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Search Results: 1 - 10 of 1024 matches for " Meehan AG "
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Comparison of the systemic bioavailability of mometasone furoate after oral inhalation from a mometasone furoate/formoterol fumarate metered-dose inhaler versus a mometasone furoate dry-powder inhaler in patients with chronic obstructive pulmonary disease
Kosoglou T, Hubbell J, Xuan F, Cutler DL, Meehan AG, Kantesaria B, Wittmer BA
International Journal of Chronic Obstructive Pulmonary Disease , 2013, DOI: http://dx.doi.org/10.2147/COPD.S36592
Abstract: mparison of the systemic bioavailability of mometasone furoate after oral inhalation from a mometasone furoate/formoterol fumarate metered-dose inhaler versus a mometasone furoate dry-powder inhaler in patients with chronic obstructive pulmonary disease Original Research (421) Total Article Views Authors: Kosoglou T, Hubbell J, Xuan F, Cutler DL, Meehan AG, Kantesaria B, Wittmer BA Published Date March 2013 Volume 2013:8 Pages 107 - 116 DOI: http://dx.doi.org/10.2147/COPD.S36592 Received: 01 August 2012 Accepted: 12 September 2012 Published: 07 March 2013 Teddy Kosoglou,1 James Hubbell,2 Fengjuan Xuan,3 David L Cutler,1 Alan G Meehan,4 Bhavna Kantesaria,5 Bret A Wittmer6, 1Clinical Pharmacology, 2Exploratory Drug Metabolism, 3Early Development Statistics, 4Medical Communications, 5Drug Metabolism/Pharmacokinetics, Merck Sharp & Dohme Corp, Whitehouse Station, NJ, USA; 6Commonwealth Biomedical Research, LLC, Madisonville, KY, USA Dr Bret A Wittmer passed away on May 9, 2012. Background: Coadministration of mometasone furoate (MF) and formoterol fumarate (F) produces additive effects for improving symptoms and lung function and reduces exacerbations in patients with asthma and chronic obstructive pulmonary disease (COPD). The present study assessed the relative systemic exposure to MF and characterized the pharmacokinetics of MF and formoterol in patients with COPD. Methods: This was a single-center, randomized, open-label, multiple-dose, three-period, three-treatment crossover study. The following three treatments were self-administered by patients (n = 14) with moderate-to-severe COPD: MF 400 μg/F 10 μg via a metered-dose inhaler (MF/F MDI; DULERA /ZENHALE ) without a spacer device, MF/F MDI with a spacer, or MF 400 μg via a dry-powder inhaler (DPI; ASMANEX TWISTHALER ) twice daily for 5 days. Plasma samples for MF and formoterol assay were obtained predose and at prespecified time points after the last (morning) dose on day 5 of each period of the crossover. The geometric mean ratio (GMR) as a percent and the corresponding 90% confidence intervals (CI) were calculated for treatment comparisons. Results: Systemic MF exposure was lower (GMR 77%; 90% CI 58, 102) following administration by MF/F MDI compared to MF DPI. Additionally, least squares geometric mean systemic exposures of MF and formoterol were lower (GMR 72%; 90% CI 61, 84) and (GMR 62%; 90% CI 52, 74), respectively, following administration by MF/F MDI in conjunction with a spacer compared to MF/F MDI without a spacer. MF/F MDI had a similar adverse experience profile as that seen with MF DPI. All adverse experiences were either mild or moderate in severity; no serious adverse experience was reported. Conclusion: Systemic MF exposures were lower following administration by MF/F MDI compared with MF DPI. Additionally, systemic MF and formoterol exposures were lower following administration by MF/F MDI with a spacer versus without a spacer. The magnitude of these differences with respe
Inference with Dyadic Data: Asymptotic Behavior of the Dyadic-Robust t-Statistic
Max Tabord-Meehan
Statistics , 2015,
Abstract: This paper is concerned with inference in the linear model with dyadic data. Dyadic data is data that is indexed by pairs of "units", for example trade data between pairs of countries. Because of the potential for observations with a unit in common to be correlated, standard inference procedures may not perform as expected. We establish a range of conditions under which a t-statistic with the dyadic-robust variance estimator of Fafchamps and Gubert (2007) is asymptotically normal. Using our theoretical results as a guide, we perform a simulation exercise of the validity of the normal approximation in finite samples. We conclude with novel guidelines for applied researchers wishing to use the dyadic-robust estimator for inference.
Positive solutions of Volterra integral equations using integral inequalities
Meehan Maria,O'regan Donal
Journal of Inequalities and Applications , 2002,
Abstract: The existence of positive solutions of certain special cases of the possibly singular Volterra integral equation is discussed, using Krasnoselskii's fixed point theorem.
Lateral gene transfer of an ABC transporter complex between major constituents of the human gut microbiome
Meehan Conor J,Beiko Robert G
BMC Microbiology , 2012, DOI: 10.1186/1471-2180-12-248
Abstract: Background Several links have been established between the human gut microbiome and conditions such as obesity and inflammatory bowel syndrome. This highlights the importance of understanding what properties of the gut microbiome can affect the health of the human host. Studies have been undertaken to determine the species composition of this microbiome and infer functional profiles associated with such host properties. However, lateral gene transfer (LGT) between community members may result in misleading taxonomic attributions for the recipient organisms, thus making species-function links difficult to establish. Results We identified a peptides/nickel transport complex whose components differed in abundance based upon levels of host obesity, and assigned the encoded proteins to members of the microbial community. Each protein was assigned to several distinct taxonomic groups, with moderate levels of agreement observed among different proteins in the complex. Phylogenetic trees of these proteins produced clusters that differed greatly from taxonomic attributions and indicated that habitat-directed LGT of this complex is likely to have occurred, though not always between the same partners. Conclusions These findings demonstrate that certain membrane transport systems may be an important factor within an obese-associated gut microbiome and that such complexes may be acquired several times by different strains of the same species. Additionally, an example of individual proteins from different organisms being transferred into one operon was observed, potentially demonstrating a functional complex despite the donors of the subunits being taxonomically disparate. Our results also highlight the potential impact of habitat-directed LGT on the resident microbiota.
An Application Directed Adaptive Framework for Autonomic Software
Bridget Meehan,Girijesh Prasad,T. M. McGinnity
Journal of Software , 2008, DOI: 10.4304/jsw.3.7.30-41
Abstract: Autonomic computing is gradually becoming accepted as a viable approach to achieving self-management in systems and networks, with the goal of lessening the impact of the complexity crisis on the computing industry. The authors propose the integration of high level selforganisation features into an Application Directed Adaptive Framework (ADAF), an autonomic-oriented software development process, which when used during the development of software applications, enables those applications to exhibit autonomic behaviour. This paper discusses the infrastructure of the ADAF and demonstrates two self-managing capabilities that come about in a software application as a result of applying the ADAF, namely selfmonitoring and self-diagnosis.
From Paramutation to Paradigm
Ian R. Adams ,Richard R. Meehan
PLOS Genetics , 2013, DOI: 10.1371/journal.pgen.1003537
Using Atmospheric Pressure Tendency to Optimise Battery Charging in Off-Grid Hybrid Wind-Diesel Systems for Telecoms
Shane Phelan,Paula Meehan,Stephen Daniels
Energies , 2013, DOI: 10.3390/en6063052
Abstract: Off grid telecom base stations in developing nations are powered by diesel generators. They are typically oversized and run at a fraction of their rated load for most of their operating lifetime. Running generators at partial load is inefficient and, over time, physically damages the engine. A hybrid configuration uses a battery bank, which powers the telecoms’ load for a portion of the time. The generator only operates when the battery bank needs to be charged. Adding a wind turbine further reduces the generator run hours and saves fuel. The generator is oblivious to the current wind conditions, which leads to simultaneous generator-wind power production. As the batteries become charged by the generator, the wind turbine controller is forced to dump surplus power as heat through a resistive load. This paper details how the relationship between barometric pressure and wind speed can be used to add intelligence to the battery charger. A Simulink model of the system is developed to test the different battery charging configurations. This paper demonstrates that if the battery charger is aware of upcoming wind conditions, it will provide modest fuel savings and reduce generator run hours in small-scale hybrid energy systems.
A phylogenomic view of ecological specialization in the Lachnospiraceae, a family of digestive tract-associated bacteria
Conor J. Meehan,Robert G Beiko
PeerJ , 2015, DOI: 10.7287/peerj.preprints.168v1
Abstract: Several bacterial families are known to be highly abundant within the human microbiome, but their ecological roles and evolutionary histories have yet to be investigated in depth. One such family, Lachnospiraceae (phylum Firmicutes, class Clostridia) is abundant in the digestive tracts of many mammals and relatively rare elsewhere. Members of this family have been linked to obesity and protection from colon cancer in humans, mainly due to the association of this group with the production of butyric acid, a substance that is important for both microbial and host epithelial cell growth. We examined the genomes of 30 Lachnospiraceae isolates to better understand the phylogenetic relationships and basis of ecological differentiation within this group. Although this family is often used as an indicator of butyric acid production, fewer than half of the examined genomes contained genes from either of the known pathways that produce butyrate, with the distribution of this function likely arising in part from lateral gene transfer. An investigation of environment-specific functional signatures indicated that human gut-associated Lachnospiraceae possessed genes for endospore formation while other members of this family lacked key sporulation-associated genes, an observation supported by analysis of metagenomes from the human gut, oral cavity and bovine rumen. Our analysis demonstrates that despite a lack of agreement between Lachnospiraceae phylogeny and assigned habitat there are several examples of genetic signatures of habitat preference derived from both lateral gene transfer and gene loss.
Fully Three-dimensional Simulation and Modeling of a Dense Plasma Focus
B. T. Meehan,J. H. J. Niederhaus
Physics , 2014,
Abstract: A Dense Plasma Focus (DPF) is a pulsed-power machine that electromagnetically accelerates and cylindrically compresses a shocked plasma in a Z-pinch. The pinch results in a brief (about 100 nanosecond) pulse of X-rays, and, for some working gases, also a pulse of neutrons. A great deal of experimental research has been done into the physics of DPF reactions, and there exist mathematical models describing its behavior during the different time phases of the reaction. Two of the phases, known as the inverse pinch and the rundown, are approximately governed by magnetohydrodynamics, and there are a number of well-established codes for simulating these phases in two dimensions or in three dimensions under the assumption of axial symmetry. There has been little success, however, in developing fully three-dimensional simulations. In this work we present three-dimensional simulations of DPF reactions and demonstrate that 3D simulations predict qualitatively and quantitatively different behavior than their 2D counterparts. One of the most important quantities to predict is the time duration between the formation of the gas shock and Z-pinch, and the 3D simulations more faithfully represent experimental results for this time duration and are essential for accurate prediction of future experiments.
Asymmetric dark matter in braneworld cosmology
Michael T. Meehan,Ian B. Whittingham
Physics , 2014, DOI: 10.1088/1475-7516/2014/06/018
Abstract: We investigate the effect of a braneworld expansion era on the relic density of asymmetric dark matter. We find that the enhanced expansion rate in the early universe predicted by the Randall-Sundrum II (RSII) model leads to earlier particle freeze-out and an enhanced relic density. This effect has been observed previously by Okada and Seto (2004) for symmetric dark matter models and here we extend their results to the case of asymmetric dark matter. We also discuss the enhanced asymmetric annihilation rate in the braneworld scenario and its implications for indirect detection experiments.
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