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Search Results: 1 - 10 of 3526 matches for " Massimo Cirillo "
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Clinical Research and prevention: fundamental elements of sustainable health care systems based on patients’ needs
Natale G. De Santo,Alessandra Alessandra F. Perna,Massimo Cirillo
Italian Journal of Public Health , 2011, DOI: 10.2427/5649
Abstract: Problems in health care systems are present on a planetary scale due to a discrepancy between scarce resources and vast needs. These are mainly generated by the aging of the population. Everywhere in the world, state health care agencies simply reduce the quantity and eventually the quality of available services. This approach is unacceptable, at least in Europe, where health care is a legal right, granted from birth to death. This paper departs from the poor support available nowadays for clinical research and the trivial investments on prevention, and hypothesizes a new approach based on clinical research and prevention which, in the long term, would generate a just, efficient, sustainable health care system stemming from patients’ needs. This is discussed from various viewpoints. It emerges that there is a need to switch the focus of health systems away from cures towards prevention and as well as a need for better translational research. It is of note that in France such a program based on clinical research and prevention was launched in 2008.
New Onset of Constipation during Long-Term Physical Inactivity: A Proof-of-Concept Study on the Immobility-Induced Bowel Changes
Paola Iovino, Giuseppe Chiarioni, Giancarlo Bilancio, Massimo Cirillo, Igor B. Mekjavic, Rado Pisot, Carolina Ciacci
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0072608
Abstract: Background The pathophysiological mechanisms underlining constipation are incompletely understood, but prolonged bed rest is commonly considered a relevant determinant. Aims Our primary aim was to study the effect of long-term physical inactivity on determining a new onset of constipation. Secondary aim were the evaluation of changes in stool frequency, bowel function and symptoms induced by this prolonged physical inactivity. Methods Ten healthy men underwent a 7-day run-in followed by 35-day study of experimentally-controlled bed rest. The study was sponsored by the Italian Space Agency. The onset of constipation was evaluated according to Rome III criteria for functional constipation. Abdominal bloating, flatulence, pain and urgency were assessed by a 100mm Visual Analog Scales and bowel function by adjectival scales (Bristol Stool Form Scale, ease of passage of stool and sense of incomplete evacuation). Daily measurements of bowel movements was summarized on a weekly score. Pre and post bed rest Quality of Life (SF-36), general health (Goldberg’s General Health) and depression mood (Zung scale) questionnaires were administered. Results New onset of functional constipation fulfilling Rome III criteria was found in 60% (6/10) of participants (p=0.03). The score of flatulence significantly increased whilst the stool frequency significantly decreased during the week-by-week comparisons period (repeated-measures ANOVA, p=0.02 and p=0.001, respectively). Stool consistency and bowel symptoms were not influenced by prolonged physical inactivity. In addition, no significant changes were observed in general health, in mood state and in quality of life at the end of bed rest Conclusions Our results provide evidence that prolonged physical inactivity is relevant etiology in functional constipation in healthy individuals. The common clinical suggestion of early mobilization in bedridden patients is supported as well.
A new surgical ventricular restoration technique to reset residual myocardium's fiber orientation: the "KISS" procedure
Marco Cirillo
Annals of Surgical Innovation and Research , 2009, DOI: 10.1186/1750-1164-3-6
Abstract: We set a new surgical procedure for endoventricular patch reconstruction technique with the aim to rebuild a physiologic shape and volume of the left ventricle caring about realignment of myocardial fibers orientation. Peculiarities of this reconstruction are the shape of the patch (reduction of minor axis compared with currently used oval-shaped patch) and the asymmetrical way of suturing it inside the ventricle.We present a detailed description of operative steps of this procedure, and we add some relevant surgical hints to clarify its peculiarities. Most of the patients operated on with this technique showed the original renewal of apical rotation and left ventricular torsion as specific index of the restoration of physiologic fiber orientation: we report an exemplary case of at-sight recovery of apical rotation in the operating room.This technique can represent a reproducible new way to realign myocardial fibers in a near-normal setting, improving the physiological restoration of ischemically injured left ventricle. It could be also the basis to reconsider surgical treatment for heart failure.Surgery for left ventricular anterior reconstruction in the setting of ischemic cardiomyopathy has a long history. It has evolved over the years from linear closure of large aneurysms to present geometric reconstruction by means of endoventricular patch [1-4]. Surgical and clinical outcome have extensively been revised in many retrospective studies, highlighting a variability in the results of this surgical treatment [5-10]. The internal border zone between normal and infarcted tissue was usually encircled by the Fontan purse-string, a running circular suture with the aim to approach residual walls and reduce the tissue gap to be closed by the patch. The original circular patch used in the reconstruction of the residual tissue gap has been replaced by an oval-shaped patch [11,12], able to assure a better ventricular shape and volume, which have been pointed out as two of th
Communication by unvoiced speech: the role of whispering
Cirillo, Jasmin;
Anais da Academia Brasileira de Ciências , 2004, DOI: 10.1590/S0001-37652004000200034
Abstract: most studies on whispering deal with its production and perception, neglecting its communicative role. i have focused on this, especially some social and psychobiological objectives. i have combined a general inquiry into the use of unvoiced speech with stimulus-response experiments on particular signal properties. (1) analyses of answers to queries revealed that judgments about whispering depend on the social contexts. in the private domain it plays a clearly positive role, but in the public domain it is more problematical. two causative factors were identified as relevant: (a) an 'ingroup' function of whispering which could induce negative 'outgroup' effects in co-listeners, and (b) a psychobiological component of whispering which could affect the auditory vigilance of co-listeners who were not addressed personally by the signaling, but often wanted to understand a whispered message. (2) analyses of experimental data confirmed the relevance of these factors. additionally, they showed that unvoiced speech has a limited transmission range, and is easily masked by background noise. taken together, the results suggest that whispering is explained best as a close-distance signal adapted for private use among partners.
Ager Falernus (southern Italy): interventions for preserving the Falciano lake
Cirillo C
Forest@ , 2006,
Abstract: Some interventions are described for the restoration of Falciano lake, Agro Falerno, Southern Italy, which is a site of interest for its naturalistic value and the persistence of important traces from Roman times.
Transport and mobility in protected areas
Cirillo C
Forest@ , 2006,
Abstract: Mobility is an essential feature of the social, economic and productive structure of any area, and become crucial for protected or high naturalistic value areas, where the transport system should have low environmental impact. Suitable tools aimed to avoid, reduce or counterbalance negative effects of transportation in protected areas are discussed.
Geografia íntima: um estudo dos documentos e arquivos nas artes visuais
Cirillo, José
Letras de Hoje , 2010,
Abstract: Os documentos e arquivos do processo de cria o trazem em si evidências da intera o da mente criadora: consigo mesma, com a matéria de sua constru o, com o ambiente e com o público, revelando uma cartografia íntima desse espa o que é a cria o nas Artes. Este trabalho tem por objetivo situar, sitiar e apresentar uma análise dos documentos de Shirley Paes Leme, materiais inestimáveis para a pesquisa genética sobre o processo de cria o nas Artes Visuais no Brasil. Entendidos como sítio de armazenamento, reflex es e experimenta es, esses documentos e arquivos de artista permitem a análise dos modos como o texto verbal e o texto visual fazem a media o entre o plano das ideias e o plano material de elabora o da obra. Juntas, imagens e palavras permitem compreender os procedimentos gerais da investiga o segundo um método próprio para os documentos de artistas, pautando-se na intera o de metodologias da crítica genética e da história da arte de modo investigativo, crítico e flexível o suficiente para que os aspectos da diversidade de cada artista, de cada processo, sejam respeitados.
Communication by unvoiced speech: the role of whispering
Cirillo Jasmin
Anais da Academia Brasileira de Ciências , 2004,
Abstract: Most studies on whispering deal with its production and perception, neglecting its communicative role. I have focused on this, especially some social and psychobiological objectives. I have combined a general inquiry into the use of unvoiced speech with stimulus-response experiments on particular signal properties. (1) Analyses of answers to queries revealed that judgments about whispering depend on the social contexts. In the private domain it plays a clearly positive role, but in the public domain it is more problematical. Two causative factors were identified as relevant: (a) an 'ingroup' function of whispering which could induce negative 'outgroup' effects in co-listeners, and (b) a psychobiological component of whispering which could affect the auditory vigilance of co-listeners who were not addressed personally by the signaling, but often wanted to understand a whispered message. (2) Analyses of experimental data confirmed the relevance of these factors. Additionally, they showed that unvoiced speech has a limited transmission range, and is easily masked by background noise. Taken together, the results suggest that whispering is explained best as a close-distance signal adapted for private use among partners.
Are your data really Pareto distributed?
Pasquale Cirillo
Quantitative Finance , 2013, DOI: 10.1016/j.physa.2013.07.061
Abstract: Pareto distributions, and power laws in general, have demonstrated to be very useful models to describe very different phenomena, from physics to finance. In recent years, the econophysical literature has proposed a large amount of papers and models justifying the presence of power laws in economic data. Most of the times, this Paretianity is inferred from the observation of some plots, such as the Zipf plot and the mean excess plot. If the Zipf plot looks almost linear, then everything is ok and the parameters of the Pareto distribution are estimated. Often with OLS. Unfortunately, as we show in this paper, these heuristic graphical tools are not reliable. To be more exact, we show that only a combination of plots can give some degree of confidence about the real presence of Paretianity in the data. We start by reviewing some of the most important plots, discussing their points of strength and weakness, and then we propose some additional tools that can be used to refine the analysis.
Psychiatry: Looking to the Future  [PDF]
Massimo Cocchi
Open Journal of Depression (OJD) , 2015, DOI: 10.4236/ojd.2015.44007
Abstract: The aim of this letter is to stimulate the psychiatrists to a greater awareness on the biomolecular aspects of the psychopathology. The letter highlights the inconsistencies of the DSM-V, where, and once again, it ignores the biological consistency of the “psychopathological” phenomenon. It is also underlined that the diagnostic error, in course of the first manifestation of a mood disorder, is extremely high, with all the risk that this error involves, as a result of an incorrect medication therapy.
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