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Search Results: 1 - 10 of 17697 matches for " Mauro Di Ianni "
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Tregs combined with mature donor T cells hasten immune reconstitution without triggering GvHD in HLA haploidentical transplantation
Mauro Di Ianni, Franca Falzetti, Massimo F Martelli
Arthritis Research & Therapy , 2011, DOI: 10.1186/ar3410
Abstract:
A Novel, Non-canonical Splice Variant of the Ikaros Gene Is Aberrantly Expressed in B-cell Lymphoproliferative Disorders
Daria Capece, Francesca Zazzeroni, Maria Michela Mancarelli, Daniela Verzella, Mariafausta Fischietti, Ambra Di Tommaso, Rita Maccarone, Sara Plebani, Mauro Di Ianni, Alberto Gulino, Edoardo Alesse
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0068080
Abstract: The Ikaros gene encodes a Krüppel-like zinc-finger transcription factor involved in hematopoiesis regulation. Ikaros has been established as one of the most clinically relevant tumor suppressors in several hematological malignancies. In fact, expression of dominant negative Ikaros isoforms is associated with adult B-cell acute lymphoblastic leukemia, myelodysplastic syndrome, acute myeloid leukemia and adult and juvenile chronic myeloid leukemia. Here, we report the isolation of a novel, non-canonical Ikaros splice variant, called Ikaros 11 (Ik11). Ik11 is structurally related to known dominant negative Ikaros isoforms, due to the lack of a functional DNA-binding domain. Interestingly, Ik11 is the first Ikaros splice variant missing the transcriptional activation domain. Indeed, we demonstrated that Ik11 works as a dominant negative protein, being able to dimerize with Ikaros DNA-binding isoforms and inhibit their functions, at least in part by retaining them in the cytoplasm. Notably, we demonstrated that Ik11 is the first dominant negative Ikaros isoform to be aberrantly expressed in B-cell lymphoproliferative disorders, such as chronic lymphocytic leukemia. Aberrant expression of Ik11 interferes with both proliferation and apoptotic pathways, providing a mechanism for Ik11 involvement in tumor pathogenesis. Thus, Ik11 could represent a novel marker for B-cell lymphoproliferative disorders.
Efficacy of high resolution computed tomography for detection of early healing in scaphoid fractures  [PDF]
Michael Di Ianni, Jatin Kaicker, Ke Wu, Hema Choudur
Open Journal of Clinical Diagnostics (OJCD) , 2012, DOI: 10.4236/ojcd.2012.23011
Abstract: Background: While plain radiography is commonly used to assess scaphoid fracture, this imaging modality may not accurately demonstrate early bone healing. This investigation evaluates the utility of 64-slice CT in the detection of early fracture healing compared to plain radiographs and magnetic resonance imaging (MRI). Methods: Outpatients attending follow-up visits for scaphoid fractures at Hamilton General Hospital were included in this investigation. Inclusion criteria included outpatients over age of 18 who consented to attend a follow-up visit for the scaphoid fracture at 6 weeks for X-Ray, 64-slice CT and MRI scan to monitor fracture healing. Assessment of healing was independently interpreted by two radiologists specialized in musculoskeletal imaging. A total of 7 adult outpatients were accrued, with each case classified as healing, not healing, or equivocal for plain radiography and 64-slice CT scan. Results: For plain radiographs, the level of interrater agreement for evidence of healing was 57% (4/7) cases. When comparing this to CT scans, there was no discrepancy between radiologists as 100% (7/7) were found to have evidence of healing. The 64-slice CT scan demonstrated evidence of early trabecular continuity in all cases, including radiographs that were interpreted as equivocal. Conclusion: This study can be considered a pilot project for the efficacy of 64-slice CT in the assessment of early healing of scaphoid fractures. For clinicians, the multiplanar reconstruction images allows for more accurate assessment of fractures than plain radiography. CT scans are able to penetrate through bony callus that may obscure visualization of healing in plain radiography, demonstrate trabecular continuity better than plain radiographs, are readily accessible and provide faster imaging acquisition. The observations from this study may have implications in terms of duration and type of casting applied, timing of strengthening exercises, and avoiding unnecessary surgery which affect patient morbidity and cost of care.
Colloidal attraction induced by a temperature gradient
R. Di Leonardo,F. Ianni,G. Ruocco
Physics , 2008,
Abstract: Colloidal crystals are of extreme importance for applied research, such as photonic crystals technology, and for fundamental studies in statistical mechanics. Long range attractive interactions, such as capillary forces, can drive the spontaneous assembly of such mesoscopic ordered structures. However long range attractive forces are very rare in the colloidal realm. Here we report a novel strong and long ranged attraction induced by a thermal gradient in the presence of a wall. Switching on and off the thermal gradient we can rapidly and reversibly form stable hexagonal 2D crystals. We show that the observed attraction is hydrodynamic in nature and arises from thermal induced slip flow on particle surfaces. We used optical tweezers to directly measure the force law and compare it to an analytic prediction based on Stokes flow driven by Marangoni forces.
Aging under Shear: Structural Relaxation of a Non-Newtonian Fluid
R. Di Leonardo,F. Ianni,G. Ruocco
Physics , 2004, DOI: 10.1103/PhysRevE.71.011505
Abstract: The influence of an applied shear field on the dynamics of an aging colloidal suspension has been investigated by the dynamic light scattering determination of the density autocorrelation function. Though a stationary state is never observed, the slow dynamics crosses between two different non-equilibrium regimes as soon as the structural relaxation time approaches the inverse shear rate. In the shear dominated regime (at high shear rate values) the structural relaxation time is found to be strongly sensitive to shear rate while aging proceeds at a very slow rate. The effect of shear on the detailed shape of the density autocorrelation function is quantitatively described assuming that the structural relaxation process arises from the heterogeneous superposition of many relaxing units each one independently coupled to shear with a parallel composition rule for timescales.
Ettore Majorana and the Theoretical Problem of Photon-Electron Scattering  [PDF]
Marco Di Mauro, Salvatore Esposito, Adele Naddeo
Advances in Historical Studies (AHS) , 2016, DOI: 10.4236/ahs.2016.53011
Abstract: Relevant contributions by Majorana regarding Compton scattering off free or bound electrons are considered in detail, where a (full quantum) generalization of the Kramers-Heisenberg dispersion formula is derived. The role of intermediate electronic states is appropriately pointed out in recovering the standard Klein-Nishina formula (for free electron scattering) by making recourse to a limpid physical scheme alternative to the (then unknown) Feynman diagram approach. For bound electron scattering, a quantitative description of the broadening of the Compton line was obtained for the first time by introducing a finite mean life for the excited state of the electron system. Finally, a generalization aimed to describe Compton scattering assisted by a non-vanishing applied magnetic field is as well considered, revealing its relevance for present day research.
Canine Prostate Carcinoma: Four Clinical Cases in Sexually Intact and Neutered Dogs  [PDF]
Enrico Bigliardi, Carla Bresciani, Anna Maria Cantoni, Francesco Di Ianni, Giorgio Morini, Simone Voccia, Attilio Corradi, Enrico Parmigiani
Open Journal of Urology (OJU) , 2012, DOI: 10.4236/oju.2012.24042
Abstract: Prostate cancer is one of the most important malignancies in men. In old men the frequency of prostate cancer at necroscopy has been reported to exceed 40%. Dogs are the only large mammals other than humans with a significant incidence of spontaneous prostate cancer. Adenocarcinoma, transitional cell carcinoma and undifferentiated carcinoma are the most common histological type but the precise cell of origin in dog is not known. The incidence of prostatic carcinoma in dogs is low (0.2% - 0.6%). Prostatic carcinomas occur in sexually intact and neutered dogs and the risk increase in castrated dogs associated to pulmonary and bone metastases. The castration does not initiate the development of prostatic carcinoma in dog but does favour tumour progression. In men the early stage detection of prostate cancer can offer various therapies as radical prostatectomy, radial therapy, thermal ablation, anti-androgen therapy, chemotherapy. In dogs the diagnosis is often in advanced stage of the cancer and the survival time for dogs with prostate cancer is poor. The median time reported is 30 days after diagnosis. In this study we reported three cases of prostatic carcinoma in intact sexually dogs and one in a neutered dog. The sexually intact subjects were older (mean age = 10.5 years) and they had prostatic adenocarcinoma (PCA). The interval between castration and onset of prostatic problems was 3 years. All the dogs showed dysuria, macroscopic hematuria, dyschezia and ataxia. All dogs have been euthanized in order to relieve pain and suffering.
Altered glycosylation profile of purified plasma ACT from Alzheimer’s disease
Ianni Manuela,Manerba Marcella,Di Stefano Giuseppina,Porcellini Elisa
Immunity & Ageing , 2010, DOI: 10.1186/1742-4933-7-s1-s6
Abstract: Background Alzheimer’s disease (AD) is one of the most frequent cause of neurodegenerative disorder in the elderly. Inflammation has been implicated in brain degenerative processes and peripheral markers of brain AD related impairment would be useful. Plasma levels of alpha-1-antichymotrypsin (ACT), an acute phase protein and a secondary component of amyloid plaques, are often increased in AD patients and high blood ACT levels correlate with progressive cognitive deterioration. During inflammatory responses changes in the micro-heterogeneity of ACT sugar chains have been described. Methods N-Glycanase digestion from Flavobacterium meningosepticum (PNGase F) was performed on both native and denatured purified ACT condition and resolved to Western blot with the purpose to revealed the ACT de-glycosylation pattern. Further characterization of the ACT glycan profile was obtained by a glycoarray; each lectin group in the assay specifically recognizes one or two glycans/epitopes. Lectin-bound ACT produced a glyco-fingerprint and mayor differences between AD and controls samples were assessed by a specific algorithms. Results Western blot analysis of purified ACT after PNGase F treatment and analysis of sugar composition of ACT showed significantly difference in “glyco-fingerprints” patterns from controls (CTR) and AD; ACT from AD showing significantly reduced levels of sialic acid. A difference in terminal GlcNac residues appeared to be related with progressive cognitive deterioration. Conclusions Low content of terminal GlcNac and sialic acid in peripheral ACT in AD patients suggests that a different pattern of glycosylation might be a marker of brain inflammation. Moreover ACT glycosylation analysis could be used to predict AD clinical progression and used in clinical trials as surrogate marker of clinical efficacy.
Calcification of Untreated Mediastinal Hodgkin's Lymphoma: A Case Report
Candice Dawn Rivest,Michael Di Ianni,Ehsan Haider
University of Toronto Medical Journal , 2010, DOI: 10.5015/utmj.v87i3.1238
Abstract: Calcification occasionally occurs in Hodgkin’s lymphoma after therapy due to tissue necrosis. Rarely, calcification may be detected prior to treatment. This likely represents a dystrophic process when bulky tumours outgrow their blood supply. Due to this rare presentation, pre treatment calcified Hodgkin’s lymphoma is often mistaken for germ cell tumours on imaging. It is thus important to include Hodgkin’s lymphoma in the differential of this presentation. We present such a case of pre-treatment calcification of Hodgkin’s lymphoma in a young male and discuss the incidence, pathophysiology and imaging findings.
Shear banding phenomena in a Laponite suspension
F. Ianni,R. Di Leonardo,S. Gentilini,G. Ruocco
Physics , 2007,
Abstract: Shear localization in an aqueous clay suspension of Laponite is investigated through dynamic light scattering, which provides access both to the dynamics of the system (homodyne mode) and to the local velocity profile (heterodyne mode). When the shear bands form, a relaxation of the dynamics typical of a gel phase is observed in the unsheared band soon after flow stop, suggesting that an arrested dynamics is present during the shear localization regime. Periodic oscillations of the flow behavior, typical of a stick-slip phenomenon, are also observed when shear localization occurs. Both results are discussed in the light of various theoretical models for soft glassy materials.
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