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Search Results: 1 - 10 of 325342 matches for " Merrill S. Kies "
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Outcomes and patterns of care of patients with locally advanced oropharyngeal carcinoma treated in the early 21st century
Garden Adam S,Kies Merrill S,Morrison William H,Weber Randal S
Radiation Oncology , 2013, DOI: 10.1186/1748-717x-8-21
Abstract: Background We performed this study to assess outcomes of patients with oropharyngeal cancer treated with modern therapy approaches. Methods Demographics, treatments and outcomes of patients diagnosed with Stage 3- 4B squamous carcinoma of the oropharynx, between 2000 – 2007 were tabulated and analyzed. Results The cohort consisted of 1046 patients. The 5- year actuarial overall survival, recurrence-free survival and local-regional control rates for the entire cohort were 78%, 77% and 87% respectively. More advanced disease, increasing T-stage and smoking were associated with higher rates of local-regional recurrence and poorer survival. Conclusions Patients with locally advanced oropharyngeal cancer have a relatively high survival rate. Patients’ demographics and primary tumor volume were very influential on these favorable outcomes. In particular, patients with small primary tumors did very well even when treatment was not intensified with the addition of chemotherapy.
MicroRNA Profiling of Salivary Adenoid Cystic Carcinoma: Association of miR-17-92 Upregulation with Poor Outcome
Yoshitsugu Mitani, Dianna B. Roberts, Hanadi Fatani, Randal S. Weber, Merrill S. Kies, Scott M. Lippman, Adel K. El-Naggar
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0066778
Abstract: Background Salivary adenoid cystic carcinoma (ACC) is a rare relentlessly progressive malignant tumor. The molecular events associated with ACC tumorigenesis are poorly understood. Variable microRNAs (miRNA) have been correlated with tumorigenesis of several solid tumors but not in ACC. To investigate the association of miRNAs with the development and/or progression of ACC, we performed a comparative analysis of primary ACC specimens and matched normal samples and a pooled salivary gland standard and correlated the results with clinicopathologic factors and validated selected miRNAs in a separate set of 30 tumors. Methods MiRNA array platform was used for the identification of target miRNAs and the data was subjected to informatics and statistical interrelations. The results were also collected with the MYB-NFIB fusion status and the clinicopathologic features. Results Differentially dysregulated miRNAs in ACC were characterized in comparison to normal expression. No significant differences in miRNA expression were found between the MYB-NFIB fusion positive and -negative ACCs. Of the highly dysregulated miRNA in ACC, overexpression of the miR-17 and miR-20a were significantly associated with poor outcome in the screening and validation sets. Conclusion Our study indicates that the upregulation of miR-17-92 may play a role in the biology of ACC and could be potentially targeted in future therapeutic studies.
Docetaxel in the treatment of squamous cell carcinoma of the head and neck
Alexander Rapidis,Nicholas Sarlis,Jean-Louis Lefebvre,Merrill Kies
Therapeutics and Clinical Risk Management , 2008,
Abstract: Alexander Rapidis1, Nicholas Sarlis2, Jean-Louis Lefebvre3, Merrill Kies41Department of Maxillofacial Surgery, Greek Anticancer Institute, Saint Savvas Hospital, Athens, Greece; 2Department of Medical Affairs, Oncology – US Sanofi-Aventis, Bridgewater, NJ, USA; 3Head and Neck Department, Centre Régional de Lutte Contre le Cancer de Lille, Lille, France; 4Department of Thoracic/Head and Neck Medical Oncology, The University of Texas – M.D. Anderson Cancer Center, Houston, TX, USAAbstract: Squamous cell carcinoma of the head and neck (SCCHN) presents at a locally advanced (LA) stage in many patients. Chemotherapy has been successfully integrated into first-line treatment programs, either during or prior to radiotherapy (RT) – the cornerstone modality for local disease control of inoperable disease or when organ preservation is desired. Concomitant chemoradiotherapy (CCRT) provides an absolute survival benefit when compared with other types of locoregional therapy that exclude chemotherapy. Nonetheless, distant metastases still represent the most common cause of treatment failure. Consequently, adding induction chemotherapy (ICT) to definitive non-surgical local therapies with a curative intent has been vigorously explored in LA SCCHN. Recently, it has been shown that ICT using the combination of the taxane docetaxel with cisplatin–5-fluorouracil provides significant survival benefit over cisplatin–5-FU, when used before either definitive RT (TAX323 trial) or carboplatin-based CCRT (TAX324 trial). Docetaxel is also being investigated in metastatic or recurrent (M/R) disease, with promising initial results. It is very likely that the future management strategies of SCCHN will incorporate biologic agents as an add-on to docetaxel-containing schemas, administered either as ICT prior to CCRT in the LA setting or for the management of M/R disease.Keywords: chemoradiotherapy, chemotherapy, docetaxel, head and neck carcinoma, induction, locally advanced, taxane
Explanations for 20th Century Tuberculosis Decline: How the Public Gets It Wrong  [PDF]
Ray M. Merrill, Spencer S. Davis, Gordon B. Lindsay, Elena Khomitch
Journal of Tuberculosis Research (JTR) , 2016, DOI: 10.4236/jtr.2016.43014
Abstract: Introduction: Historical analysis of health data indicates that the majority of the decrease in tuberculosis mortality during the past century was caused by improved social conditions and public health interventions. The purpose of this study was to assess lay public perceptions regarding why tuberculosis declined. Materials and Methods: A nationally representative sample of 705 adults was surveyed to identify their perceived reasons for the decline in tuberculosis mortality in the 20th century. Open- ended questions and responses were coded and placed into eight categories. Results: Approximately 52% of decreasing tuberculosis mortality was attributed to “modern medicine,” and 220% to “vaccination.” Comparatively few of the respondents attributed decreased tuberculosis mortality rates to public health or improvements in social health determinants of health. Males gave more credit to modern medicine and public health, with less to vaccination; the other racial group gave more credit to public health and less to modern medicine; Hispanics gave more credit to modern medicine and less to vaccinations; and the higher income groups gave more credit to vaccinations and public health, but less to modern medicine. Conclusion: The public overly attributes modern medicine as the primary cause of declining tuberculosis mortality rates, the second leading cause of death in the United States during the early 1900s, and gives little credit to the critical role played by public health and improved social conditions. These misperceptions may hinder societal efforts to address and fund important social determinants of health and public health interventions.
The Chancellor’s New Robes: Online Education  [PDF]
Stan Braude, Jon Merrill
Creative Education (CE) , 2013, DOI: 10.4236/ce.2013.47A2009
Abstract: Online education is being rapidly embraced as a cash cow for reputable universities. Although there are legitimate advantages to online learning, the data on learning outcomes are scarce. We point out the reasons why high quality, live classes are unlikely to be replaced by online alternatives. However, we do describe the poor teaching practices that can be inexpensively replaced by online courses. We finally point out that best practices and high quality online education are expensive and cannot generate the revenue expected by university administrators.
Allograft Inflammatory Factor-1 in Cardiac Ischemia Re-perfusion Injury: Release of Molecular Markers in an in Vitro Setting  [PDF]
D. Olga McDaniel, Xinchun Zhou, Debbie A. Rigney, Larry S. McDaniel, Giorgio Aru, Curtis Tribble, Lawrence Creswell, Walter H. Merrill
Open Journal of Organ Transplant Surgery (OJOTS) , 2013, DOI: 10.4236/ojots.2013.31002
Abstract:

Initial ischemia/reperfusion injury (IRI) may have an impact on recipient immune responses after transplantation. Allograft inflammatory factor-1 (AIF-1) has been implicated in the regulation of inflammation associated with organ rejection. We hypothesized that it is either passively released from injured tissues during organ procurement, or actively secreted by allograft infiltrating cells contributing to allograft dysfunction. We investigated the impact of IRI in an in vitro study of human heart tissue during the process of transplantation. The mRNA expression levels for both isoforms of the AIF-1, I2 and I3 were significantly increased after 30 minutes reperfusion (AIF-1 I2: p < 0.01 vs. AIF-1 I3: p < 0.005). Expression levels for IL-18 and the TLRs were increased after 30 minutes of reperfusion. Only IL-18 and TLR-2 were statistically significant (IL-18: p < 0.0001 vs. TLR-2: p < 0.01). The mRNA expression levels for AIF-1 I2 and IL-18 were decreased from the original levels of ischemia after 60 and 90 minutes reperfusion. The TLR-2 and -4 were presented with minimal levels of reduction after 60 minutes. However, mRNA expression levels for all were decreased to the original levels of ischemia after 90 minutes, except for AIF-1 I3, but the difference was not statistically significant. AIF-1 and IL-18 were specifically detected in myocytes and interstitial tissues by immunohistochemistry (IHC) stain after IRI. TLR-4 was non-specific, and TLR2 was minimally expressed. The study discusses the evidence supporting that the AIF-1 may have therapeutic potential for strategies in the control of innate immune responses early on, after transplantation.

Repliek comments on "a view of evolution by a Christian biologist' 1
J. D. Kies
Koers : Bulletin for Christian Scholarship , 1986, DOI: 10.4102/koers.v51i4.949
Abstract: Die Ou en Nuwe Testamente van die Bybel vorm 'n eenheid, en Christene wat uit laasgenoemde lewe, moet die uitsprake van die N T oor die OT aanvaar. Christus se eie woorde was dat man en vrou in die begin geskape is. Dit laat geen ruimte vir 'n lang evolusionére geskiedenis nie. Bowendien het Jesus gesé dat as mens nie glo wat Moses geskryf het nie, jy ook nie Sy woorde kan glo nie (Joh. 5:46,47).
Toeristenindustrie
H.E. Kies
Nieuwe West-Indische Gids , 1948,
Abstract:
Medical Image Segmentation Using Enhanced Hoshen-Kopelman Algorithm
K. Kies,N. Benamrane
Journal of Applied Sciences , 2008,
Abstract: This research present a method of 2D and 3D segmentation based on the Enhanced Hoshen-Kopelman algorithm and its extension to non-lattice structure. The main feature of this method is to combine a merging strategy of a region growing algorithm with the multiple labeling technique of the EHK algorithm for regular and non-regular lattice. An efficient reconstruction algorithm is then applied to the set of edge points for the obtained segmented regions. The latest uses 3D Delaunay weighted triangulation. The combination of these already known algorithms makes the proposed approach very fast, efficient and appropriate to volumetric segmentation and particularly the anatomical structures in MRI and CTScan images.
Increasing the output of a Littman-type laser by use of an intracavity Faraday rotator
Rebecca Merrill,Rebecca Olson,Scott Bergeson,Dallin S. Durfee
Physics , 2005,
Abstract: We present a new method of external-cavity diode laser grating stabilization which combines the high output power of the Littrow design with the fixed output pointing of the Littman-Metcalf design. Our new approach utilizes a Faraday-effect optical isolator inside the external cavity. Experimental testing and a model which describes the tuning range and optimal tuning parameters of the laser are described. Preliminary testing of this design has resulted in a short-term linewidth of 360 kHz and a side-mode suppression of 37 dB. The laser tunes mode-hop free over 7 GHz and we predict that much larger tuning ranges are possible.
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