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Search Results: 1 - 10 of 473 matches for " Mayumi Tamari "
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An interaction between Nrf2 polymorphisms and smoking status affects annual decline in FEV1: a longitudinal retrospective cohort study
Hironori Masuko, Tohru Sakamoto, Yoshiko Kaneko, Hiroaki Iijima, Takashi Naito, Emiko Noguchi, Tomomitsu Hirota, Mayumi Tamari, Nobuyuki Hizawa
BMC Medical Genetics , 2011, DOI: 10.1186/1471-2350-12-97
Abstract: We conducted a retrospective cohort study of 915 Japanese from a general population. Values of annual decline in FEV1 were computed for each individual using a linear mixed-effect model. Multiple clinical characteristics were assessed to identify associations with annual FEV1 decline. Tag single-nucleotide polymorphisms (SNPs) in the Nrf2 gene (rs2001350, rs6726395, rs1962142, rs2364722) and one functional SNP (rs6721961) in the Nrf2 promoter region were genotyped to assess interactions between the Nrf2 polymorphisms and smoking status on annual FEV1 decline.Annual FEV1 decline was associated with smoking behavior and inversely correlated with FEV1/FVC and FEV1 % predicted. The mean annual FEV1 declines in individuals with rs6726395 G/G, G/A, or A/A were 26.2, 22.3, and 20.8 mL/year, respectively, and differences in these means were statistically significant (pcorr = 0.016). We also found a significant interaction between rs6726395 genotype and smoking status on the FEV1 decline (p for interaction = 0.011). The haplotype rs2001350T/rs6726395A/rs1962142A/rs2364722A/rs6721961T was associated with lower annual decline in FEV1 (p = 0.004).This study indicated that an Nrf2-dependent response to exogenous stimuli may affect annual FEV1 decline in the general population. It appears that the genetic influence of Nrf2 is modified by smoking status, suggesting the presence of a gene-environment interaction in accelerated decline in FEV1.Among pulmonary function test (PFT) measurements, forced expiratory volume in one second (FEV1) is the most reproducible [1]. Therefore, it is suitable for analyzing changes in pulmonary function over time. Accelerated decline in FEV1 is considered as an important predictor for the development of inflammatory obstructive lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD) [2,3]. A rapid decline in FEV1 may be affected by multiple factors, including environmental and genetic factors.The most important environmental fa
Haplotypes with Copy Number and Single Nucleotide Polymorphisms in CYP2A6 Locus Are Associated with Smoking Quantity in a Japanese Population
Natsuhiko Kumasaka, Masayuki Aoki, Yukinori Okada, Atsushi Takahashi, Kouichi Ozaki, Taisei Mushiroda, Tomomitsu Hirota, Mayumi Tamari, Toshihiro Tanaka, Yusuke Nakamura, Naoyuki Kamatani, Michiaki Kubo
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044507
Abstract: Smoking is a major public health problem, but the genetic factors associated with smoking behaviors are not fully elucidated. Here, we have conducted an integrated genome-wide association study to identify common copy number polymorphisms (CNPs) and single nucleotide polymorphisms (SNPs) associated with the number of cigarettes smoked per day (CPD) in Japanese smokers ( = 17,158). Our analysis identified a common CNP with a strong effect on CPD (rs8102683; ) in the 19q13 region, encompassing the CYP2A6 locus. After adjustment for the associated CNP, we found an additional associated SNP (rs11878604; ) located 30 kb downstream of the CYP2A6 gene. Imputation of the CYP2A6 locus revealed that haplotypes underlying the CNP and the SNP corresponded to classical, functional alleles of CYP2A6 gene that regulate nicotine metabolism and explained 2% of the phenotypic variance of CPD (ANOVA -test ). These haplotypes were also associated with smoking-related diseases, including lung cancer, chronic obstructive pulmonary disease and arteriosclerosis obliterans.
Single nucleotide polymorphism-based genome-wide linkage analysis in Japanese atopic dermatitis families
Hisako Enomoto, Emiko Noguchi, Shigeruko Iijima, Takenori Takahashi, Kazuhito Hayakawa, Mikako Ito, Toshiyuki Kano, Takeshi Aoki, Yoichi Suzuki, Minori Koga, Mayumi Tamari, Tetsuo Shiohara, Fujio Otsuka, Tadao Arinami
BMC Dermatology , 2007, DOI: 10.1186/1471-5945-7-5
Abstract: We used a high-density, single nucleotide polymorphism genotyping assay, the Illumina BeadArray Linkage Mapping Panel (version 4) comprising 5,861 single nucleotide polymorphisms, to perform a genome-wide linkage analysis of 77 Japanese families with 111 affected sib-pairs with atopic dermatitis.We found suggestive evidence for linkage with 15q21 (LOD = 2.01, NPL = 2.87, P = .0012) and weak linkage to 1q24 (LOD = 1.26, NPL = 2.44, P = .008).We report the first genome-wide linkage study of atopic dermatitis in an Asian population, and novel loci on chromosomes 15q21 and 1q24 linked to atopic dermatitis. Identification of novel causative genes for atopic dermatitis will advance our understanding of the pathogenesis of atopic dermatitis.Atopic dermatitis (ATOD) is a hereditary, pruritic, inflammatory, chronic skin disease that occurs most commonly in early childhood but can persist or start in adulthood. The prevalence of ATOD has been studied in a wide variety of populations [1], and its frequency ranged from 0.73% to 23% of the study populations. The 12-month prevalence value of symptoms of atopic eczema in Japanese children 6 to 7 years of age was 16.9%, the second highest after Sweden [2]. Living in lower, more tropical latitudes, rural areas, and less industrialized regions correlates with a lower prevalence of ATOD[1]. The etiology of ATOD is not fully understood, but atopy, which is characterized by increased levels of immunoglobulin E (IgE) against common environmental allergens, is considered one of the strongest predisposing factors for ATOD.ATOD is associated with cutaneous hyperresponsiveness to environmental triggers that are innocuous to healthy individuals [3]. In the acute lesions of ATOD, marked perivascular infiltration of inflammatory cells consisting predominantly of lymphocytes and occasional monocyte-macrophages is frequently observed. In chronic lichenified lesions, there are increased numbers of Langerhans' cells and mast cells in the epidermis,
Changes in Japanese Nurses’ Awareness of Patient Interactions Following a Japanese Tea Ceremony  [PDF]
Mayumi Uno
Open Journal of Nursing (OJN) , 2017, DOI: 10.4236/ojn.2017.77058
Abstract: This study provided foundational data for use in nursing interventional methods for improving nurse-patient relationships. This was a descriptive study on the effectiveness of a Japanese tea ceremony (in Japanese: chado) intervention for improving nurse-patient relationships. I conducted a Japanese tea ceremony and examined changes in nurses’ awareness regarding interactions with patients after this intervention. The tea ceremonies were conducted with the cooperation of an Urasenke tea ceremony lecturer. A quiet environment with chairs and tables was provided for all participants while they provided written answers to a descriptive survey, which was administered before and after the intervention; they required approximately 20 min to complete the survey. The mean length of each nurse’s description was 800 characters. The tea ceremony was effective in bringing about definite changes in nurses’ awareness concerning interactions with patients. This study is useful in that it suggests how nurses can maintain good interpersonal relationships with patients.
United Dipole Field
V. F. Tamari
Physics , 2003,
Abstract: The field of an electromagnetic (E) dipole has been examined using general relativistic (R) and quantum mechanical (Q) points of view, and an E=Q=R equivalence principle presented whereas the curvature of the electromagnetic streamlines of the field are taken to be evidence of the distortion of spacetime, and hence of the presence of a gravitational field surrounding the dipole. Using a quasi-refractive index function N, with the streamlines and equipotential surfaces as coordinates, a new dipole relativistic metric is described, replacing Schwarzschild's for a point mass. The same principle equates the curvature and other physical features of the field with fundamental quantum concepts such as the uncertainty principle, the probability distribution and the wave packet. The equations of the dipole field therefore yield the three fields emerging naturally one from the other and unified without resorting to any new dimensions. It is speculated whether this model can be extended to dipolar matter-antimatter pairs.
Diffraction to De-Diffraction
V. F. Tamari
Physics , 2003,
Abstract: De-diffraction (DD), a new procedure to totally cancel diffraction effects from wave-fields is presented, whereby the full field from an aperture is utilized and a truncated geometrical field is obtained, allowing infinitely sharp focusing and non-diverging beams. This is done by reversing a diffracted wave-fields' direction. The method is derived from the wave equation and demonstrated in the case of Kirchhoff's integral. An elementary bow-wavelet is described and the DD process is related to quantum and relativity theories.
Large scale genotyping study for asthma in the Japanese population
Yoshiko Imada, Masaya Fujimoto, Kenji Hirata, Tomomitsu Hirota, Yoichi Suzuki, Hirohisa Saito, Kenji Matsumoto, Akira Akazawa, Toshio Katsunuma, Shigemi Yoshihara, Motohiro Ebisawa, Masanao Shibasaki, Tadao Arinami, Mayumi Tamari, Emiko Noguchi
BMC Research Notes , 2009, DOI: 10.1186/1756-0500-2-54
Abstract: To perform a large-scale genotyping study to identify asthma-susceptibility genes in the Japanese population.We performed a large-scale, three-stage association study on 288 atopic asthmatics and 1032 controls, by using multiplex PCR-Invader assay methods at 82,935 single nucleotide polymorphisms (SNPs) (1st stage). SNPs that were strongly associated with asthma were further genotyped in samples from asthmatic families (216 families, 762 members, 2nd stage), 541 independent patients, and 744 controls (3rd stage).SNPs located in the 5' region of PEX19 (rs2820421) were significantly associated with P < 0.05 through the 1st to the 3rd stage analyses; however, the P values did not reach statistically significant levels (combined, P = 3.8 × 10-5; statistically significant levels with Bonferroni correction, P = 6.57 × 10-7). SNPs on HPCAL1 (rs3771140) and on IL18R1 (rs3213733) were associated with asthma in the 1st and 2nd stage analyses, but the associations were not observed in the 3rd stage analysis.No association attained genome-wide significance, but several loci for possible association emerged. Future studies are required to validate these results for the prevention and treatment of asthma.Asthma is the most common chronic disorder in children, and asthma exacerbation is an important cause of childhood morbidity and hospitalization. Currently, approximately 300 million people worldwide have asthma, and this disease claims the lives of 180,000 people every year [1].Asthma and atopy are complex phenotypes that are influenced by both genetic and environmental factors. Twin studies have supported the role of a strong genetic contribution with a heritability of 0.71 [2], and asthma shows a familial risk higher than that of many common diseases such as stroke, epilepsy, and most types of cancer [3]. Atopy is characterized by increased levels of immunoglobulin E (IgE) against common environmental allergens, and is considered the strongest predisposing factor for asthma. M
Genome-Wide Association Study for Levels of Total Serum IgE Identifies HLA-C in a Japanese Population
Yohei Yatagai, Tohru Sakamoto, Hironori Masuko, Yoshiko Kaneko, Hideyasu Yamada, Hiroaki Iijima, Takashi Naito, Emiko Noguchi, Tomomitsu Hirota, Mayumi Tamari, Yoshimasa Imoto, Takahiro Tokunaga, Shigeharu Fujieda, Satoshi Konno, Masaharu Nishimura, Nobuyuki Hizawa
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0080941
Abstract: Most of the previously reported loci for total immunoglobulin E (IgE) levels are related to Th2 cell-dependent pathways. We undertook a genome-wide association study (GWAS) to identify genetic loci responsible for IgE regulation. A total of 479,940 single nucleotide polymorphisms (SNPs) were tested for association with total serum IgE levels in 1180 Japanese adults. Fine-mapping with SNP imputation demonstrated 6 candidate regions: the PYHIN1/IFI16, MHC classes I and II, LEMD2, GRAMD1B, and chr13:60576338 regions. Replication of these candidate loci in each region was assessed in 2 independent Japanese cohorts (n = 1110 and 1364, respectively). SNP rs3130941 in the HLA-C region was consistently associated with total IgE levels in 3 independent populations, and the meta-analysis yielded genome-wide significance (P = 1.07×10?10). Using our GWAS results, we also assessed the reproducibility of previously reported gene associations with total IgE levels. Nine of 32 candidate genes identified by a literature search were associated with total IgE levels after correction for multiple testing. Our findings demonstrate that SNPs in the HLA-C region are strongly associated with total serum IgE levels in the Japanese population and that some of the previously reported genetic associations are replicated across ethnic groups.
Semi-Commutative Differential Operators Associated with the Dirac Opetator and Darboux Transformation  [PDF]
Masatomo Matsushima, Mayumi Ohmiya
Advances in Pure Mathematics (APM) , 2013, DOI: 10.4236/apm.2013.31A029

In the present paper, the semi-commutative differential oparators associated with the 1-dimensional Dirac operator are constructed. Using this results, the hierarchy of the mKdV (-) polynomials are expressed in terms of the KdV polynomials. These formulas give a new interpretation of the classical Darboux transformation and the Miura transformation. Moreover, the recursion operator associated with the hierarchy of the mKdV (-) polynomials is constructed by the algebraic method.

In Situ Atomic Force Microscopy Observation of Octacalcium Phosphate (100) Face Dissolution in Weak Acidic Solutions  [PDF]
Kazuo Onuma, Mayumi Iijima
Journal of Crystallization Process and Technology (JCPT) , 2015, DOI: 10.4236/jcpt.2015.51001
Abstract: Dissolution of the (100) face of octacalcium phosphate (OCP) single crystal in weak acidic solutions (pH = 6.5; 25°;C) was observed in situ using atomic force microscopy. Monomolecular steps (2.0 nm high) were observed; they originated from etch pits or crystal edges. Advancement of the dissolution process led to precipitation of nanoparticles as small as ~10 nm even though the solution was undersaturated with respect to OCP. This precipitation of nanoparticles was accompanied by a drastic decrease in the dissolution rate; however, the substrate OCP continued to dissolve, indicating that dissolution and growth occurred simultaneously on the same surface. The precipitated nanoparticles coalesced and eventually covered the entire surface without changing the surface morphology of the substrate crystal. The step height after complete coverage was ~2.0 nm, the same as that observed on the dissolving OCP surface. These findings indicate that the precipitated phase was a pseudomorph of OCP crystal.
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