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Search Results: 1 - 10 of 1182 matches for " Mathew Gregoski "
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BluetoothTM Enabled Acceleration Tracking (BEAT) mHealth System: Validation and Proof of Concept for Real-Time Monitoring of Physical Activity  [PDF]
Aleksey Shaporev, Mathew Gregoski, Vladimir Reukov, Teresa Kelechi, David Morgan Kwartowitz, Frank Treiber, Alexey Vertegel
E-Health Telecommunication Systems and Networks (ETSN) , 2013, DOI: 10.4236/etsn.2013.23007
Abstract: Physical activity is critical to improve the condition of patients with chronic leg and foot ulcers, especially those who are obese and experienced multiple co-morbid conditions. Unfortunately, these individuals are unable to engage in guideline based physical activity (PA) programs. A prototype of BluetoothTM enabled acceleration tracking (BEAT) mHealth system was developed and manufactured for remote monitoring and stimulation of adherence to PA in deconditioned patients. The system consists of a miniature accelerometer-based sensor, smartphone application, and a network service. Validation testing showed high reliability and reproducibility of the BEAT sensors. Pilot study with human subjects demonstrated high accuracy of the BEAT system in recognition of different exercises and calculating overall outcomes of PA. Taken together, these results indicate that BEAT system could become a valuable tool for realtime monitoring of PA in deconditioned patients.

 

Differential Impact of Stress Reduction Programs upon Ambulatory Blood Pressure among African American Adolescents: Influences of Endothelin-1 Gene and Chronic Stress Exposure
Mathew J. Gregoski,Vernon A. Barnes,Martha S. Tingen,Yanbin Dong,Haidong Zhu,Frank A. Treiber
International Journal of Hypertension , 2012, DOI: 10.1155/2012/510291
Abstract: Stress-activated gene × environment interactions may contribute to individual variability in blood pressure reductions from behavioral interventions. We investigated effects of endothelin-1 (ET-1) LYS198ASN SNP and discriminatory stress exposure upon impact of 12-week behavioral interventions upon ambulatory BP (ABP) among 162 prehypertensive African American adolescents. Following genotyping, completion of questionnaire battery, and 24-hour ABP monitoring, participants were randomized to health education control (HEC), life skills training (LST), or breathing awareness meditation (BAM). Postintervention ABP was obtained. Significant three-way interactions on ABP changes indicated that among ET-1 SNP carriers, the only group to show reductions was BAM from low chronic stress environments. Among ET-1 SNP noncarriers, under low chronic stress exposure, all approaches worked, especially BAM. Among high stress exposure noncarriers, only BAM resulted in reductions. If these preliminary findings are replicated via ancillary analyses of archival databases and then via efficacy trials, selection of behavioral prescriptions for prehypertensives will be edging closer to being guided by individual's underlying genetic and environmental factors incorporating the healthcare model of personalized preventive medicine.
Differential Impact of Stress Reduction Programs upon Ambulatory Blood Pressure among African American Adolescents: Influences of Endothelin-1 Gene and Chronic Stress Exposure
Mathew J. Gregoski,Vernon A. Barnes,Martha S. Tingen,Yanbin Dong,Haidong Zhu,Frank A. Treiber
International Journal of Hypertension , 2012, DOI: 10.1155/2012/510291
Abstract: Stress-activated gene × environment interactions may contribute to individual variability in blood pressure reductions from behavioral interventions. We investigated effects of endothelin-1 (ET-1) LYS198ASN SNP and discriminatory stress exposure upon impact of 12-week behavioral interventions upon ambulatory BP (ABP) among 162 prehypertensive African American adolescents. Following genotyping, completion of questionnaire battery, and 24-hour ABP monitoring, participants were randomized to health education control (HEC), life skills training (LST), or breathing awareness meditation (BAM). Postintervention ABP was obtained. Significant three-way interactions on ABP changes indicated that among ET-1 SNP carriers, the only group to show reductions was BAM from low chronic stress environments. Among ET-1 SNP noncarriers, under low chronic stress exposure, all approaches worked, especially BAM. Among high stress exposure noncarriers, only BAM resulted in reductions. If these preliminary findings are replicated via ancillary analyses of archival databases and then via efficacy trials, selection of behavioral prescriptions for prehypertensives will be edging closer to being guided by individual's underlying genetic and environmental factors incorporating the healthcare model of personalized preventive medicine. 1. Introduction Essential hypertension (EH) is a major risk factor for cardiovascular disease (CVD), and EH incidence among youth is increasing [1]. African Americans (AAs) experience a higher prevalence, earlier onset, and greater severity of EH-related complications than other ethnic groups [2]. From late childhood onward, AAs display increased levels of resting and ambulatory blood pressure (ABP) compared to other ethnic groups [3–5]. BP levels are monotonically associated with future CVD morbidity and mortality [6]. Stage I prehypertensive adults (i.e., SBP/DBP 121–129/81–84?mmHg) have a 40% increased risk and adults with stage II prehypertension (i.e., SBP/DBP 130–139/85–89?mmHg) are twice as likely to develop CVD compared to those with optimal BP (<120/<80?mmHg) [6–8]. BP percentile ranking tracks from late childhood into adulthood [9–11] placing AA adolescents with BP between the 50th and 95th percentiles for age and sex at an increased risk of future EH and CVD development [9]. EH, like other multifactorial chronic diseases, results from a complex interplay between an individual’s genetic underpinnings, lifestyle behaviors, psychosocial factors, and exposures to various environmental toxins. Over time, this dynamic interplay eventuates in adverse
Development and Validation of a Smartphone Heart Rate Acquisition Application for Health Promotion and Wellness Telehealth Applications
Mathew J. Gregoski,Martina Mueller,Alexey Vertegel,Aleksey Shaporev,Brenda B. Jackson,Ronja M. Frenzel,Sara M. Sprehn,Frank A. Treiber
International Journal of Telemedicine and Applications , 2012, DOI: 10.1155/2012/696324
Abstract: Objective. Current generation smartphones' video camera technologies enable photoplethysmographic (PPG) acquisition and heart rate (HR) measurement. The study objective was to develop an Android application and compare HRs derived from a Motorola Droid to electrocardiograph (ECG) and Nonin 9560BT pulse oximeter readings during various movement-free tasks. Materials and Methods. HRs were collected simultaneously from 14 subjects, ages 20 to 58, healthy or with clinical conditions, using the 3 devices during 5-minute periods while at rest, reading aloud under observation, and playing a video game. Correlation between the 3 devices was determined, and Bland-Altman plots for all possible pairs of devices across all conditions assessed agreement. Results. Across conditions, all device pairs showed high correlations. Bland-Altman plots further revealed the Droid as a valid measure for HR acquisition. Across all conditions, the Droid compared to ECG, 95% of the data points (differences between devices) fell within the limits of agreement. Conclusion. The Android application provides valid HRs at varying levels of movement free mental/perceptual motor exertion. Lack of electrode patches or wireless sensor telemetric straps make it advantageous for use in mobile-cell-phone-delivered health promotion and wellness programs. Further validation is needed to determine its applicability while engaging in physical movement-related activities. 1. Introduction Many cellular phones now possess high-speed data transmission capabilities (e.g., 3G, 4G) and have embedded microprocessors (e.g., Bluetooth, ANT) with the capability to wirelessly connect to external devices. As a result, cell phones offer several advantages over desktop or laptop computers in telemonitoring-related applications such as higher population penetration, increased privacy, lower cost to purchase, easier ability to transport, and overall increased personal convenience of use [1, 2]. Cell phones are widely used in telemonitoring serving as a conduit for receiving biohealth information from portable medical devices (e.g., blood pressure, glucose and pulse oximeter monitors, weight scales) and mobile sensors (e.g., physical activity; accelerometer counts, heart rate, respiration rate, pulse pressure via chest- or armbands, and wireless electrodes). Once cell phones have received the pertinent information, it is microprocessed, encrypted, and the data packets are transferred to some form of localized or web-based server for secondary processing. At the server level, the data packets are organized into a
An Examination of Transformational Leadership among Graduating Baccalaureate Nursing Students and Practicing Nurses  [PDF]
Lizy Mathew
Open Journal of Nursing (OJN) , 2014, DOI: 10.4236/ojn.2014.411079
Abstract: Leadership skills are essential among nurses to address the challenges faced by the nursing profession. This quantitative comparative study examined five components of transformational leadership skills as outlined by Kouzes and Posner among graduating baccalaureate nursing students and practicing nurses [1]. Five leadership components were used to examine if differences existed among the groups studied. The results indicated significant differences for modeling the way, inspiring a shared vision, enabling others to act, and encouraging the heart. The study revealed that nursing students graduating from generic and accelerated programs have inferior leadership skills compared to nurses in clinical practice. The results may be useful in leadership training of nursing students through collaborative practices between practice settings and nursing schools to improve patient safety.
Design of 2,4-Dichlorophenoxyacetic Acid Imprinted Polymer with High Specificity and Selectivity  [PDF]
Kizhakekuthiathottil Mathew Annamma, Mathew Beena
Materials Sciences and Applications (MSA) , 2011, DOI: 10.4236/msa.2011.23017
Abstract: A widely used herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) was imprinted on poly (4-vinylpyridine) (4-VP) using (40%) ethyleneglycol dimethacrylate (EGDMA) as crosslinking agent. The classical imprinting technology makes use of a high degree of crosslinking which does not allow the template molecules to move freely. So the binding sites, located in the central area of the three dimensional polymer matrix are hard to be accessed and the template molecules cannot be extracted totally. But here we propose a low crosslinked system with high specificity and selectivity. The imprinted and non-imprinted polymers were characterized by various spectroscopic techniques. The extent of binding was followed by batch equilibration method and compared with the respective non-imprinted polymer. Conditions for maximum specific rebinding were set by altering certain factors like template/monomer ratio, concentration of template solution, rebinding medium, mass of polymer and time of incubation. The selectivity of the imprinted polymer was investigated by comparing the binding with structural analogues of 2,4-D like, phenoxyacetic acid (POA), 4-chlorophenoxyacetic acid (4-CPOA) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T). The imprinted polymer exhibited high affinity towards the template molecule and was selectively rebound to the specific sites. The binding towards the structural analogues depends on the number of chlorine in the benzene ring.
Dual Band David Fractal Microstrip Patch Antenna for GSM and WiMAX Applications  [PDF]
Jacob Abraham, Thomaskutty Mathew
Wireless Engineering and Technology (WET) , 2015, DOI: 10.4236/wet.2015.62004
Abstract: The design and development of a proximity fed dualband microstrip patch antenna based on David fractal geometry are presented. David fractal microstrip antenna offers good performance in the 1.754 - 1.816 GHz and 3.37 - 3.415 GHz bands and is suitable for GSM 1800, WiMAX applications. The use of David fractal geometry offers miniaturization of the antenna structure. The proposed first iteration fractal configuration is fabricated and measured results along with simulation results are presented. Good radiation patterns and moderate gain are also obtained.
Clinical Study of Cardiovascular Involvement in Patients with Connective Tissue Diseases  [PDF]
Dolly Mathew, Cicy Bastian
Open Journal of Rheumatology and Autoimmune Diseases (OJRA) , 2017, DOI: 10.4236/ojra.2017.74018
Abstract: Objective: The aim of this study was to evaluate cardiovascular involvement in patients with connective tissue diseases. Methods: A total of 99 patients (mean age 36.6 ± 10.7 years) with connective tissue diseases were included in the study. Patients were assessed based on their sex, age, disease duration, cardiovascular symptoms, erythrocyte sedimentation rate, antinuclear antibody, and anti-double stranded DNA antibodies. Moreover, cardiac investigations including electrocardiography (ECG), chest X-ray and echocardiography were performed. Results: The study included 90 (90.9%) females and 9 (9.09%) males, aged between 18 and 64 years. Chest pain, palpitation, dyspnoea on exertion, syncope, fatigue, and cardiac murmur were the most cardiac symptoms and signs of patients. ECG abnormalities associated with sinus bradycardia, sinus tachycardia, ST interval and T waves, were found in 27% patients. Chest X-ray with cardiomegaly was found in 10 (10.1%) patients. Echocardiography abnormalities were observed in 32% of patients with pericardial involvement, mitral regurgitation, and diastolic dysfunction. Moreover, the incidence of pericardial effusion was found to be significantly (p < 0.05) higher in patients with connective tissue diseases. Conclusion: The study indicates the correlation between disease activity, disease duration and abnormal echocardiography of cardiovascular involvement in connective tissue diseases.
Evaluation of Stress Strain Patterns in a Stentless Aortic Valve and Its Leaflets  [PDF]
Gideon Praveen Kumar, Lazar Mathew
Surgical Science (SS) , 2011, DOI: 10.4236/ss.2011.21007
Abstract: Objective: To design a new trileaflet aortic valve and investigate its mechanical behavior using finite ele- ment methods. Background: Quantification of aortic valve deformation during cardiac cycle is essential in understanding normal and pathological valvular function and eventually in the design of valves. We have designed and analyzed a new tissue valve model to investigate the mechanics of the valve and its components. Methods: Steps involves in 3D CAD based geometric modeling of a trileaflet aortic valve and the effects of different component dimensions on the mechanical behavior of valve is presented in this paper. Conceptual designing of individual components was used to build the total geometric model. Different physiological pressures were applied on the valve model and its deformation patterns were studied. Results: A new geometric model of a trileaflet aortic valve was designed. Its mechanical behavior was studied. Geometric analysis and simulation of these models enhanced the designer to optimize the geometry suitable for performance during and after implantation. Conclusion: The geometry-based model presented here allows determining quickly if the new set of valve component dimensions results in a functional valve. This is of great interest to designers of new prosthetic heart valve models, as well as to surgeons involved in valve- sparing surgery.
Finite element analysis of a percutaneous aortic valve stent design  [PDF]
Gideon Praveen Kumar, Lazar Mathew
Health (Health) , 2009, DOI: 10.4236/health.2009.11002
Abstract: Aim: This paper discusses the design and Finite Element Analysis (FEA) of a Percutaneous Aor-tic Valve Stent. The aim of this study was to model a percutaneous aortic valve stent and subject it to finite element analysis. The design process was carried out to meet the functional and surgical requirements. Methods and Results: Analysis was done with different materials with loads ranging from 50 kgf/mm&amp;#178; to 73 kgf/mm&amp;#178;. These forces were selected because these val-ues are far greater than the normal human blood pressure which ranges from 10kPa to 16kPa. It was also to understand the mechanical behavior of different stent materials under such high pressures. A stent model was generated and its physical, mechanical and behavioral properties were studied. Finite element analysis and simulation of the model enhanced the designer to optimize the geometry suitable for perform-ance during and after implantation. The design objective for the stent is to have long term du-rability, low thrombogenicity, resistance to mi-gration and paravalvular leak. Conclusion: The analysis performed in this paper may aid in understanding the stent’s tolerable pressures ranges in comparison with the physiological pressures exerted by the heart and cardiac blood flow during abnormal cardiovascular conditions.
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