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Search Results: 1 - 10 of 139707 matches for " Matthieu K. Bokolo "
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Interaction of Iron(III)-5,10,15,20-Tetrakis (4-Sulfonatophenyl) Porphyrin with Chloroquine, Quinine and Quinidine  [PDF]
Dikima D. Bibelayi, Pitchouna I. Kilunga, Albert S. Lundemba, Matthieu K. Bokolo, Pius T. Mpiana, Philippe V. Tsalu, Juliette Pradon, Colin C. Groom, Celine W. Kadima, Luc Van Meervelt, Zephyrin G. Yav
Crystal Structure Theory and Applications (CSTA) , 2017, DOI: 10.4236/csta.2017.63003
Abstract: Iron(III)-5,10,15,20-tetrakis(4-sulfonatophenyl) porphyrin (FeTPPS) is used as non-physiological metalloporphyrin model for the natural iron (III)-protoporphyrin IX (FePPIX) resulting from hemoglobin degradation to investigate ligand binding reactions in aqueous solution. Studies were conducted on the interaction of FeTPPS with Chloroquine, Quinine, and Quinidine, which are historically the most common quinoline-based drugs used to treat malaria, an infectious disease afflicting several hundred millions every year worldwide, mainly in tropical regions. Using UV-Visible spectrophotometry, the binding reaction was studied at pH 7.40 in purely aqueous solution, and in aqueous solution containing NaNO3 at concentration of 0.1 M. Fitted titration curves obtained were in agreement with experimental data according to a formation scheme of 1:1 complex (1 FeTPPS μ-oxo-dimer: 1 Antimalarial). Values of apparent binding constant (K) obtained were between 4.3 × 103 M-1 to 7.59 × 104 M-1, demonstrating that FeTPPS and the antimalarials formed stable complexes. The stability of the complex decreased when NaNO3 was added to the solution. This ionic strength dependence was ascribed to electrostatic effects.
Antifertility Potentials of Metronidazole in Male Wistar Rats
A.E. Ligha,B. Bokolo,B.C. Didia
Pakistan Journal of Biological Sciences , 2012,
Abstract: There is a growing concern about the decline in the quality of human sperm in recent years. Following reports by previous studies on the toxic effects of metronidazole on testicular functions, this study is designed to investigate further its direct effects on fertility potentials and that of the introduction of vitamin E and testosterone to metronidazole treated rats. A total of 105 adult male and 50 female Wistar rats weighing 170±10 g (70-90 day old) were used for the experiment. The rats were randomly divided into a control and experimental groups. There were four major groups with 5 subgroups consisting of 5 rats each. Varying doses of metronidazole were used depending on the experiment. Experiment 1; animals were fed with 15 mg kg-1 of metronidazole, experiment 2, fed with 30 mg kg-1 of metronidazole, experiment 3, administered with 200 mg kg-1 of metronidazole and experiment 4, fed with 400 mg kg-1 of metronidazole. Each experimental group has 5 sub-groups. A: control, B: group fed with the experimental dose, C: experimental dose with vitamin E, D: experimental dose with testosterone, E: fed with experimental dose, vitamin E and testosterone and sub-group F, a reversal group which was left for 8 weeks after cessation of treatment. Parameters assessed were sperm count/motility, hormonal assay, Fertility test for control and treated rats were also carried out. Results showed that metronidazole at the therapeutic dose of 15 mg kg-1 did not have significant negative effect on the parameters assessed. At the dose of 200 and 400 mg kg-1, there was reduction in testosterone and follicle stimulating hormone while on the other hand, luteinizing hormone was increased mostly with 400 mg kg-1 of metronidazole treatment. Body weight was also found to be significantly reduced in rats treated with 200 and 400 mg kg-1 of metronidazole. The results of this study indicate that metronidazole administration (200 or 400 mg kg-1), for 8 weeks, caused a harmful effect on fertility potentials in male rats.
The SU(N) Heisenberg model on the square lattice: a continuous-N quantum Monte Carlo study
K. S. D. Beach,Fabien Alet,Matthieu Mambrini,Sylvain Capponi
Physics , 2008, DOI: 10.1103/PhysRevB.80.184401
Abstract: A quantum phase transition is typically induced by tuning an external parameter that appears as a coupling constant in the Hamiltonian. Another route is to vary the global symmetry of the system, generalizing, e.g., SU(2) to SU(N). In that case, however, the discrete nature of the control parameter prevents one from identifying and characterizing the transition. We show how this limitation can be overcome for the SU(N) Heisenberg model with the help of a singlet projector algorithm that can treat N continuously. On the square lattice, we find a direct, continuous phase transition between Neel-ordered and crystalline bond-ordered phases at Nc=4.57(5) with critical exponents z=1 and beta/nu=0.81(3).
Comment on "Quantum Monte Carlo scheme for frustrated Heisenberg antiferromagnets"
K. S. D. Beach,Matthieu Mambrini,Fabien Alet
Physics , 2008, DOI: 10.1103/PhysRevB.77.146401
Abstract: Quantum Monte Carlo methods are sophisticated numerical techniques for simulating interacting quantum systems. In some cases, however, they suffer from the notorious "sign problem" and become too inefficient to be useful. A recent publication [J. Wojtkiewicz, Phys. Rev. B 75, 174421 (2007)] claims to have solved the sign problem for a certain class of frustrated quantum spin systems through the use of a bipartite valence bond basis. We show in this Comment that the apparent positivity of the path integral is due to a misconception about the resolution of the identity operator in this basis, and that consequently the sign problem remains a severe obstacle for the simulation of frustrated quantum magnets.
The Matrix Ansatz, Orthogonal Polynomials, and Permutations
Sylvie Corteel,Matthieu Josuat-Vergès,Lauren K. Williams
Mathematics , 2010,
Abstract: In this paper we outline a Matrix Ansatz approach to some problems of combinatorial enumeration. The idea is that many interesting quantities can be expressed in terms of products of matrices, where the matrices obey certain relations. We illustrate this approach with applications to moments of orthogonal polynomials, permutations, signed permutations, and tableaux.
Morphological Conservation in Human-Animal Hybrids in Science Fiction and Fantasy Settings: Is Our Imagination as Free as We Think It Is?  [PDF]
Matthieu J. Guitton
Advances in Anthropology (AA) , 2013, DOI: 10.4236/aa.2013.33021

The question of whether human imagination knows no boundaries or is, alternatively, constrained by conscious or unconscious cognitive templates is a key issue in defining human mind. We try here to address this extremely large question by focusing on one particular element of imaginary creations, the specific case of human-animal hybrids. Human-animal hybrids are common inhabitants of human imaginary spaces, being regularly encountered across numerous mythologies, as well as in modern popular culture. If human imagination was unconstrained, it would be expected that such hybrid creatures would display roughly half human and half animalistic features. Using several different popular science fiction and fantasy settings, we conducted an analysis of the morphological traits of human-animal hybrids, both anatomical and phenotypic. Surprisingly, we observed extremely high conservation of human morphological traits in human-animal hybrids, with a contrasting high use of phenotypic (“cosmetic”) alterations, and with highly stereotyped patterns of morphological alterations. While these alterations were independent of the setting considered, shape alterations were setting-dependent and used as a way to increase internal coherence. Finally, important gender differences were observed, as female human-animal hybrids retained significantly more human traits than males did, suggesting that conservation of female appearance may bear essential evolutionary importance. Taken together, these results demonstrate the existence of strong cognitive templates which frame and limit the expression of the capacity of human imagination, and unveil some of the psychological mechanisms which constrain the emergence of imaginary spaces.

The Perspectives and Health Implications of Female Genital Mutilation among Amassoma Women in Bayelsa State, Nigeria
Victor O. Adika,Rose E. Ezonbodor-Akwagbe,Joyce E.T. Bokolo,Franko A. Apiyanteide
International Journal of Tropical Medicine , 2012, DOI: 10.3923/ijtmed.2012.80.85
Abstract: A study of the perspectives and health implications of Female Genital Mutilation (FGM) was carried out in Amassoma, Bayelsa State, Nigeria. The purpose of this study was to describe the perspective of practice, perspective of knowledge and quality of life after FGM. A survey was conducted, using a four-stage probability sampling technique between April 2010 and June 2010. About 98.7% of the respondents were women of Ijaw ethnic nationality. About 99.3% have knowledge of the practice of FGM and 94% have witness this event and 48.6% were not satisfied with the practice of FGM and family members constitute 92% of the main source of consent influencing the practice of FGM. However, 2% was contributed by health professionals. The study reveals that the effect of FGM on intercourse was 2.7%; quality of life assessment on pain, hemorrhage, urinary retentions infections and complications after FGM was 1.3% among study respondents. The campaign and interventions of opponents of FGM should be focused on the family and particularly parents.
Tensions et coordinations entre les acteurs des sciences de la performance sportive
Matthieu Delalandre
SociologieS , 2012,
Abstract: Cet article part d’une étude qui questionne les conditions de production des savoirs scientifiques sur la performance sportive, en portant le regard sur les modes de coordination entre les chercheurs et les entra neurs avec qui ils collaborent. L’analyse d’un matériau empirique constitué d’entretiens et d’un corpus écrit nous a conduit à mettre en évidence trois régimes de scientificité, qui constituent à la fois des modes de coordination des chercheurs et des entra neurs et des formes particulières de production des savoirs. L’article met en lumière des tensions inhérentes à chacun de ces régimes et les solutions adoptées par les acteurs pour coopérer. Nous nous intéressons enfin aux contraintes que les chercheurs rencontrent pour passer d’un régime à l’autre. Tensions and coordinations between the actors of sports performance sciencesThis article is based on a study which examines how knowledge is produced in the field of sports performance, looking at the modes of coordination between researchers and the coaches with whom they collaborate. The analysis of empirical data made of interviews and texts leads us to show three scientific regimes, which are at the same time specific modes of coordination between scientists and coaches and particular forms of knowledge production. The paper sheds light on the tensions inherent in each regime and the solutions which the actors adopt in order to co-operate. Finally, we study the constraints scientists face when they go from one regime to another. Tensiones y coordinaciones entre los integrantes de las ciencias de la performance deportivaEste trabajo estudia las condiciones de producción del conocimiento científico respecto a la performance deportiva, destacando el modo de coordinación y colaboración entre investigadores y entrenadores. El análisis de un material empírico está constituido por entrevistas y por un corpus escrito que nos ha conducido a determinar tres regímenes de cientificidad, que constituyen a la vez diversos modos de coordinación entre investigadores y entrenadores; junto con formas particulares de producción del conocimiento. El artículo pone de manifiesto las tensiones inherentes en el seno de cada uno de estos regímenes, así como las soluciones adoptadas por sus integrantes para cooperar. Nos interesamos también por los obstáculos que encuentran los investigadores cuando desean pasar de un régimen a otro.
Panique dans le ciel intertextuel
Matthieu Letourneux
Strenae : Recherches sur les Livres et Objets Culturels de l'Enfance , 2012, DOI: 10.4000/strenae.537
Abstract: Lancée en 1953, la série des Bob Morane hérite des modèles narratifs du roman d’aventures coloniales et de ses reformulations anglo-saxonnes d’après-guerre dont elle investit massivement les stéréotypes ; mais elle se retrouve rapidement confrontée au processus de décolonisation qui condamne à terme les conventions sur lesquelles repose le genre investi par Henri Vernes. L’histoire de la série est donc celle d’un processus de réarticulation des codes d’un genre, celui du roman d’aventures coloniales, suivant des contraintes géopolitiques et un nouveau système architextuel dont elle illustre les mutations. Au croisement de problèmes historiques et esthétiques, cette série au long cours pose à la fois la question des pratiques de fictions sérielles et celle de la prise en compte par la littérature de jeunesse du phénomène de la décolonisation, mettant en évidence les tensions qui existent entre les logiques référentielles intertextuelles et la mise en scène de l’espace référentiel extratextuel. Si elle tend à privilégier les logiques sérielles, elle assimile l’évolution des représentations, mais de biais, par le détour des intertextes et des imaginaires romanesques. Dès lors, le discours sur le monde ne peut être saisi que médiatement, comme réalité sous-jacente au jeu des imaginaires intertextuels, quand ceux-ci tendent à pérenniser les héritages du genre, comme autant de couches archéologiques du récit. Procéder à cette archéologie de l’ uvre sérielle, décomposer les couches narratives et les imaginaires successifs dont elle est le résultat, déterminer la fa on dont l’auteur les organise en un discours propre, c’est à la fois révéler la part des idéologies dont le récit est le produit, et échapper à une lecture trop monologique d’une uvre qui est aussi la manifestation en un discours auctorial unique d’une multitude de voix.
Hiroki Azuma, Génération Otaku : les enfants de la post-modernité
Matthieu Letourneux
Strenae : Recherches sur les Livres et Objets Culturels de l'Enfance , 2010,
Abstract: Dirigée par Charles Pépin, la collection Haute Tension s’est spécialisée dans la publication d’essais philosophiques en prise avec l’actualité. C’est un de ces sujets de société qu’évoque l’ouvrage d’Hiroki Azuma, Génération Otaku, renvoyant à cet ensemble d’adolescents et d’adultes japonais, consommant massivement des productions de la culture de masse – jeux vidéo, séries animées, bandes dessinées, figurines et produits dérivés. Si son travail ne porte pas directement sur la culture de ...
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