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Search Results: 1 - 10 of 215868 matches for " Michelle P Luo "
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Psychometric characteristics of the short form 36 health survey and functional assessment of chronic illness Therapy-Fatigue subscale for patients with ankylosing spondylitis
Dennis A Revicki, Anne M Rentz, Michelle P Luo, Robert L Wong
Health and Quality of Life Outcomes , 2011, DOI: 10.1186/1477-7525-9-36
Abstract: We analyzed clinical and patient-reported outcome (PRO) data collected during 12-week, double-blind, placebo-controlled periods of two randomized controlled trials comparing adalimumab and placebo for the treatment of active AS. The Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional Index, and other clinical measures were collected during the clinical trial. We evaluated internal consistency/reliability, construct validity, and responsiveness to change for the SF-36 and FACIT-Fatigue.The SF-36 (Cronbach alpha, 0.74-0.92) and FACIT-Fatigue (Cronbach alpha, 0.82-0.86) both had good internal consistency/reliability. At baseline, SF-36 and FACIT-Fatigue scores correlated significantly with Ankylosing Spondylitis Quality of Life scores (r = -0.36 to -0.66 and r = -0.70, respectively; all p < 0.0001). SF-36 scores varied by indicators of clinical severity, with greater impairment observed for more severe degrees of clinical activity (all p < 0.0001). FACIT-Fatigue scores correlated significantly with SF-36 scores (r = 0.42 to 0.74; all p < 0.0001) and varied by clinical severity (p < 0.05 to p < 0.0001).The SF-36 is a reliable, valid, and responsive measure of health-related quality of life and the FACIT-Fatigue is a brief and psychometrically sound measure of the effects of fatigue on patients with AS. These PROs may be useful in evaluating effectiveness of new treatments for AS.ClinicalTrials.gov: NCT00085644 and NCT00195819Ankylosing spondylitis (AS) is a chronic and progressive inflammatory disorder that primarily affects the axial skeleton, sacroiliac joints of the pelvis, and thoracic cage [1,2]. Patients experience pain, joint stiffness, and the eventual loss of spinal mobility with disease progression. Patients with AS frequently experience impaired physical function and well-being, require time away from work because of disability, and suffer from diminished health-related quality of life (HRQOL) [3-7]. The impact of AS on
Translation and validation of non-English versions of the Ankylosing Spondylitis Quality of Life (ASQOL) questionnaire
Lynda C Doward, Stephen P McKenna, David M Meads, James Twiss, Dennis Revicki, Robert L Wong, Michelle P Luo
Health and Quality of Life Outcomes , 2007, DOI: 10.1186/1477-7525-5-7
Abstract: The UK English ASQOL was translated into US English; Canadian French and English; French; German; Italian; Spanish; and Swedish (dual-panel methods). Cognitive debriefing interviews were conducted with AS patients. Psychometric/scaling properties were assessed using data from two Phase III studies of adalimumab. Baseline and Week-2 data were used to assess test-retest reliability. Validity was determined by correlation of ASQOL with SF-36 and BASFI and by discriminative ability of ASQOL based on disease severity. Item response theory (Rasch model) was used to test ASQOL's scaling properties.Cognitive debriefing showed the new ASQOL versions to be clear, relevant and comprehensive. Sample sizes varied, but were sufficient for: psychometric/scaling assessment for US English and Canadian English; psychometric but not scaling analyses for German; and preliminary evidence of these properties for the remaining languages. Test-retest reliability and Cronbach's alpha coefficients were high: US English (0.85, 0.85), Canadian English (0.87, 0.86), and German (0.77, 0.79). Correlations of ASQOL with SF-36 and BASFI for US English, Canadian English, and German measures were moderate, but ASQOL discriminated between patients based on perceived disease severities (p < 0.01). Results were comparable for the other languages. US English and Canadian English exhibited fit to the Rasch model (non-significant p-values: 0.54, 0.68), confirming unidimensionality.The ASQOL was successfully translated into all eight languages. Psychometric properties were excellent for US English, Canadian English, and German, and extremely promising for the other languages.Ankylosing spondylitis (AS) is a chronic rheumatic disease with a worldwide prevalence of up to 0.9% [1] and rates as high as 2.0% reported for some ethnic groups [2]. The sacroiliac joints are affected and, to a varying degree, the spinal column. The disease may also involve the peripheral joints and extra-articular structures [1]. Pat
Retraction: Psychometric characteristics of the ankylosing spondylitis quality of life questionnaire, short form 36 health survey, and functional assessment of chronic illness therapy-fatigue subscale
Dennis A Revicki, Anne M Rentz, Michelle P Luo, Robert L Wong, Lynda C Doward, Stephen P McKenna
Health and Quality of Life Outcomes , 2009, DOI: 10.1186/1477-7525-7-34
Abstract: Not all authors approved of the final content or publication of this article [1]. Subsequently, all authors have agreed that the article should be retracted. This article is being retracted as assumptions were made about the nature of the outcome data that should have been tested before the analyses were conducted. In addition, there is disagreement among the authors about the statistical analyses that were used and it is possible that incorrect conclusions may have been drawn that are not supported by the data presented. The authors wish to apologise for any inconvenience this may have caused the editorial, publishing staff and readers.
Psychometric characteristics of the ankylosing spondylitis quality of life questionnaire, short form 36 health survey, and functional assessment of chronic illness therapy-fatigue subscale
Dennis A Revicki, Anne M Rentz, Michelle P Luo, Robert L Wong, Lynda C Doward, Stephen P McKenna
Health and Quality of Life Outcomes , 2009, DOI: 10.1186/1477-7525-7-6
Tracking dynamics of plant biomass composting by changes in substrate structure, microbial community, and enzyme activity
Hui Wei, Melvin P Tucker, John O Baker, Michelle Harris, Yonghua Luo, Qi Xu, Michael E Himmel, Shi-You Ding
Biotechnology for Biofuels , 2012, DOI: 10.1186/1754-6834-5-20
Abstract: However, the complexity of both the structure of plant biomass and its counterpart microbial degradation communities makes it difficult to investigate the composting process.In this study, a composter was set up with a mix of yellow poplar (Liriodendron tulipifera) wood-chips and mown lawn grass clippings (85:15 in dry-weight) and used as a model system. The microbial rDNA abundance data obtained from analyzing weekly-withdrawn composted samples suggested population-shifts from bacteria-dominated to fungus-dominated communities. Further analyses by an array of optical microscopic, transcriptional and enzyme-activity techniques yielded correlated results, suggesting that such population shifts occurred along with early removal of hemicellulose followed by attack on the consequently uncovered cellulose as the composting progressed.The observed shifts in dominance by representative microbial groups, along with the observed different patterns in the gene expression and enzymatic activities between cellulases, hemicellulases, and ligninases during the composting process, provide new perspectives for biomass-derived biotechnology such as consolidated bioprocessing (CBP) and solid-state fermentation for the production of cellulolytic enzymes and biofuels.The intertwining matrix of biopolymers (celluloses, hemicelluloses, and lignins, as prominent examples) of which plant cell walls are composed poses a major obstacle to the deconstruction of these walls to simple sugars and chemicals that can serve as raw materials for the fermentative production of alternative liquid fuels and other bioproducts. This major bottleneck in biomass conversion technology can be mitigated by 1) reducing plant biomass recalcitrance through genetic engineering of energy crops, thereby 2) minimizing the requirement for thermo-chemical feedstock pretreatment, 3) improving performance of the enzymes used for saccharification, and 4) introducing the one step conversion concept, or consolidated biopro
Teacher Metacognition within the Professional Learning Community
Michelle P Prytula
International Education Studies , 2012, DOI: 10.5539/ies.v5n4p112
Abstract: A study of teacher metacognition within the context of the professional learning community (PLC) was conducted to understand how teachers describe their metacognition, what they describe as the catalysts to their metacognition, and how metacognition influences their work. Although the PLC was used as a context for the study, the findings include that the PLC was an environment in which teacher metacognition could be nurtured, and that the PLC leaders’ recognition of their own metacognition impacted the type of work that they led in the PLC, thus potentially impacting the learning of others.
Brain CB2 Receptors: Implications for Neuropsychiatric Disorders
Michelle Roche,David P Finn
Pharmaceuticals , 2010, DOI: 10.3390/ph3082517
Abstract: Although previously thought of as the peripheral cannabinoid receptor, it is now accepted that the CB 2 receptor is expressed in the central nervous system on microglia, astrocytes and subpopulations of neurons. Expression of the CB 2 receptor in the brain is significantly lower than that of the CB 1 receptor. Conflicting findings have been reported on the neurological effects of pharmacological agents targeting the CB 2 receptor under normal conditions. Under inflammatory conditions, CB 2 receptor expression in the brain is enhanced and CB 2 receptor agonists exhibit potent anti-inflammatory effects. These findings have prompted research into the CB 2 receptor as a possible target for the treatment of neuroinflammatory and neurodegenerative disorders. Neuroinflammatory alterations are also associated with neuropsychiatric disorders and polymorphisms in the CB 2 gene have been reported in depression, eating disorders and schizophrenia. This review will examine the evidence to date for a role of brain CB 2 receptors in neuropsychiatric disorders.
Health Promotion in Cardiac Rehabilitation Patients through the Use of a High-Intensity Interval Training Protocol  [PDF]
Michelle Tinkham
World Journal of Cardiovascular Diseases (WJCD) , 2014, DOI: 10.4236/wjcd.2014.410059
Abstract: According to the American Heart Association’s (AHA) recent statistical update, over 2150 Americans die each day from cardiovascular disease (CVD), which equals approximately 1 death every 40 seconds; many of which were under the age of 65 years old [1]. In 2009, 386,324 people, 1 in 6 Americans, died as a result of coronary artery disease (CAD) alone [1]. They also estimate 150,000 people have “silent” heart attacks each year [1]. Even though the number of cardiovascular disease deaths has declined in the last 10 years, they still accounted for 32.3% of American deaths [1]. As a result, the AHA updated their 2020 goals to improve the nation’s cardiovascular health by 20% [1]. One of these methods is through the use of cardiac rehabilitation. Cardiac rehabilitation (CR) is a health promotion strategy to help return cardiac patients to their previous level of functioning, increase health, decrease comorbidities and promote education and lifestyle change. For select patients, another alternative exercise plan may exist to gain even better results. High intensity interval training (HIIT) has shown positive training results for athletes and many studies show that it may also be an effective exercise modality for many cardiac patients instead of the traditional circuit training method. This article will review current literature on the effects of HIIT on CR patients as well as a sample HIIT protocol for instituting this treatment with appropriate patients.
Emotionally Competent Behaviors and Nurse Bullying: Is There a Direct Link?  [PDF]
Michelle Doas
Open Journal of Psychiatry (OJPsych) , 2015, DOI: 10.4236/ojpsych.2015.51008
Abstract: An abundance of literature spanning many years depicts the devastating effects of nurse bullying within the profession. The evidence suggests that bullying in general is a deliberate act aimed at another person. Conceptualizing nurse bullying appears to be a key ingredient in creating both awareness and preventative strategies. Emotional competence includes a set of behaviors which are unique to each individual. These behaviors according to Goldman (1995) include, but are not limited to emotional self-assessment, accurate self-assurance, self-confidence, emotional self-control, and empathy. The majority of researchers agree that emotionally competent behaviors are impacted by both positive and negative interactions and experiences. Thus, it is hypothesized that emotionally competent behaviors are continually cultivated throughout one’s life based upon lived experiences. This article assesses direct relationships between implementation of emotionally competent behaviors as a means of combatting nurse bullying within the profession. Creating awareness of these two areas can be initial steps in cultivating the needed tools and supportive interventions to assist nurses from novice to expert to professionally mentor and role model for generations to come.
Are We Losing the Art of Actively Listening to Our Patients? Connecting the Art of Active Listening with Emotionally Competent Behaviors  [PDF]
Michelle Doas
Open Journal of Nursing (OJN) , 2015, DOI: 10.4236/ojn.2015.56060
Abstract: Active listening is an essential communication technique that requires the listener to focus and provide feedback on what is heard. The ability to listen actively demonstrates sincerity, and assumes that nothing is being shrugged or taken for granted. As a result, active listeners strive to improve professional and personal relationships, decrease misinterpretation of information, strengthen compliance, and foster understanding. Likewise, active listening can foster trust, mutual respect, and patient compliance. This paper will explore vital connections between active listening and displaying emotionally competent behaviors. Additionally, analysis of a case study as a means of strengthening these connections while improving patient outcomes will be assessed.
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