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Search Results: 1 - 10 of 1997 matches for " Metastasis "
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Metastatic Oesophagus Carcinoma Presented with Neck and Arm Pain: A Case Report  [PDF]
?zlem Demircio?lu, Berat Meryem Alkan, Fatma Fidan, Aliye Tosun, Selami Akku?
Case Reports in Clinical Medicine (CRCM) , 2014, DOI: 10.4236/crcm.2014.34053

Oesophageal carcinoma is among malignancies with poor prognosis due to the late onset symptoms related with large submucosal involvement, early lymphatic metastasis and its multicentric characteristics, majority of the patients decrease within the first year of diagnosis. However, bone metastasis is uncommon and reported to be 1% to 14% in autopsy series. Herein we report a case that was admitted to our outpatient clinics with severe neck and arm pain as presenting symptoms and diagnosed as metastatic oesophageal carcinoma afterwards.

A Rare Case of Diaphragmatic Mass: The Key to Diagnosis of a Lung Adenocarcinoma  [PDF]
Cláudia Rocha, Vera Clérigo, Lígia Fernandes, André Rodrigues, Dora Sargento, Glória Silva
Advances in Lung Cancer (ALC) , 2014, DOI: 10.4236/alc.2014.33009
Abstract: Lung cancer is a leading cause of death due to malignancy worldwide. Diaphragmatic metastasis secondary to primary lung cancer is rare. In the literature, only a few cases have been described as the majority of cases of diaphragmatic metastasis which are secondary to gastrointestinal neoplasia. The authors report a rare case of diaphragmmatic metastasis from a primary adenocarcinoma of the lung in a 76-year-old female patient with no history of active or passive smoking with progressive worsening fatigue, asthenia, malaise, and unquantified weight loss with three months of evolution, associated with pleuritic chest pain and edema of the lower limbs for fifteen days previous to hospital admission. Chest X-ray showed elevation of the right hemi-diaphragm and thoracic-abdominal-pelvic computed tomography revealed a complex multilobuled mass with neoformative characteristics intersecting the diaphragm and invading the dome liver and the right lung region. Biopsy of the mass was performed whose histological examination was consistent with moderately differentiated adenocarcinoma. Immunohistochemical examination was positive for cytokeratin 7 and negative forcytokeratin 20, suggesting primary lung tumor. A positron emission tomography was performed without uptake in other locations. Diagnosis of adenocarcinoma with diaphragmatic metastasis was then admitted and the patient started chemotherapy with carboplatin and gemcitabine. The patient died six months after the diagnosis. The authors also present a brief theoretical discussion based on the current and scarce literature on this rare entity.
Axillary Lymph Node Metastasis of Colon Cancer—Case Report and Literature Review  [PDF]
Helena Devesa, Luísa Pereira, álvaro Gon?alves, Telma Brito, Teresa Almeida, Rui Torres, Alberto Mid?es
Case Reports in Clinical Medicine (CRCM) , 2014, DOI: 10.4236/crcm.2014.312141
The most common metastatic sites of colon cancer are local lymph nodes, liver and lungs. Lymph node metastasis at distant sites is rare. In this article, we describe the case of a patient with ascending colon cancer with a metastasis in an axillary lymph node. The clinical presentation of this tumor was with an intestinal obstruction, and an emergency resection surgery was undertaken. The patient died at the third post-operative month, with lymph node and hepatic metastasis, and implants in the abdominal fat and in the mesentery, near the ileocolic anastomosis.
Unusually aggressive primary cloacogenic carcinoma of the vulva: A case report and literature review  [PDF]
Rajni Chibbar, Kimberly A. Wood, Christopher K. Giede, Anita Agrawal
Case Reports in Clinical Medicine (CRCM) , 2013, DOI: 10.4236/crcm.2013.25081
Abstract: Vulvar cancer is an uncommon tumor and represents 3%-5% of all female genital tract malignancies. The overall incidence is 1.5/100,000 women. Histopathologically the vast majority (90%) are squamous cell carcinomas. Primary cloacogenic carcinoma of the vulva is extremely rare with less than 20 cases reported in English literature [1]. These tumors are thought to arise from embryonic or ectopic rests of cloacogenic tissue. The majority of these reported cases is relatively indolent cancer, only one case of cloacogenic carcinoma of the vulva reported metastatic spread to the inguinal lymph nodes and none that describe distant metastases. Here we present an aggressive and diagnostically challenging case of cloacogenic carcinoma of the vulva and a review of current literature to date.

Case report: A rare case of dysgerminoma presenting with skin and breast metastasis  [PDF]
Oguntayo O. Adekunle, Marliya Zayyan, Abimbola O. D. Kolawole, Saa’d Ahmed
Case Reports in Clinical Medicine (CRCM) , 2013, DOI: 10.4236/crcm.2013.22046

A 30 years old grandmultiparous woman presented with 6 month history of severe abdominal pain and 4 month history of progressive abdominal swelling associated with multiple swellings on her abdomen and her breasts. She had laparotomy two years earlier for a suspected fibroid. A repeat laparatomy discovered a huge left ovarian tumour; which are multilobulated and hard. She had Total Abdominal Hysterectomy and Salpingectomy with Lumpectomy on both breast. Histology report turned out as Dysgerminoma, breast, Subcutaneous Tissue and Skin Metastatic Dysgerminoma.

Recurrent ameloblastoma of the mandible: Surgical seeding or metastasis of malignant ameloblastoma?  [PDF]
Christina Klee, Sven Lindskog, Jan-M. Hirsch, Andreas Thor
Case Reports in Clinical Medicine (CRCM) , 2013, DOI: 10.4236/crcm.2013.22042

The controversy of surgical seeding or metastasis of a recurrent ameloblastoma is discussed in this paper, where we present a case with a history of 28 years since primary diagnosis including several tumor removals and reconstructive events. 23 years after primary diagnosis, we removed a metastasis from the neck with similar histological features as the primary tumor and the following recurrences of the mandible. We argue that the removed tumor in the neck most possibly has its origin in surgical seeding of cells during earlier resection and reconstruction and not by common ways of metastasis. The seeding of tumor cells during tumor surgery and metastasis rate of malignant ameloblastoma is discussed and the literature in this area is reviewed in the paper.

Solitary Intramedullary Spinal Cord Metastasis from Colon Carcinoma: A Case Report and Literature Review  [PDF]
Pierpaolo Lunardi, Rodolfo Corinaldesi, Tommaso Lunardi, Roberto Floris
Open Journal of Modern Neurosurgery (OJMN) , 2014, DOI: 10.4236/ojmn.2014.41011
Abstract: It is extremely rare for cancer to present as an intramedullary spinal cord metastasis. The authors report on a case of a 74-year-old woman presenting with progressive tetraparesis to metastatic colon adenocarcinoma in the spinal cord. A review of the literature reveals that intramedullary localization is associated with a very short life expectancy, with a median survival of 3-4 months from the time of the diagnosis; nevertheless microsurgical removal of tumor can improve quality of life.
Abdominal Muscular Metastases of a Pulmonar Adenocarcinoma  [PDF]
Joana de Castro Rocha, Pedro Nuno Brand?o, Ana Rita Cruz, Vítor Valente
Advances in Lung Cancer (ALC) , 2015, DOI: 10.4236/alc.2015.42004
Abstract: Metastases are synonymous of malignant neoplasm in advanced stage and so associated with a poor prognosis. As the first manifestation of cancer disease, the muscle metastasis is very rare. The definitive diagnosis of its presence is made based on histology. The authors presented the case of a patient with a lung adenocarcinoma, being with first manifestation of it, a muscle metastasis only about a month later there were clinical manifestations with imaging appearance that led to the diagnosis of a primary neoplasm. The rare manifestation of the disease motivated the study and surveillance of the patient and lead to the diagnosis.
Nanoscale Stiffness Distribution in Bone Metastasis  [PDF]
Ludovic Richert, Laetitia Keller, Quentin Wagner, Fabien Bornert, Catherine Gros, Sophie Bahi, Fran?ois Clauss, William Bacon, Philippe Clézardin, Nadia Benkirane-Jessel, Florence Fioretti
World Journal of Nano Science and Engineering (WJNSE) , 2015, DOI: 10.4236/wjnse.2015.54023
Abstract: Nanomechanical heterogeneity is expected to have an effect on elasticity, injury and bone remodelling. In normal bone, we have two types of cells (osteoclasts and osteoblasts) working together to maintain existing bone. Bone cancers can produce factors that make the osteoclasts work harder. This means that more bone is destroyed than rebuilt, and leads to weakening of the affected bone. We report here the first demonstration of the nanoscale stiffness distribution in bone metastases before and after treatment of animals with the bisphosphonate Risedronate, a drug which is currently used for the treatment of bone metastases in patients with advanced cancers. The strategy used here is applicable to a wide class of biological tissues and may serve as a new reflection for biologically inspired scaffolds technologies.
Optic Nerve Metastasis from Breast Carcinoma after Treatment with Taxanes  [PDF]
Mónica Asencio-Duran, José-Luis Vallejo-Garcia, Isabel Rodriguez-Rodriguez, Margarita Sánchez-Orgaz, álvaro Arbizu-Duralde
Case Reports in Clinical Medicine (CRCM) , 2014, DOI: 10.4236/crcm.2014.36074

Introduction: The incidence of ocular metastasis from Breast Carcinoma is only between 5% - 30%, mainly located in choroid, but the location in optic nerve is even more infrequent. We present a rare case that combined both locations sequentially in the same eye. Methods: Case report. Results: A 58-year-old woman with advanced breast cancer was referred with a choroidal metastasis in her right eye which responded well to systemic Taxol and Avastin. Afterwards, she developed an optic nerve metastasis in the same eye when she was under the treatment, so it was changed to Docetaxel. Unfortunately the patient didn’t respond to this treatment and died. Conclusions: Choroidal metastasis secondary to breast cancer generally responds well to radiotherapy. Even so, in cases that a great deterioration of visual acuity is expected after radiation, chemotherapy like taxanes is an alternative to preserve vision with complete tumor regression. Nevertheless, the presentation of a second metastasis in optic nerve can be indicative of inadequate treatment of metastatic disease or complication of the treatment, or both.

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