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Search Results: 1 - 10 of 14876 matches for " Mauro Rocha;Pinho "
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A Biologia molecular das doen?as inflamatórias intestinais
Pinho, Mauro;
Revista Brasileira de Coloproctologia , 2008, DOI: 10.1590/S0101-98802008000100018
Abstract: despite its high prevalence and many years of basic and clinical research, pathophysiology of crohn's disease and ulcerative colitis remains a great challenge. the recent advances in molecular biology techniques have provided identification of a great number of molecules related to these diseases that may help in a near future to understand its still obscure aspects. many evidences have recently demonstrated that inflammatory bowel diseases (ibd) result from an imbalance between bowel commensal bacterial flora and the immunological mucosal apparatus. the very consistent finding that mutations in nod2/card15 gene occur in a high percentage of crohn's disease patients and its phenotype correlation have boosted further research to identify other ibd-related molecules. indeed, many other variations in gene expression have been demonstrated to be related to pathophysiology of ibd including different aspects such as inate immunity, inflammatory response and mucosal barrier disfunction. the observation of the correlation between these gene expression variation, disease behaviour and response to therapeutics may contribute in a near future to understand most questions regarding these complex diseases.
Resposta completa à terapia neoadjuvante no cancer de reto: apenas sorte ou um resultado previsível?
Pinho, Mauro;
Revista Brasileira de Coloproctologia , 2007, DOI: 10.1590/S0101-98802007000400017
Abstract: the good results obtained by chemoradiotherapy as neoadjuvant therapy in the treatment of rectal cancer have included it as a routine procedure in order to improve resectability and sphincter preservation. recent studies suggest a non operative approach in cases of complete tumour response and demonstrate the need of a better definition for prognosis of tumour response to neoadjuvant therapy as individual therapeutic approach. there are now evidences that this responsiveness is related to biomolecular tumour profile. tissue expression of several proteins such as p53 and thymidylate synthase have shown significant correlation with tumour regression, although its predictive value has been insufficient to influence clinical decision. on the other hand, studies using microarray techniques to analyze a specific subsets of gene expressions have shown very encouraging results, with predictive values for tumour regression close to 100%, as a consistent possibility for clinical application in defining a more precise and individual indication for neoadjuvant therapy.
Coopera??o em empresas de base tecnológica: uma primeira avalia??o baseada numa pesquisa abrangente
C?rtes, Mauro Rocha;Pinho, Marcelo;Fernandes, Ana Cristina;Smolka, Rodrigo Bustamante;Barreto, Antonio Luiz C. M.;
S?o Paulo em Perspectiva , 2005, DOI: 10.1590/S0102-88392005000100007
Abstract: this paper approaches the issue of cooperation activities carried out by technology-based firms (tbfs). drawing on a database built from a survey including 100 brazilian tbfs, we argue that among these firms the practice of cooperation is quite restricted, too concentrated on relationships with universities, and reflects a low density networking. such circumstances clearly hinder the innovative performance of brazilian tbfs, thus undermining their competitiveness as a whole in the long run.
Physical and Quality Characteristics of Jupi Pineapple Fruits on Macronutrient and Boron Deficiency  [PDF]
Maria José Mota Ramos, Leandro Glaydson da Rocha Pinho
Natural Resources (NR) , 2014, DOI: 10.4236/nr.2014.58034
The deficiencies of mineral elements, change the development of plants in a broad sense, and therefore may alter the growth and fruit quality. The objective of this work was to evaluate the influence of macronutrient and boron deficiencies on morphological characteristics of Jupi pineapple fruits. The treatments complete, -N, -P, -K, -Ca, -Mg, -S and -B were applied as nutrient solutions in plastic pots with 14 kg of purified beach sand and one pineapple plant as the experimental unit. The trial was set up a randomized complete blocks design with six replicate. Nitrogen deficiency reduced fruit mass with and without crown, fruit length and diameter and peduncle diameter, increased TA, TSS and vitamin C, reduced TSS/TA, pH, pulp coloration and sensory acceptance of the fruits; phosphorus deficiency reduced fruit mass with and without crown, fruit and crown length, potassium deficiency reduced fruit mass with and without crown, length and diameter peduncle and calcium deficiency reduced peduncle diameter. Peel thickness was not affected by any deficiency. Nitrogen is the nutrient that most influenced the fruits quality of pineapple Jupi.
Biologia molecular do cancer colorretal: uma revolu??o silenciosa em andamento
Pinho, Mauro de Souza Leite;
Revista Brasileira de Coloproctologia , 2008, DOI: 10.1590/S0101-98802008000300017
Abstract: despite remaining as the main hope for emerging new concepts and strategies for treatment of colorectal cancer, the lack of results with clinical impact over the last years may contribute to frustrate those not entirely aware about current research data. so, the aim of this paper is to present a brief review since the first molecular biology studies in colorectal carcinogenesis until recent advances in proteomics, in order to demonstrate the consistent production of new data supporting a realistic expectancy for a near future availability of high impact resources that may change dramatically the results of treatment of colorectal cancer.
Pesquisa em biologia molecular: como fazer?
Pinho, Mauro de Souza Leite;
Revista Brasileira de Coloproctologia , 2006, DOI: 10.1590/S0101-98802006000300016
Abstract: molecular biology studies are presently regarded as a major source for research in medicine, and an increasing number of medical professionals are interested in improving their knowledge and scientific production in this subject. however, structuring the research project may become a difficult challenge due to the wide range of methods and techniques available in this area, most of them depending on existing technological facilities and personal skill. the aim of this study is to contribute for the task of setting up a research project by presenting a brief review of most used structure models in molecular biology studies as well as its related principles and methods.
Célula tronco tumoral: novo conceito em carcinogênese colorretal
Pinho, Mauro de Souza Leite;
Revista Brasileira de Coloproctologia , 2009, DOI: 10.1590/S0101-98802009000100018
Abstract: despite the great number of studies using molecular biology tools several questions remain about the mechanisms of colorectal carcinogenesis. a recent concept has emerged from the literature regarding the existence of a specific group of indiferentiated cells situated at the bottom of intestinal crypts with a long life cycle that may last more than one year, described as intestinal stem cells. this particular property may explain the expected occurrence of a sequence of mutations necessary to the development of a carcinoma, which cannot be observed in a normal colonocyte with a mean cycle life of five days. another important evidence to this concept is the induction in rodents of a tumor with similar characteristics to the original human carcinoma by injection of a small number of these stem cells, which is not achieved by using large number of normal cancer cells. it is suggested that mutation of apc gene, present as an early step in most colorectal carcinomas, may contribute to a superpopulation of intestinal stem cells with consequent disturbance of proliferative epithelial balance.
A estória biomolecular do pólipo adenomatoso
Pinho, Mauro de Souza Leite;
Revista Brasileira de Coloproctologia , 2006, DOI: 10.1590/S0101-98802006000200012
Abstract: one of the main objectives of molecular biology studies is the understanding of biochemical mechanisms which will ultimately contribute to biological behavior of tissues as observed by macroscopic or microscopic analysis. hystological examination of normal colonic mucosa shows a relevant cellular turnover, determined by local concentration of proteins related to circle cell control. among these proteins, apc seems to be a key element, promoting inhibition of other important circle cell stimulating proteins as beta-catenin and survivin. thus, besides its role as genotypic landmark in familiar polipose patients, there are several strong evidences that apc acts in a trigger function in proliferative disorders of colonic mucosa from small adenomas to advanced infiltrative carcinomas. the current use of immunohystochemistry has provided relevant information of this close relationship between cellular protein profile and histological findings and have contributed to an improved comprehension of colorectal cancer carcinogenesis.
The Role of Chemokines in Mediating Graft Versus Host Disease: Opportunities for Novel Therapeutics
Vanessa Pinho,Mauro M. Teixeira
Frontiers in Pharmacology , 2012, DOI: 10.3389/fphar.2012.00023
Abstract: Bone marrow transplantation (BMT) is the current therapy of choice for several malignancies and severe autoimmune diseases. Graft versus host disease (GVHD) is the major complication associated with BMT. T lymphocytes and other leukocytes migrate into target organs during GVHD, become activated and mediate tissue damage. Chemokines are well known inducers of leukocyte trafficking and activation and contribute to the pathogenesis of GVHD. Here, we review the major animal models used to study GVHD and the role of chemokines in mediating tissue damage in these models. The role of these molecules in promoting potential beneficial effects of the graft, especially graft versus leukemia, is also discussed. Finally, the various pharmacological strategies to block the chemokine system or downstream signaling events in the context of GVHD are discussed.
Sobre anjos e folhas secas: em torno do Angelus Novus de Paul Klee
Mauro Rocha Baptista
Horizonte : Revista de Estudos de Teologia e Ciências da Religi?o , 2009, DOI: 10.5752/427
Abstract: Este trabalho foi desenvolvido a partir de uma apresenta o feita na IV Semana Didático-Cultural e I Congresso de Pesquisa e Extens o da UEMG – Campus Barbacena. O título deste evento era História: Identidade e memória, e seu símbolo o quadro Angelus Novus de Paul Klee. Nosso objetivo era o de apresentar a rela o entre o quadro e a temática do evento, para isso buscamos o apoio de três autores: Benjamin, dono do quadro, que demarcou a sua interpreta o do Angelus Novus comparando-o com o Anjo da história; Scholem, herdeiro do mesmo após a morte de seu amigo Benjamin, autor de um poema sobre o quadro de Klee; e Kafka, escritor que sempre povoou o debate epistolar dos dois anteriores, e que, apesar de n o ter tido contato com o quadro de Klee, descreve o cenário em que é possível a sua produ o. Por fim reavaliamos o quadro a partir do humor judaico que unifica a estes três autores, afim de redimensionar o valor de alerta representado pelo semblante aterrorizado do anjo de Klee. Nesta vers o escrita a seqüência dos argumentos foi mantida, mas o texto foi substancialmente alterado para se adaptar ao novo veículo de divulga o.
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