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Search Results: 1 - 10 of 45003 matches for " Michael Lees "
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Taste Hedonics Influence the Disposition of Fat by Modulating Gastric Emptying in Rats
Katsuyoshi Saitou, John N. Lees, Michael G. Tordoff
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0090717
Abstract: We investigated how preferred and nonpreferred tastes influence the disposition of fat. Adult male Sprague Dawley rats were infused with 5 ml of 20% intralipid through an intragastric catheter and with 0.3 ml of a taste solution through an intraoral catheter. At 120 min postinfusion, plasma concentrations of fat fuels (triglycerides and non-esterified fatty acids) were either unchanged or slightly higher after rats tasted a preferred sweet taste solution (0.125% saccharin +3% glucose) than after they tasted water. They were markedly lower after rats tasted a non-preferred solution–either a bitter solution (0.15% quinine hydrochloride) or a sweet solution that had previously been the conditioned stimulus for lithium-induced taste aversion. The distribution of 14C-triolein mixed with the gastric load was determined at 4 h postinfusion. Rats that received a non-preferred bitter taste had significantly more 14C remaining in the stomach than did those that received a preferred sweet taste. These results suggest that taste hedonics–either unconditioned or conditioned aversive tastes–influence fat disposition by altering gastric emptying.
Bio-Development of Motorway Networks in the Netherlands: A Slime Mould Approach
Andrew Adamatzky,Michael Lees,Peter M. A. Sloot
Physics , 2012, DOI: 10.1142/S0219525912500348
Abstract: Plasmodium of acellular slime mould Physarum polycephalum is a very large eukaryotic microbe visible to the unaided eye. During its foraging behaviour the plasmodium spans sources of nutrients with a network of protoplasmic tubes. In this paper we attempt to address the following question: is slime mould capable of computing transport networks? By assuming the sources of nutrients are cities and protoplasmic tubes connecting the sources are motorways, how well does the plasmodium approximate existing motorway networks? We take the Netherlands as a case study for bio-development of motorways, while it has the most dense motorway network in Europe, current demand is rapidly approaching the upper limits of existing capacity. We represent twenty major cities with oat flakes, place plasmodium in Amsterdam and record how the plasmodium spreads between oat flakes via the protoplasmic tubes. First we analyse slime-mould-built and man-built transport networks in a framework of proximity graphs to investigate if the slime mould is capable of computing existing networks. We then go on to investigate if the slime mould is able calculate or adapt the network through imitating restructuring of the transport network as a response to potential localized flooding of the Netherlands.
Impact of schizophrenia and schizophrenia treatment-related adverse events on quality of life: direct utility elicitation
Andrew Briggs, Diane Wild, Michael Lees, Matthew Reaney, Serdar Dursun, David Parry, Jayanti Mukherjee
Health and Quality of Life Outcomes , 2008, DOI: 10.1186/1477-7525-6-105
Abstract: Health state descriptions for stable schizophrenia, extra pyramidal symptoms (EPS), hyperprolactinemia, diabetes, weight gain and relapse were developed based on a review of the literature and expert opinion. The quality of life impact of each health state was elicited using a time trade-off instrument administered by interview to 49 stable schizophrenia patients and 75 laypersons. Regression techniques were employed to examine the importance of subject characteristics on health-related utility scores.Patients and laypersons completed the interview in similar times. Stable schizophrenia had the highest mean utility (0.87 and 0.92 for laypersons and patients respectively), while relapse (0.48 and 0.60) had the lowest mean utility. Of the treatment-related adverse events, EPS had the lowest mean utility (0.57 and 0.72, respectively). Age, gender and PANSS score did not influence the utility results independently of health state. On average, patient utilities are 0.077 points higher than utilities derived from laypersons, although the ranking was similar between the two groups.Events associated with schizophrenia and treatment of schizophrenia can bring about a significant detriment in patient quality of life, with relapse having the largest negative impact. Results indicate that patients with stable schizophrenia are less willing to trade years of life to avoid schizophrenia-related symptoms compared to laypersons. Both sets of respondents showed equal ability to complete the questionnaire.Schizophrenia is a severe form of mental illness affecting approximately 24 million people worldwide [1]. Clinical management of schizophrenia is possible using a range of different antipsychotics, although treatment is associated with a variety of treatment-related adverse events. In order to capture the true impact of treatment benefit, it is important to quantify not only the impact of the disease on health-related quality of life, but also the impact of treatment-related adverse
Quantitative Comparison Between Crowd Models for Evacuation Planning and Evaluation
Vaisagh Viswanathan,Chong Eu Lee,Michael Harold Lees,Siew Ann Cheong,Peter M. A. Sloot
Computer Science , 2014, DOI: 10.1140/epjb/e2014-40699-x
Abstract: Crowd simulation is rapidly becoming a standard tool for evacuation planning and evaluation. However, the many crowd models in the literature are structurally different, and few have been rigorously calibrated against real-world egress data, especially in emergency situations. In this paper we describe a procedure to quantitatively compare different crowd models or between models and real-world data. We simulated three models: (1) the lattice gas model, (2) the social force model, and (3) the RVO2 model, and obtained the distributions of six observables: (1) evacuation time, (2) zoned evacuation time, (3) passage density, (4) total distance traveled, (5) inconvenience, and (6) flow rate. We then used the DISTATIS procedure to compute the compromise matrix of statistical distances between the three models. Projecting the three models onto the first two principal components of the compromise matrix, we find the lattice gas and RVO2 models are similar in terms of the evacuation time, passage density, and flow rates, whereas the social force and RVO2 models are similar in terms of the total distance traveled. Most importantly, we find that the zoned evacuation times of the three models to be very different from each other. Thus we propose to use this variable, if it can be measured, as the key test between different models, and also between models and the real world. Finally, we compared the model flow rates against the flow rate of an emergency evacuation during the May 2008 Sichuan earthquake, and found the social force model agrees best with this real data.
OCLC Registry of Digital Masters – Opportunities for European Cooperation
Janet Lees
Liber Quarterly : The Journal of European Research Libraries , 2005,
Abstract: I would like to thank the Preservation Division for the invitation to participate in the programme today. I would also like to thank the LIBER Board for their interest in the early stages of this project culminating in the announcement LIBER President Erland Kolding Nielsen made last night about LIBER support and collaboration with OCLC PICA with respect to the Digital Registry. This initiative reflects my new role within OCLC PICA, which is to identify opportunities for joint development with our major shareholder OCLC, and sometimes 3rd parties such as LIBER. My main purpose today is to provide a descriptive paper to inform LIBER members about the OCLC Digital Registry and to outline the possible role for LIBER and its membership in a model for European participation. My presentation will be in three phases: the need for a registry, a description of the Registry and finally, and perhaps most importantly, to outline opportunities for LIBER and its members in establishing a model for European contribution. We are all familiar with the concept of a registry through our participation in union catalogues and perhaps also from our experience with microfilms through the European Register of Microform Masters (EROMM) hosted by our friends in G ttingen.
WorldCat Discovery - making European libraries more visible on the web
Janet Lees
Liber Quarterly : The Journal of European Research Libraries , 2006,
Abstract: Firstly may I thank Trix Bakker and the Collection Development Division for inviting me to participate in their session today. I’m going to address the issue of making library collections more visible on the web and in particular the OCLC Open WorldCat program, the recent European enhancements to this program and the pilot that is currently underway.
Lees Andrew
Arquivos de Neuro-Psiquiatria , 1998,
Long-range order for the spin-1 Heisenberg model with a small antiferromagnetic interaction
Benjamin Lees
Physics , 2014, DOI: 10.1063/1.4895758
Abstract: We look at the general SU(2) invariant spin-1 Heisenberg model. This family includes the well known Heisenberg ferromagnet and antiferromagnet as well as the interesting nematic (biquadratic) and the largely mysterious staggered-nematic interaction. Long range order is proved using the method of reflection positivity and infrared bounds on a purely nematic interaction. This is achieved through the use of a type of matrix representation of the interaction making clear several identities that would not otherwise be noticed. Using the reflection positivity of the antiferromagnetic interaction one can then show that the result is maintained if we also include an antiferromagnetic interaction that is sufficiently small.
Existence of Néel order in the S=1 bilinear-biquadratic Heisenberg model via random loops
Benjamin Lees
Mathematics , 2015,
Abstract: We consider the general spin-1 SU(2) invariant Heisenberg model with a two-body interaction. A random loop model is introduced and relations to quantum spin systems is proved. Using this relation it is shown that for dimensions 3 and above N\'eel order occurs for a large range of values of the relative strength of the bilinear ($-J_1$) and biquadratic ($-J_2$) interaction terms. The proof uses the method of reflection positivity and infrared bounds. Links between spin correlations and loop correlations are proved.
HUWE1 and TRIP12 Collaborate in Degradation of Ubiquitin-Fusion Proteins and Misframed Ubiquitin
Esben G. Poulsen, Cornelia Steinhauer, Michael Lees, Anne-Marie Lauridsen, Lars Ellgaard, Rasmus Hartmann-Petersen
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0050548
Abstract: In eukaryotic cells an uncleavable ubiquitin moiety conjugated to the N-terminus of a protein signals the degradation of the fusion protein via the proteasome-dependent ubiquitin fusion degradation (UFD) pathway. In yeast the molecular mechanism of the UFD pathway has been well characterized. Recently the human E3 ubiquitin-protein ligase TRIP12 was connected with the UFD pathway, but little is otherwise known about this system in mammalian cells. In the present work, we utilized high-throughput imaging on cells transfected with a targeted siRNA library to identify components involved in degradation of the UFD substrate UbG76V-YFP. The most significant hits from the screen were the E3 ubiquitin-protein ligase HUWE1, as well as PSMD7 and PSMD14 that encode proteasome subunits. Accordingly, knock down of HUWE1 led to an increase in the steady state level and a retarded degradation of the UFD substrate. Knock down of HUWE1 also led to a stabilization of the physiological UFD substrate UBB+1. Precipitation experiments revealed that HUWE1 is associated with both the UbG76V-YFP substrate and the 26S proteasome, indicating that it functions late in the UFD pathway. Double knock down of HUWE1 and TRIP12 resulted in an additive stabilization of the substrate, suggesting that HUWE1 and TRIP12 function in parallel during UFD. However, even when both HUWE1 and TRIP12 are downregulated, ubiquitylation of the UFD substrate was still apparent, revealing functional redundancy between HUWE1, TRIP12 and yet other ubiquitin-protein ligases.
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