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Search Results: 1 - 10 of 4329 matches for " Michelle Butler "
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Snowmass 2013 Computing Frontier Storage and Data Management
Michelle Butler,Richard Mount,Mike Hildreth
Physics , 2013,
Abstract: The data storage and data management needs are summarized for the energy frontier, intensity frontier, cosmic frontier, lattice field theory, perturbative QCD and accelerator science. The outlook for data storage technologies and costs is then outlined, followed by a summary of the current state of data, software and physics analysis capability preservation. The HEP outlook is summarized, pointing out where future data volumes may strain against what is technologically and financially feasible. Finally recommendations for areas of particular attention and action are made.
Pertussis vaccination in Child Care Workers: room for improvement in coverage, policy and practice
Kirsty Hope, Michelle Butler, Peter D Massey, Patrick Cashman, David N Durrheim, Jody Stephenson, April Worley
BMC Pediatrics , 2012, DOI: 10.1186/1471-2431-12-98
Abstract: A cross sectional survey of all child care centre directors in the Hunter New England (HNE) area of northern NSW was conducted in 2010 using a computer assisted telephone interviewing service.Ninety-eight percent (319/325) of child care centres identified within the HNE area participated in the survey. Thirty-five percent (113/319) of centres indicated that they had policies concerning respiratory illness in staff members. Sixty-three percent (202/319) of centres indicated that they kept a record of staff vaccination, however, of the 170 centre’s who indicated they updated their records, 74% (125/170) only updated records if a staff member notified them. Of centres with records, 58% indicated that fewer than half of their staff were vaccinated.Many childcare workers have not had a recent pertussis immunisation. This potentially places young children at risk at an age when they are most vulnerable to severe disease. With increasing use of child care, national accreditation and licensing requirements need to monitor the implementation of policies on child care worker vaccination. Higher levels of vaccination would assist in reducing the risk of pertussis cases and subsequent outbreaks in child care centres.The resurgence of pertussis (whooping cough) in Australia has attracted community concern, especially with recent deaths in two infants from the Australian state of New South Wales (NSW) [1,2]. Although pertussis incidence declined after the widespread use of whole cell pertussis vaccines in the mid-1940’s, this disease remains an important cause of morbidity in Australia, especially in young infants [3].This bacterial infection of the respiratory tract, caused by Bordetella pertussis, usually begins with coryza (nasal conjestion), fatigue and sometimes a mild fever. A cough then develops, which is often paroxysmal, may be followed by a deep gasp (or whoop). Pertussis affects people of all ages with infants being at greatest risk of severe disease, complications, ho
Small Molecule Inhibitors as Countermeasures for Botulinum Neurotoxin Intoxication
Bing Li,Norton P. Peet,Michelle M. Butler,James C. Burnett,Donald T. Moir,Terry L. Bowlin
Molecules , 2011, DOI: 10.3390/molecules16010202
Abstract: Botulinum neurotoxins (BoNTs) are the most potent of known toxins and are listed as category A biothreat agents by the U.S. CDC. The BoNT-mediated proteolysis of SNARE proteins inhibits the exocytosis of acetylcholine into neuromuscular junctions, leading to life-threatening flaccid paralysis. Currently, the only therapy for BoNT intoxication (which results in the disease state botulism) includes experimental preventative antibodies and long-term supportive care. Therefore, there is an urgent need to identify and develop inhibitors that will serve as both prophylactic agents and post-exposure ‘rescue’ therapeutics. This review focuses on recent progress to discover and develop small molecule inhibitors as therapeutic countermeasures for BoNT intoxication.
Health Promotion in Cardiac Rehabilitation Patients through the Use of a High-Intensity Interval Training Protocol  [PDF]
Michelle Tinkham
World Journal of Cardiovascular Diseases (WJCD) , 2014, DOI: 10.4236/wjcd.2014.410059
Abstract: According to the American Heart Association’s (AHA) recent statistical update, over 2150 Americans die each day from cardiovascular disease (CVD), which equals approximately 1 death every 40 seconds; many of which were under the age of 65 years old [1]. In 2009, 386,324 people, 1 in 6 Americans, died as a result of coronary artery disease (CAD) alone [1]. They also estimate 150,000 people have “silent” heart attacks each year [1]. Even though the number of cardiovascular disease deaths has declined in the last 10 years, they still accounted for 32.3% of American deaths [1]. As a result, the AHA updated their 2020 goals to improve the nation’s cardiovascular health by 20% [1]. One of these methods is through the use of cardiac rehabilitation. Cardiac rehabilitation (CR) is a health promotion strategy to help return cardiac patients to their previous level of functioning, increase health, decrease comorbidities and promote education and lifestyle change. For select patients, another alternative exercise plan may exist to gain even better results. High intensity interval training (HIIT) has shown positive training results for athletes and many studies show that it may also be an effective exercise modality for many cardiac patients instead of the traditional circuit training method. This article will review current literature on the effects of HIIT on CR patients as well as a sample HIIT protocol for instituting this treatment with appropriate patients.
Emotionally Competent Behaviors and Nurse Bullying: Is There a Direct Link?  [PDF]
Michelle Doas
Open Journal of Psychiatry (OJPsych) , 2015, DOI: 10.4236/ojpsych.2015.51008
Abstract: An abundance of literature spanning many years depicts the devastating effects of nurse bullying within the profession. The evidence suggests that bullying in general is a deliberate act aimed at another person. Conceptualizing nurse bullying appears to be a key ingredient in creating both awareness and preventative strategies. Emotional competence includes a set of behaviors which are unique to each individual. These behaviors according to Goldman (1995) include, but are not limited to emotional self-assessment, accurate self-assurance, self-confidence, emotional self-control, and empathy. The majority of researchers agree that emotionally competent behaviors are impacted by both positive and negative interactions and experiences. Thus, it is hypothesized that emotionally competent behaviors are continually cultivated throughout one’s life based upon lived experiences. This article assesses direct relationships between implementation of emotionally competent behaviors as a means of combatting nurse bullying within the profession. Creating awareness of these two areas can be initial steps in cultivating the needed tools and supportive interventions to assist nurses from novice to expert to professionally mentor and role model for generations to come.
Are We Losing the Art of Actively Listening to Our Patients? Connecting the Art of Active Listening with Emotionally Competent Behaviors  [PDF]
Michelle Doas
Open Journal of Nursing (OJN) , 2015, DOI: 10.4236/ojn.2015.56060
Abstract: Active listening is an essential communication technique that requires the listener to focus and provide feedback on what is heard. The ability to listen actively demonstrates sincerity, and assumes that nothing is being shrugged or taken for granted. As a result, active listeners strive to improve professional and personal relationships, decrease misinterpretation of information, strengthen compliance, and foster understanding. Likewise, active listening can foster trust, mutual respect, and patient compliance. This paper will explore vital connections between active listening and displaying emotionally competent behaviors. Additionally, analysis of a case study as a means of strengthening these connections while improving patient outcomes will be assessed.
Prevention of Cytotoxic T Cell Escape Using a Heteroclitic Subdominant Viral T Cell Determinant
Noah S. Butler equal contributor,Alex Theodossis equal contributor,Andrew I. Webb,Roza Nastovska,Sri Harsha Ramarathinam,Michelle A. Dunstone,Jamie Rossjohn,Anthony W. Purcell ,Stanley Perlman
PLOS Pathogens , 2008, DOI: 10.1371/journal.ppat.1000186
Abstract: High affinity antigen-specific T cells play a critical role during protective immune responses. Epitope enhancement can elicit more potent T cell responses and can subsequently lead to a stronger memory pool; however, the molecular basis of such enhancement is unclear. We used the consensus peptide-binding motif for the Major Histocompatibility Complex molecule H-2Kb to design a heteroclitic version of the mouse hepatitis virus-specific subdominant S598 determinant. We demonstrate that a single amino acid substitution at a secondary anchor residue (Q to Y at position 3) increased the stability of the engineered determinant in complex with H-2Kb. The structural basis for this enhanced stability was associated with local alterations in the pMHC conformation as a result of the Q to Y substitution. Recombinant viruses encoding this engineered determinant primed CTL responses that also reacted to the wildtype epitope with significantly higher functional avidity, and protected against selection of virus mutated at a second CTL determinant and consequent disease progression in persistently infected mice. Collectively, our findings provide a basis for the enhanced immunogenicity of an engineered determinant that will serve as a template for guiding the development of heteroclitic T cell determinants with applications in prevention of CTL escape in chronic viral infections as well as in tumor immunity.
O parentesco é sempre tido como heterossexual?
Butler, Judith;
Cadernos Pagu , 2003, DOI: 10.1590/S0104-83332003000200010
Abstract: using the french debate on the gay marriage as a starting point, the author concludes that either answer to the question, both the "yes" and the "no", work to circumscribe a much more complex reality and considers the political and theoretical risks of so doing.
O limbo de Guantánamo
Butler, Judith;
Novos Estudos - CEBRAP , 2007, DOI: 10.1590/S0101-33002007000100011
Abstract: the article discusses the legal statute of the united states? procedures concerning taliban detainees at guantánamo bay. when questioning the refusal of american authorities to concede these prisoners the status of "prisoners of war" in the terms of the geneva conventions, the author claims a critical revision of this international protocol.
Desdiagnosticando o gênero
Butler, Judith;
Physis: Revista de Saúde Coletiva , 2009, DOI: 10.1590/S0103-73312009000100006
Abstract: the paper takes stock of the current debate on the undoing of the pathologization process of transsexuality in the united states. the author asserts that, if, on one hand, the diagnosis of gender identity disorder is still considered worthwhile to be maintained as to ease the financial means to the transition, on the other hand, opposing the diagnosis is also needed in that the diagnosis presumes as a mental illness what should rather be understood as a possibility among many of gender self-determination. bringing to light how complex and paradoxal this debate is, she contends that these two stands should, however, not be considered fully contradictory since, in her viewpoint, transautonomy will not be achieved as long as a legal, medical and social supportive net is not brought about, which only will really make it possible that one lives a transsexual life.
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