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Search Results: 1 - 10 of 44882 matches for " Michael Crump "
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The Dark Side of the MBTI: Psychological Type and Interpersonal Derailers  [PDF]
Adrian Furnham, John Crump
Psychology (PSYCH) , 2014, DOI: 10.4236/psych.2014.52026

Over 4000 British adults completed the Hogan Development Survey (HDS) (Hogan & Hogan, 1997) which measures eleven potential derailment behaviours (“dark side” traits) based on the personality disorders and the Myers-Briggs Type Indicator (Briggs & Myers, 1987) a famous measure of “normal” personality functioning. In all, five of the eleven “dark side” traits were correlated with the Extraversion-Introversion dimensions, none with Sensing-Intuition, seven with Thinking-Feeling and four with the Judging-Perceiving scale. Correlations were modest. Regressions with the four MBTI scales as criterion variables showed nine of the HDS factors were related to the T-F scale and accounted for 12% of the variance. Thinking types tended to be Sceptical, Reserved and Diligent. Overall correlations were low suggesting the MBTI assesses some aspects of dark side traits.

Personality and Management Level: Traits That Differentiate Leadership Levels  [PDF]
Adrian Furnham, John Crump
Psychology (PSYCH) , 2015, DOI: 10.4236/psych.2015.65053
Abstract: Over 5000 senior managers attending a structured assessment centre completed three tests (Revised NEO Personality Inventory, NEO-FFI; the Myers Briggs Type Indicators, MBTI; the Fundamental Interpersonal Relations Orientation, FIRO-B). Given their rank and responsibilities they were categorised as Non-Managers or specialists, Middle Managers and Senior Managers (Manager of Managers or Leaders). Results showed the more Senior Managers tended to be less Neurotic and Agreeable, but more Extraverted and Conscientious. They also had less Wanted Inclusion and more Expressed Control scores on the FIRO-B and tended to be higher on MBTI Intuition and on Thinking (vs Feeling). The results of the discriminant analysis showed two FIRO-B factors (Expressed Control and Wanted Control) and two Big Five (Neuroticism and Extraversion) were best discriminators of managerial seniority. Leaders tended to score high on Expressed Control and Extraversion and low on Wanted Inclusion and Neuroticism. Implications for selection and promotion, as well as limitations of the study are considered.
The Myers-Briggs Type Indicator (MBTI) and Promotion at Work  [PDF]
Adrian Furnham, John Crump
Psychology (PSYCH) , 2015, DOI: 10.4236/psych.2015.612147
Abstract: Over 6000 adult managers attending an assessment centre completed the MBTI and also specified in detail how long it had been before they were promoted to a managerial role, and also, where appropriate, to a senior managerial role. Correlational analyses showed shorter times to promotion were associated with being Extraverted and a Sensing Type. Regressions showed that Feeling types took longer to be promoted to managerial roles, and that Perceiving types took longer to be promoted to senior positions. Implications for the selection and management of people were considered.
Forbidden Minors For 3-Connected Graphs With No Non-Splitting 5-Configurations
Iain Crump
Mathematics , 2013,
Abstract: For a set of five edges, a graph splits if one of the associated Dodgson polynomials is equal to zero. A graph G splitting for every set of five edges is a minor-closed property. As such there is a finite set of forbidden minors F such that if a graph H does not contain a minor isomorphic to any graph in F, then H splits. In this paper we prove that if a graph G is simple, 3-connected, and splits, then G must not contain any minors isomorphic to K5, K3,3, the octahedron, the cube, or a graph that is a single delta-Y transformation away from the cube. As such this is the set of all simple 3-connected forbidden minors. The complete set of 2-connected or non-simple forbidden minors remains unresolved, though a number have been found.
Multiple Insulin Degrading Enzyme Variants Alter In Vitro Reporter Gene Expression
Olivia Belbin, Michael Crump, Gina D. Bisceglio, Minerva M. Carrasquillo, Kevin Morgan, Steven G. Younkin
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0021429
Abstract: The insulin degrading enzyme (IDE) variant, v311 (rs6583817), is associated with increased post-mortem cerebellar IDE mRNA, decreased plasma β-amyloid (Aβ), decreased risk for Alzheimer's disease (AD) and increased reporter gene expression, suggesting that it is a functional variant driving increased IDE expression. To identify other functional IDE variants, we have tested v685, rs11187061 (associated with decreased cerebellar IDE mRNA) and variants on H6, the haplotype tagged by v311 (v10; rs4646958, v315; rs7895832, v687; rs17107734 and v154; rs4646957), for altered in vitro reporter gene expression. The reporter gene expression levels associated with the second most common haplotype (H2) successfully replicated the post-mortem findings in hepatocytoma (0.89 fold-change, p = 0.04) but not neuroblastoma cells. Successful in vitro replication was achieved for H6 in neuroblastoma cells when the sequence was cloned 5′ to the promoter (1.18 fold-change, p = 0.006) and 3′ to the reporter gene (1.29 fold change, p = 0.003), an effect contributed to by four variants (v10, v315, v154 and v311). Since IDE mediates Aβ degradation, variants that regulate IDE expression could represent good therapeutic targets for AD.
British Columbia Hospitals: examination and assessment of payment reform (B-CHeaPR)
Jason M Sutherland, Kimberlyn M McGrail, Michael R Law, Morris L Barer, R Crump
BMC Health Services Research , 2011, DOI: 10.1186/1472-6963-11-150
Abstract: This study proposal addresses two research questions designed to determine whether ABF policies affect health system costs, access and hospital quality. The first question examines the impact of the hospital funding policy change on internal hospital activity based on expenditures and quality. The second question examines the impact of the change on non-hospital care, including readmission rates, amount of home care provided, and physician expenditures.A longitudinal study design will be used, incorporating comprehensive population-based datasets of all B.C. residents; hospital, continuing care and physician services datasets will also be used. Data will be linked across sources using anonymized linking variables. Analytic datasets will be created for the period between 2005/2006 and 2012/2013.With Canadian hospitals unaccustomed to detailed scrutiny of what services are provided, to whom, and with what results, the move toward ABF is significant. This proposed study will provide evidence on the impacts of ABF, including changes in the type, volume, cost, and quality of services provided. Policy- and decision-makers in B.C. and elsewhere in Canada will be able to use this evidence as a basis for policy adaptations and modifications. The significance of this proposed study derives from the fact that the change in hospital funding policy has the potential to affect health system costs, residents' access to care and care quality.Accounting for $46-billion - or 36% of public spending on health care [1] - hospitals are a major target for cost reductions through efficiency initiatives in Canada. Some provinces are considering payment reform as a vehicle to achieve this goal. The use of financial incentives to increase hospital efficiency is now widespread in Europe and has occurred in the United States (US) since 1983 [2-4]; however, the approach remains largely untested in Canada [5].In April 2010, the British Columbia (B.C.) provincial government implemented activity ba
Optimization and analysis of a quantitative real-time PCR-based technique to determine microRNA expression in formalin-fixed paraffin-embedded samples
Rashmi S Goswami, Levi Waldron, Jerry Machado, Nilva K Cervigne, Wei Xu, Patricia P Reis, Denis J Bailey, Igor Jurisica, Michael R Crump, Suzanne Kamel-Reid
BMC Biotechnology , 2010, DOI: 10.1186/1472-6750-10-47
Abstract: Our study demonstrates that the TaqMan Human MicroRNA Array v1.0 (Early Access) platform is suitable for miR expression analysis in FFPE tissue with a high reproducibility (correlation coefficients of 0.95 between duplicates, p < 0.00001) and outlines the optimal performance conditions of this platform using clinical FFPE samples. We also outline a method of data analysis looking at differences in miR abundance between FFPE and fresh-frozen samples. By dividing the profiled miR into abundance strata of high (Ct<30), medium (30≤Ct≤35), and low (Ct>35), we show that reproducibility between technical replicates, equivalent dilutions, and FFPE vs. frozen samples is best in the high abundance stratum. We also demonstrate that the miR expression profiles of FFPE samples are comparable to those of fresh-frozen samples, with a correlation of up to 0.87 (p < 0.001), when examining all miRs, regardless of RNA extraction method used. Examining correlation coefficients between FFPE and fresh-frozen samples in terms of miR abundance reveals correlation coefficients of up to 0.32 (low abundance), 0.70 (medium abundance) and up to 0.97 (high abundance).Our study thus demonstrates the utility, reproducibility, and optimization steps needed in miR expression studies using FFPE samples on a high-throughput quantitative PCR-based miR platform, opening up a realm of research possibilities for retrospective studies.MicroRNAs (miRs) are small, non-coding RNA molecules of 17-27 nucleotides in length, involved in gene regulation at the post-transcriptional level [1]. They inhibit translation by partially or totally binding to the complementary 3' UTR of their target mRNAs within the multiprotein RNA-induced silencing complex (RISC). Full complementarity between a miR and its target mRNA results in mRNA degradation; partial complementarity leads to inhibition of mRNA translation. The literature on miRs has grown exponentially within the past decade as these small molecules have demonstrated
Estimating Leptospirosis Incidence Using Hospital-Based Surveillance and a Population-Based Health Care Utilization Survey in Tanzania
Holly M. Biggs,Julian T. Hertz,O. Michael Munishi,Renee L. Galloway,Florian Marks,Wilbrod Saganda,Venance P. Maro,John A. Crump
PLOS Neglected Tropical Diseases , 2013, DOI: 10.1371/journal.pntd.0002589
Abstract: Background The incidence of leptospirosis, a neglected zoonotic disease, is uncertain in Tanzania and much of sub-Saharan Africa, resulting in scarce data on which to prioritize resources for public health interventions and disease control. In this study, we estimate the incidence of leptospirosis in two districts in the Kilimanjaro Region of Tanzania. Methodology/Principal Findings We conducted a population-based household health care utilization survey in two districts in the Kilimanjaro Region of Tanzania and identified leptospirosis cases at two hospital-based fever sentinel surveillance sites in the Kilimanjaro Region. We used multipliers derived from the health care utilization survey and case numbers from hospital-based surveillance to calculate the incidence of leptospirosis. A total of 810 households were enrolled in the health care utilization survey and multipliers were derived based on responses to questions about health care seeking in the event of febrile illness. Of patients enrolled in fever surveillance over a 1 year period and residing in the 2 districts, 42 (7.14%) of 588 met the case definition for confirmed or probable leptospirosis. After applying multipliers to account for hospital selection, test sensitivity, and study enrollment, we estimated the overall incidence of leptospirosis ranges from 75–102 cases per 100,000 persons annually. Conclusions/Significance We calculated a high incidence of leptospirosis in two districts in the Kilimanjaro Region of Tanzania, where leptospirosis incidence was previously unknown. Multiplier methods, such as used in this study, may be a feasible method of improving availability of incidence estimates for neglected diseases, such as leptospirosis, in resource constrained settings.
Bmps and Id2a Act Upstream of Twist1 To Restrict Ectomesenchyme Potential of the Cranial Neural Crest
Ankita Das,J. Gage Crump
PLOS Genetics , 2012, DOI: 10.1371/journal.pgen.1002710
Abstract: Cranial neural crest cells (CNCCs) have the remarkable capacity to generate both the non-ectomesenchyme derivatives of the peripheral nervous system and the ectomesenchyme precursors of the vertebrate head skeleton, yet how these divergent lineages are specified is not well understood. Whereas studies in mouse have indicated that the Twist1 transcription factor is important for ectomesenchyme development, its role and regulation during CNCC lineage decisions have remained unclear. Here we show that two Twist1 genes play an essential role in promoting ectomesenchyme at the expense of non-ectomesenchyme gene expression in zebrafish. Twist1 does so by promoting Fgf signaling, as well as potentially directly activating fli1a expression through a conserved ectomesenchyme-specific enhancer. We also show that Id2a restricts Twist1 activity to the ectomesenchyme lineage, with Bmp activity preferentially inducing id2a expression in non-ectomesenchyme precursors. We therefore propose that the ventral migration of CNCCs away from a source of Bmps in the dorsal ectoderm promotes ectomesenchyme development by relieving Id2a-dependent repression of Twist1 function. Together our model shows how the integration of Bmp inhibition at its origin and Fgf activation along its migratory route would confer temporal and spatial specificity to the generation of ectomesenchyme from the neural crest.
Arrhythmogenic KCNE gene variants: current knowledge and future challenges
Shawn Crump,Geoffrey W. Abbott
Frontiers in Genetics , 2014, DOI: 10.3389/fgene.2014.00003
Abstract: There are twenty-five known inherited cardiac arrhythmia susceptibility genes, all of which encode either ion channel pore-forming subunits or proteins that regulate aspects of ion channel biology such as function, trafficking and localization. The human KCNE gene family comprises five potassium channel regulatory subunits, sequence variants in each of which are associated with cardiac arrhythmias. KCNE gene products exhibit promiscuous partnering and in some cases ubiquitous expression, hampering efforts to unequivocally correlate each gene to specific native potassium currents. Likewise, deducing the molecular etiology of cardiac arrhythmias in individuals harboring rare KCNE gene variants, or more common KCNE polymorphisms, can be challenging. In this review we provide an update on putative arrhythmia-causing KCNE gene variants, and discuss current thinking and future challenges in the study of molecular mechanisms of KCNE-associated cardiac rhythm disturbances.
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