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Search Results: 1 - 10 of 6425 matches for " Matrix Tablet "
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Design, Fabrication and in Vitro Evaluation of Metformin HCl Matrix Tablets for Treatment of Diabetes Mellitus
Science and Technology , 2012, DOI: 10.5923/j.scit.20120206.05
Abstract: Diabetes mellitus is a growing problem in today’s world. The aim of the present study was to design and develop matrix tablets of metformin HCl (MTH) with hydroxy propyl methyl cellulose K15M (HPMCK15M) and ethyl cellulose (EC) in different ratios. The prepared tablets were evaluated in terms of hardness, friability, drug content and in vitro drug release profiles. It was observed that formulation with HPMC and EC in a ratio of 2:1 gave reproducible results in all aspects and showed sustained drug release profile for 12h.
Prajapati SK,,Richhaiya R,Singh VK,Singh AK
Journal of Drug Delivery and Therapeutics , 2012,
Abstract: In present study, an attempt has been made to evaluate the effect of natural gums on the release profile of drug from matrix system for once daily sustained release tablets formulations. Aceclofenac NSAIDs was used as a model drug to evaluate it release characteristics from different matrices. Matrix tablets of Aceclofenac were prepared by direct compression process using natural gums (xanthan gum and karaya gum) in different ratios drug: gum ratios of FX, FK and FXK (FX and FK in 1:1 ratios). The tablets were evaluated for physical characteristic like hardness, weight variation, friability, swelling index and drug content, in-vitro release of drug was performed in Phosphate buffer pH 7.4 for 24 hours. All the physical characteristic of fabricated tablet was within acceptable limits. The release of Aceclofenac from a gelatinous swollen mass, which controls the diffusion of drug molecules through the polymeric materials in to aqueous medium. The FXK matrices show prices controlled release than FX and FK matrices because of burst effect and fast release in case of FX and FK matrices respectively and there was no chemical interaction between drug and polymers in FXK formulation as confirmed by FTIR studies.The release mechanism was explained with zero order, first order, higuchi and korsmeyer equations via swelling and non fickian diffusion mechanism. The FXK matrices leads to more prices result than FX and FK alone by utilization of synergistic interaction between two biopolymers and uniformity in the hydration layer in dissolution media
The Effect of Various Surfactants on Release Behavior of Procainamide HCl from Ethylcellulose Based Matrices
Noushin Bolourtchian,Farrin Sattari Javid,Simin Dadashzadeh
Iranian Journal of Pharmaceutical Research , 2005,
Abstract: The effect of different kinds of surfactants in various concentrations incorporated in an inert matrix, on the release of procainamide hydrochloride, as a cationic model compound, was investigated in this study. Sodium lauryl sulfate and sodium stearate as anionic surfactants, cetyl pyridinium chloride and cetyltrimethyl ammonium bromide as cationic and span 60 and tween 80 as non-ionic surfactants were selected. Hydrophobic matrices were prepared using procainamide HCl, ethyl cellulose, dicalcium phosphate and different percentages of each surfactant and the dissolution rate of drug from various matrices was determined in pH values1.2 (for 2 h) and 7.2 (up to 10 h). The results showed that incorporation of anionic surfactants in matrix preparations resulted in a remarkable decrease in the release rate of procainamide HCl (P < 0.05), which was attributed to the formation of a poorly soluble complex between the cationic drug and the anionic surfactant. The formation of complex was confirmed by the precipitation titration test. On the other hand, presence of cationic surfactants considerably increased the drug release rate and it was noted that by raising the percentage of surfactant, a faster drug release rate release was achieved. With span 60 there was no change in drug release rate, probably due to its lower wetting capability. While in the case of tween 80, as a hydrophilic non-ionic surfactant, the drug release rate was increased, although statistically not significant. In general, it seems that the influence of cationic and non-ionic surfactants on drug release rate was in accordance with the ability of each surfactant in wetting the matrices and producing a greater number of channels for the dissolution fluid to leach out the drug. Kinetics evaluation of the release profiles showed that the Higuchi equation is the main model, fitting the data.
Effect of Waxy Materials on the Release Kinetics of Ibuprofen from HPMC Based Sustained Release Matrix Tablet
Md. Belal Hossain,Mamunur Rashid,A.K.M. Motahar Hossain
Pakistan Journal of Biological Sciences , 2004,
Abstract: The aim of the present study was to investigate the release of ibuprofen (IB) from matrix tablets using a combination of water insoluble waxy materials with hydrophilic polymers. The waxy materials were added as additives to the hydrophilic polymer, hydroxy propyl methyl cellulose (HPMC). Bees wax (BW), cetyl alcohol (CA) and stearic acid (SA) used as waxy materials that were added in increasing amount (up to 30% of total weight of tablet) to the HPMC based sustained release (SR) matrix tablets. The results showed that the matrix tablets using all the additives released the drug by zero order mechanism. Addition of waxy materials into the matrix significantly decreased the rate of drug release due to the reduction in penetration of the dissolution fluid. From the release profiles excellent correlation was found between the concentration of waxy materials and ibuprofen release rate.
Probiotic-assisted colon-specific delivery of diclofenac sodium from guar gum matrix tablets: In vitro evaluation
Ghosh Prashant,Gupta Vipin,Gondoliya Bhavik,Rathore Mahendra
Asian Journal of Pharmaceutics , 2010,
Abstract: Purpose : The aim of present work was to investigate the in vitro release profile of diclofenac sodium from matrix tablets, which were prepared using guar gum with and without probiotics. Methods : Six matrix tablets formulations (F1-F6) of diclofenac sodium containing varying proportions of guar gum, 10-60% of tablet weight were prepared by wet granulation method and evaluated in vitro for their release profile. Four matrix tablets formulations (F7-F10) of diclofenac with guar gum (40%) were prepared incorporating varying concentration of commercial spores of lactobacillus and bifidobacterium species that are commonly found in colon microflora. Results : The tablets having same concentration of guar gum without probiotics (F4) showed a 54.47% cumulative release of diclofenac after 24 hr while that in presence of probiotics (F9) was 73.01%. These drug release studies were conducted without rat caecal content. In another set of experiments, the drug release studies were carried out in presence of rat caecal content. In such experiments, more than 95% drug was released from F4 and F9 formulations after 24 hr. Conclusion : The results showed that commercial probiotics are capable in digesting guar gum. These probiotics may be used to assist in colon delivery of drugs from formulations prepared with guar gum.
Formulation and in vitro evaluation of nifedipine-controlled release tablet: Influence of combination of hydrophylic and hydrophobic matrix forms
Derakhshandeh Katayoun,Soleymani Marzieh
Asian Journal of Pharmaceutics , 2010,
Abstract: The aim of the present work was to develop controlled release matrix formulation of nifedipine and investigate the effects of both hydrophilic and hydrophobic polymers on in vitro drug release. Matrix tablets were prepared by wet granulation technique using different concentration of hydroxy propyl methyl cellulose (HPMC), ethyl cellulose (EC), compressible Eudragits (RSpo and RLpo) and their combination in different ratios to examine their influence on tablet properties and drug release profile. Tablets were evaluated by measurement of hardness, friability, content uniformity, weight variation and drug release pattern. Release studies were carried out using USP type II apparatus in 900 ml of sodium phosphate buffer (pH 7.4) with 0.5% (w/v) SDS. The amount of drug released was determined at 238 nm by UV-visible spectrophotometer.In vitro dissolution studies indicated that hydrophobic polymers significantly reduced the rate of drug release compared to hydrophilic ones in 12 hrs and combination of both polymers exhibited the best release profile to sustain the drug release for prolong period of time. As a result, the tablet containing HPMC:EC in ratio of 0.75:1 showed better controlled release pattern over a period of 12 hrs. In selected formulation, the calculated regression coefficients for release models fitted best to zero-order models.
V. S. Patil*
International Journal of Pharmacy and Technology , 2010,
Abstract: In the present work, floating gastroretentive formulation of Ranitidine HCl was formulated to sustained release of Ranitidine HCl above its site of absorption. To modulate the release characteristics,HPMC (K4M) and natural swelling agent Psyllum husk are used for single-unit floating matrix tablets by a direct compression technique. The floating approach was achieved by the use of Sodium bicarbonate.The prepared floating tablets were evaluated for their floating behavior, swelling studies, in-vitro drug release studies and kinetic analysis of the release data. The optimize formulation shows floating lag time within 3 min. The effect of HPMC (K4M) and swelling agent Psyllum husk on drug release was observed.Ranitidine HCl shows drug release till 12 hrs due to gel forming property of HPMC (K4M) and swelling capacity of Psyllum husk. Form the results, it can be conclude that the prepared gastroretentive tablet of Ranitidine HCl shows desirable release profile, good floating and sustained effect in stomach. The Fourier Transform Infra Red Spectroscopy studies revealed that there is no molecular interaction which may have implications on drug release haracteristics.
M. Ahmed, S. Koushik Ahamed, Syed Masudur Rahman Dewan, Md. Mizanur Rahman Moghal*
International Journal of Pharmaceutical Sciences and Research , 2013,
Abstract: ABSTRACT: The objective of the current study was to design an oral sustained release matrix tablet of Ramipril and to evaluate the effect of polymer on release pattern of the drug. Tablets were prepared by direct compression method using Methocel (Hydroxy Propyl Methyl Cellulose) K100MCR and Methocel (Hydroxy Propyl Methyl Cellulose) K4MCR, as matrix forming polymer. Dissolution studies were carried out in 500 ml phosphate buffer (pH 6.5) for 8 hours. The release mechanism was explored with zero order, first order, Higuchi equation and Korsmeyer's equation. The drug release followed Higuchi equation. It was found that the release of drug from matrix tablet decrease with the increasing of percentage of polymer. The two high viscosity polymers (Methocel K4MCR and Methocel K100MCR) were found suitable for the study.
Kanwarpreet Singh Bakshi*, K. Vivek, Rajan K. Verma, Murali Krishna B., Sreekanth Narravula, Romi Barat Singh and Ajay K. Singla
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: In this study, Monolayer matrix (MLM) tablet and triple layer matrix (TLM) tablet formulation of metoprolol succinate were fabricated by using Hydroxypropyl-methylcellulose and Polymethacrylates (Eudragit) as the matrix forming agent in both the tablet core layer and barrier layers. The prepared tablets were analyzed for their drug content and in-vitro drug release studies. In-vitro evaluation and comparison of the MLM dosage form and TLM dosage form was done. The role of impermeable barrier layer in controlling the drug release from the core was studied. The in-vitro dissolution studies were carried out and showed a significant difference statistically (P value > 0.05 by ANOVA tool). Mean dissolution time (MDT) increased, while dissolution efficiency (DE %) decreased, indicating that the release of metoprolol succinate is slower from triple layer matrix tablets. The thermal analysis studies (DSC) performed on the initial TLM formulation and three month old accelerated stability sample of the same showed no variation in the thermograph, indicating TLM as stable formulation. The finding of the study indicated that the MLM tablets may prolonged the drug release, but a non linear drug release profile was observed with an initial burst release. In TLM tablets, layering with Hydroxypropyl-methylcellulose and Polymethacrylates (Eudragit) as impermeable barrier on the matrix core, resulted in linear/zero order drug release kinetics. The initial burst release was not observed in TLM tablets.TLM tablets showed significant and marked controlled release of a freely water soluble drug as compared to MLM tablets.
Development and in Vitro-in Vivo Evaluation of Controlled Release Matrix Tablets of Desvenlafaxine  [PDF]
Shashidhar Reddy Dodda, Prakash Rao B
Pharmacology & Pharmacy (PP) , 2012, DOI: 10.4236/pp.2012.31003
Abstract: The objective of this investigation was to prepare extended release tablet containing matrix granules of Desvenlafaxine succinate monohydrate and to study its in vitro release and in vivo absorption. The design of dosage form was performed by choosing hydrophilic hydroxypropyl methyl cellulose (HPMC K100M), sodium carboxyl methyl cellulose (Blanose), microcrystalline cellulose (MCC) and lactose monohydrate polymers as matrix builders and polyvinyl pyrolidine (Kollidon K30) as granulating polymers. Granules were prepared by composing drug with HPMC K100M, sodium CMC, MCC and lactose monohydrate by spray drying method. Optimized formulation of Desvenlafaxine succinate monohydrate was formed by using 20% HPMC K100M, 26.6% MCC, 6.6% of sodium CMC (Blanose), 13.3% of lactose monohydrate and 5% ratio of Kollidon K30 as binder. Tablets were compressed with free flowing optimized granules of uniform drug content. This extended the release period up to 24 h in vitro study. Similarity factor and mean dissolution time were also reported to compare various dissolution profiles. The network formed by HPMC, MCC and Blanose had been coupled satisfactorily with the controlled resistance. Biopharmaceutical study of this optimized dosage form in rabbit model showed 24 h prolonged drug release in vivo. A close correlation (R2 = 0.9833) was established between the in vitro release and the in vivo absorption of drug. The results suggested that wet granulation with spray dried technique, is a suitable method to formulate sustained release Desvenlafaxine succinate monohydrate and it can Perform therapeutically better than conventional immediate release dosage form.
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