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Search Results: 1 - 10 of 96965 matches for " Michael Y. Tsai "
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RETRACTED: Pros and Cons of General Anaesthesia on Total Knee Angioplasty (TKA) and Total Hip Angioplasty (THA)  [PDF]
Jeffrey Y. Tsai
Open Journal of Orthopedics (OJO) , 2015, DOI: 10.4236/ojo.2015.54009
Abstract:

Short Retraction Notice

The paper does not meet the standards of \"Open Journal of Orthopedics\".

This article has been retracted to straighten the academic record. In making this decision the Editorial Board follows COPE's Retraction Guidelines. The aim is to promote the circulation of scientific research by offering an ideal research publication platform with due consideration of internationally accepted standards on publication ethics. The Editorial Board would like to extend its sincere apologies for any inconvenience this retraction may have caused.

Editor guiding this retraction: Dr. Samer El Hage (EB of OJO)

The full retraction notice in PDF is preceding the original paper, which is marked \"RETRACTED\".

The Relation between Erythrocyte Trans Fat and Triglyceride, VLDL- and HDL-Cholesterol Concentrations Depends on Polyunsaturated Fat
Edmond K. Kabagambe, Jose M. Ordovas, Paul N. Hopkins, Michael Y. Tsai, Donna K. Arnett
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0047430
Abstract: Background Trans fatty acids (TFA) lower HDL and increase triglyceride concentrations while polyunsaturated fatty acids (PUFA) lower triglycerides and may decrease HDL concentrations. The effect of the interaction between trans fat and PUFA on lipids is uncertain. Methods Men and women (n = 1032) in the Genetics of Lipid-Lowering Drugs and Diet Network (GOLDN) study were included. Fatty acids in erythrocyte membranes were measured with gas chromatography while data on potential confounders were obtained from questionnaires. To test the interaction between total erythrocyte PUFA (ePUFA) and TFA (eTFA) on lipid concentrations we distributed eTFA into tertiles and dichotomized ePUFA at the median concentration. Results For the 1st, 2nd and 3rd tertiles of eTFA, multivariate-adjusted means±s.e.m for HDL were 46.2±1.1, 46.3±1.1 and 45.5±1.0 mg/dL among those with low ePUFA, respectively, while they were 50.0±1.1, 46.9±1.1 and 44.7±1.1 mg/dL among those with high ePUFA, respectively (P for interaction = 0.01). For the 1st, 2nd and 3rd tertiles of eTFA, multivariate-adjusted means±s.e.m for triglycerides were 178.6±11.3, 144.7±10.9 and 140.8±10.6, respectively, among those with low ePUFA, while they were 133.8±11.3, 145.7±10.9 and 149.3±11.5, respectively, among those with high ePUFA (P for interaction = 0.005). Results for VLDL were similar to those for triglycerides. No significant interactions were observed for LDL or total cholesterol. Conclusions The relation between trans fat and HDL, VLDL and triglycerides may depend on PUFA. The benefit of avoiding trans fat may be greater among individuals with higher PUFA intake. Supplementation with PUFA among individuals with relatively high trans fat intake may have limited benefits on lipid profiles.
The influence of persistent pathogens on circulating levels of inflammatory markers: a cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis
Aydin Nazmi, Ana V Diez-Roux, Nancy S Jenny, Michael Y Tsai, Moyses Szklo, Allison E Aiello
BMC Public Health , 2010, DOI: 10.1186/1471-2458-10-706
Abstract: Using data from a subsample of the Multi-Ethnic Study of Atherosclerosis, we examined circulating levels of interleukin-6 (IL-6), C-reactive protein (CRP) and fibrinogen in relation to five common persistent pathogens: cytomegalovirus, herpes simplex virus-1, Hepatitis A virus, Helicobacter pylori and Chlamydia pneumoniae. We tested the hypothesis that the number of seropositive pathogens (based on conventional cut-off points) would not be as sensitive a marker of inflammation as immune response measured by antibody levels to pathogens.High antibody response to multiple pathogens showed graded and significant associations with IL-6 (p < 0.001), CRP (p = 0.04) and fibrinogen (p = 0.001), whereas seropositive pathogen burden did not. In multiple linear regression models, high antibody response to multiple pathogens maintained a positive association only with IL-6 (4.4% per pathogen exhibiting high antibody response, 95% CI 0.0-8.9).High antibody response to pathogens was a more consistent marker of inflammatory outcomes compared to seropositivity alone and high antibody response to multiple pathogens was a stronger marker compared to any single pathogen.Persistent pathogens, those acquired early in life and maintained without causing obvious illness, are implicated in cardiovascular disease etiology. Numerous studies have suggested that persistent viruses such as cytomegalovirus (CMV), herpes simplex virus-1 (HSV), Hepatitis A virus (HAV) and bacterial pathogens such as Helicobacter pylori (H. pylori) and Chlamydia pneumoniae (C. pneumoniae) are associated with cardiovascular disease [1-4], although some studies do not support a significant relationship [5-7]. Effects of multiple infectious agents may be synergistic, and some authors suggest that pathogen burden (total number of pathogens) has a greater impact on cardiovascular risk than isolated pathogens [4,8,9]. It is hypothesized that the association between pathogens and cardiovascular disease is, in part, mediat
Direct CP, T and/or CPT violations in the K^0-\bar{K^0} system - Implications of the recent KTeV results on $2π$ decays -
Y. Takeuchi,S. Y. Tsai
Physics , 1999, DOI: 10.1103/PhysRevD.61.077302
Abstract: The recent results on the CP violating parameters Re(e'/e) and \Delta\phi = \phi_{00}-\phi_{+-} reported by the KTeV Collaboration are analyzed with a view to constrain CP, T and CPT violations in a decay process. Combining with some relevant data compiled by the Particle Data Group, we find Re(e_2-e_0) = (0.85 +- 3.11)*10^{-4} and Im(e_2-e_0) = (3.2 +- 0.7)*10^{-4}, where Re(e_I) and Im(e_I) represent respectively CP/CPT and CP/T violations in decay of K^0 and \bar{K^0} into a 2\pi state with isospin I.
Associations of Plasma Phospholipid Omega-6 and Omega-3 Polyunsaturated Fatty Acid Levels and MRI Measures of Cardiovascular Structure and Function: The Multiethnic Study of Atherosclerosis
Jennifer S. Anderson,Jennifer A. Nettleton,W. Gregory Hundley,Michael Y. Tsai,Lyn M. Steffen,Rozenn N. Lemaitre,David Siscovick,Jo o Lima,Martin R. Prince,David Herrington
Journal of Nutrition and Metabolism , 2011, DOI: 10.1155/2011/315134
Abstract: Background. The association between plasma omega-6 fatty acids and cardiovascular disease (CVD) is unclear, and discrepancy remains concerning the cardiovascular benefit of the omega-3 fatty acid alpha-linolenic acid. Methods. Associations of plasma phospholipid fatty acid levels (arachidonic acid, linoleic acid, eicosapentaenoic acid, docosahexaenoic acid (DHA), and alpha-linolenic acid) with cardiac magnetic resonance imaging measures of left ventricular (LV) mass, LV volume, ejection fraction, stroke volume, and aortic distensibility were investigated in 1,274 adults. Results. Results of multivariate analysis showed no statistically significant associations of plasma omega-6 or omega-3 levels with cardiac magnetic resonance imaging measures. Stratification by gender revealed a positive association between DHA and LV mass in women (=1.89, =0.02; P interaction = 0.003) and a trend for a positive association between DHA and ejection fraction in men (=0.009, =0.05; P interaction = 0.03). Conclusion. Additional research is warranted to clarify the effects of plasma DHA on cardiac structure and function in women versus men.
TCF7L2 polymorphisms and inflammatory markers before and after treatment with fenofibrate
Edmond K Kabagambe, Stephen P Glasser, Jose M Ordovas, Daruneewan Warodomwichit, Michael Y Tsai, Paul N Hopkins, Ingrid B Borecki, Mary Wojczynski, Donna K Arnett
Diabetology & Metabolic Syndrome , 2009, DOI: 10.1186/1758-5996-1-16
Abstract: Men and women in the Genetics of Lipid-Lowering Drugs and Diet Network study (n = 1025, age 49 ± 16 y) were included. All participants suspended use of lipid-lowering drugs for three weeks and were then given 160 mg/day of fenofibrate for three weeks. Inflammatory markers and lipids were measured before and after fenofibrate. ANOVA was used to test for differences across TCF7L2 genotypes.Under the additive or dominant model, there were no significant differences (P > 0.05) in the concentrations of inflammatory markers (hsCRP, IL-2, IL-6, TNF-α and MCP-1) across TCF7L2 genotypes in the period before or after treatment. For both rs12255372 and rs7903146, homozygote T-allele carriers had significantly higher (P < 0.05) post-fenofibrate concentrations of MCP-1 in the recessive model. No other significant associations were detected.Overall these data show no association between TCF7L2 polymorphisms and the inflammatory markers suggesting that the effects of TCF7L2 on diabetes may not be via inflammation.Two polymorphisms (rs12255372 and rs7903146) in the transcription factor 7 like-2 (TCF7L2) gene have been consistently associated with diabetes in various populations [1-3]. Diabetes is an inflammatory condition in which up-regulation of inflammatory markers such as tumor necrosis factor (TNF)-α leads to impaired insulin signaling [4]. In vitro, TNF-α has been shown to enhance the transcriptional activity of TCF7L2 leading to reduced adipogenesis [5,6]. However, the sequence of events relating inflammation and TCF7L2 activity in vivo is not well understood. There are no published reports on whether the biological effects of TCF7L2 gene on diabetes are partly via inflammation or whether inflammation alters the effects of TCF7L2 on insulin secretion and other metabolic traits. Moreover how the potential association between TCF7L2 and inflammatory markers may be modified by diet and other environmental exposures such as fenofibrate is not known.The subjects were 1025 Caucasi
Suggestion for linkage of chromosome 1p35.2 and 3q28 to plasma adiponectin concentrations in the GOLDN Study
Laura J Rasmussen-Torvik, James S Pankow, James M Peacock, Ingrid B Borecki, James E Hixson, Michael Y Tsai, Edmond K Kabagambe, Donna K Arnett
BMC Medical Genetics , 2009, DOI: 10.1186/1471-2350-10-39
Abstract: Baseline and post-fenofibrate adiponectin measurements were highly correlated (r = 0.95). Suggestive (LOD > 2) peaks were found on chromosomes 1p35.2 and 3q28 (near the location of the adiponectin gene).Two candidate genes, IL22RA1 and IL28RA, lie under the chromosome 1 peak; further analyses are needed to identify the specific genetic variants in this region that influence circulating adiponectin concentrations.Adiponectin is an adipokine that is inversely related to both adiposity and many chronic disease risk factors in several populations. Adiponectin increases insulin sensitivity (i.e., the converse of insulin resistance) when administered intravenously to rats [1] and has decreased transcription in the visceral fat of obese as compared to lean humans [2]. In epidemiologic studies, adiponectin has been associated cross-sectionally with both waist or visceral adiposity [3,4] and euglycemic-clamp derived insulin sensitivity [5,6]. Adiponectin is also hypothesized to be protective in the pathogenesis of atherosclerosis [7,8], perhaps by reducing activity of iNOS in the vascular adventia [9] or by reducing accumulation of lipids in macrophage foam cells [10].Given the relations of adiponectin with chronic disease risk factors, there is much interest in learning about the pathways through which adiponectin itself is regulated. Several studies have found circulating adiponectin to be heritable, with heritability estimates ranging from 0.42 to 0.93 [11-15], suggesting that genetic variants play a role in regulating adiponectin. To find these variants, several studies have performed whole-genome linkage scans to determine which areas of the genome may harbor genes influencing circulating adiponectin concentrations [12-16]. Unfortunately, likely because of the diverse study populations used in each of these scans, few significant linkage results have been replicated across studies.The Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study is a genetic family st
High-fat meal effect on LDL, HDL, and VLDL particle size and number in the Genetics of Lipid-Lowering drugs and diet network (GOLDN): an interventional study
Mary K Wojczynski, Stephen P Glasser, Albert Oberman, Edmond K Kabagambe, Paul N Hopkins, Michael Y Tsai, Robert J Straka, Jose M Ordovas, Donna K Arnett
Lipids in Health and Disease , 2011, DOI: 10.1186/1476-511x-10-181
Abstract: Postprandially, LDL-C, HDL-C, VLDL-C, and triglycerides increased regardless of baseline triglyceride status, with the largest increases in VLDL-C and TG; however, those with elevated triglycerides demonstrated larger magnitude of response. Total LDL particle number decreased over the 6-hour time interval, mostly from a decrease in the number of small LDL particles. Similarly, total VLDL particle number decreased due to reductions in medium and small VLDL particles. Large VLDL particles and chylomicrons demonstrated the largest increase in concentration. HDL particles demonstrated minimal overall changes in total particle number.We have characterized the changes in LDL and VLDL particle number, and their subclass patterns following a high-fat meal.Most studies use the measurement of fasting lipoproteins to assess cardiovascular disease (CVD) risk [1,2]; however, humans spend most of the day in a postprandial state. Postprandial lipemia (PPL) is a physiological response occurring 2 to 12 hours after consuming a meal [3]. Gross lipid profile changes during PPL include increases in triglyceride (TG), very low-density lipoprotein cholesterol (VLDL-C), and chylomicron concentrations; decreases in high-density lipoprotein cholesterol (HDL-C) concentration; and little to no change in low-density lipoprotein cholesterol (LDL-C) concentration. Each of these lipoprotein classes is, however, heterogeneous and composed of various subclasses [4-6]. Lipoprotein particles are composed of different proportions of cholesterol ester (CE) and TG, and each subclass also has specific apolipoproteins on its surface for recognition of receptors and enzymes [7]. Constituent fractions of the lipoprotein profile can vary with respect to particle size, particle number, and particle concentrations [8]. The ingestion of a meal high in fat leads to distributional shifts of VLDL, LDL (including intermediate density lipoproteins (IDL)), and HDL particle sizes, numbers, and plasma concentrations [9
Lipoprotein Lipase S447X variant associated with VLDL, LDL and HDL diameter clustering in the MetS
Alexis C Wood, Stephen Glasser, W Garvey, Edmond K Kabagambe, Ingrid B Borecki, Hemant K Tiwari, Michael Y Tsai, Paul N Hopkins, Jose M Ordovas, Donna K Arnett
Lipids in Health and Disease , 2011, DOI: 10.1186/1476-511x-10-143
Abstract: Mixed linear models that controlled for age, sex, center of data collection, and family pedigree revealed no differences between the two groups for the D9N polymorphism (P = .36). However, group 2 contained significantly more carriers (25%) of the 447X variant than group 1 (14%; P = .04).This was the first study this kind to show an association between LPL and large VLDL particle size within the MetS, a pattern associated with higher IR. Future work should extend this to larger samples to confirm these findings, and examine the long term outcomes of those with this lipoprotein diameter pattern.The MetS is characterized by three or more of the following features: increased waist circumference (WC), high triglycerides (TGs), lowered high density cholesterol (HDL-C), hypertension and impaired fasting glucose [1]. Shifts in overall lipoprotein diameter to smaller LDL and HDL particles, and to larger VLDL particles have additionally been shown to associate with the individual features of the MetS [2].Our previous research grouped individuals according to the fasting diameters of their VLDL, LDL and HDL particles. Two groups emerged where individuals, on average, met the adult treatment panel (ATP) III criteria for the MetS. Both groups had small LDL diameters (mean = 19.9 nm), but one group with larger VLDL diameters (65.74 vs 53.1 nm) showed higher IR as measured by homeostatic model assessment (HOMA-IR; Table 1); and increased features of the MetS associated with higher IR: higher fasting glucose, TG, and WC (Table 1).LPL hydrolyzes TGs from VLDL forming LDL, thus is a source of lipoprotein size heterogeneity. We therefore aimed to examine whether there were differences in two variants in the LPL gene between two groups of MetS individuals, defined by their fasting lipoprotein diameter pattern.The study sample includes 251 men and women participating in the general population of the GOLDN study. The majority of participants were re-recruited from three-generational ped
Associations of Plasma Phospholipid Omega-6 and Omega-3 Polyunsaturated Fatty Acid Levels and MRI Measures of Cardiovascular Structure and Function: The Multiethnic Study of Atherosclerosis
Jennifer S. Anderson,Jennifer A. Nettleton,W. Gregory Hundley,Michael Y. Tsai,Lyn M. Steffen,Rozenn N. Lemaitre,David Siscovick,Jo?o Lima,Martin R. Prince,David Herrington
Journal of Nutrition and Metabolism , 2011, DOI: 10.1155/2011/315134
Abstract: Background. The association between plasma omega-6 fatty acids and cardiovascular disease (CVD) is unclear, and discrepancy remains concerning the cardiovascular benefit of the omega-3 fatty acid alpha-linolenic acid. Methods. Associations of plasma phospholipid fatty acid levels (arachidonic acid, linoleic acid, eicosapentaenoic acid, docosahexaenoic acid (DHA), and alpha-linolenic acid) with cardiac magnetic resonance imaging measures of left ventricular (LV) mass, LV volume, ejection fraction, stroke volume, and aortic distensibility were investigated in 1,274 adults. Results. Results of multivariate analysis showed no statistically significant associations of plasma omega-6 or omega-3 levels with cardiac magnetic resonance imaging measures. Stratification by gender revealed a positive association between DHA and LV mass in women ( , ; P interaction = 0.003) and a trend for a positive association between DHA and ejection fraction in men ( , ; P interaction = 0.03). Conclusion. Additional research is warranted to clarify the effects of plasma DHA on cardiac structure and function in women versus men. 1. Introduction Contemporary work suggests that consumption of polyunsaturated fatty acids (PUFAs), in place of saturated fats, decreases the risk of cardiovascular disease (CVD) [1]. In addition, dietary long-chain omega-3 PUFAs (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both found in fatty fish) have been associated with measurable improvements in cardiac hemodynamics and function as assessed by echocardiography. However, more accurate objective measures assessing the relationship of PUFAs and LV mass as well as LV mass/volume ratio (the latter associated with both nonheart failure cardiovascular events and diastolic dysfunction [2]) in human subjects are lacking. Furthermore, similar associations among fatty acids other than long-chain omega-3 PUFAs have not been defined. Thus, the purpose of this study is to determine the associations between plasma phospholipid omega-6 PUFAs (arachidonic acid (AA) and linoleic acid (LA)) and plasma phospholipid omega-3 PUFAs (EPA, DHA, and ALA) with cardiac magnetic resonance (CMR) measures of cardiovascular structure and function, including aortic distensibility, LV mass, LV mass/volume ratio, ejection fraction, and stroke volume. 2. Materials and Methods 2.1. Study Population and Data Collection MESA is a prospective cohort study that began in July 2000 to investigate the prevalence, correlates, and progression of subclinical CVD in individuals without known CVD at baseline [3]. The main cohort
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