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Creatine supplementation in exercised rats: Effects on the aerobic capacity  [PDF]
Michel Barbosa de Araújo, Roberto C. Vieira Junior, Leandro P. Moura, Marcelo Costa Junior, Rodrigo A. Dalia, Amanda Christine da Silva Sponton, Carla Ribeiro, Maria Alice R. Mello
Open Journal of Animal Sciences (OJAS) , 2013, DOI: 10.4236/ojas.2013.31003
Abstract: This study aimed to analyze the possible metabolic disturbances caused by creatine supplementation on aerobic capacity of rats, inferred by the maximal lactate steady state. Forty male Wistar rats (90 days old) were distributed into two groups for eight weeks: trained group (T): rats that were submitted to a training protocol, and supplemented-trained group (TCr): rats that were submitted to a training protocol and received balanced diet supplemented with 2% creatine. The blood lactate concentrations equivalent to maximal lactate steady state during treadmill running were analyzed at the beginning and also at the end of the experiment. At the end of the experiment were done comparing the test results MLSS between the two groups. At the beginning of the experiment, prior to groups division, the majority of animals obtained MLSS at a speed of26 m/min, blood lactate concentration of 3.79 ± 0.76 mmol/L. At the end of the experiment, most of trained rats in T presented MLSS at the speed of28 m/min, blood lactate concentration of 3.37 ± 0.68 mmol/L. Most TCr had MLSS at the speed of28 m/min, blood lactate concentration of 3.52 ± 0.69 mmol/L. We conclude that creatine supplementation was not the cause of the improvement in the aerobic capacity of rats in the tread-mill exercise.
Respostas fisiológicas ao exercício agudo em ratos obesos tratados com metformina
Araujo, Gustavo Gomes de;Araújo, Michel Barbosa de;Mota, Clécia Soares de Alencar;Ribeiro, Carla;D'Angelo, Ricardo Antonio;Manchado, Fúlvia de Barros;Luciano, Eliete;
Revista Brasileira de Medicina do Esporte , 2007, DOI: 10.1590/S1517-86922007000600007
Abstract: the purpose of the present study was to investigate the physiological responses to intense exercise in obese wistar rats treated with metformin. to induce obesity, all animals were infused with monosodic glutamate (4 mg/g of body weight) via subcutaneous injection. the rats were divided in 4 groups according to the received treatment: obese control (oc); obese metformin ( om); obese control exercise (oce) and obese metformin exercise (ome). before and after one session of intense exercise the following parameters were measured: serum glucose (mg/dl), triglycerides (g/100g), total cholesterol (mg/dl) and haematocrit (%). the values of serum glucose and total cholesterol were significantly reduced in control exercise group (oce - 68.4 ± 14.7 and 70.8 ±18.3) compared to obese control sedentary group (oc - 83.6 ± 12.8 and 91.3 ± 9.6). the isolate metformin infusion decreased the glucose concentration from 83.6 ± 12.8 (oc) to 70.8 ± 5.9 (om). on the other hand, metformin associated with exercise increased the availability of free triglycerides after exercise (om - 166.6 ± 11.3, ome - 184.0 ± 4.3). in conclusion, the present intervention program (intense physical exercise) showed to be efficient on glicemic homeostasis, as well as on lipids circulatory levels in obese rats treated with metformin.
Different Protocols of Physical Training: Effect on Markers of Oxidative Stress in Erythrocytes in Rats  [PDF]
Marcelo Costa-Junior, Wener Barbosa-Resende, Michel Barbosa de Araújo, Rodrigo Augusto Dalia, Leandro Pereira de Moura, Luciana Alves de Medeiros, Lucas Moreira Cunha, Eliete Luciano
Open Access Library Journal (OALib Journal) , 2018, DOI: 10.4236/oalib.1104411
Abstract:
The imbalance between oxidant molecules and antioxidant agents is characterized as oxidative stress (OS) and may lead to severe damage to the organism. In contrast, the physical training of aerobic and resistive character promotes increases of the antioxidant response, resulting in a balance and/or minimizing damage. Therefore, the objective of the study is to verify the effect of aerobic training, resistive training and concurrent training on oxidative stress of Wistar rats. Methods: To perform the experiment, 40 Wistar rats were subjected to eight weeks of training. The animals were distributed into 4 different groups: control, aerobic, resistive and concurrent (combination of aerobic and resistive protocols in the same section) an h/day, five days/week, for eight weeks. At the end of the experimental period: the antioxidant enzymes (catalase, glutathione peroxidase and superoxide dismutase), biomarkers of oxidative stress (TBARs and H2O2) as well as the activity of reduced and oxidized glutathione were analyzed. Results: Regarding the markers, TBARs and H2O2 trainings were not effective in promoting significant reduction. In contrast, the three training protocols caused an increase in SOD and GSH-GPx enzymes. Conclusion: Therefore, we concluded that both training protocols promoted benefit to the organism, because they caused the increase of antioxidant enzymes without disturbance in the pro-oxidant markers.
Máxima Fase estável de lactato em ratos obesos de ambos os gêneros
Araujo, Gustavo Gomes de;Araújo, Michel Barbosa de;DAngelo, Ricardo Antonio;Manchado, Fúlvia de Barros;Mota, Clécia Soares de Alencar;Ribeiro, Carla;Mello, Maria Alice Rostom de;
Revista Brasileira de Medicina do Esporte , 2009, DOI: 10.1590/S1517-86922009000100010
Abstract: the purpose of this study was to identify the exercise intensity equivalent to the aerobic/anaerobic metabolic transition in obese rats of both genders using the maximal lactate steady state (mlss) protocol. four groups of rats were tested on mlss protocol (swimming exercise): male control n=10, female control n=10, male obese n=10 and female obese n=10, after suitable adaptation to exercise in liquid medium and obesity induction by monossodic glutamate (msg) administration. the obese groups had significant increase in subcutaneous adipose tissue as well as mesenteric and retroperitoneal fat depots comparing to the control groups. the lee index was higher in the obese animals in comparison to their respective controls. it was possible to identify the mlss at 6.0% of body weight for both obese groups. concerning the female control group, the mlss was determined at the intensity of 5.0% of body weight, whereas for the male control at 4.5% of body weight. it was concluded that obesity induced by msg interferes in lactate kinetics during exercise and alters the effort intensity corresponding to the metabolic transition in both genders.
Efeitos do treinamento de corrida em diferentes intensidades sobre a capacidade aeróbia e produ??o de lactato pelo músculo de ratos Wistar
Araújo, Michel Barbosa de;Manchado-Gobatto, Fúlvia de Barros;Voltarelli, Fabrício Azevedo;Ribeiro, Carla;Mota, Clécia Soares de Alencar;Gobatto, Claudio Alexandre;Mello, Maria Alice Rostom de;
Revista Brasileira de Medicina do Esporte , 2009, DOI: 10.1590/S1517-86922009000600009
Abstract: there are few studies that associate indicators of aerobic capacity and the substrates produced by the muscular metabolism in rats. the aim of the present study was to analyze the effects of physical training in different intensities on the aerobic capacity and lactate production by the isolated soleus muscle of wistar rats (90 days) that had the aerobic/anaerobic metabolic transition determined by the maximal lactate steady state test (mlss). subsequently, the rats were trained 40 minutes/day, 5 days/week, in the speed equivalent to mlss (mt) or 5% above it (at), for 8 weeks. rats maintained sedentary (s) were used as controls. at the end, all rats were sacrificed for analysis of lactate production by the isolated soleus muscle. the main results were: in the beginning of the experiment, in most of the rats the mlss was obtained in the speed of 25m/min, to the concentration of 4.38+0.22mmol/l of blood lactate. at the end of the experiment, most of the rats trained at the mlss intensity presented mlss in the speed of 25m/min, to the concentration of 3.10+0.27 mmol/l of blood lactate. most of the animals trained above-mlss had mlss in the speed of 25m/min, to the concentration of 3.36+0.62 mmol/l of blood lactate. sedentary rats showed mlss in the speed of 20m/min to the concentration of blood lactate of 4.83+0.67mmol/l. the lactate production (μmol/g.h): s 4.31+0.58, mt 4.71+0.39, at 3.83+0.62 was lower in the st group., it can be concluded from the results of the present study that the aerobic training prevented the deterioration of the aerobic conditioning imposed by the age advance, and that physical training above the mlss reduced muscle lactate production.
Fatores preditores precoces de reinterna??o em unidade de terapia intensiva
Japiassú, André Miguel;Cukier, Michel Schatkin;Queiroz, Ana Gabriela Coelho de Magalh?es;Gondim, Carlos Roberto Naegeli;Penna, Guilherme Loures de Araújo;Almeida, Gustavo Ferreira;Kurtz, Pedro Martins Pereira;Rodrigues, André Salgado;Freitas, Márcia Barbosa de;Souza, Ronaldo Vegni e;Rosa, Paula Araújo;Faria, Clovis Jean da Cruz;Drumond, Luis Eduardo Fonseca;Kalichsztein, Marcelo;Nobre, Gustavo Freitas;
Revista Brasileira de Terapia Intensiva , 2009, DOI: 10.1590/S0103-507X2009000400004
Abstract: objective: to predict readmission in intensive care unit analyzing the first 24 hours data after intensive care unit admission. methods: the first intensive care unit admission of patients was analyzed from january to may 2009 in a mixed unit. readmission to the unit was considered those during the same hospital stay or within 3 months after intensive care unit discharge. deaths during the first admission were excluded. demographic data, use of mechanical ventilation, and report of stay longer than 3 days were submitted to uni and multivariate analysis for readmission. results: five hundred seventy-seven patients were included (33 excluded deaths). the readmission group had 59 patients, while 518 patients were not readmitted. the lead time between the index admission and readmission was 9 (3-28) days (18 were readmitted in less than 3 days), and 10 died. patients readmitted at least once to the intensive care unit had the differences below in comparison to the control group: older age: 75 (67-81) versus 67 (56-78) years, p<0.01; admission for respiratory insufficiency or sepsis: 33 versus 13%, p<0.01; medical admission: 49 versus 32%, p<0.05; higher saps ii score: 27 (21-35) versus 23 (18-29) points, p<0.01; charlson index: 2 (1-2) versus 1 (0-2) points, p<0.01; first icu stay longer than 3 days: 35 versus 23%, p<0.01. after logistic regression, higher age, charlson index and admission for respiratory and sepsis were independently associated to readmissions in intensive care unit. conclusion: age, comorbidities and respiratory- and/or sepsis-related admission are associated with increased readmission risk in the studied sample.
Theoretical Evaluation of Two-Phase Flow in a Horizontal Duct with Leaks  [PDF]
Morgana de Vasconcellos Araújo, Severino Rodrigues de Farias Neto, Antonio Gilson Barbosa de Lima
Advances in Chemical Engineering and Science (ACES) , 2013, DOI: 10.4236/aces.2013.34A1002
Abstract: The transport of oil and its derivates are done, mostly, by pipeline. The time to detect leaks has to be short for pre-venting big disasters in the nature and decreasing losses for industries. The techniques available for leak detection vary from visual inspection to the use of computational techniques such as mathematical modeling. This paper aims to study the fluid dynamics of two-phase flow (water-oil) in the pipe with leakage. The equations of the mass and momentum conservation are numerically solved by using the ANSYSCFX commercial code with the aid of a structured mesh of a horizontal pipe with three holes of leaks. The Eulerian-Eulerian model was adopted considering the oil as continuous phase and water as dispersed phase, and constant fluid properties. With profiles of pressure and volume fraction along the time in the pipe, the influence of leakage on the single-phase (oil) and two-phase (water-oil) was evaluated.
Uma pesquisa sobre "Meu tio o iauaretê" de Guimar es Rosa: passos iniciais
Adriana de Fátima Barbosa Araújo
Revista de Letras , 2008,
Abstract: This article informs the first steps into the research I have been carrying on about the long short story “Meu tio o iauaretê”, by Jo o Guimar es Rosa. Although the researcher claims to be leading a sociological, historical and political interpretation, it was not cast away the text’s genetics, as shows its opening movement: an examination of the author’s manuscripts at IEB/USP. Nevertheless, this study assumes literary form as the taking of a position towards the contradictions of the social process. Furthermore, the research defends the idea that the unbalanced conversation, the narrative pattern also present in other texts by the same author, tackles Brazilian inequalities issue understanding and criticizing it all at once.
O voto de saias: a Constituinte de 1934 e a participa??o das mulheres na política
Araújo, Rita de Cássia Barbosa de;
Estudos Avan?ados , 2003, DOI: 10.1590/S0103-40142003000300009
Abstract: this article analyzes the political participation of women, in the set of deep changes brought by the revolution of 1930 and, especially, by the perspective of the elections to the national constitutional assembly in 1934. this analysis, of the so-called micro-history style, is based on the results of a research conducted by the daily newspaper diário de pernambuco, in the beginning of 1933. nineteen middle and upper class women of pernambuco, paraíba e alagoas, as well as two women's associations, were interviewed on the political momentum, the task of the future assembly, the political role and the space they believed women should occupy in the changing brazilian scene of the 30's. this important, and widely unknown, material was studied with the purpose of enabling the original interviewees to speak up their minds, given the due consideration of their context.
O voto de saias: a Constituinte de 1934 e a participa o das mulheres na política
Araújo Rita de Cássia Barbosa de
Estudos Avan?ados , 2003,
Abstract: ESTE artigo trata da participa o política da mulher, no quadro das transforma es trazidas pela Revolu o de 1930 e, sobretudo, pela perspectiva da elei o da Assembléia Nacional Constituinte, em 1934. Situado no campo da chamada microhistória, a análise está baseada nos resultados de uma enquete, realizada pelo Diario de Pernambuco, no início de 1933. Dezenove mulheres de classe média e da elite urbanas de Pernambuco, Paraíba e Alagoas, e duas associa es femininas foram ouvidas pelo jornal, a propósito do momento político, das tarefas da futura Constituinte, do papel político e do lugar que julgavam dever ser o da mulher no processo de transforma o vivenciado no Brasil, naquele período. Este importante e pouco conhecido material foi tratado com o objetivo da fazer falar as depoentes de ent o, embora trazendo o aporte histórico que as situa e as contextualiza.
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