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Search Results: 1 - 10 of 23247 matches for " Meian He "
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Genetic Determinants for Body Iron Store and Type 2 Diabetes Risk in US Men and Women
Meian He, Tsegaselassie Workalemahu, JoAnn E. Manson, Frank B. Hu, Lu Qi
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0040919
Abstract: Background High body iron store has been associated with an increased risk of type 2 diabetes (T2D); it remains unknown whether the genetic variants related to body iron status affect T2D risk. We aimed at comprehensively investigating the associations between the genetic variants related to body iron status and the T2D risk. Methodology/Principal Findings Six common SNPs related to body iron status from recent genome-wide association (GWA) studies were determined in the Nurses’ Health Study (NHS; 1,467 diabetic cases and 1,754 controls) and the Health Professionals Follow-up Study (HPFS; 1,124, diabetic cases and 1,298 controls). Plasma levels of ferritin, soluble transferrin receptor (sTfR), and transferrin were measured in NHS. Significant associations were observed for loci in TPMRSS6 with sTfR (P = 3.47×10?6), TF with transferrin (P = 0.0002 to 1.72×10?10); and HFE with ferritin (P = 0.017 to 1.6×10?8), sTfR (P = 0.007 to 7.9×10?6), and transferrin (P = 0.006 to 0.0007). The six SNPs together explained 5.7%, 2.7%, and 13.3% of the variation in plasma levels of ferritin, sTfR, and transferrin. After adjustment for the conventional risk factors, the T allele of SNP rs855791 in the TPMRSS6 gene was significantly associated with a 19% decreased risk of T2D (OR = 0.81; 95% CI = 0.66–0.98; P = 0.03) in men. Multiple tests attenuated this significant association to null. No associations were observed in women. SNPs at HFE and TF were not associated with diabetes risk in either sex. Dietary iron intake did not modify the associations of the newly identified loci with diabetes risk. Conclusions/Significance The newly identified iron-related SNP rs855791 in TPMRSS6 was nominally associated with a decreased risk of T2D in men but not in women. The apparent differences by gender warrant further study.
The Effects of Shift Work on Sleeping Quality, Hypertension and Diabetes in Retired Workers
Yanjun Guo, Yuewei Liu, Xiji Huang, Yi Rong, Meian He, Youjie Wang, Jing Yuan, Tangchun Wu, Weihong Chen
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0071107
Abstract: Background Shift work has been associated with adverse health effects by disturbing circadian rhythms. However,its potential long-term health effects and the persistent effects after leaving shifts have not been well established. Methods and Results We studied 26,463 workers from Tongji-Dongfeng Cohort in China. All the participants are retired employees of Dongfeng Motor Company. Information on demographics, occupational history and medical history were gathered through questionnaires. After adjusting potential confounders in the logistic regression models, shift work was associated with poor sleeping quality, diabetes and hypertension independently. We observed significant effects of shift work on poor sleeping quality, diabetes and hypertension; the ORs (95%CI) are 1.18 (1.09–1.27), 1.10 (1.03–1.17) and 1.05 (1.01–1.09) respectively. In the further analysis, we found elevated ORs (95%CI) for participants with poor sleeping quality, the ORs (95%CI) are 1.34 (1.08–1.60), 1.13 (1.05–1.21), 1.05 (1.03–1.07) and 1.05 (1.01–1.09) for 1–4, 5–9, 10–19, ≥20 years of shift work respectively. However, with the extension of leaving shift work duration, the effects of shift work on sleep quality gradually reduced. Conclusions Shift work may be an independent risk factor for sleeping quality, diabetes and hypertension even in retired workers. Applicable intervention strategies are needed for prevention of sleep loss, diabetes, and hypertension for shift workers.
Genetic Variants at Newly Identified Lipid Loci Are Associated with Coronary Heart Disease in a Chinese Han Population
Li Zhou, Hu Ding, Xiaomin Zhang, Meian He, Suli Huang, Yujun Xu, Ying Shi, Guanglin Cui, Longxian Cheng, Qing K. Wang, Frank B. Hu, Daowen Wang, Tangchun Wu
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0027481
Abstract: Background Recent genome-wide association studies (GWAS) have mapped several novel loci influencing blood lipid levels in Caucasians. We sought to explore whether the genetic variants at newly identified lipid-associated loci were associated with CHD susceptibility in a Chinese Han population. Methodology/Principal Findings We conducted a two-stage case-control study in a Chinese Han population. The first-stage, consisting of 1,376 CHD cases and 1,376 sex and age- frequency matched controls, examined 5 novel lipid-associated single-nucleotide polymorphisms (SNPs) identified from GWAS among Caucasians in relation to CHD risk in Chinese. We then validated significant SNPs in the second-stage, consisting of 1,269 cases and 2,745 controls. We also tested associations between SNPs within the five novel loci and blood lipid levels in 4,121 controls. We identified two novel SNPs (rs599839 in CELSR2-PSRC1-SORT1 and rs16996148 in NCAN-CILP2) that were significantly associated with reduced CHD risk in Chinese (odds ratios (95% confidence intervals) in the dominant model 0.76 (0.61-0.90; P = 0.001), 0.67 (0.57-0.77; P = 3.4×10?8), respectively). Multiple linear regression analyses using dominant model showed that rs599839 was significantly associated with decreased LDL levels (P = 0.022) and rs16996148 was significantly associated with increased LDL and HDL levels (P = 2.9×10?4 and 0.001, respectively). Conclusions/Significance We identified two novel SNPs (rs599839 and rs16996148) at newly identified lipid-associated loci that were significantly associated with CHD susceptibility in a Chinese Han population.
Functional SNPs in HSPA1A Gene Predict Risk of Coronary Heart Disease
Meian He, Huan Guo, Xiaobo Yang, Xiaomin Zhang, Li Zhou, Longxian Cheng, Hesong Zeng, Frank B. Hu, Robert M. Tanguay, Tangchun Wu
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0004851
Abstract: Background HSP70 plays crucial roles in endothelial cell apoptosis, which is involved in the early phase and progress of coronary heart disease (CHD). However, the association between polymorphisms of HSP70 genes and the risk of CHD still remains unclear. Our aim was to determine whether genetic variants in the HSPA1A gene are associated with the risk of CHD. Methodology/Principal Findings By resequencing and genotyping, the associations of 2 single nucleotide polymorphisms (SNPs) +190G/C (rs1043618) and ?110A/C (rs1008438) in the HSPA1A gene with risk of CHD were determined in a 1,003 pairs case-control study. The SNP function was further analyzed using a luciferase reporter assay in two cell lines. The results indicated that +190CC genotype was associated with significantly higher risk of CHD when compared with +190GG genotype (OR = 1.56, 95% CI: 1.10–2.20, P = 0.012), while association between ?110A/C polymorphism and CHD was not statistically significant (P>0.05). However, the ?110C/+190C haplotype had a significantly higher risk of CHD when compared with the ?110A/+190G haplotype (OR = 1.17, 95% CI: 1.01–1.34, P = 0.031). Luciferase reporter assays showed that the +190C allele resulted in 14%~45% reduction in luciferase expression in endothelial and non-endothelial cells when compared with the +190G allele. Conclusions/Significance The identified genetic variants in the HSPA1A gene combinatorially contribute towards the susceptibility to CHD likely by affecting the level of synthesis of HSP70. This study may provide useful markers for identification of subjects at risk for CHD.
Genetic Variations in HSPA8 Gene Associated with Coronary Heart Disease Risk in a Chinese Population
Meian He,Huan Guo,Xiaobo Yang,Li Zhou,Xiaomin Zhang,Longxian Cheng,Hesong Zeng,Frank B. Hu,Robert M. Tanguay,Tangchun Wu
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0009684
Abstract: There is ample evidence that Hsp70 takes part in the progress of coronary heart disease (CHD). This implies that genetic variants of Hsp70 genes such as HSPA8 (HSC70) gene might contribute to the development of CHD. The present study aimed to investigate whether certain genetic variants of HSPA8 gene are associated with CHD in Han Chinese people.
Genetic Variation in BCL2 3′-UTR Was Associated with Lung Cancer Risk and Prognosis in Male Chinese Population
Ping Xu, Li Liu, Jianzhong Wang, Kai Zhang, Xiaohua Hong, Qifei Deng, Jingjun Xiang, Xiaomin Zhang, Meian He, Tangchun Wu, Huan Guo
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0072197
Abstract: Objectives Bcl-2 is a critical apoptosis inhibitor with established carcinogenic potential, and can confer cancer cell resistance to therapeutic treatments by activating anti-apoptotic cellular defense. We hypothesized that genetic variants of BCL2 gene may be associated with lung cancer susceptibility and prognosis. Methods Three selected tagSNPs of BCL2 (rs2279115, rs1801018, and rs1564483) were genotyped in 1017 paired male Chinese lung cancer cases and controls by TaqMan assay. The associations of these variants with risk of lung cancer and overall survival of 242 male advanced non-small-cell lung cancer (NSCLC) patients were separately investigated. Results Compared with the BCL2 3′UTR rs1564483GG genotype, the rs1564483GA, AA, and GA+AA genotypes were associated with significantly decreased susceptibilities of lung cancer in male Chinese (adjusted OR = 0.78, 0.73, and 0.76, P = 0.016, 0.038, and 0.007, respectively), while rs1564483A allele has a inverse dose-response relationship with lung cancer risk (Ptrend = 0.010). These effects were more evident in the elders, smokers, and subjects without family history of cancer (Ptrend = 0.017, 0.043 and 0.005, respectively). Furthermore, advanced NSCLC males carrying BCL2 rs1564483 GA+AA genotypes had significantly longer median survival time (Long-rank P = 0.036) and decreased death risk (adjusted HR = 0.69, P = 0.027) than patients with rs1564483GG genotype. These effects were more obvious in patients with smoking, stage IIIA, and in patients without surgery but underwent chemotherapy or radiotherapy (adjusted HR = 0.68, 0.49, 0.67, 0.69, 0.50, respectively, all P<0.05). Conclusion The BCL2 3′UTR rs1564483A allele was associated with a decreased lung cancer risk and better survival for advanced NSCLC in male Chinese, which may offer a novel biomarker for identifying high-risk population and predicting clinical outcomes.
Higher Carbohydrate Antigen 125 Levels Are Associated with Increased Risk of Coronary Heart Disease in Elderly Chinese: A Population-Based Case-Control Study
Xiaorong Li, Meian He, Jiang Zhu, Ping Yao, Xiulou Li, Jing Yuan, Xinwen Min, Mingjian Lang, Handong Yang, Frank B. Hu, Tangchun Wu, Sheng Wei
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0081328
Abstract: Background High carbohydrate antigen 125 (CA-125) level was reported to be associated with some cardiac dysfunctions, such as chronic heart failure, but the relationship between CA-125 level and coronary heart disease (CHD) risk remains unclear. The aim of this study was to explore the potential association in a Chinese older population. Methods In a population-based case-control study conducted in a Chinese older population, serum CA-125 levels were measured in 1177 diagnosed CHD patients and 3531 age and sex matched control subjects without CHD. Results Serum CA-125 level was significantly higher in CHD patients than controls (P < 0.001) with adjustment for age, gender, smoking, drinking, BMI, physical activity, hypertension, dyslipidemia, diabetes mellitus, medication history and family history of CHD and myocardial infarction. CHD risk was doubled (OR: 2.10, 95%CI: 1.69-2.60) among subjects in the highest quartile compared to those in the lowest quartile of CA-125 level (Ptrend < 0.001). Furthermore, CA-125 levels were associated with CHD risks in subjects with age over 60 years (OR: 2.19, 95%CI: 1.75-2.73), current smokers (OR: 2.29, 95%CI: 1.50-3.49), current drinkers (OR: 2.35, 95%CI: 1.57-3.53) and subjects with hypertension (OR: 2.04, 95%CI: 1.71-2.43). Conclusions Elevated serum CA-125 level might be associated with increased risk of coronary heart disease in the Chinese older population. Further investigations are needed to identify the possible biological role of CA-125 in CHD development in the future.
The Dose–Response Decrease in Heart Rate Variability: Any Association with the Metabolites of Polycyclic Aromatic Hydrocarbons in Coke Oven Workers?
Xiaohai Li, Yingying Feng, Huaxin Deng, Wangzhen Zhang, Dan Kuang, Qifei Deng, Xiayun Dai, Dafeng Lin, Suli Huang, Lili Xin, Yunfeng He, Kun Huang, Meian He, Huan Guo, Xiaomin Zhang, Tangchun Wu
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044562
Abstract: Background Air pollution has been associated with an increased risk of cardiopulmonary mortality and decreased heart rate variability (HRV). However, it is unclear whether coke oven emissions (COEs) and polycyclic aromatic hydrocarbons (PAHs) are associated with HRV. Objectives Our goal in the present study was to investigate the association of exposure to COEs and the urinary metabolite profiles of PAHs with HRV of coke oven workers. Methods We measured benzene soluble matter, carbon monoxide, sulfur dioxide, particulate matters, and PAHs at different workplaces of a coke oven plant. We determined 10 urinary PAH metabolites and HRV indices of 1333 workers using gas chromatography–mass spectrometry and a 3-channel digital Holter monitor, respectively. Results Our results showed that there was a significant COEs-related dose-dependent decrease in HRV, and an inverse relationship between the quartiles of urinary 2-hydroxynaphthalene and five HRV indices (ptrend<0.01 for all). After adjustment for potential confounders, elevation per interquartile range (IQR) (1.81 μg/mmol creatinine) of urinary 2-hydroxynaphthalene was associated with a 5.46% (95% CI, 2.50–8.32) decrease in standard deviation of NN intervals (SDNN). As workers worked more years, SDNN gradually declined in the same quartiles of 2-hydroxynaphthalene levels (ptrend = 1.40×10?4), especially in workers with the highest levels of 2-hydroxynaphthalene. Conclusions Occupational exposure to COEs is associated with a dose-response decrease in HRV. In particular, increased exposure to 2-hydroxynaphthalene is associated with significantly decreased HRV. Increase of working years and exposure levels has resulted in a gradual decline of HRV.
Different Physical Activity Subtypes and Risk of Metabolic Syndrome in Middle-Aged and Older Chinese People
Mu Chen, Meian He, Xinwen Min, An Pan, Xiaomin Zhang, Ping Yao, Xiulou Li, Yuewei Liu, Jing Yuan, Weihong Chen, Li Zhou, Weimin Fang, Yuan Liang, Youjie Wang, Xiaoping Miao, Mingjian Lang, Peng Zhang, Dongfeng Li, Huan Guo, Handong Yang, Frank B. Hu, Tangchun Wu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0053258
Abstract: Background The prevalence of metabolic syndrome (MetS) is growing rapidly in China. Tai chi and dancing are common types of exercise among middle-aged and elderly Chinese. It remains unclear whether these activities are associated with a lower risk of MetS. Methodology/Principal Findings A total of 15,514 individuals (6,952 men, 8,562 women) aged 50 to 70 years from the Dongfeng-Tongji Cohort in Shiyan, China participated in a cross-sectional study. Physical activity and other lifestyle factors were assessed with semi-structured questionnaires during face-to-face interviews. MetS was defined by the current National Cholesterol Education Program/Adult treatment Panel III criteria for Asian Americans. The prevalence of MetS was 33.2% in the study population. In the multivariable-adjusted logistic regression analyses, total physical activity levels were monotonically associated with a lower odds of MetS [OR 0.75 comparing extreme quintiles, 95% confidence interval (CI) 0.66–0.86, P<0.001]. Compared with non-exercisers in a specific exercise type, jogging (OR 0.82, 95% CI 0.68–1.00, P = 0.046), tai chi (OR 0.72, 95% CI 0.60–0.88, P<0.001), and dancing (OR 0.56, 95% CI 0.47–0.67, P<0.001) were associated with significantly lower odds of MetS. Furthermore, each 1–h/week increment in tai chi and dancing was associated with a 5% (95% CI 2%–9%) and a 9% (95% CI 6%, 12%) lower risk of MetS. Conclusions/Significance Jogging, tai chi and dancing are associated with a significantly lower risk of having MetS in middle-aged and older Chinese. Future intervention studies should consider the role of jogging, tai chi and dancing in preventing MetS.
A Review of Nearest Neighbor-Support Vector Machines Hybrid Classification Models
Lam Hong, Lee,Chin Heng, Wan,Tien Fui, Yong,Hui Meian, Kok
Journal of Applied Sciences , 2010,
Abstract: This study presents our investigation on different hybrid classification models which integrate support vector machines with nearest neighbor algorithm. We study the advantages and disadvantages of Support Vector Machines (SVM) classification and k-nearest neighbor (KNN) classification in performing their classification tasks. In our investigation, we found that the well-performing SVM classification approach may suffer from high time consumption, high CPU and physical memory usages, due to its convoluted training and classifying processes, especially when the dimensionality of data is high. On the other hand, KNN classification approach which implements NN algorithm is outstanding with its simplicity and low cost training process. However, it has been reported to be less accurate than the SVM classification. Many research works have been carried out in order to further improve the performance of the established SVM classifier by integrating Nearest Neighbor (NN) algorithm into the conventional SVM classification approach. The research works which have been reviewed and investigated in this paper emphasize in simplifying the convoluted training and classifying processes and further improving the classification algorithm of the conventional SVM, using NN algorithm. Overall, we concluded that while SVM classification approach has been reported as one of the best-performing classifiers since some decades now, it could be further improved by using NN algorithm in order to obtain more effective and efficient classification models.
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