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Search Results: 1 - 10 of 231574 matches for " Michael D Roller "
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Immediate breast reconstruction with a saline implant and AlloDerm, following removal of a Phyllodes tumor
Shirley A Crenshaw, Michael D Roller, Jeffery K Chapman
World Journal of Surgical Oncology , 2011, DOI: 10.1186/1477-7819-9-34
Abstract: A 22-year-old woman presented with a 4 cm mass in the left breast upon initial examination. Although the initial needle biopsy report indicated a fibroadenoma, the final pathologic report revealed a 6.5 cm × 6.4 cm × 6.4 cm benign phyllodes tumor ex vivo. Treatment was a simple nipple-sparing mastectomy coupled with immediate breast reconstruction. After the mastectomy, a subpectoral pocket was created for a saline implant and AlloDerm was stitched to the pectoralis and serratus muscle in the lower-pole of the breast.Saline implant with AlloDerm can be used for immediate breast reconstruction post-mastectomy for treatment of a phyllodes tumor.Cystosarcoma phyllodes was first described in 1838 by Johannes Müller but was not found to be malignant until 1943 by Cooper and Ackerman [1]. It is now commonly called phyllodes tumor. It is less than 1% of breast tumors and exhibits unpredictable behaviour.Reports in literature have been focused on surgical approaches to the tumor removal. Although patient assessment prior to tumor removal often includes plans for immediate breast reconstruction, these approaches are rarely reported unless the tumor is classified as giant or is in an adolescent female [2-5]. Usual tumor treatment is wide local excision and simple mastectomy [6-8]. However, there have been few reports on breast reconstruction with phyllodes tumors, especially within the last 10 years. Because of the fast growth rate of these tumors, a greater than a 1 cm negative margin is preferred with tumor removal and a mastectomy may have to be performed to prevent local reoccurrence. Breast reconstruction usually consists of a transverse rectus abdominis musculocutaneous (TRAM) flap or a latissimus dorsi (LD) musculocutaneous flap as in other breast cancers.Here we report a single surgery that includes reconstruction of the breast immediately post-mastectomy using a saline implant and AlloDerm. AlloDerm is becoming increasingly popular for immediate breast reconstruction
Tandem RCM–Claisen Rearrangement–[2+2] Cycloaddition of O,O'-(But-2-en-1,4-diyl)-bridged Binaphthols
Michael Abraham,Wolfgang Reischl,Karl A. Kirchner,Alexander Roller,Luis F. Veiros,Michael Widhalm
Molecules , 2012, DOI: 10.3390/molecules171214531
Abstract: Attempted RCM of 2,2'-bis(allyloxy)-1,1'-binaphthyl resulted in a Claisen-type rearrangement of a postulated labile dioxacyclodecine proceeding at room temperature and followed by [2+2] cycloaddition. Structures of products were confirmed by X-ray crystallography. A mechanistic rationalisation based on relative stabilities of proposed intermediates and transition states is provided.
Carvacrol and p-cymene inactivate Escherichia coli O157:H7 in apple juice
Gabriella Kiskó, Sibel Roller
BMC Microbiology , 2005, DOI: 10.1186/1471-2180-5-36
Abstract: The aim of this study was to evaluate the addition of very low concentrations (0.25–1.25 mM) of carvacrol and p-cymene both individually and in combination as a novel means of controlling Escherichia coli O157:H7 in un-pasteurised apple juice.When inoculated at a level of 4 log CFU/ml into un-pasteurised apple juice (pH 3.20 ± 0.06), Escherichia coli O157:H7 survived for up to 3 and 19 days at 25° and 4°C, respectively. Treatment of the juice with 1.25 mM carvacrol or p-cymene reduced the numbers of E. coli O157:H7 to undetectable levels within 1–2 days at both storage temperatures. The effective concentrations of carvacrol could be reduced even further by combining it at 0.5 mM with cymene at 0.25 mM. The phenolic compounds were biocidal against both spoilage yeasts and E. coli O157:H7 thereby increasing the shelf-life and improving the safety of un-pasteurised apple juice, particularly when stored at chill temperatures.The results showed that the natural antimicrobial compounds carvacrol and p-cymene could potentially be used to extend the shelf life and improve the safety margins in un-pasteurised chilled fruit juices.Conventional fruit juice processing involves a heating step to inactivate the vegetative forms of pathogenic and spoilage microorganisms. Any remaining bacterial spores are generally unable to germinate due to the acidic nature of the juices [1]. This ensures acceptable safety margins and extends the shelf-life of the juice. However, heat treatment causes vitamin losses and changes in flavour of the juices and some consumers regard heat-treated, shelf-stable products as low in quality. In the last 15 years, there have been several outbreaks of food poisoning associated with drinking un-pasteurised apple juice contaminated with enterohaemorrhagic Escherichia coli O157:H7 and several children have died in the USA [2]. Warning labels are now required in the USA for all fruit juices unless a 5-log pathogen reduction treatment has been applied to the pro
Eratosthenes' Geography: Fragments Collected and Translated with Commentary and Additional Material
Duane W. Roller
Aestimatio : Critical Reviews in the History of Science , 2011,
The Molecular Chaperone GRP78/BiP in the Development of Chemoresistance: Mechanism and Possible Treatment
Corinna Roller,Danilo Maddalo
Frontiers in Pharmacology , 2013, DOI: 10.3389/fphar.2013.00010
Abstract: Treatment of several types of cancer such as lung, breast, prostate, and pancreas has shown notable progresses in the past decades. However, after an initial response, tumors eventually became resistant to chemotherapy. This phenomenon, known as chemoresistance, accounts for the death of most cancer patients. Several studies in patients refractory to therapy have revealed the upregulation of the molecular chaperone GRP78/Binding Protein, BiP (BiP) both at the RNA and protein expression level. Furthermore GRP78/BiP relocates to the cell membrane in malignant but not in benign cells. In this communication we review studies on the role and the mechanism of action of GRP78/BiP during development of chemoresistance in cancer cells. In addition we discuss the possible role of GRP78 as a biomarker and as a target in cancer therapy.
Relevant Knowledge First - Reinforcement Learning and Forgetting in Knowledge Based Configuration
Ingo Kreuz,Dieter Roller
Computer Science , 2001,
Abstract: In order to solve complex configuration tasks in technical domains, various knowledge based methods have been developed. However their applicability is often unsuccessful due to their low efficiency. One of the reasons for this is that (parts of the) problems have to be solved again and again, instead of being "learnt" from preceding processes. However, learning processes bring with them the problem of conservatism, for in technical domains innovation is a deciding factor in competition. On the other hand a certain amount of conservatism is often desired since uncontrolled innovation as a rule is also detrimental. This paper proposes the heuristic RKF (Relevant Knowledge First) for making decisions in configuration processes based on the so-called relevance of objects in a knowledge base. The underlying relevance-function has two components, one based on reinforcement learning and the other based on forgetting (fading). Relevance of an object increases with its successful use and decreases with age when it is not used. RKF has been developed to speed up the configuration process and to improve the quality of the solutions relative to the reward value that is given by users.
Climate Change Science & Propaganda  [PDF]
Michael D. Nelson
International Journal of Geosciences (IJG) , 2015, DOI: 10.4236/ijg.2015.612105
Abstract: This article addresses the relationship between science and propaganda using the Climate Change controversy as a study model. The United Nations International Panel on Climate Change (IPCC) is the recognized leader on this model issuing multiple Assessment Reports. This review begins with a discussion of the basics—what is propaganda and how does it work, followed by whether the IPCC adopted or rejected it. Next explored is how propaganda can be seamlessly fused into “report writing” in a way that arouses and makes interesting humdrum details. Some unexpected results emerged from current and historical observation data involving the Greenhouse theory, CO2 sources, ocean pH, sea levels, and ice balances. The final section confronts whether “a point of view” constrains objectivity in favor of outcome. The overall conclusion is that the earth is boringly healthy.
Determining Appropriate Damages for Patent Infringement: An Alternative Approach  [PDF]
Michael D’Rosario
Theoretical Economics Letters (TEL) , 2017, DOI: 10.4236/tel.2017.73023
Abstract: Determining the quantum of damages that should be afforded to an applicant when patent infringement has occurred is problematic for a number of reasons. Incorporeal works are difficult to value, and consequently certain categories of intellectual property present real challenges for the courts. This paper contends that citation information may be particularly helpful in relation to patents for a number of reasons. Citation information may afford useful insights into the level of industry uptake and the amount of subsequent innovation made possible by the patent. This insight may be particularly beneficial in situations where the courts are considering awarding additional damages. While the courts have not considered patent citation information thus far, the paper presents a number of patent citation-related metrics that may assist with the determination of patent damages.
The Regulation of All Pay Auctions: Is There Need for Greater Regulation of Online Auctioneers?  [PDF]
Michael D’Rosario
Theoretical Economics Letters (TEL) , 2017, DOI: 10.4236/tel.2017.75081
Abstract: Auctions are a ubiquitous process, with auctioneers playing a critical role in serving as a bridge between buyers and sellers, and as such assisting in the process of price discovery. Given this critical role, the regulation of auctions and auctioneers is of particular concern. The emergence of online selling has raised a number of pertinent questions about how the industry should be regulated. In particular so-called penny auctions (in economic parlance “unit bid auction”) have raised a number of pertinent questions about consumer protections. Whether these online selling models constitute auctions, and whether they mirror “bricks and mortar” rivals remain pertinent questions. Moreover, the adequacy of the regulatory apparatus that moderates the activities of auctioneers operating within conventional “analogue markets” is uncertain when such apparatus is applied to “digital markets” involving online selling through auction like processes. The current study considers need for regulation of unit bit auction in light of the underlying economics of such auction models. The model suggests that enhanced disclosure and greater regulation may ultimately be necessary.
Effect of the standardized Cimicifuga foetida extract on Hsp 27 expression in the MCF-7 cell line
Soler,Maritza C; Molina,Jessica L; Díaz,Hugo A; Pinto,Vivian C; Barrios,Yasenka L; He,Kan; Roller,Marc; Weinstein-Oppenheimer,Caroline R;
Biological Research , 2011, DOI: 10.4067/S0716-97602011000300005
Abstract: cimicifuga foetida, an asian cimicifuga species, has been employed as a cooling and detoxification agent in traditional chinese medicine since ancient times. for this herb, two cycloartane triterpene glycosides isolated from the rhizomes have demonstrated cytotoxicity on rat tumor and human cancer cell lines. since human hsp27 is increased in various human cancers and exhibits cytoprotective activity that affects tumorigenesis and the susceptibility of tumours to cancer treatment, the purpose of this research was to study the expression of this protein in mcf-7 breast cancer cells. to accomplish this aim, mcf-7 cells were exposed to different concentrations of cimicifuga foetida extract showing a reduction in cell number measured by the sulforhodamine assay. in addition, the expression of hsp-27 mrna detected by rt-pcr and hsp-27 protein detected by immnofluorescence was present in all conditions, except when using the highest concentration of cimicifuga foetida extract (2,000 jig /l). we conclude that hsp 27 expression at 2,000 jig /l cimicifuga foetida extract is diminished. this is the first report showing the hsp-27 expression after exposure to cimicifuga foetida extract in mcf-7 cells.
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