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Search Results: 1 - 10 of 78 matches for " Mesfioui Abdelhalim "
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The Influence of Gonadectomy on Anxiolytic and Antidepressant Effects of Melatonin in Male and Female Wistar Rats: A Possible Implication of Sex Hormones  [PDF]
El Mrabet Fatima Zahra, Lagbouri Ibtissam, Mesfioui Abdelhalim, El Hessni Aboubakr, Ouichou Ali
Neuroscience & Medicine (NM) , 2012, DOI: 10.4236/nm.2012.32021
Abstract: The main objective of this study was to analyze the effects of sex, ovariectomy (Ovx) and orchidectomy (Orx) on antidepressant and anxiolytic effect of melatonin in forced swimming test, open field test and elevated plus maze test. Initially, 4 mg/kg of melatonin was daily administered, at 4:00 pm, to intact male and female rats during 8 weeks. Our results have shown that the effect of chronic injection of Mel is sex dependent in the three behaviors tests. Females rats have responded better than males in behavior test study after administration of melatonin, this difference between the sexes may be related to the action of sex hormones (androgens and estrogens) on behavior in males as well as in females. Secondly, to determine the possible interaction between Melatonin and steroid hormones, Ovx/sham female received Mel at dose of 4mg/kg alone or NaCl (0.9%) alone, and Orx/sham male received Mel at dose of 4 mg/kg alone or NaCl (0.9%) alone daily and during 8 weeks of treatment at 4:00 pm. All animals were tested in the open-field test, elevated plus maze test for anxiety behavior study, and forced swimming test for depression behavior study. Results revealed that Mel exerts an anxiolytic and antidepressant effects in the orchidectomized males and in intact females, confirming that the suppression of androgens by orchidectomy improved anxiolytic and antidepressant effects of melatonin in males. However in females, the suppression of estrogen by ovariectomy masked the antidepressant and anxiolytic effects of melatonin. Our results confirmed that the antidepressant and anxiolytic effects of melatonin are linked to sex hormones.
Pinealectomy and Exogenous Melatonin Regulate Anxiety-Like and Depressive-Like Behaviors in Male and Female Wistar Rats  [PDF]
El Mrabet Fatima Zahra, Ouaaki Siham, Mesfioui Abdelhalim, El Hessni Aboubakr, Ouichou Ali
Neuroscience & Medicine (NM) , 2012, DOI: 10.4236/nm.2012.34049
Abstract: The main objective of this work was to 1) study the influence of endogenous melatonin (Mel) abolishment via pinealectomy and 2) explore exogenous Mel effect on anxiety-like and depressive-like behavior in male and female rats. Rats were shamoperated (Sh) or pinealectomized (Px) and following subgroups were selected 1) Px/NaCl (0.9%) and Sh/NaCl (0.9%) : rats injected subcutaneously, once daily for 8 weeks, with saline solution NaCl (0.9%) as vehicle; 2) Px/Mel (4 mg/Kg) and Sh/Mel (4 mg/Kg): Rats similarly injected with 4 mg/Kg of Mel. All animals were housed under a photoperiod of (LD:16/8). After different treatments animals were tested in the open-field test (OFT), elevated plus maze test (EPM) to determine anxiety-like behavior, and forced swimming test (FST) to evaluate depressive-like level. Our results revealed that level of anxiety-like and depressive-like behavior are significantly higher in Px/NaCl (0.9%) when compared to Sh/NaCl (0.9%) group, suggesting that pinelectomy induced an anxiogenic and depressant effects. The Px effects would be due to the absence of endogenous Mel synthesis and release. Additionally, we clearly demonstrated that the level of anxiety-like and depressive-like behavior are higher in Px/Mel (4 mg/Kg) and Sh/Mel when compared respectively to Px/NaCl (4 mg/Kg) and Sh/NaCl groups suggesting an anxiolytic and antidepressant effects of exogenous Mel. Behavioral responses were sex dependent since the difference between females and males, especially, after melatonin administration, were statistically significant. These experiments provide evidence that pinealectomy and Mel regulated emotionally behavior in male and female rats.
Composite Likelihood for Bilinear GARCH Model  [PDF]
Abdelhalim Bouchemella, Fatima Zahra Benmostefa
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.515225
Abstract:

In this study, we focus on the class of BL-GARCH models, which is initially introduced by Storti & Vitale [1] in order to handle leverage effects and volatility clustering. First we illustrate some properties of BL-GARCH (1, 2) model, like the positivity, stationarity and marginal distribution; then we study the statistical inference, apply the composite likelihood on panel of BL-GARCH (1, 2) model, and study the asymptotic behavior of the estimators, like the consistency property and the asymptotic normality.

Cosmopolitanism and the Right to be Legal: The Practical Poverty of Concepts
Julten Abdelhalim
Transcience : a Journal of Global Studies , 2010,
Abstract: The idea of cosmopolitanism is rooted in European Enlightenment thought. However, the right to move around the globe is reserved to privileged citizens. The article discusses this dilemma in a theoretical and an empirical manner.
Terminological phenomenon in the history of criticism among the Arabs
Abbas Abdelhalim
Historical Kan Periodical , 2010,
Abstract: . . .
The rheological properties of different GNPs
Mohamed Anwar K Abdelhalim
Lipids in Health and Disease , 2012, DOI: 10.1186/1476-511x-11-14
Abstract: 10, 20 and 50 nm GNPs was used in this study. Several rheological parameters of GNPs such as viscosity, torque%, shear stress and shear rate were evaluated using Brookfield LVDV-III Programmable rheometer supplied with temperature bath and controlled by a computer. To measure fluid properties (viscosity as function of shear rate), e.g., to determine whether the flow is Newtonian or non-Newtonian flow behaviour, and viscoelasticity (viscosity as function of temperature), rheological parameters were firstly measured at starting temperature of 37°C and wide range of shear rates from 375 to 1875 s-1, and secondly at a gradual increase of temperature from 37 to 42°C and fixed shear rate of 1875 s-1.The 10, 20 and 50 nm GNPs showed mean size of 9.45 ± 1.33 nm, 20.18 ± 1.80 nm, and 50 nm GNPs, respectively. The 10 and 20 nm GNPs showed spherical morphology while 50 nm GNPs showed hexagonal morphology using the transmission electron microscope (TEM). The relation between viscosity (cp) and shear rate (s-1) for 10, 20 and 50 nm GNPs at a temperature of 37°C showed non-Newtonian behaviour. Although the relationship between SS (dyne/cm2) and SR (s-1) for 10, 20 and 50 nm GNPs was linearly related however their fluid properties showed non-Newtonian behaviour.The torque%, viscosity (cp) and SS (dyne/cm2) of all GNP sizes decreased with increasing the temperature and with decreasing the GNP size (for each fixed temperature value). For each shear rate value, the viscosity of all GNPs decreased with decreasing the GNP size. This study demonstrates that the physical, dimensional and morphological changes of GNPs have effective influence on their rheological properties. To understand and categorize the role of GNPs in drug delivery and cancer therapy, GNPs of varying size, number of particles, shape and surface should be taken into consideration. Moreover, further additional in vivo studies after administration of GNPs in rats should be performed to support this hypothesis.Nanotechno
Exposure to gold nanoparticles produces cardiac tissue damage that depends on the size and duration of exposure
Mohamed Anwar K Abdelhalim
Lipids in Health and Disease , 2011, DOI: 10.1186/1476-511x-10-205
Abstract: Animals were randomly divided into 3 GNPs-treated rats groups and one control group (CG). The 10, 20 and 50 nm GNPs were administered intraperitonealy at the rate of 3 or 7 days as follows: Group 1: received infusion of 100 μl GNPs of size 10 nm for 3 or 7 days; Group 2: received infusion of 100 μl GNPs of size 20 nm for 3 or 7 days; Group 3: received infusion of 100 μl GNPs of size 50 nm for 3 or 7 days. Control group: received no GNPs.In comparison with the respective control rats, GNPs-treated rat received 100 μl of 10 and 20 nm particles for 3 days or 7 days demonstrating congested heart muscle with prominent dilated blood vessels, scattered and extravasations of red blood cells, focus of muscle hyalinosis, disturbed muscle fascicles, dense prominent focus of inflammatory cells infiltrate by small lymphocytes and few plasma cells while GNPs-treated rat received 100 μl of 50 nm particles for 3 or 7 days demonstrating benign normal looking heart muscle with normal muscle direction and fascicles, and very few scattered small lymphocytes.The histological alterations induced by intraperitoneal administration of GNPs were size-dependent with smaller ones induced more affects and related with time exposure of GNPs. This study suggests that interaction of GNPs with proteins and various cell types might be evaluated as part of the toxicological assessment in addition to further experiments related to tissues antioxidant enzymes, oxidative parameters, lipid peroxidation, production of free radicals and/or ROS and cytokine, histomorphologcal and ultrastrucural will be performed to cover and understand the toxicity and the potential use of GNPs as therapeutic and diagnostic tool.The NPs are being investigated for gene delivery purposes [1-3] and cancer therapy [4]. Data concerning the behavior and toxicity of particles mainly comes from studies on inhaled NPs [5].NPs may differ in reactivity and solubility and may interact with all kinds of endogenous proteins, lipids, poly
Gold nanoparticles administration induces disarray of heart muscle, hemorrhagic, chronic inflammatory cells infiltrated by small lymphocytes, cytoplasmic vacuolization and congested and dilated blood vessels
Mohamed Anwar K Abdelhalim
Lipids in Health and Disease , 2011, DOI: 10.1186/1476-511x-10-233
Abstract: A total of 40 healthy male Wistar-Kyoto rats received 50 μl infusions of 10, 20 and 50 nm GNPs for 3 or 7 days. Animals were randomly divided into groups: 6 GNP-treated rats groups and one control group (NG). Groups 1, 2 and 3 received infusions of 50 μl GNPs of size 10 nm (3 or 7 days), 20 nm (3 or 7 days) and 50 nm (3 or 7 days), respectively.In comparison with the respective control rats, exposure to GNPs doses produced heart muscle disarray with a few scattered chronic inflammatory cells infiltrated by small lymphocytes, foci of hemorrhage with extravasation of red blood cells, some scattered cytoplasmic vacuolization and congested and dilated blood vessels. None of the above alterations were observed in the heart muscle of any member of the control group.The alterations induced by intraperitoneal administration of GNPs were size-dependent, with smaller ones inducing greater affects, and were also related to the time exposure to GNPs. These alterations may indicate scattered cytoplasmic vacuolization, which may induce the toxicity effect through an inability to deal with the accumulated residues resulting from metabolic and structural disturbances caused by these NPs. These histological alterations were more prominent with 10 nm size particles than with the larger ones. The interaction of GNPs with proteins and various cell types should be considered as part of the toxicological evaluation. Additional experiments related to plasma, tissues cytokine, antioxidant defense mechanism, lipid peroxidation, histomorphologcal and ultrastructure will be performed to identify and understand the toxicity and the potential use of GNPs as therapeutic and diagnostic tools.Nanoparticles (NPs) are being investigated for gene delivery purposes [1-3] and cancer therapy [4]. Data concerning the behavior and toxicity of particles mainly comes from studies on inhaled NPs [5].NPs may differ in reactivity and solubility and may interact with various endogenous proteins, lipids, polysac
The effects of size and period of administration of gold nanoparticles on rheological parameters of blood plasma of rats over a wide range of shear rates: In vivo
Mohamed Anwar K Abdelhalim
Lipids in Health and Disease , 2011, DOI: 10.1186/1476-511x-10-191
Abstract: Healthy, thirty male Wistar-Kyoto rats, 8-12 weeks old (approximately 250 g body weight) were divided into control group (NG: n = 10), group 1 (G1A: intraperitoneal infusion of 10 nm GNPs for 3 days, n = 5 and G1B: intraperitoneal infusion of 10 nm GNPs for 7 days, n = 5), group 2 (G2A: intraperitoneal infusion of 50 nm GNPs for 3 days, n = 5 and G2B: intraperitoneal infusion of 50 nm GNPs for 7 days, n = 5). Dose of 100 μl of GNPs was administered to the animals via intraperitoneal injection. Blood samples of nearly 1 ml were obtained from each rat. Various rheological parameters such as torque, shear stress, shear rate, viscosity, plastic velocity, yield stress, consistency index (k) and flow index (n) were measured in the blood plasma of rats after the intraperitoneal administration of 10 and 50 nm GNP for 3 and 7 days using Brookfield LVDV-III Programmable rheometer.The relationship between shear stress and shear rate for control, G1A, G1B, G2A and G2B was linearly related. The plastic viscosity and the yield stress values for G1A, G1B, G2A and G2B significantly (p < 0.05) decreased compared with the control. The n and k values calculated from equation (1). The k values for G1A, G1B and G2B decreased compared with the control; however the means were not significantly different. While G2A indicates no significant change compared with the control. The values of the flow behaviour index (n) were equal ≤ 1 for all the different GNPs sizes. The viscosity values measured for 10 and 50 nm GNPs (G1A, G1B, G2A and G2B) decreased compared with the control; however the means were not significantly different. The decrease in blood plasma viscosity values observed with all GNPs is particle size and administration period independent.At these particular shear rates, the estimated rheological parameters are not influenced by GNPs size and shape, number of NPs, surface area and administration period of GNPs. This study demonstrates that the highly decrease in blood plasma viscos
Converting Declarative Rules into Decision Trees
Amany Abdelhalim,Issa Traore
Lecture Notes in Engineering and Computer Science , 2009,
Abstract:
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