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Search Results: 1 - 10 of 32262 matches for " Miao Sun "
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Graded/Gradient Porous Biomaterials
Xigeng Miao,Dan Sun
Materials , 2010, DOI: 10.3390/ma3010026
Abstract: Biomaterials include bioceramics, biometals, biopolymers and biocomposites and they play important roles in the replacement and regeneration of human tissues. However, dense bioceramics and dense biometals pose the problem of stress shielding due to their high Young’s moduli compared to those of bones. On the other hand, porous biomaterials exhibit the potential of bone ingrowth, which will depend on porous parameters such as pore size, pore interconnectivity, and porosity. Unfortunately, a highly porous biomaterial results in poor mechanical properties. To optimise the mechanical and the biological properties, porous biomaterials with graded/gradient porosity, pores size, and/or composition have been developed. Graded/gradient porous biomaterials have many advantages over graded/gradient dense biomaterials and uniform or homogenous porous biomaterials. The internal pore surfaces of graded/gradient porous biomaterials can be modified with organic, inorganic, or biological coatings and the internal pores themselves can also be filled with biocompatible and biodegradable materials or living cells. However, graded/gradient porous biomaterials are generally more difficult to fabricate than uniform or homogenous porous biomaterials. With the development of cost-effective processing techniques, graded/gradient porous biomaterials can find wide applications in bone defect filling, implant fixation, bone replacement, drug delivery, and tissue engineering.
Study on the Effect of Monochromatic Light on the Growth of the Red Tide Diatom Skeletonema Costatum  [PDF]
Hongli Miao, Lina Sun, Qingzhen Tian, Shanshan Wang, Jing Wang
Optics and Photonics Journal (OPJ) , 2012, DOI: 10.4236/opj.2012.23022
Abstract: Effects of light intensity and quality of three kinds of LED monochromatic lights (blue, green, and red) on the growth of Skeletonema costatum are investigated in batch culture conditions. Seven light intensities (20, 30, 40, 45, 50, 60 and 80 μmol·m-2·s-1) are used to evaluate the specific growth rate, spectrum absorption coefficient and saturated light intensity of LED monochromatic light. Results show that the growth rates of Skeletonema costatum increase with the enhanced light intensity; however, the light level beyond the saturation light intensity inhibited the growth of Skeletonema costatum. Compared with red and green light, the growth rate of Skeletonema costatum under blue light is higher within saturated light intensity, and saturated light intensity of LED monochromatic light is lower under blue light and higher under green light. It is concluded that under different monochromatic light, the saturated light intensity decreases and the growth rate increases with the increasing of spectrum absorption coefficient.
Zinc and Diabetic Retinopathy
Xiao Miao,Weixia Sun,Lining Miao,Yaowen Fu
Journal of Diabetes Research , 2013, DOI: 10.1155/2013/425854
Carbon Nanoparticles for Identifying Lymph Nodes during Surgery in Colorectal Cancer: A Meta-Analysis  [PDF]
Miao Liu, Ai Shen, Wei Li, Lihui Chen, Xiufeng Chen, Hao Sun
Journal of Cancer Therapy (JCT) , 2019, DOI: 10.4236/jct.2019.102010
Abstract: Aim: To investigative the efficacy of carbon nanoparticles (CNs) to identify the lymph nodes during radical surgery in colorectal cancer. Method: The MEDLINE, EMBASE and Cochrane Library databases were searched electronically to identify the studies that compared the use of CNs (CN group) with control group in patients undergoing colorectal cancer radical surgery (from January 2009 to November 2018). The primary outcome was the number of retrieved central lymph nodes. Results: This meta-analysis identified 2 randomized controlled trials and 5 non-randomized controlled trials. Compared with the control group, the CN group resulted in an average of 7.16 more lymph nodes removed per patient (WMD = 7.16, 95% CI = 3.76 to 10.57, p < 0.01), 7.26 minutes less required for retrieving lymph nodes (WMD = -7.26, 95% CI = -13.43 to -1.09, p = 0.02), and 15.1 ml less blood loss during operation (WMD = -15.11, 95% CI = -23.15 to -7.06, p < 0.01). Although there was no significant difference in the metastatic lymph nodes between the two groups (OR = 1.02, 95% CI = 0.79 to 1.31, p = 0.87), there was 1.45 times more metastatic lymph of the stained nodes in CN group than in the control group (OR = 1.45, 95% CI = 1.13 to 1.85, p < 0.01). In addition, lymph nodes less than 5 mm were detected significantly more in the CN group than in the control group (OR = 2.15, 95% CI = 1.77 to 2.63, p < 0.01). Conclusions: The technique of CNs labeled lymph node staining in curative colorectal carcinoma is easy and effective, which can improve the retrieved number of lymph nodes, especially for nodes < 5 mm. The black stained lymph node indicates higher risk of metastasis. Further high quality RCT is needed to verify these conclusions.
[HCO3-]-regulated expression and activity of soluble adenylyl cyclase in corneal endothelial and Calu-3 cells
Xing Sun, Miao Cui, Joseph A Bonanno
BMC Physiology , 2004, DOI: 10.1186/1472-6793-4-8
Abstract: RT-competitive PCR indicated that sAC mRNA expression in BCECs is dependent on [HCO3-] and incubation time in HCO3-. Immunoblots showed that 10 and 40 mM HCO3- increased sAC protein expression by 45% and 87%, respectively, relative to cells cultured in the absence of HCO3-. Furthermore, 40 mM HCO3- up-regulated sAC protein expression in Calu-3 cells by 93%. On the other hand, sAC expression in BCECs and Calu-3 cells was unaffected by changes in bath pH or osmolarity. Interestingly, BCECs pre-treated with10 μM adenosine or 10 μM forskolin, which increase cAMP levels, showed decreased sAC mRNA expression by 20% and 30%, respectively. Intracellular cAMP production by sAC paralleled the time and [HCO3-]-dependent expression of sAC. Bicarbonate-induced apical Cl- permeability increased by 78% (P < 0.01) in BCECs cultured in HCO3-. However for cells cultured in the absence of HCO3-, apical Cl- permeability increased by only 10.3% (P > 0.05).HCO3- not only directly activates sAC, but also up-regulates the expression of sAC. These results suggest that active cellular uptake of HCO3- can contribute to the basal level of cellular cAMP in tissues that express sAC.Soluble adenylyl cyclase (sAC) has recently been characterized as a unique means to generate the ubiquitous signaling molecule, cyclic adenosine 3', 5'-monophosphate (cAMP) [1-3]. Elucidation of the properties of sAC indicate that this enzyme is biochemically and chromatographically different from the transmembrane adenylyl cyclases (tmACs) [4,5]. Unlike the tmACs, sAC activity depends on the divalent cation Mn2+ [1,3,6], is insensitive to G protein regulation and forskolin [2,4], and displays approximately 10-fold lower affinity for ATP (Km ≈ 1 mM) [4] than the tmACs (Km ≈ 100 μM) [7]. HCO3- directly binds to and activates sAC in a pH-independent manner [1]. HCO3- is the primary physiological activator of sAC and a recent study has shown that this can be modulated by Ca2+ [8].Immunocytochemistry studies have demonstr
A Rank-Corrected Procedure for Matrix Completion with Fixed Basis Coefficients
Weimin Miao,Shaohua Pan,Defeng Sun
Mathematics , 2012,
Abstract: For the problems of low-rank matrix completion, the efficiency of the widely-used nuclear norm technique may be challenged under many circumstances, especially when certain basis coefficients are fixed, for example, the low-rank correlation matrix completion in various fields such as the financial market and the low-rank density matrix completion from the quantum state tomography. To seek a solution of high recovery quality beyond the reach of the nuclear norm, in this paper, we propose a rank-corrected procedure using a nuclear semi-norm to generate a new estimator. For this new estimator, we establish a non-asymptotic recovery error bound. More importantly, we quantify the reduction of the recovery error bound for this rank-corrected procedure. Compared with the one obtained for the nuclear norm penalized least squares estimator, this reduction can be substantial (around 50%). We also provide necessary and sufficient conditions for rank consistency in the sense of Bach (2008). Very interestingly, these conditions are highly related to the concept of constraint nondegeneracy in matrix optimization. As a byproduct, our results provide a theoretical foundation for the majorized penalty method of Gao and Sun (2010) and Gao (2010) for structured low-rank matrix optimization problems. Extensive numerical experiments demonstrate that our proposed rank-corrected procedure can simultaneously achieve a high recovery accuracy and capture the low-rank structure.
Diagnosis of Premature Senescence of Cotton Using SPAD Value  [PDF]
Pengcheng Li, Helin Dong, Aizhong Liu, Jingran Liu, Miao Sun, Guoping Wang, Siping Zhang, Yabing Li, Shuchun Mao
Agricultural Sciences (AS) , 2014, DOI: 10.4236/as.2014.511107
Abstract: Field experiments were conducted in 2011 on an experimental farm at the Cotton Research Insti-tute, Chinese Academy of Agricultural Sciences, Anyang, China. We conducted experiments with a “SPAD-502” meter to quickly measure the relative value of chlorophyll content in the leaf blades of field cotton. Our goal was to seek a suitable leaf on a cotton plant to diagnose senescence status of crop plants at later stages of growth. We began by studying the dynamic change rule of the dis-tal-most four leaves of the cotton plant during the entire growth period with two early-maturing cultivars (CCRI 36, CCRI 50) and two mid-maturing cultivars (CCRI 41, SCRC 28). We also examined the effect of different nitrogen and potassium fertilizer rates on SPAD values of the leaves of SCRC 28. Our results suggest that SPAD values of the 1st distal stem leaves from two early cultivars can act as good indicators of senescence status in the plants, if they are measured between 10 d before the boll-opening stage and 10 d after boll opening stage. Differences of SPAD values of the 3rd distal stem leaves of two mid-maturing cultivars measured between about 15 d before the boll opening stage and 15 d after the boll opening stage can also be used to measure senescence status in these cotton cultivars. The conclusion can be used for cotton producer to manage N fertilizer better at later growth stage.
Effect of Electroplating Waste water on Immune Function in Kunming Mice  [PDF]
Zongqi Ma, Guirong Wang, Yufen Tian, Deli Xu, Xiaofeng Miao, Ying Zhang, Jiao Meng, Hong Ni, Weiwei Sun
Natural Science (NS) , 2016, DOI: 10.4236/ns.2016.87036
Abstract: Electroplating waste water is considered to be harmful to health of animals. In the present study, we tested the hypothesis that electroplating waste water would suppress immune functions in Kunming mice. Twenty-six mice were randomly divided into the control group (n = 13) and the experimental group (n = 13), in which the latter drank electroplating waste water. We found that body mass and most organ wet masses (heart, lungs, liver, kidneys, stomach, caecum, colon, testes, epididymis, seminal vesicals) were not influenced by electroplating waste water. However, stomach with its content, small intestine, small intestine with its contents and colon with its contents were higher in the experimental group than in the control group. As expected, phytohaemagglutinin (PHA) response indicative of cellular immunity was suppressed by electroplating waste water. White blood cells, thymus and spleen mass were all not response to electroplating waste water. Taken together, electroplating waste water had different effects on distinct components of immune system in Kunming mice.
Loss of Ahi1 Impairs Neurotransmitter Release and Causes Depressive Behaviors in Mice
Liyan Ren, Xuanchen Qian, Lijing Zhai, Miao Sun, Zhigang Miao, Jizhen Li, Xingshun Xu
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0093640
Abstract: Major depression is becoming one of the most prevalent forms of psychiatric disorders. However, the mechanisms of major depression are still not well-understood. Most antidepressants are only effective in some patients and produce some serious side effects. Animal models of depression are therefore essential to unravel the mechanisms of depression and to develop novel therapeutic strategies. Our previous studies showed that Abelson helper integration site-1 (Ahi1) deficiency causes depression-like behaviors in mice. In this study, we characterized the biochemical and behavioral changes in Ahi1 knockout (KO) mice. In Ahi1 KO mice, neurotransmitters including serotonin and dopamine were significantly decreased in different brain regions. However, glutamate and GABA levels were not affected by Ahi1 deficiency. The antidepressant imipramine attenuated depressive behaviors and partially restored brain serotonin level in Ahi1 KO mice. Our findings suggest that Ahi1 KO mice can be used for studying the mechanisms of depression and screening therapeutic targets.
Analysis of Organic Volatile Flavor Compounds in Fermented Stinky Tofu Using SPME with Different Fiber Coatings
Yuping Liu,Zhiwei Miao,Wei Guan,Baoguo Sun
Molecules , 2012, DOI: 10.3390/molecules17043708
Abstract: The organic volatile flavor compounds in fermented stinky tofu (FST) were studied using SPME-GC/MS. A total of 39 volatile compounds were identified, including nine esters, seven alcohols, five alkenes, four sulfides, three heterocycles, three carboxylic acids, three ketones, two aldehydes, one phenol, one amine and one ether. These compounds were determined by MS, and conformed by comparison of the retention times of the separated constituents with those of authentic samples and by comparison of retention indexes (RIs) of separated constituents with the RIs reported in the literature. The predominant volatile compound in FST was indole, followed by dimethyl trisulfide, phenol, dimethyl disulfide and dimethyl tetrasulfide. In order to find a better extraction time, the extraction times was optimized for each type of SPME fiber; the results show that the best extraction time for Carboxen/PDMS is 60 min, for PDMS/DVB 30 min, for DVB/CAR/PDMS 60 min and for PDMS 75 min. Of the four fibers used in this work, Carboxen/PDMS is found to be the most suitable to extract the organic volatile flavor compounds in fermented stinky tofu.
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