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Search Results: 1 - 10 of 370 matches for " Mateja ?ud "
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Solvent-Free Mechanochemical Deprotection of N-Boc Group  [PDF]
Davor Margeti?, Matejaud
International Journal of Organic Chemistry (IJOC) , 2017, DOI: 10.4236/ijoc.2017.72011
Abstract: Boc protection group could be readily removed in a very mild mechanochemical conditions. In a short reaction time, ball milling of Boc-protected amines with p-toluenesulfonic acid in solvent-free conditions affords corresponding amine p-TsOH salts.
The impact of a responsive and proactive market orientation on innovation and business performance
Mateja Bodlaj
Economic and Business Review , 2010,
Abstract: The purpose of the presented empirical study was to examine the impact of a responsive and proactive market orientation on the degree of novelty, innovation performance and business performance. Data obtained from 325 Slovenian companies that introduced product, process, marketing and organisational innovations during the 2005-2007 period were analysed via structural equation modelling. The main findings reveal that only a proactive market orientation is positively related to the degree of novelty, whereas no support was found for the direct impact of both market orientations on innovation performance and business performance.
Ethics of professional relations to functionally handicapped users
Mateja Griljc
Knji?nica : Revija za Podro?je Bibliotekarstva in Informacijske Znanosti , 1999,
Abstract: The basic purpose of 1ibrarianship code is to form and build librarian personality who can make possible the same opportunity to acquiring knowledge for all users, irrespective of their different demands or special needs.When we discuss the importance of building librarian personality the demanding work with users we confront the problem of ethical treatment very often. Ethics advises only general rules which are rarely simple and they are frequently opposite to each other.The process of reacting between the librarian and the user - as with general information needs as with special functional needs - is also dependent on librarian's professional relation which is formed on important elements such as professional qualification,experiences, creativeness and ethics.We are also interested in question where is the border between ethical and non - ethical action in key situations when the 1ibrarian meets functionally handicapped user. Opportunities for non - ethical reaction of professional workers are much more possible if the library's premises and the furniture don't offer suitable conditions for adaptable communication with the handicapped.But on the other side the 1ibrarian has just because of the bad arhitectural conditions better occasion to introduce himself as one of the best ethically formed personalies compared with other professions. With adaptable communication, creative work and with professional relation in offering help to disabled people, the librarian can contribute to more quality service and even more - he/she becomes an example to other professions - also in ethical sense.
Trace element distribution in three karst soil profiles from Slovenia
Mateja Gosar
Geologija , 2007,
Abstract: In the karstic area in three deep soil profiles in typical karst pockets of the socalled terra rossa the trace element contents were considered. In total 45 samples were collected at various depths. Results show that Mo, Ni, As, V, Hg, Sb, Bi, U, Cu, Li, Cr and Co contentsin profiles considerably exceed the Sloveni anaverages.Pb,Zn and Sb contentsareon the level of Slovenian median values. Contents of Ba, Sr and Mn in considered soils are slightly lower of the Slovenian soil averages. The value of mean enrichment factors in profiles with respect to Slovenian median values is by far the highest for molybdenum.In the Pliskovica profile it amounts to 31,and in the other profiles to around 5.Also for mercury,uranium and in part nickel the enrichment factor in the Pliskovica profile is more than twice as high as in other two profiles. Most considered trace element contents show an increasing tendency with depth. In the upper part of profiles,in the Ahorizont,the trace element contents are lower, and in the soil pocket distinctly increased.
Soil-plant mercury concentrations in the Idrijca river terraces (Slovenia)
Mateja Gosar
Geologija , 2004,
Abstract: The subjects of research are mercury contents in plants and soils on river terraces in the lower reaches of the Idrijca River. Samples of averaged meadow forage and plaintain (Plantago lanceolata) contain from 0.055 to 0.220 mg Hg/kg in dry matter. In comparison to samples from Idrija in the 1970's these contents are relatively low with respect to mercury in soil. They are similar to those established in the surroundings of the abandoned Podljubelj mercury mine. However, with respect to contents in non-polluted soils the contents on Idrijca river terraces are considerably above the background.Total mercury in plants is influenced only to some degree by its contents in soils. Comparison of samples on terraces at the Temnikar farm shows that the contents in soil increase discontinuously from the third towards the first terrace. But in plants these differences are small, probably owing to the large part of mercury being contained in cinnabar that is inaccessible to plants. On the first river terrace (TEM3 locality) where soil contains about 55 times more Hg than on the second terrace, the average forage sample contains only 1.6 times and plantain sample 1.8 times higher Hg than the corresponding samples on the third terrace.
Market Orientation and Degree of Novelty
Mateja Bodlaj
Managing Global Transitions , 2011,
Abstract: This study aims to examine the relationship between a responsive and aproactive market orientation and the degree of novelty. Data obtainedvia an Internet survey were analysed using structural equation modelling.An analysis of 325 Slovenian firms reveals that only a proactivemarket orientation is positively related to the degree of novelty. Whilethere is no evidence of statistically significant differences in the examinedrelationships given the firm size and environmental characteristics,separate analyses in each group indicate that a proactive market orientationmay be more important for small firms and firms operatingamidst a higher level of technological turbulence. This study suggeststhat a distinction between a responsive and a proactive market orientationis important for a better understanding of the effect of a marketorientation on the degree of novelty.
Cardiac -adrenoceptor expression is markedly depressed in Ossabaw swine model of cardiometabolic risk
Dincer UD
International Journal of General Medicine , 2011, DOI: http://dx.doi.org/10.2147/IJGM.S18175
Abstract: rdiac -adrenoceptor expression is markedly depressed in Ossabaw swine model of cardiometabolic risk Original Research (2348) Total Article Views Authors: Dincer UD Published Date June 2011 Volume 2011:4 Pages 493 - 499 DOI: http://dx.doi.org/10.2147/IJGM.S18175 U Deniz Dincer Department of Pharmacology, Ufuk University School of Medicine, Ankara, Turkey Abstract: Ossabaw swine have a “thrifty genotype” and consumption of excess calories induces many classical components of the metabolic syndrome, including obesity, insulin resistance, impaired glucose tolerance, dyslipidemia, hyperleptinemia, and hypertension. Earlier studies indicate that the metabolic syndrome is associated with diminished cardiac function; however, to what degree this impairment is associated with alterations in myocardial 1- and 2-adrenoceptor (AR) expression has not been fully elucidated. Accordingly, the present study was designed to investigate the effects of the metabolic syndrome on cardiac 1- and 2-AR expression. Studies were conducted on left ventricular tissue samples obtained from control lean and chronically (50 weeks) high-fat-fed obese animals. Chronic feeding significantly increased fasting plasma insulin, total cholesterol, triglycerides, blood glucose, systolic and diastolic blood pressure, and heart rate. Real-time polymerase chain reaction revealed no significant alterations in cardiac 1- and 2-AR mRNA expression. In contrast, Western blot analysis revealed a significant decrease in ventricular 1- and 2-AR protein expression. This is the first report in a novel large animal model that induction of metabolic syndrome is accompanied by a significant reduction in cardiac 1- and 2-AR protein expression that could contribute to impaired cardiac function.
Cardiac ryanodine receptor in metabolic syndrome: is JTV519 (K201) future therapy?
Dincer UD
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy , 2012, DOI: http://dx.doi.org/10.2147/DMSO.S30005
Abstract: rdiac ryanodine receptor in metabolic syndrome: is JTV519 (K201) future therapy? Review (2704) Total Article Views Authors: Dincer UD Published Date April 2012 Volume 2012:5 Pages 89 - 99 DOI: http://dx.doi.org/10.2147/DMSO.S30005 Received: 17 January 2012 Accepted: 07 February 2012 Published: 05 April 2012 U Deniz Dincer Department of Pharmacology, Ufuk University School of Medicine. Mevlana Bulvari, Balgat, Ankara, Turkey Abstract: Metabolic syndrome is characterized by a combination of obesity, hypertension, insulin resistance, dyslipidemia, and impaired glucose tolerance. This multifaceted syndrome is often accompanied by a hyperdynamic circulatory state characterized by increased blood pressure, total blood volume, cardiac output, and metabolic tissue demand. Experimental, epidemiological, and clinical studies have demonstrated that patients with metabolic syndrome have significantly elevated cardiovascular morbidity and mortality rates. One of the main and frequent complications seen in metabolic syndrome is cardiovascular disease. The primary endpoints of cardiometabolic risk are coronary and peripheral arterial disease, myocardial infarction, congestive heart failure, arrhythmia, and stroke. Alterations in expression and/or functioning of several key proteins involved in regulating and maintaining ionic homeostasis can cause cardiac disturbances. One such group of proteins is known as ryanodine receptors (intracellular calcium release channels), which are the major channels through which Ca2+ ions leave the sarcoplasmic reticulum, leading to cardiac muscle contraction. The economic cost of metabolic syndrome and its associated complications has a significant effect on health care budgets. Improvements in body weight, blood lipid profile, and hyperglycemia can reduce cardiometabolic risk. However, constant hyperadrenergic stimulation still contributes to the burden of disease. Normalization of the hyperdynamic circulatory state with conventional therapies is the most reasonable therapeutic strategy to date. JTV519 (K201) is a newly developed 1,4-benzothiazepine drug with antiarrhythmic and cardioprotective properties. It appears to be very effective in not only preventing but also in reversing the characteristic myocardial changes and preventing lethal arrhythmias. It is also a unique candidate to improve diastolic heart failure in metabolic syndrome.
Cardiac ß-adrenoceptor expression is markedly depressed in Ossabaw swine model of cardiometabolic risk
Dincer UD
International Journal of General Medicine , 2011,
Abstract: U Deniz DincerDepartment of Pharmacology, Ufuk University School of Medicine, Ankara, TurkeyAbstract: Ossabaw swine have a “thrifty genotype” and consumption of excess calories induces many classical components of the metabolic syndrome, including obesity, insulin resistance, impaired glucose tolerance, dyslipidemia, hyperleptinemia, and hypertension. Earlier studies indicate that the metabolic syndrome is associated with diminished cardiac function; however, to what degree this impairment is associated with alterations in myocardial 1- and 2-adrenoceptor (AR) expression has not been fully elucidated. Accordingly, the present study was designed to investigate the effects of the metabolic syndrome on cardiac 1- and 2-AR expression. Studies were conducted on left ventricular tissue samples obtained from control lean and chronically (50 weeks) high-fat-fed obese animals. Chronic feeding significantly increased fasting plasma insulin, total cholesterol, triglycerides, blood glucose, systolic and diastolic blood pressure, and heart rate. Real-time polymerase chain reaction revealed no significant alterations in cardiac 1- and 2-AR mRNA expression. In contrast, Western blot analysis revealed a significant decrease in ventricular 1- and 2-AR protein expression. This is the first report in a novel large animal model that induction of metabolic syndrome is accompanied by a significant reduction in cardiac 1- and 2-AR protein expression that could contribute to impaired cardiac function.Keywords: hypertension, metabolic syndrome, -AR, impaired cardiac function
Earthquake sequences and seismicity of the Watsonville Region of Central California
A. UDìAS
Annals of Geophysics , 1969, DOI: 10.4401/ag-5085
Abstract: The Watsonville area designates here the region of Central California between the latitude 36°40' and 37°05' N and the longitudes 121°25' and 121°50' W. This area can be considered as a regional seismic unit. The seismic activity during the years 1960-1966 gives a background level of 2 or 3 earthquake of magnitude 2 < il/ ^ 3, per month, with periods of increased activity associated with the occurrence of larger shocks. The presence and nature of sequences of earthquakes in the area is investigated for the period 1952-1966. Three sequences in 1963 are studied in more detail. Tentatively the sequences of the area are grouped in three general types.
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