oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2019 ( 471 )

2018 ( 818 )

2017 ( 755 )

2016 ( 1108 )

Custom range...

Search Results: 1 - 10 of 461974 matches for " Matsubara A "
All listed articles are free for downloading (OA Articles)
Page 1 /461974
Display every page Item
Effects of losartan on ventricular remodeling in experimental infarction in rats
Zornoff, Leonardo A. M.;Matsubara, Luiz S.;Matsubara, Beatriz B.;Paiva, Sergio A. R.;Spadaro, Joel;
Arquivos Brasileiros de Cardiologia , 2000, DOI: 10.1590/S0066-782X2000001200001
Abstract: objective: to evaluate the effects of losartan on ventricular remodeling and on survival after myocardial infarction in rats. methods: after surgical occlusion of left coronary artery, 84 surviving male wistar rats were divided into two groups: lo treated with losartan (20mg/kg/day, n=33) and nt (n=51), without medication. after 3 months, we analyzed mortality; ventricular to body mass ratio (vm /bm); myocardial hydroxyproline concentration (hop); isovolumetric pressure, +dp/dt, -dp/dt, and diastolic volume/left ventricle mass ratio (vo/lv). results: mortality was: lo = 22%, and nt = 47% (p<0.05). ventricular mass,(vm/bm, mg/g) was 4.14 ± 0.76 and 3.54±0.48, in the nt and lo groups, respectively (p<0.05). hop (median) was 4.92 ug/mg in the lo and 5.54 ug/g in the nt group (p>0.05). the v0/lv values (median) were 0.24 ml/g in group lo and 0.31 ml/g in group nt (p<0.05) compared to nt group. there were no differences between the groups for +dp/dt and -dp/dt parameters. conclusion: 1- the use of losartan myocardial infarction causes an attenuation of ventricular remodeling, bringing about an increased survival, an attenuation of ventricular hypertrophy and dilation, and an improvement of the isovolumetric pressure; 2- the treatment does not modify the myocardial collagen concentration.
Effects of lisinopril on experimental ischemia in rats. Influence of infarct size
Zornoff Leonardo A. M.,Matsubara Beatriz B.,Matsubara Luiz S.,Paiva Sérgio A. R.
Arquivos Brasileiros de Cardiologia , 1999,
Abstract: OBJECTIVE - Angiotensin-converting enzyme inhibitors (ACEIs) have gained importance in preventing or attenuating the process of ventricular remodeling after myocardial infarction. The significance of infarct size in regard to the response to ACEIs, however, is controversial. This study aimed to analyze the effects of lisinopril on mortality rate, cardiac function, degree of cardiac hypertrophy and fibrosis in rats with different infarct sizes. METHODS - Lisinopril (20 mg/kg/day) dissolved in drinking water was administered to rats immediately after coronary artery occlusion. After being sacrificed, the infarcted animals were divided into two groups: one group of animals with small infarcts (< 40% of the left ventricle) and another group of animals with large infarcts (> 40% of the left ventricle). RESULTS - The mortality rate was 31.7% in treated rats and 47% in the untreated rats. There was no statistical difference between the groups with small and large infarcts in regard to myocardial concentration of hydroxyproline. In small infarcts, the treatment attenuated the heart dysfunction characterized by lower levels of blood pressure and lower values of the first derivative of pressure and of the negative derivative of pressure. The degree of hypertrophy was also attenuated in small infarcts. In regard to large infarcts, no differences between the groups were observed. CONCLUSION - Treatment with the ACEIs had no effect on mortality rate and on the amount of fibrosis. The protective effect of lisinopril on heart function and on the degree of hypertrophy could only be detected in small infarcts
Effects of losartan on ventricular remodeling in experimental infarction in rats
Zornoff Leonardo A. M.,Matsubara Luiz S.,Matsubara Beatriz B.,Paiva Sergio A. R.
Arquivos Brasileiros de Cardiologia , 2000,
Abstract: OBJECTIVE: To evaluate the effects of losartan on ventricular remodeling and on survival after myocardial infarction in rats. METHODS: After surgical occlusion of left coronary artery, 84 surviving male Wistar rats were divided into two groups: LO treated with losartan (20mg/kg/day, n=33) and NT (n=51), without medication. After 3 months, we analyzed mortality; ventricular to body mass ratio (VM /BM); myocardial hydroxyproline concentration (HOP); isovolumetric pressure, +dp/dt, -dp/dt, and diastolic volume/left ventricle mass ratio (VO/LV). RESULTS: Mortality was: LO = 22%, and NT = 47% (p<0.05). Ventricular mass,(VM/BM, mg/g) was 4.14 ± 0.76 and 3.54±0.48, in the NT and LO groups, respectively (p<0.05). HOP (median) was 4.92 upsilong/mg in the LO and 5.54 upsilong/g in the NT group (p>0.05). The V0/LV values (median) were 0.24 mL/g in group LO and 0.31 mL/g in group NT (p<0.05) compared to NT group. There were no differences between the groups for +dp/dt and -dp/dt parameters. CONCLUSION: 1- The use of losartan myocardial infarction causes an attenuation of ventricular remodeling, bringing about an increased survival, an attenuation of ventricular hypertrophy and dilation, and an improvement of the isovolumetric pressure; 2- the treatment does not modify the myocardial collagen concentration.
The Construction of Pairwise Additive Minimal BIB Designs with Asymptotic Results  [PDF]
Kazuki Matsubara, Sanpei Kageyama
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.514207
Abstract: An asymptotic existence of balanced incomplete block (BIB) designs and pairwise balanced designs (PBD) has been discussed in [1]-[3]. On the other hand, the existence of additive BIB designs and pairwise additive BIB designs with k = 2 and λ = 1 has been discussed with direct and recursive constructions in [4]-[8]. In this paper, an asymptotic existence of pairwise additive BIB designs is proved by use of Wilson’s theorem on PBD, and also for some and k the exact existence of l pairwise additive BIB designs with block size k and λ = 1 is discussed.
Development of Preparative Chromatography for Proteomic Approach of Mycorrhizal Symbiosis  [PDF]
Tomoko Matsubara, Takaaki Ishii
Advances in Biological Chemistry (ABC) , 2015, DOI: 10.4236/abc.2015.51002
Abstract: Although mechanism of symbiosis between arbuscular mycorrhizal fungi (AMF) and host plants has been investigated by genetic analysis, very little knowledge has been obtained because genome analysis of AMF is not perfect yet. Thus, we tried to develop mass purification of proteins using preparative chromatography in order to accelerate roteomic analysis of proteins related to mycorrhizal symbiosis, such as 24 and 53 kDa proteins. In particular, our data showed that 53 kDa proteins would be restrictively expressed when mycorrhizal fungi and host plants were stressed. However, 24 kDa proteins, which appear to be a usable indicator for the existence of various my-corrhizal fungi, were habitually detected in not only AMF but also other mycorrhizal fungi such as ectomycorrhizal fungi (EF). Moreover, we discovered new preparative chromatographical techniques for isolation and mass purification of those proteins. We are convinced that this chromato-graphical technique will greatly contribute to proteomic approach of mycorrhizal symbiosis.
Radicais livres: conceitos, doen as relacionadas, sistema de defesa e estresse oxidativo
Ferreira A.L.A.,Matsubara L.S.
Revista da Associa??o Médica Brasileira , 1997,
Abstract:
Estrogen and progesterone play pivotal roles in endothelial progenitor cell proliferation
Yuko Matsubara, Keiichi Matsubara
Reproductive Biology and Endocrinology , 2012, DOI: 10.1186/1477-7827-10-2
Abstract: The number of EPCs in peripheral blood from subjects in the menstrual phase (n = 12), follicular phase (n = 8), and luteal phase (n = 16), was measured using flow cytometry. Peripheral blood mononuclear cells (PBMCs) were cultured for seven days with or without 17beta-estradiol (E2beta) or P4, followed by assessment of EPC proliferation based upon the uptake of acetylated low density lipoprotein (LDL) and lectin. The expression of estrogen receptor (ER) or progesterone receptor (PR) in EPCs was also evaluated using real-time PCR.E2beta and P4 significantly increased the proliferation of EPCs derived from the peripheral blood of subjects in menstrual phase, but not subjects in the luteal phase. In addition, the expression level of ERalpha was markedly higher than ERbeta in EPCs derived from women in menstrual phase.EPC proliferation is induced during the menstrual phase and proliferation can be affected by estrogen through ERalpha activation.Angiogenesis in female reproductive organs, including the uterus, corpus luteum, and placenta, is essential for implantation and is critical for the dramatic (30-50 fold) elevation of uterine blood flow during pregnancy [1,2]. Disturbances in uterine vascular development are associated with pregnancy loss, preeclampsia, and intrauterine growth restriction [3]. Periodic uterine endometrial neovascularization begins after menstruation and continues into the luteal phase [4]. In general, it is thought that neovascularization is mainly caused by angiogenesis, which is the sprouting of capillaries from pre-existing vessels, such as in tumors and embryos. However, vasculogenesis, which is mediated by endothelial progenitor cells (EPCs), has recently been proposed to be involved in endometrial neovascularization [5,6]. The presence of EPCs in peripheral blood provides a maintenance reservoir of endothelial cells (ECs) and contributes to up to 25% of ECs in newly formed vessels [7]. It has been hypothesized that EPCs may be involved in t
Chorion laeve trophoblasts of preeclamptic fetal membranes: histochemically detectable enzyme activities do not change at a subcellular level
S Matsubara,T Takayama,R Iwasaki,A Izumi
European Journal of Histochemistry , 2009, DOI: 10.4081/1631
Abstract: We examined the subcellular localization of ADPdegrading activity and cytochrome c oxidase (CCO) activity in chorion laeve trophoblasts from term and near term human fetal membranes, and compared them with those from severe preeclamptic fetal membranes. The methods used for the detection of enzyme activities were the lead nitrate method for ADP-degrading activity and the diaminobenzidine method for CCO. Precipitates indicative of ADP-degrading activity were visible on surface microvillous plasma membranes of chorion laeve trophoblasts both from normal and preeclamptic fetal membranes. The intensity and distribution patterns were the same in the normal and preeclamptic subjects. CCO labeling was visible in almost all laeve trophoblastic mitochondria both in normal and preeclamptic cases. Previously, we demonstrated that in preeclamptic villous trophoblasts there were decreases in ADP-degrading activity and the presence of CCO-negative mitochondria, which were proposed to lead to dysfunction of each villous trophoblast, and finally to placental insufficiency in preeclampsia. Reductions or changes in enzyme intensities/distribution patterns, which are characteristic features of preeclamptic villous trophoblasts, were absent in chorion laeve trophoblasts in preeclampsia. These results suggest that in preeclampsia there are no, or at least less severe, abnormalities in the enzyme activities of chorion laeve trophoblasts, compared with villous trophoblasts, as far as enzyme-histochemically detectable enzymes are concerned.
Cluster Heat Bath Algorithm in Monte Carlo Simulations of Ising Models
F. Matsubara,A. Sato,O. Koseki,T. Shirakura
Physics , 1997, DOI: 10.1103/PhysRevLett.78.3237
Abstract: We have proposed a cluster heat bath method in Monte Carlo simulations of Ising models in which one of the possible spin configurations of a cluster is selected in accordance with its Boltzmann weight. We have argued that the method improves slow relaxation in complex systems and demonstrated it in an axial next-nearest-neighbor Ising(ANNNI) model in two-dimensions.
Rela??o entre a esfericidade, a fun??o ventricular e o tamanho do infarto em ratos
Minicucci, Marcos F.;Azevedo, Paula S.;Matsubara, Beatriz B.;Matsubara, Luiz S.;Paiva, Sergio A. R.;Zornoff, Leonardo A. M.;
Arquivos Brasileiros de Cardiologia , 2010, DOI: 10.1590/S0066-782X2010005000023
Abstract: background: the left ventricular (lv) sphericity is a factor associated with ventricular dysfunction, but it is not well-characterized in the experimental infarction model in rats. objective: to analyze the association between the sphericity index (si), the ventricular function and the infarcted area in an experimental rat model. methods: six months after the infarction (ami, n=33) or simulated surgery (sham, n=18), the animals were submitted to an echocardiogram. the si was obtained through the ratio between the diastolic areas at the lv long axis and the short axis. results: the ami group presented the lowest index of sphericity (1.32 × 0.23 vs 1.57 × 0.33; p=0.002), systolic function and relative thickness (0.13 × 0.003 vs 0.18 × 0.04; p<0.001) and the highest index of parietal stress (1.27 × 0.33 vs 0.88 × 0.25; p<0.001). there was a significant correlation between the infarct size and sphericity (p=0.046). at the linear regression analysis, the infarct size (p=0.014), but not the sphericity (p=0.683) and the parietal stress (p=0.176), was the predictive factor of the systolic function. eccentric remodeling (p=0.011), but not sphericity (p=0.183) or the infarct size (p=0.101), was a predictive factor of parietal stress. additionally, the infarct size (p=0.046), but not the eccentric remodeling (0.705), was a predictive factor of sphericity. the infarct size (p=0.015) and the parietal stress (p=0.011), but not the sphericity (p=0.705), were the predictors of eccentric remodeling. conclusion: the sphericity is associated, but it is not a determinant factor of parietal stress, of eccentric remodeling and ventricular systolic function in an experimental infarction model in rats.
Page 1 /461974
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.