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Search Results: 1 - 10 of 643 matches for " Michaela Schunk "
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Multimorbidity and health-related quality of life in the older population: results from the German KORA-Age study
Matthias Hunger, Barbara Thorand, Michaela Schunk, Angela D?ring, Petra Menn, Annette Peters, Rolf Holle
Health and Quality of Life Outcomes , 2011, DOI: 10.1186/1477-7525-9-53
Abstract: The EQ-5D was administered in the population-based KORA-Age study of 4,565 Germans aged 65 years or older. A generalised additive regression model was used to assess the effects of chronic conditions on HRQL and to account for the nonlinear associations with age and body mass index (BMI). Disease interactions were identified by a forward variable selection method.The conditions with the greatest negative impact on the EQ-5D index were the history of a stroke (regression coefficient -11.3, p < 0.0001) and chronic bronchitis (regression coefficient -8.1, p < 0.0001). Patients with both diabetes and coronary disorders showed more impaired HRQL than could be expected from their separate effects (coefficient of interaction term -8.1, p < 0.0001). A synergistic effect on HRQL was also found for the combination of coronary disorders and stroke. The effect of BMI on the mean EQ-5D index was inverse U-shaped with a maximum at around 24.8 kg/m2.There are important interactions between coronary problems, diabetes mellitus, and the history of a stroke that negatively affect HRQL in the older German population. Not only high but also low BMI is associated with impairments in health status.Multimorbidity, defined as the coexistence of two or more chronic conditions, is a common phenomenon among the older population worldwide: two recent population-based studies indicated that the prevalence of multimorbidity ranges between 40% and 56% in the general population aged 65 years and older [1,2]. Multimorbidity is known to negatively affect health outcomes including mortality, hospitalisation, and readmission [3].Health-related quality of life (HRQL) is a health outcome measure which is increasingly used to assess the medical effectiveness of interventions and to support allocation decisions in the health care sector. Generic HRQL instruments like the EQ-5D are appropriate for non-disease-specific analyses and allow comparisons between patient groups with different medical conditions [
Blood pressure and lipid management fall far short in persons with type 2 diabetes: results from the DIAB-CORE Consortium including six German population-based studies
Ina-Maria Rückert, Michaela Schunk, Rolf Holle, Sabine Schipf, Henry V?lzke, Alexander Kluttig, Karin-Halina Greiser, Klaus Berger, Grit Müller, Ute Ellert, Hannelore Neuhauser, Wolfgang Rathmann, Teresa Tamayo, Susanne Moebus, Silke Andrich, Christa Meisinger
Cardiovascular Diabetology , 2012, DOI: 10.1186/1475-2840-11-50
Abstract: The present analysis was based on the DIAB-CORE project, in which data from five regional population-based studies and one nationwide German study were pooled. All studies were conducted between 1997 and 2006. We assessed the frequencies of risk factors and co-morbidities, especially hypertension and dyslipidemia, in participants with and without T2D. The odds of no or insufficient treatment and the odds of pharmacotherapy were computed using multivariable logistic regression models. Types of medication regimens were described.The pooled data set comprised individual data of 15, 071 participants aged 45–74?years, including 1287 (8.5%) participants with T2D. Subjects with T2D were significantly more likely to have untreated or insufficiently treated hypertension, i.e. blood pressure of?>?= 140/90?mmHg (OR?=?1.43, 95% CI 1.26-1.61) and dyslipidemia i.e. a total cholesterol/HDL-cholesterol ratio?>?= 5 (OR?=?1.80, 95% CI 1.59-2.04) than participants without T2D. Untreated or insufficiently treated blood pressure was observed in 48.9% of participants without T2D and in 63.6% of participants with T2D. In this latter group, 28.0% did not receive anti-hypertensive medication and 72.0% were insufficiently treated. In non-T2D participants, 28.8% had untreated or insufficiently treated dyslipidemia. Of all participants with T2D 42.5% had currently elevated lipids, 80.3% of these were untreated and 19.7% were insufficiently treated.Blood pressure and lipid management fall short especially in persons with T2D across Germany. The importance of sufficient risk factor control besides blood glucose monitoring in diabetes care needs to be emphasized in order to prevent cardiovascular sequelae and premature death.Atherosclerosis accounts for most deaths in people with type 2 diabetes (T2D) and the age adjusted relative risk of coronary artery disease and peripheral arterial disease has been reported to be threefold higher than in the general population [1-3]. In a population-based stu
Adsorption Organic Cationic Dyes of Oxycelluloses and Linters  [PDF]
Michaela Filipi, Miloslav Milichovsky
Journal of Encapsulation and Adsorption Sciences (JEAS) , 2014, DOI: 10.4236/jeas.2014.41001
Abstract: Natural cellulose and oxycellulose are heterogeneous highly hydrated substances. They have the same chemical composition, but different size of molecules and representation of COOH groups organized into complex supramolecular structure. The oxycellulosic adsorption capacity of organic cationic dyes increases with increasing -COOH group content and distinctly increases with other competitive ions in the aqueous solution.
Separation of Fe(II) by the DEMI and TEMPO Oxidized Cellulose  [PDF]
Michaela Filipi, Miloslav Milichovsky
Journal of Encapsulation and Adsorption Sciences (JEAS) , 2015, DOI: 10.4236/jeas.2015.53008
Abstract: The description of some adsorption properties and behaviour of oxycellulose with Fe2+ ions is presented. Filter media from oxycelluloses materials have enormous sorption activity. There is described a sorption mechanism of poly 1,4-β-D anhydroglucuronic acid (PAGA). Utilisation of UV-VIS spectroscopy is shown on the adsorption process of optimalisation of oxycelluloses application. Supporting influence is demonstrated on the adsorption isotherms of Fe2+ ions in the competitive environment of NaCl, MgCl2.
Treatment Pattern of Type 2 Diabetes Differs in Two German Regions and with Patients' Socioeconomic Position
Teresa Tamayo, Heiner Claessen, Ina-Maria Rückert, Werner Maier, Michaela Schunk, Christine Meisinger, Andreas Mielck, Rolf Holle, Barbara Thorand, Maria Narres, Susanne Moebus, Amir-Abbas Mahabadi, Noreen Pundt, Bastian Krone, Uta Slomiany, Raimund Erbel, Karl-Heinz J?ckel, Wolfgang Rathmann, Andrea Icks
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0099773
Abstract: Background Diabetes treatment may differ by region and patients' socioeconomic position. This may be particularly true for newer drugs. However, data are highly limited. Methods We examined pooled individual data of two population-based German studies, KORA F4 (Cooperative Health Research in the Region of Augsburg, south), and the HNR (Heinz Nixdorf Recall study, west) both carried out 2006 to 2008. To ascertain the association between region and educational level with anti-hyperglycemic medication we fitted poisson regression models with robust error variance for any and newer anti-hyperglycemic medication, adjusting for age, sex, diabetes duration, BMI, cardiovascular disease, lifestyle, and insurance status. Results The examined sample comprised 662 participants with self-reported type 2 diabetes (KORA F4: 83 women, 111 men; HNR: 183 women, 285 men). The probability to receive any anti-hyperglycemic drug as well as to be treated with newer anti-hyperglycemic drugs such as insulin analogues, thiazolidinediones, or glinides was significantly increased in southern compared to western Germany (prevalence ratio (PR); 95% CI: 1.12; 1.02–1.22, 1.52;1.10–2.11 respectively). Individuals with lower educational level tended to receive anti-hyperglycemic drugs more likely than their better educated counterparts (PR; 95% CI univariable: 1.10; 0.99–1.22; fully adjusted: 1.10; 0.98–1.23). In contrast, lower education was associated with a lower estimated probability to receive newer drugs among those with any anti-hyperglycemic drugs (PR low vs. high education: 0.66; 0.48–0.91; fully adjusted: 0.68; 0.47–0.996). Conclusions We found regional and individual social disparities in overall and newer anti-hyperglycemic medication which were not explained by other confounders. Further research is needed.
IMPACTOS DA POLUI O QUíMICA AMBIENTAL NA SAúDE DA POPULA O
Erik Schunk Vasconcelos,Carlos Minayo Gomes
Vértices , 2010,
Abstract: Este trabalho aborda a quest o do risco decorrente de indústrias que produzem, trasnportam, armazenam, consomem ou despejam produtos químicos tóxicos em regi es povoadas. Discute-se o risco da contamina o humana decorrente da polui o industrial gerada regularmente, ilustrando com alguns exemplos de ocorrências de grande express o como as de Donora (EUA) e a da Baía de Minimata (Jap o). Aponta-se a necessidade de o Estado e as insdústrias assumirem suas responsabilidades na ameniza o dos riscos derivados do manuseio do produtos químicos tóxicos, particularmente, quando um grande contingente populacional pode ser atingido, como aconteceu nos acidentes de Seveso(ítalia) e Bophal (índia).
Jet shapes for boosted jet two-prong decays from first-principles
Mrinal Dasgupta,Lais Schunk,Gregory Soyez
Physics , 2015,
Abstract: Several boosted jet techniques use jet shape variables to discriminate the multi-pronged signal from Quantum Chromodynamics backgrounds. In this paper, we provide a first-principles study of an important class of jet shapes all of which put a constraint on the subjet mass: the mass-drop parameter ($\mu^2$), the $N$-subjettiness ratio ($\tau_{21}^{(\beta=2)}$) and energy correlation functions ($C_2^{(\beta=2)}$ or $D_2^{(\beta=2)}$). We provide analytic results both for QCD background jets as well as for signal processes. We further study the situation where cuts on these variables are applied recursively with Cambridge-Aachen de-clustering of the original jet. We also explore the effect of the choice of axis for $N$-subjettiness and jet de-clustering. Our results bring substantial new insight into the nature, gain and relative performance of each of these methods, which we expect will influence their future application for boosted object searches.
Keeping innate immunity at bay
Michaela Torkar
Genome Biology , 2002, DOI: 10.1186/gb-spotlight-20020731-01
Abstract: Kobayashi et al. show that lack of IRAK-M causes increased production of inflammatory cytokines, including interleukin-6 and tumor-necrosis factor α, and an enhanced inflammatory response in the gut of IRAK-M-/- mice infected with the Gram-negative pathogen Salmonella typhimurium. IRAK-M-/- macrophages did not develop endotoxin tolerance to the bacterial lipopolysaccharide, a little-understood regulatory mechanism that protects from endotoxic shock. TLR signaling following stimulation of macrophages was enhanced in the absence of IRAK-M, and immunoprecipitations suggested that, in wild-type mice, IRAK-M inhibits the release of activating IRAK kinases from the TLR signaling complex, thereby blocking downstream signaling events.Kobayashi et al. conclude that the negative regulatory function of IRAK-M may be required for preventing endotoxic shock and immunopathologies such as Crohn's and other inflammatory bowel diseases.
Molecular evolution of language
Michaela Torkar
Genome Biology , 2002, DOI: 10.1186/gb-spotlight-20020815-01
Abstract: P??bo and colleagues show that human FOXP2 differs in the coding of two amino acids from chimpanzee, gorilla, orang-utan, rhesus monkey and from mouse. A third amino-acid difference is found between human and mouse, but not between human and other apes. Exon 7, which encodes the two amino acids, is highly conserved among humans, and no amino-acid polymorphism was found in 44 human chromosomes from all major continents. Analysis of allele frequencies in humans and apes indicated that the two amino-acid replacements specific to humans are the best candidates for selected sites. This FOXP2 variant was probably fixed in the human population during the past 200,000 years and may have enabled humans to control orofacial movements and therefore the development of speech.
DNA sequences associated with chromatin proteins
Michaela Torkar
Genome Biology , 2000, DOI: 10.1186/gb-2000-1-2-reports0051
Abstract: Escherichia coli DNA adenine methyltransferase (Dam), which catalyzes methylation of adenine, was used as a reporter enzyme fused to Drosophila HP1. The fusion construct was transfected into Drosophila cell lines or used to generate transgenic fly lines. HP1 became integrated into the chromatin structure and directed the Dam methyltransferase to HP1-associated DNA sequences. These sequences were subsequently marked by adenine methylation. Because methylation of adenine does not normally occur in eukaryotes, sites of Dam methylation could be mapped using methylation-specific antibodies or restriction enzymes. The authors show that HP1 guided the Dam enzyme to heterochromatic loci in vivo. Previously unidentified potential HP1 targets included the histone gene-cluster repeat, which is thought to have heterochromatic features although located in euchromatin, as well as the rDNA repeat. The new technique may allow genome-wide mapping of DNA sequences targeted by chromatin-associated factors in various eukaryotes.The new technique, called DamID (for Dam identification), was first tested using the yeast regulator protein Gal4 as the fusion partner. The complex was successfully targeted to inserted Gal4-binding sites in the genome of a transgenic Drosophila line. Although Dam has an intrinsic DNA-binding activity (resulting in some 'background' adenine methylation in the absence of the fused chromatin protein), targeting of the enzyme led to a tenfold increase of methylation in the vicinity of DNA-binding sites of the Dam fusion partner. This enrichment was sufficient for positive identification of target sequences. The technique was applied to cell-culture systems and the whole organism, which was possible because expression of the bacterial enzyme does not seem to affect Drosophila development. A PCR-based assay allowed sensitive quantification of protein-DNA interactions.The paper is accompanied by a News and Views article accessible to subscribers through the Nature Bi
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