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is among malignancies with poor prognosis due to the late onset symptoms
related with large submucosal involvement, early lymphatic metastasis and its
majority of the patients decrease within the first year of diagnosis. However,
bone metastasis is uncommon and reported to be 1% to 14% in autopsy series.
Herein we report a case that was admitted to our outpatient clinics with severe
neck and arm pain as presenting symptoms and diagnosed as metastatic oesophageal carcinoma afterwards.
A 30 years old grandmultiparous woman presented with 6 month
history of severe abdominal pain and 4 month history of progressive abdominal
swelling associated with multiple swellings on her abdomen and her breasts. She
had laparotomy two years earlier for a suspected fibroid. A repeat laparatomy
discovered a huge left ovarian tumour; which are multilobulated and hard. She
had Total Abdominal Hysterectomy and Salpingectomy with Lumpectomy on both
breast. Histology report turned out as Dysgerminoma, breast, Subcutaneous Tissue
and Skin Metastatic Dysgerminoma.
The controversy of surgical seeding or metastasis of a
recurrent ameloblastoma is discussed in this paper, where we present a case
with a history of 28 years since primary diagnosis including several tumor
removals and reconstructive events. 23 years after primary diagnosis, we
removed a metastasis from the neck with similar histological features as the
primary tumor and the following recurrences of the mandible. We argue that the
removed tumor in the neck most possibly has its origin in surgical seeding of
cells during earlier resection and reconstruction and not by common ways of
metastasis. The seeding of tumor cells during tumor surgery and metastasis rate
of malignant ameloblastoma is discussed and the literature in this area is reviewed
in the paper.
incidence of ocular metastasis from Breast Carcinoma is only between 5% - 30%,
mainly located in choroid, but the location in optic nerve is even more
infrequent. We present a rare case that combined both locations sequentially in
the same eye. Methods: Case report. Results: A 58-year-old woman with advanced
breast cancer was referred with a choroidal metastasis in her right eye which
responded well to systemic Taxol and Avastin. Afterwards, she developed an
optic nerve metastasis in the same eye when she was under the treatment, so it
was changed to Docetaxel. Unfortunately the patient didn’t respond to this
treatment and died. Conclusions: Choroidal metastasis secondary to breast
cancer generally responds well to radiotherapy. Even so, in cases that a great
deterioration of visual acuity is expected after radiation, chemotherapy like
taxanes is an alternative to preserve vision with complete tumor regression.
Nevertheless, the presentation of a second metastasis in optic nerve can be
indicative of inadequate treatment of metastatic disease or complication of the
treatment, or both.