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Search Results: 1 - 10 of 159967 matches for " Michael T Andreoli "
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Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration
Margaux A Morrison, Alexandra C Silveira, Nancy Huynh, Gyungah Jun, Silvia E Smith, Fani Zacharaki, Hajime Sato, Stephanie Loomis, Michael T Andreoli, Scott M Adams, Monte J Radeke, Austin S Jelcick, Yang Yuan, Aristoteles N Tsiloulis, Dimitrios Z Chatzoulis, Giuliana Silvestri, Maria G Kotoula, Evangelia E Tsironi, Bruce W Hollis, Rui Chen, Neena B Haider, Joan W Miller, Lindsay A Farrer, Gregory S Hageman, Ivana K Kim, Debra A Schaumberg, Margaret M DeAngelis
Human Genomics , 2011, DOI: 10.1186/1479-7364-5-6-538
Abstract: Based on the relationship between ultraviolet irradiance and vitamin D production, we employed a candidate gene approach for evaluating common variation in key vitamin D pathway genes (the genes encoding the vitamin D receptor [VDR]; cytochrome P450, family 27, subfamily B, polypeptide 1 [CYP27B1]; cytochrome P450, family 24, subfamily A, polypeptide 1 [CYP24A1]; and CYP27A1) in this same family-based cohort. Initial findings were then validated and replicated in the extended family cohort, an unrelated case-control cohort from central Greece and a prospective nested case-control population from the Nurse's Health Study and Health Professionals Follow-Up Studies, which included patients with all subtypes of AMD for a total of 2,528 individuals. Single point variants in CYP24A1 (the gene encoding the catabolising enzyme of the vitamin D pathway) were demonstrated to influence AMD risk after controlling for smoking history, sex and age in all populations, both separately and, more importantly, in a meta-analysis. This is the first report demonstrating a genetic association between vitamin D metabolism and AMD risk. These findings were also supplemented with expression data from human donor eyes and human retinal cell lines. These data not only extend previous biological studies in the AMD field, but further emphasise common antecedents between several disorders with an inflammatory/immunogenic component such as cardiovascular disease, cancer and AMD.Several biological processes/cellular pathways involved in conditions such as cancer, cardiovascular disease and type 1 diabetes have also been implicated in the pathophysiology of the neovascular form of age-related macular degeneration (AMD). AMD, a disease characterised by the loss of ability to drive, recognise faces and read, is the leading cause of blindness in the US elderly population. Most prominent among these shared disease-associated processes is angiogenesis, the defining hallmark of neovascular AMD [1-3]. Add
Simplifica??o da equa??o de viabilidade para predizer a longevidade de sementes de milho e soja
Andreoli, Claudinei;
Pesquisa Agropecuária Brasileira , 2004, DOI: 10.1590/S0100-204X2004000900011
Abstract: temperature, moisture and initial quality are important factors in ellis and roberts' equation to predict seed longevity, however it relies on complex experiments of seed aging. the objective of this work was to simplify the equation for predicting changes in seed viability during open warehouse storage. the simplified equation proposed is given by the model vp = vi - (tgb).p, in which vp is seed viability in probit for a period p (days), vi is the initial seed viability in probit and tgb is the seed deterioration rate for each specie at determined storage conditions. seeds of hybrid corn brs201 and brs206 and soybean varieties iac-8 and mg/br 46 (conquista) were packed in multiwall paper bags and stored for 0, 30, 60, 90, 120, 150, 180, 240, 300 and 360 days in open warehouse at two locations, sete lagoas, minas gerais state and brasília, federal district. the data were transformed in probit and the deterioration rate (tgb) between 0 and 30 days was calculated. the coefficient tgb ranged from 1.476x10-3 to 2.687x10-3 for corn and from 2.868x10-3 to 3.617x10-3 for soybean, depending on locations. these data indicate that soybean seed germination declined faster than corn. this model has accurately predicted corn and soybean seed germination after an open storage period.
Avalia??o agron?mica de biossólidos tratados por diferentes métodos químicos para aplica??o na cultura do milho
Barros, Ivaldete T.;Andreoli, Cleverson V.;Souza Junior, Ivan G. de;Costa, Antonio C. S. da;
Revista Brasileira de Engenharia Agrícola e Ambiental , 2011, DOI: 10.1590/S1415-43662011000600014
Abstract: the presence of pathogens and potentially toxic metals are the main limitations for the agronomic recycling of sewage sludge. this study evaluated the application of biosolids, chemically treated in a distrophic red latosol in the production and in the absorption of nutrients by the maize crop. the sludge was treated with lime, sodium hypochlorite, hydrogen peroxide, peracetic and acetic acids. biosolids treated with organic acids were neutralized with lime. the biosolids were applied in pots at a dose equivalent to 50 t ha-1 and maize was grown for a period of 55 days, and later the dry matter production and concentrations of nutrients were determined in the shoots. the highest dry matter production was observed in treatment with peracetic acid (apa) and the lowest in the treatment with lime. the application of biosolids increased the levels of macronutrients in the plant shoots. the concentration levels of zn, cu, mn, fe and pb in the plants were below the phytotoxic limits. the biosolids showed to be an important source of nutrients for the initial development of the maize crop. alternative treatments of the sludge can be effective in controlling pathogens and facilitate agricultural recycling of biosolids.
Simulation in Residency Training: A Review  [PDF]
Michael T. Flannery, Sharon Zahorsky
Creative Education (CE) , 2014, DOI: 10.4236/ce.2014.51007

Background: Simulation suddenly came into the limelight of regulation a few years ago when the Accreditation Council on Graduate Medical Education (ACGME) recommended simulation training without specifics. That left internal medicine program directors confused as they tried to figure out what was best for their residents. Summary: The author’s review discusses the many issues and unanswered questions regarding simulation training. It appears clear to this faculty member that residents enjoy the additional training to make them more comfortable doing procedures related to their training. A few studies mention longevity in retention of skills learned over time and very few discuss the numbers of procedures to attain competency and outcome improvements if they occur. Conclusion: This leaves several areas that need further study on the effects of simulation training in residency and meeting the needs of post-graduate descriptions via surveys following training. What kind of procedures and clinical scenarios (codes, medical dilemmas, ethical/communication issues), how often/how many, timing and appropriate measurements especially if focusing on improved patient outcomes. This narrative summary utilized a review focusing on simulation, internal medicine and various simulation outcomes.

The reliability of the Brazilian version of the Composite International Diagnostic Interview (CIDI 2.1)
Quintana, M.I.;Andreoli, S.B.;Jorge, M.R.;Gastal, F.L.;Miranda, C.T.;
Brazilian Journal of Medical and Biological Research , 2004, DOI: 10.1590/S0100-879X2004001100020
Abstract: the objective of the present study was to determine the reliability of the brazilian version of the composite international diagnostic interview 2.1 (cidi 2.1) in clinical psychiatry. the cidi 2.1 was translated into portuguese using who guidelines and reliability was studied using the inter-rater reliability method. the study sample consisted of 186 subjects from psychiatric hospitals and clinics, primary care centers and community services. the interviewers consisted of a group of 13 lay and three non-lay interviewers submitted to the cidi training. the average interview time was 2 h and 30 min. general reliability ranged from kappa 0.50 to 1. for lifetime diagnoses the reliability ranged from kappa 0.77 (bipolar affective disorder) to 1 (substance-related disorder, alcohol-related disorder, eating disorders). previous year reliability ranged from kappa 0.66 (obsessive-compulsive disorder) to 1 (dissociative disorders, maniac disorders, eating disorders). the poorest reliability rate was found for mild depressive episode (kappa = 0.50) during the previous year. training proved to be a fundamental factor for maintaining good reliability. technical knowledge of the questionnaire compensated for the lack of psychiatric knowledge of the lay personnel. inter-rater reliability was good to excellent for persons in psychiatric practice.
A Novel Knee Orthosis in the Treatment of Patellofemoral Pain Syndrome  [PDF]
Michael J. Khadavi, Y. T. Chen, Michael Fredericson
Open Journal of Therapy and Rehabilitation (OJTR) , 2015, DOI: 10.4236/ojtr.2015.32008
Abstract: Context: Patellofemoral Pain (PFPS) accounts for up to 25% of knee injuries in sports medicine clinics, with up to 91% of symptoms unresolved after conservative treatment at 5 years. The variability of response to treatment reflects its multi-factorial biomechanical etiologies. Bracing has been utilized to modify patellofemoral kinematics, generally by increasing patellofemoral contact area. The DJO Reaction orthosis is unique in its shock-absorbing elastomeric design, which is created to dissipate peak stress and enhance patellar tracking. Objective: To assess whether the DJO Reaction Brace reduces pain and improves functional outcomes in patients with chronic PFPS. Design: Cohort Series. Setting: Academic Sports Medicine Clinic. Patients: Twenty-two individuals between 18 and 40 years old with chronic patellofemoral pain have failed conservative treatment. Intervention: DJO Reaction Brace. Main Outcome Measures: Kujala Anterior Knee Pain Scale, Knee Injury and Osteoarthritis Outcome Score. Results: Seven males and 10 females with an age range of 19 - 39 years old complete the study. At an average follow-up time of 55 days, the Kujala score significantly improves by 9.8%, and KOOS Scores increase by the following statistically significant amounts: symptom 3.2%, pain 10.7%, sports and recreation 12.9%, quality of life 20.2%. Conclusion: The DJO Reaction orthosis reduces knee pain, increases function, and enhances quality of life with individuals with PFPS and is effective in the conservative care of patellofemoral pain syndrome.
Surface effects on lyotropic liquid crystals
Oliveira, Elisabeth Andreoli de;
Brazilian Journal of Physics , 1998, DOI: 10.1590/S0103-97331998000400009
Abstract: liquid crystals are very sensitive to surface effects. in fact, these effects are very useful in designing eletro-optical devices. we present a review of the theoretical models that describe the surface interactions in liquid crystals, focusing on lyotropic systems. experimental results will be presented and compared to theoretical predictions.
Representa es de masculinidade na dan a contemporanea
Giuliano Souza Andreoli
Movimento , 2011,
Surface effects on lyotropic liquid crystals
Oliveira Elisabeth Andreoli de
Brazilian Journal of Physics , 1998,
Abstract: Liquid crystals are very sensitive to surface effects. In fact, these effects are very useful in designing eletro-optical devices. We present a review of the theoretical models that describe the surface interactions in liquid crystals, focusing on lyotropic systems. Experimental results will be presented and compared to theoretical predictions.
A Transient but Protracted Geomagnetic Anomaly in the Sudbury Basin Following Two Near-Contiguous Intense Geomagnetic Storms  [PDF]
Michael A Persinger, Blake T Dotta
International Journal of Geosciences (IJG) , 2011, DOI: 10.4236/ijg.2011.23038
Abstract: During the maintained quiescence between solar cycle 23 and 24, two unusually intense (K-indices = 7) global geomagnetic disturbances separated by 6 days occurred. They were followed by a protracted increase of between 150 and 200 nT in the vertical component of our local magnetic field (Sudbury, Ontario). The duration of the variation anomaly was unusually long, about 3 weeks, before returning to baseline following a one week period of below average intensity characterized by approximately 50 min periodicities. We suggest this anomaly supports previous research that specific temporal patterns of increased global geomagnetic activity when matched with local impedance/reluctance of ore bodies created the condition for remarkable transient changes in the surface static intensity of magnetic fields.
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