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Search Results: 1 - 10 of 34476 matches for " Meixia Lu "
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New Model for L2 Norm Flow  [PDF]
Jiaojiao Li, Meixia Dou
Journal of Applied Mathematics and Physics (JAMP) , 2015, DOI: 10.4236/jamp.2015.37089

We introduce a new L2 norm preserving heat flow in matrix geometry. We show that this flow exists globally and preserves the positivity property of Hermitian matrices.

Association between the NBS1 E185Q polymorphism and cancer risk: a meta-analysis
Meixia Lu, Jiachun Lu, Xiaobo Yang, Miao Yang, Hao Tan, Bai Yun, Luyuan Shi
BMC Cancer , 2009, DOI: 10.1186/1471-2407-9-124
Abstract: We performed a meta-analysis using 16 eligible case-control studies (including 17 data sets) with a total of 9,734 patients and 10,325 controls to summarize the data on the association between the NBS1 8360G>C (E185Q) polymorphism and cancer risk.Compared with the common 8360GG genotype, the carriers of variant genotypes (i.e., 8360 GC/CC) had a 1.06-fold elevated risk of cancer (95% CI = 1.00–1.12, P = 0.05) in a dominant genetic model as estimated in a fixed effect model. However, the association was not found in an additive genetic model (CC vs GG) (odds ratio, OR = 0.98, 95% CI = 0.85–1.13, P = 0.78) nor in a recessive genetic model (CC vs GC +GG) (OR = 0.94, 95% CI = 0.82–1.07, P = 0.36). The effect of the 8360G>C (E185Q) polymorphism was further evaluated in stratification analysis. It was demonstrated that the increased risk of cancer associated with 8360G>C variant genotypes was more pronounced in the Caucasians (OR = 1.07, 95% CI = 1.01–1.14, P = 0.03).Our meta-analysis suggests that the NBS1 E185Q variant genotypes (8360 GC/CC) might be associated with an increased risk of cancer, especially in Caucasians.DNA damage may increase cancer risk, and DNA double-strand breaks (DSBs) cause the most potentially serious damage to the genome. If unrepaired, DSBs may lead to genomic instability and thus cancer [1]. The repair of DSBs in human cells includes two different pathways, homologous recombination repair (HR) and non-homologous end joining (NHEJ) pathways [2]. The initial step in both pathways is the recognition and signaling of DNA DSBs by a protein complex containing Nijmegen breakage syndrome 1 (NBS1), meiotic recombination 11 homologue (MRE11), and human RAD50 homologue (RAD50) proteins [3]. NBS1 plays an important role as a sensor in repairing the DSBs and activates the cell-cycle checkpoint signaling; it also directly binds to the phosphorylated histone H2AX that is located around DSBs, participating in maintaining genomic stability [4], and prevents ce
Association between MGMT Promoter Methylation and Non-Small Cell Lung Cancer: A Meta-Analysis
Changmei Gu, Jiachun Lu, Tianpen Cui, Cheng Lu, Hao Shi, Wenmao Xu, Xueli Yuan, Xiaobo Yang, Yangxin Huang, Meixia Lu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0072633
Abstract: Background O6-methylguanine-DNA methyltransferase (MGMT) is one of most important DNA repair enzyme against common carcinogens such as alkylate and tobacco. Aberrant promoter methylation of the gene is frequently observed in non-small cell lung cancer (NSCLC). However, the importance of epigenetic inactivation of the gene in NSCLC published in the literature showed inconsistence. We quantified the association between MGMT promoter methylation and NSCLC using a meta-analysis method. Methods We systematically reviewed studies of MGMT promoter methylation and NSCLC in PubMed, EMBASE, Ovid, ISI Web of Science, Elsevier and CNKI databases and quantified the association between MGMT promoter methylation and NSCLC using meta-analysis method. Odds ratio (OR) and corresponding 95% confidence interval (CI) were calculated to evaluate the strength of association. Potential sources of heterogeneity were assessed by subgroup analysis and meta-regression. Results A total of 18 studies from 2001 to 2011, with 1, 160 tumor tissues and 970 controls, were involved in the meta-analysis. The frequencies of MGMT promote methylation ranged from 1.5% to 70.0% (median, 26.1%) in NSCLC tissue and 0.0% to 55.0% (median, 2.4%) in non-cancerous control, respectively. The summary of OR was 4.43 (95% CI: 2.85, 6.89) in the random-effects model. With stratification by potential source of heterogeneity, the OR was 20.45 (95% CI: 5.83, 71.73) in heterogeneous control subgroup, while it was 4.16 (95% CI: 3.02, 5.72) in the autologous control subgroup. The OR was 5.31 (95% CI: 3.00, 9.41) in MSP subgroup and 3.06 (95% CI: 1.75, 5.33) in Q-MSP subgroup. Conclusion This meta-analysis identified a strong association between methylation of MGMT gene and NSCLC. Prospective studies should be required to confirm the results in the future.
Evaluating the Pharmacological Mechanism of Chinese Medicine Si-Wu-Tang through Multi-Level Data Integration
Zhao Fang, Bingxin Lu, Mingyao Liu, Meixia Zhang, Zhenghui Yi, Chengping Wen, Tieliu Shi
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0072334
Abstract: Si-Wu-Tang (SWT) is a Traditional Chinese Medicine (TCM) formula widely used for the treatments of gynecological diseases. To explore the pharmacological mechanism of SWT, we incorporated microarray data of SWT with our herbal target database TCMID to analyze the potential activity mechanism of SWT's herbal ingredients and targets. We detected 2,405 differentially expressed genes in the microarray data, 20 of 102 proteins targeted by SWT were encoded by these DEGs and can be targeted by 2 FDA-approved drugs and 39 experimental drugs. The results of pathway enrichment analysis of the 20 predicted targets were consistent with that of 2,405 differentially expressed genes, elaborating the potential pharmacological mechanisms of SWT. Further study from a perspective of protein-protein interaction (PPI) network showed that the predicted targets of SWT function cooperatively to perform their multi-target effects. We also constructed a network to combine herbs, ingredients, targets and drugs together which bridges the gap between SWT and conventional medicine, and used it to infer the potential mechanisms of herbal ingredients. Moreover, based on the hypothesis that the same or similar effects between different TCM formulae may result from targeting the same proteins, we analyzed 27 other TCM formulae which can also treat the gynecological diseases, the subsequent result provides additional insight to understand the potential mechanisms of SWT in treating amenorrhea. Our bioinformatics approach to detect the pharmacology of SWT may shed light on drug discovery for gynecological diseases and could be utilized to investigate other TCM formulae as well.
The Differences in Homocysteine Level between Obstructive Sleep Apnea Patients and Controls: A Meta-Analysis
Xun Niu, Xiong Chen, Ying Xiao, Jiaqi Dong, Rui Zhang, Meixia Lu, Weijia Kong
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0095794
Abstract: Background Studies have reported inconsistent findings regarding the relationship between obstructive sleep apnea (OSA) and homocysteine (HCY) level. This study aimed to assess the difference in plasma HCY level between OSA patients and controls by conducting a meta-analysis of published studies. Methods Database of PubMed, SCI, and China National Knowledge Internet (CNKI) were comprehensively searched. Eligible studies regarding plasma HCY level in OSA patients were identified by two independent reviewers. RevMan (version 5.2) and STATA (version 12.0) were employed for data synthesis. Results A total of 10 studies involving 432 subjects were included. Meta-analysis showed that plasma HCY levels in OSA group were 3.11 μmol/l higher than that in control group (95% confidence interval: 2.08 to 4.15, P<0.01). Subgroup analysis revealed a more significant differences between OSA patients and controls when average body mass index ≥30 (the total weighted mean difference (WMD) was 3.64), average age<50 (the total WMD was 3.96) and average apnea hypopnea index ≥35 (the total WMD was 4.54). Conclusions In this meta-analysis, plasma HCY levels were found to be higher in OSA patients compared to control subjects.
A Class of Nonmontone Line Search Method with Perturbations
Meixia Li
Journal of Computers , 2012, DOI: 10.4304/jcp.7.4.941-946
Abstract: In this paper, a new kind of nonmontone line search method which is called new hybrid projection method with perturbations is proposed. At the same time, global convergence of this kind of method is proved only in the case where the gradient function is uniformly continuous on an open convex set containing the iteration sequence. In doing so, we remove various boundedness conditions. Furthermore, we obtain that the convergence property of gradient-type method with new nonmontone linear search method will not be changed when search directions are perturbed slightly. Numerical examples are given in the third section of this paper.
Research on Mechanism of Application and Exit of Venture Capital in University Science Park in China
Meixia DONG
International Business and Management , 2011, DOI: 10.3968/j.ibm.1923842820110302.1z0594
Abstract: Venture capital in the investment of University Science Parks (USP) in China is low and has difficult to play a leading role. Also venture capital can’t be integrated with projects and is in a poor efficiency. Adopting diversified methods to build a network of using venture capital and establishing a scientific evaluation system to construct a management system for venture capital ensures the efficient use of venture capital. Since recycling of venture capital promote the development of the USP, research on the exit mechanism of venture capital is very important. In order to make the venture capital exit smoothly, the USP should use appropriate introducing way and select the best exiting way and time and train venture capitalists. Key words: University science park; Venture capital; Efficient utilization; Exit mechanism
Effects of Non-Identical Rayleigh Fading on Differential Unitary Space-Time Modulation
Meixia Tao
Mathematics , 2007,
Abstract: This paper has been withdrawn by the author.
Association between RASSF1A Promoter Methylation and Ovarian Cancer: A Meta-Analysis
Hao Shi, Ya Li, Xiaozhong Wang, Cheng Lu, Lilan Yang, Changmei Gu, Jiaqiang Xiong, Yangxin Huang, Shixuan Wang, Meixia Lu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0076787
Abstract: Background The RAS association domain family protein 1a gene (RASSF1A) is one of the tumor suppressor genes (TSG). Inactivation of RASSF1A is critical to the pathogenesis of cancer. Aberrant TSG methylation was considered an important epigenetic silencing mechanism in the progression of ovarian cancer. A number of studies have discussed association between RASSF1A promoter methylation and ovarian cancer. However, they were mostly based on a small number of samples and showed inconsist results, Therefore, we conducted a meta-analysis to better identify the association. Methods Eligible studies were identified by searching the PubMed, EMBASE, Web of Science, and CNKI databases using a systematic searching strategy. We pooled the odds ratio (ORs) from individual studies using a fixed-effects model. We performed heterogeneity and publication bias analysis simultaneously. Results Thirteen studies, with 763 ovarian cancer patients and 438 controls were included in the meta-analysis. The frequencies of RASSF1A promoter methylation ranged from 30% to 58% (median is 48%) in the cancer group and 0 to 21% (median is 0) in the control group. The frequencies of RASSF1A promoter methylation in the cancer group were significantly higher than those in the control group. The pooled odds ratio was 11.17 (95% CI = 7.51–16.61) in the cancer group versus the corresponding control group under the fixed-effects model. Conclusion The results suggested that RASSF1A promoter methylation had a strong association with ovarian cancer.
Global Attractor and Dimension Estimation for a 2D Generalized Anisotropy Kuramoto-Sivashinsky Equation  [PDF]
Meixia Wang, Cuicui Tian, Guoguang Lin
International Journal of Modern Nonlinear Theory and Application (IJMNTA) , 2014, DOI: 10.4236/ijmnta.2014.34018
Abstract: In this paper, firstly, some priori estimates are obtained for the existence and uniqueness of solutions of a two dimensional generalized anisotropy Kuramoto-Sivashinsky Equation. Then we prove the existence of the global attractor. Finally, we get the upper bound estimation of the Haus-dorff and fractal dimension of attractor.
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