeding disorders. A pediatrician and pediatric social worker conducted the training in two groups: outpatient or inpatient setting. Both groups were treated with parental education and guidance. The inpatient group also had a temporarily (2 weeks) resetting of the pedagogic climate in a pediatric ward of a general hospital under guidance of a pediatric social worker. Results: Almost all parents were inconsistent in applying appropriate behavioral contingencies during meals. Eleven patients followed 8 months of outpatient treatment and 25 patients followed 2 weeks of inpatient treatment. The overall success rate of outpatient treatment after 2 weeks was 18%, and that of inpatient treatment after 8 months was 88%. The corrected relapse rates are 18% and 56% respectively after 6 months. Conclusion: Short clinical intervention in a structured pedagogic environment is a successful treatment in behavioral feeding disorders. Herewith, pediatricians have a powerful tool for treating behavioral feeding disorders by temporarily resetting and changing the pedagogic climate.

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