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Search Results: 1 - 10 of 56 matches for " Mathijs Baens "
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T(11;18)(q21;q21)-positive gastrointestinal MALT lymphomas are heterogeneous with respect to the V gene mutation status
Xavier Sagaert,Brigitte Maes,Vera Vanhentenrijk,Mathijs Baens
World Journal of Gastrointestinal Oncology , 2011,
Abstract: AIM: To investigate how t(11;18)(q21;q21)-positive gastrointestinal MALT lymphomas relate to other marginal zone lymphomas with respect to the somatic mutation pattern of the VH genes and the expression of the marker CD27.METHODS: The VH gene of 7 t(11;18)(q21;q21)-positive gastrointestinal MALT lymphomas was amplified by PCR using family specific VH primers and a consensus JH primer. PCR products were sequenced and mutation analysis of the CDR and the FR regions was performed. All cases were immunostained for CD27.RESULTS: One case showed unmutated VH genes while the others showed mutated VH genes with mutation frequencies ranging from 1.3 to 14.7% and with evidence of antigen selection in 2 cases. These data suggest that the translocation t(11;18)(q21;q21) can target either B-cells at different stages of differentiation or naive B-cells that retain the capacity to differentiate upon antigen stimulation. All cases but one displayed weak to strong CD27 expression which did not correlate with the VH gene mutation status.CONCLUSION: t(11;18)(q21;q21)-positive gastrointestinal MALT lymphomas are heterogeneous with respect to the VH mutation status and CD27 is not a marker of somatically mutated B-cells.
The Dark Side of EGFP: Defective Polyubiquitination
Mathijs Baens, Heidi Noels, Vicky Broeckx, Sofie Hagens, Sabine Fevery, An D. Billiau, Hugo Vankelecom, Peter Marynen
PLOS ONE , 2006, DOI: 10.1371/journal.pone.0000054
Abstract: Enhanced Green Fluorescent Protein (EGFP) is the most commonly used live cell reporter despite a number of conflicting reports that it can affect cell physiology. Thus far, the precise mechanism of GFP-associated defects remained unclear. Here we demonstrate that EGFP and EGFP fusion proteins inhibit polyubiquitination, a posttranslational modification that controls a wide variety of cellular processes, like activation of kinase signalling or protein degradation by the proteasome. As a consequence, the NF-κB and JNK signalling pathways are less responsive to activation, and the stability of the p53 tumour suppressor is enhanced in cell lines and in vivo. In view of the emerging role of polyubiquitination in the regulation of numerous cellular processes, the use of EGFP as a live cell reporter should be carefully considered.
Auto-Ubiquitination-Induced Degradation of MALT1-API2 Prevents BCL10 Destabilization in t(11;18)(q21;q21)-Positive MALT Lymphoma
Heidi Noels, Riet Somers, Hongxiang Liu, Hongtao Ye, Ming-Qing Du, Christiane De Wolf-Peeters, Peter Marynen, Mathijs Baens
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0004822
Abstract: Background The translocation t(11;18)(q21;q21) is the most frequent chromosomal aberration associated with MALT lymphoma and results in constitutive NF-κB activity via the expression of an API2-MALT1 fusion protein. The properties of the reciprocal MALT1-API2 were never investigated as it was reported to be rarely transcribed. Principal Findings Our data indicate the presence of MALT1-API2 transcripts in the majority of t(11;18)(q21;q21)-positive MALT lymphomas. Based on the breakpoints in the MALT1 and API2 gene, the MALT1-API2 protein contains the death domain and one or both immunoglobulin-like domains of MALT1 (~90% of cases) - mediating the possible interaction with BCL10 - fused to the RING domain of API2. Here we show that this RING domain enables MALT1-API2 to function as an E3 ubiquitin ligase for BCL10, inducing its ubiquitination and proteasomal degradation in vitro. Expression of MALT1-API2 transcripts in t(11;18)(q21;q21)-positive MALT lymphomas was however not associated with a reduction of BCL10 protein levels. Conclusion As we observed MALT1-API2 to be an efficient target of its own E3 ubiquitin ligase activity, our data suggest that this inherent instability of MALT1-API2 prevents its accumulation and renders a potential effect on MALT lymphoma development via destabilization of BCL10 unlikely.
Introduction to telemedicine. Second edition
Mathijs Soede
International Journal of Integrated Care , 2007,
Een intellectuele trait d'union. La Revue de Hollande (1915-1918): literaire betrekkingen tussen Nederland en Frankrijk
Mathijs Sanders
TS·> Tijdschrift voor Tijdschrift-studies , 2011,
Abstract: During the First World War, some Dutch journals were explicitly oriented towards the culture of one of the belligerent nations. In periodicals such as the pro-German weekly De Toekomst (The Future) and the French oriented La Revue de Hollande, Dutch and foreign intellectuals and artists discussed the cultural identity of the Netherlands. This article draws attention to the latter journal. La Revue de Hollande pretended to be an intellectual trait d'union between the Netherlands and France. How did the editors try to achieve that aim? What does a first exploration of this magazine reveal about bilateral periodicals and their circles during the Great War?
Guerra e narrazione autodiegetica nel primo Gadda
Mathijs Duyck
Incontri : Rivista Europea di Studi Italiani , 2013,
Abstract: The experience of the Great War is a vital element in Carlo Emilio Gadda’s literaryapprenticeship. Although the autobiographical theme of war permeates practicallyall of Gadda’s writing, it is interesting to note how the author in his fictioneffectuates a process of distantiation. An important exception to this tendency are a series of ‘war articles’ which were first published in the newspaper L’Ambrosiano ,and which later formed the first part of the short story collection Il castello di Udine(1934). This sequence of five short texts presents an autodiegetic narrator which canbe identified with Gadda, and who develops a highly varied discourse on the war he fought, oscillating between essayistic, lyrical and narrative modes.10The paper intends to individuate the essential components of Gadda’s autodiegeticwar fiction through an intertextual analysis of the author's early works. The surprising intertextual relations between the war articles and the philosophical treatise Meditazione milanese will lead to a reflection on the relation between war experience, gnoseology, ethics and narration of war.
De receptie van buitenlandse literatuur in Nederland in de twintigste eeuw
Sanders, Mathijs
Neerlandistiek.nl , 2007,
Some remarks on the construction of quantum symmetric spaces
Mathijs S. Dijkhuizen
Mathematics , 1995,
Abstract: We present a general survey of some recent developments regarding the construction of compact quantum symmetric spaces and the analysis of their zonal spherical functions in terms of $q$-orthogonal polynomials. In particular, we define a one-parameter family of two-sided coideals in $\Uq(\gog\gol(n,\CC))$ and express the zonal spherical functions on the corresponding quantum projective spaces as Askey-Wilson polynomials containing two continuous and one discrete parameter.
Scheduling with two non-unit task lengths is NP-complete
Jan Elffers,Mathijs de Weerdt
Computer Science , 2014,
Abstract: We consider the non-preemptive task scheduling problem with release times and deadlines on a single machine parameterized by the set of task lengths the tasks can have. The identical task lengths case is known to be solvable in polynomial time. We prove that the problem with two task lengths is NP-complete, except for the case in which the short jobs have unit task length, which was already known to be efficiently solvable.
Cytotoxic T Cells in H. pylori-Related Gastric Autoimmunity and Gastric Lymphoma
Mathijs P. Bergman,Mario M. D'Elios
Journal of Biomedicine and Biotechnology , 2010, DOI: 10.1155/2010/104918
Abstract: Helicobacter pylori infection is the major cause of gastroduodenal pathologies, but only a minority of infected patients develop gastric B-cell lymphoma, gastric autoimmunity, or other life threatening diseases, as gastric cancer or peptic ulcer. The type of host immune response against H. pylori, particularly the cytolytic effector functions of T cells, is crucial for the outcome of the infection. T cells are potentially able to kill a target via different mechanisms, such as perforins or Fas-Fas ligand interaction. In H. pylori-infected patients with gastric autoimmunity cytolytic T cells, that cross-recognize different epitopes of H. pylori proteins and H
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