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Search Results: 1 - 10 of 298215 matches for " Mel J Maranian "
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Saliva samples are a viable alternative to blood samples as a source of DNA for high throughput genotyping
Jean E Abraham, Mel J Maranian, Inmaculada Spiteri, Roslin Russell, Susan Ingle, Craig Luccarini, Helena M Earl, Paul DP Pharoah, Alison M Dunning, Carlos Caldas
BMC Medical Genomics , 2012, DOI: 10.1186/1755-8794-5-19
Abstract: Patients were recruited from the Pharmacogenetics of Breast Cancer Chemotherapy (PGSNPS) study. Paired blood and saliva samples were collected from 79 study participants. The Oragene DNA Self-Collection kit (DNAgenotek?) was used to collect and extract DNA from saliva. DNA from EDTA blood samples (median volume 8 ml) was extracted by Gen-Probe, Livingstone, UK. DNA yields, standard measures of DNA quality, genotype call rates and genotype concordance between paired, duplicated samples were assessed.Total DNA yields were lower from saliva (mean 24 μg, range 0.2–52 μg) than from blood (mean 210 μg, range 58–577 μg) and a 2-fold difference remained after adjusting for the volume of biological material collected. Protein contamination and DNA fragmentation measures were greater in saliva DNA. 78/79 saliva samples yielded sufficient DNA for use on Illumina Beadchip arrays and using Taqman assays. Four samples were randomly selected for genotyping in duplicate on the Illumina Beadchip arrays. All samples were genotyped using Taqman assays. DNA quality, as assessed by genotype call rates and genotype concordance between matched pairs of DNA was high (>97%) for each measure in both blood and saliva-derived DNA.We conclude that DNA from saliva and blood samples is comparable when genotyping using either Taqman assays or genome-wide chip arrays. Saliva sampling has the potential to increase participant recruitment within clinical trials, as well as reducing the resources and organisation required for multicentre sample collection.
CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen
Jean E Abraham, Mel J Maranian, Kristy E Driver, Radka Platte, Bolot Kalmyrzaev, Caroline Baynes, Craig Luccarini, Mitul Shah, Susan Ingle, David Greenberg, Helena M Earl, Alison M Dunning, Paul DP Pharoah, Carlos Caldas
Breast Cancer Research , 2010, DOI: 10.1186/bcr2629
Abstract: This was a population based case-cohort study. We genotyped known functional variants (n = 7; minor allele frequency (MAF) > 0.01) and single nucleotide polymorphisms (SNPs) (n = 5; MAF > 0.05) tagging all known common variants (tagSNPs), in CYP2D6 in 6640 DNA samples from patients with invasive breast cancer from SEARCH (Studies of Epidemiology and Risk factors in Cancer Heredity); 3155 cases had received tamoxifen therapy. There were 312 deaths from breast cancer, in the tamoxifen treated patients, with over 18000 years of cumulative follow-up. The association between genotype and BCSS was evaluated using Cox proportional hazards regression analysis.In tamoxifen treated patients, there was weak evidence that the poor-metaboliser variant, CYP2D6*6 (MAF = 0.01), was associated with decreased BCSS (P = 0.02; HR = 1.95; 95% CI = 1.12-3.40). No other variants, including CYP2D6*4 (MAF = 0.20), previously reported to be associated with poorer clinical outcomes, were associated with differences in BCSS, in either the tamoxifen or non-tamoxifen groups.CYP2D6*6 may affect BCSS in tamoxifen-treated patients. However, the absence of an association with survival in more frequent variants, including CYP2D6*4, questions the validity of the reported association between CYP2D6 genotype and treatment response in breast cancer. Until larger, prospective studies confirming any associations are available, routine CYP2D6 genetic testing should not be used in the clinical setting.Tamoxifen has been the standard treatment for oestrogen receptor (ER)-positive breast cancer for more than three decades. Indications for its use [1] include: metastatic disease in women (pre- and post-menopausal) and men; adjuvant therapy in pre- and post-menopausal women with breast cancer (lymph node positive and negative); preventative therapy in women at high risk of breast cancer; ductal carcinoma in situ post-resection; and for the prevention of contra-lateral breast cancer. There are proven benefits ass
Note complementaire sur les echinodermes ordoviciens de Sierra Morena
Chauvel, J.,Meléndez, B.
Estudios Geologicos , 1986,
Abstract: Addendum on the Ordovician Cystoids of Sierra Morena. A number of specimens from the synclinorium of Almadén (Ciudad Real), have allowed the description of a new species of the genus Calix, and a more complete description of the genus Batalleria. Also, it is confirmed the presence there of genus Pblyctocystis, as well as the first finding of the genus Destombesia in this area. Une nouvelle espéce du genre Calix est décrite, le genre Batalleria est redécrit, la présence de Phlyctocystis dans les Monts de Toléde-Sierra Morena est confirmée, et celle de Destombesia est signalée. Mots clés: Sierra Morena; Ordovicien; Cystoids; Systématique; Biestratigraphy. Se describe una nueva especie del género Calix del Sinclinorio de Almadén; se presenta una nueva descripción del género Batalleria a base de nuevos ejemplares ahora estudiados; se confirma la presencia de Phlyctocystis en la provincia de Ciudad Real y se se ala, por primera vez, el género Destombesia.
Nouvelle interpretation des echinodermes de Collado de Tosas (Gerona, Espagne)
Le Menn, J.,Meléndez, B.
Estudios Geologicos , 1988, DOI: 10.3989/egeol.88445-6563
Abstract: The revision of the echinoderms from Collado de Tosas, based on the original specimens and additional material, is undertaken. The study shows that the initial attribution to the genus Trochocystites belonging to the Homalozoa Cincta has been induced by the tectonic deformation and the presence of recristallization lamellae in the natural molds. New observations allow to conclude without ambiguity that these skeletal elements are isolated columnals with a broad lumen, of crinoids. The presence of Cambrian in the section, established exclusively on the initial determinations, cannot longer be maintained. Los fósiles de Equinodermos del Collado de Tosas fueron dados a conocer en 1911 por F. Azpeitia que los atribuyó a Trochocystites bohemicus Bar. Posteriormente, M. Faura (1912) hizo notar la presencia de fósiles ordovícicos en esta misma localidad, y propuso una interpretación estratigráfica que incluía un contacto anómalo con el supuesto Cámbrico determinado por los Trochocystites. Todo ello fue revisado por B. Meléndez en 1954, que creyó poder confirmar que los fósiles en cuestión (fig. 1), eran realmente Carpoideos. El estudio de nuevo material recogido in situ, así como de los ejemplares conservados en el Museo del Seminario Conciliar de Barcelona, nos ha llevado a la conclusión de que la atribución inicial de estos discutidos fósiles al género Trochocystites, fue debida a la deformación tectónica que les ha dado forma ovalada, y a la presencia de láminas de recristalización, en disposición radial, en los moldes (fig. 6, lám. 1), que dan la falsa apariencia de placas marginales. Las nuevas observaciones nos permiten afirmar que estos fósiles son placas columnales, aisladas, probablemente del pedúnculo de Crinoides, con cavidad central muy amplia (Iám. 1, figs. 15), aunque eventualmente, también podrían haber pertenecido a Cystideos. En consecuencia, la presencia del Cámbrico en esta localidad, basada únicamente en la determinación inicial, errónea, de estos fósiles, debe ser descartada. De acuerdo con el contexto estratigráfico y las características litológicas del material, los repetidos fósiles podrían pertenecer al Ordovícico, probablemente al Caradoc.
Construction Workers’ Perceptions of Safety Practices: A Case Study in Mexico  [PDF]
mel G. Solís-Carca?o, Ricardo J. Franco-Poot
Journal of Building Construction and Planning Research (JBCPR) , 2014, DOI: 10.4236/jbcpr.2014.21001
Abstract: Organizational characteristics and worker perceptions are among the main factors affecting the safety climate in construction sites. Although some perceptions of the workers may seem absurd to others, these components are part of their reality. Worker behavior is an extremely important factor in workplace safety as many accidents are often caused by insecure actions, in which combinations of human behavior are the consequence of such perceptions. The aim of this study was to explore workers’ perceptions of safety practices in their habitual work environment, a building site in Mexico. Worker perceptions of safety practices were captured using an instrument in which the following dimensions were taken into consideration: Education and training, Work motivation, Family and social integration, Work place integration, Safety awareness integration, and Accidents. The conclusion was that the workers have received very little education and possess a limited culture of safety awareness, which has led them to perceive that their lack of precaution is the main cause of accidents.
Gap soliton gating, dissociation, and retrieval via defect mode excitation in a resonant photonic crystal
Igor V. Mel'nikov,J. Stewart Aitchison
Physics , 2005,
Abstract: We consider the interaction within a bunch of two coherent optical pulses in a one dimensional, resonant photonic crystal which includes a defect produced by a coherent pump. Using numerical methods, the defect is shown to provide a selective reversible trap for a gap soliton mediated by the long-range coupling. This opens up new opportunities for signal transmission control and light localization.
In2O3 doped with hydrogen: electronic structure and optical properties from the pseudopotential Self-Interaction Corrected Density Functional Theory and the Random Phase Approximation
Juan J. Meléndez,Ma?gorzata Wierzbowska
Physics , 2015,
Abstract: We discuss the applicability of the pseudopotential-like self-interaction correction (pSIC) to the study of defect energetics and electronic structure of In2O3. Our results predict that substitutional (at oxygen sites) and interstitial (at antibonding positions) hydrogen, as well as oxygen vacancies with charges +1 and +2, are stable configurations of defects in cubic In2O3; the former form shallow levels (only as substitutional defects), whereas the latter form deep levels. The band structure calculated with the pSIC shows an excellent agreement with experimental data. In particular, the gap for defect-free In2O3 is 2.85 eV, which compares fairly with the experimental range 2.3-2.9 eV. The pSIC results also point to a change from indirect to direct gaps depending on doping. In relation to the optical properties, obtained within the random phase approximation, it is shown that they are mostly affected by the presence of oxygen vacancies.
Existence of Lévy's area and pathwise integration
Peter Imkeller,David J. Pr?mel
Mathematics , 2014,
Abstract: Rough path analysis can be developed using the concept of controlled paths, and with respect to a topology in which L\'evy's area plays a role. For vectors of irregular paths we investigate the relationship between the property of being controlled and the existence of associated L\'evy areas. For two paths, one of which is controlled by the other, a pathwise construction of the L\'evy area and therefore of mutual stochastic integrals is possible. If the existence of quadratic variation along a sequence of partitions is guaranteed, this leads us to a study of the pathwise change of variable (It\^o) formula in the spirit of F\"ollmer, from the perspective of controlled paths.
Rough differential equations driven by signals in Besov spaces
David J. Pr?mel,Mathias Trabs
Mathematics , 2015,
Abstract: Rough differential equations are solved for signals in general Besov spaces unifying in particular the known results in H\"older and p-variation topology. To this end the paracontrolled distribution approach, which has been introduced by Gubinelli, Imkeller and Perkowski ["Paracontrolled distribution and singular PDEs", Forum of Mathematics, Pi (2015)] to analyze singular stochastic PDEs, is extended from H\"older to Besov spaces. As an application we solve stochastic differential equations driven by random functions in Besov spaces and Gaussian processes in a pathwise sense.
Pathwise stochastic integrals for model free finance
Nicolas Perkowski,David J. Pr?mel
Quantitative Finance , 2013,
Abstract: We present two different approaches to stochastic integration in frictionless model free financial mathematics. The first one is in the spirit of It\^o's integral and based on a certain topology which is induced by the outer measure corresponding to the minimal superhedging price. The second one is based on the controlled rough path integral. We prove that every "typical price path" has a naturally associated It\^o rough path, and justify the application of the controlled rough path integral in finance by showing that it is the limit of non-anticipating Riemann sums, a new result in itself. Compared to the first approach, rough paths have the disadvantage of severely restricting the space of integrands, but the advantage of being a Banach space theory. Both approaches are based entirely on financial arguments and do not require any probabilistic structure.
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