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Search Results: 1 - 10 of 596 matches for " Meena Upadhyaya "
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An emerging role for microRNAs in NF1 tumorigenesis
Sedani Ashni,Cooper David N,Upadhyaya Meena
Human Genomics , 2012, DOI: 10.1186/1479-7364-6-23
Abstract: MicroRNAs (miRNAs) are a class of non-coding RNA, which have recently been shown to have a wide variety of regulatory functions in relation to gene expression. Since their identification nearly 20 years ago, miRNAs have been found to play an important role in cancer, including in neurofibromatosis type 1 (NF1)-associated tumours. NF1 is the most commonly inherited tumour predisposition syndrome and can lead to malignancy via the development of malignant peripheral nerve sheath tumours (MPNSTs). Although the mechanisms by which benign neurofibromas develop into MPNSTs still remain to be elucidated, it is becoming increasingly clear that miRNAs play a key role in this process and have the potential to be used as both diagnostic and prognostic markers of tumorigenesis.
Neurofibromatosis type 1-associated tumours: Their somatic mutational spectrum and pathogenesis
Sebastian Spyk, Nick Thomas, David N Cooper, Meena Upadhyaya
Human Genomics , 2011, DOI: 10.1186/1479-7364-5-6-623
Abstract: Neurofibromatosis type 1 (NF1) is a common auto-somal dominantly inherited tumour predisposition syndrome affecting 1/3,000-4,000 individuals worldwide [1,2]. NF1 manifests a variety of characteristic features that include: hyperpigmentary abnormalities of the skin (café-au-lait macules and inguinal/axillary freckling), iris hamartomas (Lisch nodules) and the growth of benign peripheral nerve sheath tumours (neurofibromas) in the skin. Neurofibromas display many different subtypes and are associated with a variety of different clinical complications. Cutaneous neurofibromas are present in almost all adult NF1 patients [3]. Plexiform neurofibromas (PNFs), a more diffuse type of tumour, are present in 30-50 per cent of NF1 patients, and some 10-15 per cent of these benign tumours are transformed to malignant peripheral nerve sheath tumours (MPNSTs), the main cause of morbidity in NF1 [4]. Other NF1-associated clinical features include: skeletal abnormalities, such as tibial bowing or pseudoarthrosis; skeletal and orbital dysplasia; ostopenia/osteoporosis; aqueduct stenosis; macrocephaly; pectus excavatum; short stature; cardiovascular malformations; learning difficulties; and attention deficit disorder [1,5].Cancer represents the transformation of a cell whose growth is normally tightly controlled into one that is no longer under strict regulation, allowing the cell to multiply uncontrollably and even metastasize. This dramatic alteration in cellular control arises as a consequence of the accumulation of genetic and epigenetic changes: activated oncogenes speed up cell growth through the acquisition of gain-of-function mutations, whereas tumour suppressor genes (TSGs) promote progression by acquiring loss-of-function mutations. TSGs typically encode proteins involved in growth regulation, apoptosis initiation, cellular adhesion and DNA repair. In accordance with Knudson's two-hit hypothesis,[6] both alleles of a TSG must be inactivated for cellular transformation to o
Effect of Sulphur and Zinc on Rice Performance and Nutrient Dynamics in Plants and Soil of Indo Gangetic Plains
Anil Kumar Singh,Manibhushan Manibhushan,M. K. Meena,Ashutosh Upadhyaya
Journal of Agricultural Science , 2012, DOI: 10.5539/jas.v4n11p162
Abstract: Rice is the staple food of more than three billion people in the world, most of who live in Asia.Rice is important crop of Indo Gangetic Plains of Bihar, productivity of system is stagnate and somewhere going down, to ascertain the role of sulphur and zinc an experiment was conducted at main campus of ICAR Research Complex of Eastern Region Patna with four levels of both nutrients i.e. sulphur and zinc, total 16 treatments were tested in Randomized Block Design. Both the nutrients were applied to rice and their direct and residual response was ascertained to rice and lentil in sequence. Based on three years of experimentation, results revealed that rice plant height is significantly affected by sulphur and zinc. Tallest plant (101.7cm) was recorded at maturity with application 6kg Zn application Zn. With the advance of stage dry matter accumulation was increased, it was not like the LAI which was decreased after Panicle initiation stage. Highest LAI (4.29) at anthesis was produced in the plots treated with Zn at 6 kg/ha. Dry matter share of root was in general less than 15% across the levels of sulphur and zinc during all the phenological stages. Maximum rice yield (7.63 t/ha) was recorded with combined application of 30kg sulphur and 6kg zinc, whereas corresponding minimum rice yield (7.09 t/ha) was recorded with absolute control plots where no application of zinc and sulphur was done during entire experimentation period.Maximum (281.2 kg/ha) nitrogen uptake was recorded with 6kg zinc treatment. However highest uptake of P (91.1 kg/ha) and K (150.4 kg/ha) was recorded in the plot supplemented with no Zn and sulphur at 40 kg/ha, respectively. Soil parameters viz., pH, EC and organic carbon content did not influenced with the S and Zn. N, P, K, S and Znwere affected significantly due to sulphur and zinc nutrition.
Molecular heterogeneity in malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1
Thomas Laura,Mautner Victor-Felix,Cooper David N,Upadhyaya Meena
Human Genomics , 2012, DOI: 10.1186/1479-7364-6-18
Abstract: Neurofibromatosis type-1 (NF1), resulting from NF1 gene loss of function, is characterized by an increased risk of developing benign and malignant peripheral nerve sheath tumors (MPNSTs). Whereas the cellular heterogeneity of NF1-associated tumors has been well studied, the molecular heterogeneity of MPNSTs is still poorly understood. Mutational heterogeneity within these malignant tumors greatly complicates the study of the underlying mechanisms of tumorigenesis. We have explored this molecular heterogeneity by performing loss of heterozygosity (LOH) analysis of the NF1, TP53, RB1, PTEN, and CDKN2A genes on sections of 10 MPNSTs derived from 10 unrelated NF1 patients. LOH data for the TP53 gene was found to correlate with the results of p53 immunohistochemical analysis in the same tumor sections. Further, approximately 70% of MPNSTs were found to display intra-tumoral molecular heterogeneity as evidenced by differences in the level of LOH between different sections of the same tumor samples. This study constitutes the first systematic analysis of molecular heterogeneity within MPNSTs derived from NF1 patients. Appreciation of the existence of molecular heterogeneity in NF1-associated tumors is important not only for optimizing somatic mutation detection, but also for understanding the mechanisms of NF1 tumorigenesis, a prerequisite for the development of specifically targeted cancer therapeutics.
Antibodies to Tumor Necrosis Factors in the Treatment of Rheumatoid Arthritis and Spondyloarthritis: The Basic Science, Clinical Science and Unmet Needs; Results from a Single Center  [PDF]
Sundeep Kumar Upadhyaya
Open Journal of Rheumatology and Autoimmune Diseases (OJRA) , 2014, DOI: 10.4236/ojra.2014.42013
Abstract: Inflammatory rheumatological diseases like rheumatoid arthritis (RA) and ankylosing spondylitis/Spondyloarthritis (AS/SpA), have been treated with NSAIDs (non steroidal anti-inflammatory drugs), corticosteroids, and DMARDs (disease modifying anti-rheumatic drugs).These have been only partially effective for the management of symptoms, since they are rarely associated with the complete control of disease and rarely slow down radiological damage. Several cytokines have been implicated in the pathogenesis of the inflammation and tumor necrosis factor (TNF) is the most important. The last decade and a half has seen advances in the form of “anti-TNF” therapies for RA and AS/SpA patients which target and neutralize the TNF cytokines, and thus reduce the disease activity. Two anti-TNF therapies have been used in India for treating DMARD resistant RA and AS/SpA for the last 13 years; Infliximab and Etanercept respectively. This paper is a description of the clinical outcomes and unmet needs/toxicities associated with the treatment of RA and AS/SpA with anti-TNF therapies (Infliximab, Etanercept), at a single rheumatology center (tertiary care, super-specialty hospital, Indraprastha Apollo Hospitals, New Delhi) in north India.
JIAPS: Future projections
Upadhyaya Purushottam
Journal of Indian Association of Pediatric Surgeons , 2005,
Dinoprostone Use and Rupture of Uterus in Primigravida: A Report of Two Cases
I Upadhyaya
Nepal Journal of Obstetrics and Gynaecology , 2011, DOI: 10.3126/njog.v6i2.6758
Abstract: Two cases of complete and incomplete uterine rupture following the use of dinoprostone gel for induction of labor (IOL) at 41 weeks of pregnancy in primigravidas; one of the two being diagnosed after vaginal delivery is presented herewith to alert cautious use of this important agent. NJOG 2011 Nov-Dec; 6 (2): 49-50 DOI: http://dx.doi.org/10.3126/njog.v6i2.6758
Role of Ultrasonography in Evaluation of Peripheral Nerves  [PDF]
Mandugula Aruna Devi, Ak Meena
Open Journal of Internal Medicine (OJIM) , 2018, DOI: 10.4236/ojim.2018.84022
Abstract: Ultrasonography is first line, cost-effective modality in imaging of peripheral nerves. High frequency probes allow high resolution imaging of peripheral nerves located at relatively superficial location. USG can diagnose and localize various pathologies that involve the peripheral nerves such as traumatic, inflammatory, infective, neoplastic, and traumatic neuropathies. USG exceptionally has an important role to play in evaluation of patients with suspected nerve injury, as MRI may not differentiate neural contusion from nerve disruption. Neurapraxic injury is seen as swollen nerve with hypoechoic appearance.
Comparison of primary total hip replacements performed with a direct anterior approach versus the standard lateral approach: perioperative findings
Sanjay Meena
Journal of Orthopaedics and Traumatology , 2012, DOI: 10.1007/s10195-012-0190-2
Golden Research Thoughts , 2013, DOI: 10.9780/22315063
Abstract: In any society women population is close to half of the total population. Therefore, for any meaningful development of any society effective participation of women becomes mandatory. This simple fact, though very obvious, has eluded being addressed comprehensively for decades. No modern society can claim to be progressive without the inclusive role of women in all walks of life, leading to socioeconomic change and development.
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