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Dynamics of Adrenal Steroids Are Related to Variations in Th1 and Treg Populations during Mycobacterium tuberculosis Infection in HIV Positive Persons
Maria Florencia Quiroga, Matias Tomas Angerami, Natalia Santucci, Diego Ameri, Jose Luis Francos, Jorge Wallach, Omar Sued, Pedro Cahn, Horacio Salomón, Oscar Bottasso
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0033061
Abstract: Tuberculosis (TB) remains the most frequent cause of illness and death from an infectious agent, and its interaction with HIV has devastating effects. We determined plasma levels of dehydroepiandrosterone (DHEA), its circulating form DHEA-suphate (DHEA-s) and cortisol in different stages of M. tuberculosis infection, and explored their role on the Th1 and Treg populations during different scenarios of HIV-TB coinfection, including the immune reconstitution inflammatory syndrome (IRIS), a condition related to antiretroviral treatment. DHEA levels were diminished in HIV-TB and HIV-TB IRIS patients compared to healthy donors (HD), HIV+ individuals and HIV+ individuals with latent TB (HIV-LTB), whereas dehydroepiandrosterone sulfate (DHEA-s) levels were markedly diminished in HIV-TB IRIS individuals. HIV-TB and IRIS patients presented a cortisol/DHEA ratio significantly higher than HIV+, HIV-LTB and HD individuals. A positive correlation was observed between DHEA-s and CD4 count among HIV-TB individuals. Conversely, cortisol plasma level inversely correlated with CD4 count within HIV-TB individuals. M. tuberculosis-specific Th1 lymphocyte count was increased after culturing PBMC from HIV-TB individuals in presence of DHEA. We observed an inverse correlation between DHEA-s plasma level and Treg frequency in co-infected individuals, and CD4+FoxP3+ Treg frequency was increased in HIV-TB and IRIS patients compared to other groups. Strikingly, we observed a prominent CD4+CD25-FoxP3+ population across HIV-TB and HIV-TB IRIS patients, which frequency correlated with DHEA plasma level. Finally, DHEA treatment negatively regulated FoxP3 expression without altering Treg frequency in co-infected patients. These data suggest an enhancing role for DHEA in the immune response against M. tuberculosis during HIV-TB coinfection and IRIS.
InSólitus Urbanus: espa os metafí-sicos
Paulo Angerami
Galáxia , 2008,
Jet Quenching in Relativistic Heavy Ion Collisions at the LHC
Aaron Angerami
Physics , 2012,
Abstract: Jet production in relativistic heavy ion collisions is studied using Pb+Pb collisions at a center of mass energy of 2.76 TeV per nucleon. The measurements reported here utilize data collected with the ATLAS detector at the LHC from the 2010 Pb ion run corresponding to a total integrated luminosity of 7 inverse microbarns. The results are obtained using fully reconstructed jets using the anti-kt algorithm with a per-event background subtraction procedure. A centrality-dependent modification of the dijet asymmetry distribution is observed, which indicates a higher rate of asymmetric dijet pairs in central collisions relative to peripheral and pp collisions. Simultaneously the dijet angular correlations show almost no centrality dependence. These results provide the first direct observation of jet quenching. Measurements of the single inclusive jet spectrum, measured with jet radius parameters R = 0.2,0.3,0.4 and 0.5, are also presented. The spectra are unfolded to correct for the finite energy resolution introduced by both detector effects and underlying event fluctuations. Single jet production, through the central-to-peripheral ratio RCP, is found to be suppressed in central collisions by approximately a factor of two, nearly independent of the jet pT. The RCP is found to have a small but significant increase with increasing R, which may relate directly to aspects of radiative energy loss.
Cytokine responses during chronic denervation
Saku Ruohonen, Mohsen Khademi, Maja Jagodic, Hanna-Stiina Taskinen, Tomas Olsson, Matias R?ytt?
Journal of Neuroinflammation , 2005, DOI: 10.1186/1742-2094-2-26
Abstract: Transected rat sciatic nerve was sutured and ligated to prevent reinnervation. The samples were collected from the left sciatic nerve distally and proximally from the point of transection. The endoneurium was separated from the surrounding epi- and perineurium to examine the expression of cytokines in both of these compartments. Macrophage invasion into endoneurium was investigated and Schwann cell proliferation was followed as well as the expression of cytokines IL-1β, IL-10, IFN-γ and TNF-α mRNA. The samples were collected from 1 day up to 5 weeks after the primary operation.At days 1 to 3 after injury in the epi-/perineurium of the proximal and distal stump, a marked expression of the pro-inflammatory cytokines TNF-α and IL-1β and of the anti-inflammatory cytokine IL-10 was observed. Concurrently, numerous macrophages started to gather into the epineurium of both proximal and distal stumps. At day 7 the number of macrophages decreased in the perineurium and increased markedly in the endoneurium of both stumps. At this time point marked expression of TNF-α and IFN-γ mRNA was observed in the endo- and epi-/perineurium of the proximal stump. At day 14 a marked increase in the expression of IL-1β could be noted in the proximal stump epi-/perineurium and in the distal stump endoneurium. At that time point many macrophages were observed in the longitudinally sectioned epineurium of the proximal 2 area as well as in the cross-section slides from the distal stump. At day 35 TNF-α, IL-1β and IL-10 mRNA appeared abundantly in the proximal epi-/perineurium together with macrophages.The present studies show that even during chronic denervation there is a cyclic expression pattern for the studied cytokines. Contrary to the previous findings on reinnervating nerves the studied cytokines show increased expression up to 35 days. The high expressions of pro-inflammatory and anti-inflammatory cytokines in the proximal epi-/perineurial area at day 35 may be involved in the formatio
Measurement of Jets and Jet Suppression in sqrt(s_NN)=2.76 TeV Lead-Lead Collisions with the ATLAS detector at the LHC
Aaron Angerami,ATLAS Collaboration
Physics , 2011, DOI: 10.1088/0954-3899/38/12/124085
Abstract: The first results of single jet observables in Pb+Pb collisions at sqrt(s_NN)=2.76 TeV measured with the ATLAS detector at the LHC are presented. Full jets are reconstructed with the anti-kt algorithm with R= 0.2 and 0.4, using an event-by-event subtraction procedure to correct for the effects of the underlying event including elliptic flow. The geometrically-scaled ratio of jet yields in central and peripheral events,Rcp, indicates a clear suppression of jets with ET >100 GeV. The transverse and longitudinal distributions of jet fragments is also presented. We find little no substantial change to the fragmentation properties and no significant change in the level of suppression when moving to the larger jet definition.
Measurements of jet quenching and heavy flavor production with the ATLAS detector
Aaron Angerami for the ATLAS Collaboration
Physics , 2012,
Abstract: Measurements of jet suppression in PbPb collisions by the ATLAS Collaboration are reported. The production of inclusive jet yields as a function of jet pt, collision centrality and jet size parameter R are measured and presented through the central-to-peripheral ratio, Rcp. Jets are found to be suppressed in central collisions relative to peripheral collisions by approximately a factor of two. The suppression is found to show almost no variation with jet pt, and the Rcp is found to increase slighly with increasing R. Measurements of heavy quark energy loss are also presented using muons from semi-leptonic decays of heavy flavor hadrons. The maximal suppression is observed to be Rcp ~ 0.5 and shows no significant depedence on the muon pt.
Body Adiposity Index Utilization in a Spanish Mediterranean Population: Comparison with the Body Mass Index
Angel A. López, Mey L. Cespedes, Teofila Vicente, Matias Tomas, Miguel Bennasar-Veny, Pedro Tauler, Antoni Aguilo
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0035281
Abstract: Background Body fat content and fat distribution or adiposity are indicators of health risk. Several techniques have been developed and used for assessing and/or determining body fat or adiposity. Recently, the Body Adiposity Index (BAI), which is based on the measurements of hip circumference and height, has been suggested as a new index of adiposity. The aim of the study was to compare BAI and BMI measurements in a Caucasian population from a European Mediterranean area and to assess the usefulness of the BAI in men and women separately. Research Methodology/Principal Findings A descriptive cross-sectional study was conducted in a Caucasian population. All participants in the study (1,726 women and 1,474 men, mean age 39.2 years, SD 10.8) were from Mallorca (Spain). Anthropometric data, including percentage of body fat mass obtained by Bioelectrical Impedance Analysis, were determined. Body Mass Index (BMI) and BAI were calculated. BAI and BMI showed a good correlation (r = 0.64, p<0.001). A strong correlation was also found between BAI and the % fat determined using BIA (r = 0.74, p<0.001), which is even stronger than the one between BMI and % fat (r = 0.54, p<0.001). However, the ROC curve analysis showed a higher accuracy for BMI than for the BAI regarding the discriminatory capacity. Conclusion The BAI could be a good tool to measure adiposity due, at least in part, to the advantages over other more complex mechanical or electrical systems. Probably, the most important advantage of BAI over BMI is that weight is not needed. However, in general it seems that the BAI does not overcome the limitations of BMI.
40 anos: a maturidade conquistada
Angerami, Emília Luigia Saporiti;
Revista Latino-Americana de Enfermagem , 1993, DOI: 10.1590/S0104-11691993000200002
Abstract: in this narrative, i do not plan to be a cold spectator who captures and relates facts for use, but one who "lived" each moment. this is also a contribution to history, once one tries to illuminate the present remembering the happenings of 4 decades (1953 to 1993) of the college of nursing at ribeir?o preto, university of s?o paulo, focusing on the beginning, the changes , the adjustment and perspectives.
O desenvolvimento da pesquisa no Brasil
Angerami, Emília Luigia Saporiti;
Revista Latino-Americana de Enfermagem , 1993, DOI: 10.1590/S0104-11691993000300007
Abstract: the author presents the development of nursing research in brazil, verifying priorities, methodology and logistics of the studies. the presented five stages follow the model proposed by bergman. the analysis reveals that, in brazil, the tendency related to the type of studies and methodology, is similar to other countries.
O mister da investiga??o do enfermeiro
Angerami, Emília Luigia Saporiti;
Revista Latino-Americana de Enfermagem , 1993, DOI: 10.1590/S0104-11691993000100003
Abstract: the author locates the trajectory of the knowledge in nursing, based on light of professionalism and presents a synthesis of the community effort of nursing in conditions for the administration of knowledge. the analyze of the beginning of the seventy decade point out the knowledge explosion in nursing literature, and an advance in the interchange, getting together, so for, the challenge of the over flow from the descriptive phase and the difficult of research in transforming the practice.
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