oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2019 ( 115 )

2018 ( 311 )

2017 ( 327 )

2016 ( 350 )

Custom range...

Search Results: 1 - 10 of 176207 matches for " Matheus Puggina de Freitas "
All listed articles are free for downloading (OA Articles)
Page 1 /176207
Display every page Item
In Silico Pharmacokinetics Studies for Quinazolines Proposed as EGFR Inhibitors  [PDF]
Gabriela Souza Fernandes, Michelle Bueno de Moura Pereira, Ana Cláudia Barbosa Marinho, Brisa Machado, Ana Carla Moreira, Matheus Puggina de Freitas, Karen Luise Lang, Jo?o Eustáquio Antunes
Open Journal of Medicinal Chemistry (OJMC) , 2015, DOI: 10.4236/ojmc.2015.54007
Abstract: In silico pharmacokinetics studies can aid the search for molecules with potential ability to be drug candidates. In this paper, a number of quinazoline candidates for epidermal growth factor receptor inhibitors—EGFR, important targets for the treatment of cancer, are computationally analyzed. The literature described that 69 quinazoline molecules were synthesized and the respective half maximum inhibitory concentrations (IC50) were obtained. A bilinear parabolic model was built to investigate the druglikeness by correlating the corresponding lipophilicities, which can be represented by the ideal Log P , with the optimal biological activity in terms of pIC50 values. Structural characteristics leading to improved pharmacokinetics parameters were then analyzed. Compound 56 exhibited the lowest IC50 and, therefore, it had the highest ability to inhibit the EGFR. In the present work, the most potent inhibitor 56 is not calculated to be the most promising drug candidate, since it’s out of the parabolic model obtained due to a Log P above 5, which is not within the expected optimum range. Finally, this work is an example of computational prediction that an experimentally, highly active EGFR inhibitor can be unsuccessful as drug candidate because of pitfalls in pharmacokinetics parameters.
Evaluation of Antinociceptive and Anti-Inflammatory Effects of Synthetic O-Prenylated Phenolic Derivatives  [PDF]
Niraldo Paulino, Amarilis Scremin Paulino, Priscila Vaultier, Laura Pisco, Carolina Passarelli, José Matheus de Freitas Costa, Dirk Michalik, Paulo Celso Pardi, José Agustín Quincoces Suárez
Pharmacology & Pharmacy (PP) , 2012, DOI: 10.4236/pp.2012.33047
Abstract: This work describes the synthesis, antinociceptive and anti-inflammatory effect of O-prenyl derivatives: O-prenyl derivatives 2-(3-methylbut-2-enyloxy)acetophenone (L1) and 3-methoxy-4-(3-methylbut-2-enyloxy)benzaldehyde (V1). Treatment with L1- or V1-produced antinociceptive effect on classical pain models: acetic acid abdominal contortions and formalin test (first and second phases), and in hot plate or tale flick models in mice without changing the locomotors performance, and anti-oedematogenic or anti-inflammatory effect in vivo: carrageenan-induced paw oedema and peritonitis in mice. In addition, L1 and V1 derivatives reduced nitric oxide production on RAW 264.7 cells stimulated with lipopolysaccharide without changing the cell viability. Taken together, our results show for the first time that L1 and V1 can produce antinociception and modulate inflammatory response when administered in mice.
Rela??o entre os desempenhos em diferentes testes frequentemente utilizados na avalia??o da fun??o manual
Lima, Kauê Carvalho de Almeida;Francisco, Matheus Menezes;Freitas, Paulo Barbosa de;
Fisioterapia em Movimento , 2012, DOI: 10.1590/S0103-51502012000300007
Abstract: introduction: tests that measure the maximum grip strength (gsmax) and hand dexterity as the nine hole peg test (9-hpt) and the jebsen & taylor hand function test (jthft) are commonly used to assess hand function (hf). however, gsmax may be questioned regarding its validity because we rarely exert maximum grip force to perform everyday manipulation tasks. to explore gsmax validity we investigated the relation between gsmax and tests that assess hand dexterity. also, we tested the relationship between tests used to evaluate hand dexterity. aim: to assess the relationship between gsmax and the performance in jthft and the relationship between the performance in 9-hpt and jthft. method: thirty-six healthy young adults (18 males and 18 females) performed the jthft followed by the 9-hpt and the gsmax test, with their dominant and non-dominant hands. pearson's correlation analyses were performed between them. results: moderate negative correlation between the gsmax and the jthft was revealed (r < - 0.74), indicating that stronger individuals perform the jthft faster. also, results revealed a weak correlation between the performance in 9-hpt and the jthft, and only for the non-dominant hand. conclusion: gsmax can be used as an indicator of hf, but it should be used prudently because this variable does not represent all aspects related to hand force control and coordination during object manipulation and tasks related to digits dexterity. also, both jthft and 9-hpt, that are used to assess hf, indicate distinct aspects related to the individual's manipulation ability.
Conformational analysis, stereoelectronic interactions and NMR properties of 2-fluorobicyclo[2.2.1]heptan-7-ols
Fátima M. P. de Rezende,Marilua A. Moreira,Rodrigo A. Cormanich,Matheus P. Freitas
Beilstein Journal of Organic Chemistry , 2012, DOI: 10.3762/bjoc.8.137
Abstract: Four diastereoisomers of 2-fluorobicyclo[2.2.1]heptan-7-ols were computationally investigated by using quantum-chemical calculations, and their relative energies were analyzed on the basis of stereoelectronic interactions, particularly the presence or otherwise of the F HO intramolecular hydrogen bond in the syn-exo isomer. It was found through NBO and AIM analyses that such an interaction contributes to structural stabilization and that the 1hJF,H(O) coupling constant in the syn-exo isomer is modulated by the nF→σ*OH interaction, i.e., the quantum nature of the F HO hydrogen bond.
O problema de roteamento de veículos com coleta e entrega simultanea: uma abordagem via Iterated Local Search e GENIUS
Marcio Tadayuki Mine,Matheus de Souza Alves Silva,Luiz Satoru Ochi,Marcone Jamilson Freitas Souza
Transportes , 2011,
Abstract: Resumo: Este trabalho apresenta o algoritmo GENILS para resolver o Problema de Roteamento de Veículos com Coleta e Entrega Simultanea (PRVCES). GENILS é um algoritmo heurístico baseado nas técnicas heurísticas Iterated Local Search, Variable Neighborhood Descent e adapta es das heurísticas Inser o Mais Barata e GENIUS. O algoritmo proposto foi testado em três conjuntos consagrados de problemas-teste da literatura e se mostrou superior aos demais algoritmos da literatura com rela o à capacidade de encontrar as melhores solu es conhecidas.Abstract: This work presents GENILS for solving the Vehicle Routing Problem with Simultaneous Pickup and Delivery (VRPSPD). GENILS is a heuristic algorithm based on Iterated Local Search, Variable Neighborhood Descent and adaptations of the Cheapest Insertion and GENIUS heuristics. The proposed algorithm was tested on three well-known sets of instances found in literature and it overcame other existing algorithms in relation to the ability of finding the best known solutions.
Age and growth of the dog snapper Lutjanus jocu (Bloch & Schneider, 1801) in Abrolhos Bank, Northeastern Brazil
Marília Previero,Carolina V. Minte-Vera,Matheus Oliveira Freitas,Rodrigo Le?o de Moura
Neotropical Ichthyology , 2011,
Abstract: We determined the age and growth of the dog snapper (Lutjanus jocu), caught in the region of Abrolhos Bank, Bahia State, by the fishermen from coastal communities of Prado, Alcoba a, Caravelas, and Nova Vi osa. We examined 205 sectioned otoliths of fish caught by harpoon, longline, hand line, and gill nets (14.5 to 79.5 cm fork length). The formation of each ring was considered annual. The sectioned otoliths showed between 0 and 29 rings. Nearly half of the analyzed specimens had between 0 and 7 rings (88 of 205). Fish caught with nets in the estuarine region were the juvenile, while fish caught with lines and harpoons were the oldest. Two von Bertalanffy growth models were fitted to length-at-age data: one assuming constant variance of length-at-age (SVB) and another assuming constant coefficient of variation, i.e. variance increasing as a function of average size (CVVB). The SVB estimates were Loo = 87.82 cm, K = 0.10, and t0 = -1.486 and the CVVB estimates were Loo = 117.60 cm, K = 0.06, and t0 = -2.470. The largest Loo values estimated by the CVVB model are supported by reports from the literature of larger animals occurring in the deeper outer shelf of Abrolhos Bank. Growth parameters were also estimated for males and females separately (SVB model) (Loo = 92.80 cm, K = 0.099, and t0 = -1.680 for males, and Loo = 82.10 cm, K = 0.105, and t0 = -1.570 for females). Foi determinada a idade e o crescimento do dent o (Lutjanus jocu) capturado na regi o do Banco dos Abrolhos, Bahia, pelos pescadores das comunidades costeiras de Prado, Alcoba a, Caravelas e Nova Vi osa. Foram examinados 205 otólitos seccionados de peixes capturados por arp o, espinhel de fundo, linhas e redes de emalhe (14,5-79,5 cm comprimento furcal). A forma o de cada anel foi considerada anual. Os otólitos seccionados apresentaram entre 0 e 29 anéis. Cerca de metade dos espécimes analisados teve entre 0 e 7 anéis (88 de 205). Os peixes capturados com redes na regi o estuarina foram os mais jovens enquanto os peixes capturados com arp es e linha foram os mais velhos. Dois modelos de crescimento de von Bertalanffy foram ajustados aos comprimentos individuais: um assumindo variancia constante do comprimento em cada idade (SVB) e outro assumindo coeficiente de varia o constante, isto é variancia aumentando em fun o do tamanho médio (CVVB). As estimativas SVB foram (Loo = 87,82 cm, K = 0,105 e t0 = -1,486) e as estimativas CVVB foram Loo = 117,60 cm, K = 0,060 e t0 = -2,470). Os maiores valores de Loo estimados pelo modelo CVVB s o sustentados por relatos da literatura de grandes animais
Prevalência e fatores associados a sobrepeso e obesidade em escolares da rede pública
Rodrigues,Paula Afonso; Marques,Maria Helena; Chaves,Maria das Gra?as Afonso Miranda; Souza,Camila Freitas de; Carvalho,Matheus Furtado de;
Ciência & Saúde Coletiva , 2011, DOI: 10.1590/S1413-81232011000700094
Abstract: this study assessed the association between environmental factors and the prevalence of overweight and obesity in public schools. it was studied 480 students, by means of anthropometric measurements evaluation, weight and height bmi by sex and age and in accordance with the parameters of who and iotf. environmental information was obtained using a questionnaire applied to students. the epi info program, version 3.3.2, was used to data collection and analysis. prevalence rates of obesity varied according to the criteria it was used. according to the iotf, prevalence of obesity was 7.1%, while, according parameters of the who, the prevalence was 18%. the significant risk factor for obesity was the father obesity (pr = 1.08; ci: 0.57-2.04). we concluded that the nutritional profile of the school serves as a subsidy for tracking trends of overweight in this group. this study could instruct the rationalization of the use of the time and public financial resources, proving the need to invest in the school feeding and in the health students.
Age and growth of the dog snapper Lutjanus jocu (Bloch & Schneider, 1801) in Abrolhos Bank, Northeastern Brazil
Previero, Marília;Minte-Vera, Carolina V.;Freitas, Matheus Oliveira;Moura, Rodrigo Le?o de;Dei Tos, Claudenice;
Neotropical Ichthyology , 2011, DOI: 10.1590/S1679-62252011005000024
Abstract: we determined the age and growth of the dog snapper (lutjanus jocu), caught in the region of abrolhos bank, bahia state, by the fishermen from coastal communities of prado, alcoba?a, caravelas, and nova vi?osa. we examined 205 sectioned otoliths of fish caught by harpoon, longline, hand line, and gill nets (14.5 to 79.5 cm fork length). the formation of each ring was considered annual. the sectioned otoliths showed between 0 and 29 rings. nearly half of the analyzed specimens had between 0 and 7 rings (88 of 205). fish caught with nets in the estuarine region were the juvenile, while fish caught with lines and harpoons were the oldest. two von bertalanffy growth models were fitted to length-at-age data: one assuming constant variance of length-at-age (svb) and another assuming constant coefficient of variation, i.e. variance increasing as a function of average size (cvvb). the svb estimates were loo = 87.82 cm, k = 0.10, and t0 = -1.486 and the cvvb estimates were loo = 117.60 cm, k = 0.06, and t0 = -2.470. the largest loo values estimated by the cvvb model are supported by reports from the literature of larger animals occurring in the deeper outer shelf of abrolhos bank. growth parameters were also estimated for males and females separately (svb model) (loo = 92.80 cm, k = 0.099, and t0 = -1.680 for males, and loo = 82.10 cm, k = 0.105, and t0 = -1.570 for females).
Syzygium aromaticum L. (Clove) Essential Oil as a Reducing Agent for the Green Synthesis of Silver Nanoparticles  [PDF]
Matheus Vinicius de Oliveira Brisola Maciel, Aline da Rosa Almeida, Michelle Heck Machado, Ana Paula Zapelini de Melo, Cleonice Gon?alves da Rosa, Daniele Ziglia de Freitas, Carolina Montanheiro Noronha, Gerson Lopes Teixeira, Rafael Dutra de Armas, Pedro Luiz Manique Barreto
Open Journal of Applied Sciences (OJAppS) , 2019, DOI: 10.4236/ojapps.2019.92005
Abstract: The present investigation details a green synthesis of silver nanoparticles (AgNP) using the essential oil of Syzygium aromaticum L. (clove) as reducing agent, which is a matrix with a high content of eugenol, an important compound for the reducing action of silver nitrate. The synthesis of AgNP was performed at different pH conditions (pH 7, 8, 9 and 10), and was monitored by UV-Vis Spectroscopy, Dynamic Light Scattering (DLS) and Transmission Electron Microscopy. The synthesized nanoparticles presented characteristic Surface Plasmon Resonance bands with maximum absorbance between 405 and 460 nm. The DLS analysis revealed particle sizes from 31 to 72 nm and zeta potential between -30.1 and -50.8 mV indicating good stability against the agglomeration of the particles in solution. The micrographs obtained by TEM showed different particle shapes and a predominance of spherical-shaped nanoparticles, and average size ranging from 27 to 94 nm. The clove-based silver nanoparticles were efficient in controlling the growth of Escherichia coli and Staphylococcus aureus bacteria, and the minimum inhibitory concentration ranged from 60 to 100 μL/mL. This study highlights the feasibility of clove essential oil as an alternative for the synthesis of silver nanoparticles by a simple, inexpensive and eco-friendly method.
Activity of Secondary Bacterial Metabolites in the Control of Citrus Canker  [PDF]
Letícia Sayuri Murate, Admilton Gon?alves de Oliveira, Allan Yukio Higashi, André Riedi Barazetti, Ane Stefano Simionato, Caroline Santos da Silva, Glenda Cavalari Sim?es, Igor Matheus Oliveira dos Santos, Marlon Renan Ferreira, Martha Viviana Torres Cely, Miguel Octavio Pérez Navarro, Vanessa Foga?a de Freitas, Marco Antonio Nogueira, Jo?o Carlos Palazzo de Mello, Rui Pereira Leite Jr., Galdino Andrade
Agricultural Sciences (AS) , 2015, DOI: 10.4236/as.2015.63030
Abstract:

This study investigated the protective effects of secondary bacterial metabolites, produced by Pseudomonas sp. (bacterium strain LN), on citrus canker disease caused by Xanthomonas axonopodis pv. citri (Xac 306). The LN bacteria strain was cultured in liquid medium and the supernatant free-cells was treated with methanol (AMF) and ethyl acetate (AEF), respectively, and then the extract was concentrated, filtrated, lyophilized and fractionated by vacuum liquid chromatography (VLC). After VLC, eight fractions were obtained. All fractions’ activity against Xac 306 by agar well diffusion assay and minimum inhibitory concentration but in different concentrationswere tested. Cytotoxicity effects were observed in all fractions in 50 μg·mL-1 concentration. The comet assay demonstrated that the fractions EAF, VLC2 and VLC3 presented no genotoxic effects at tested concentrations. In plants only VLC3 showed significant results (p<0.05), reducing the incidence of citrus canker lesions.

Page 1 /176207
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.