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Search Results: 1 - 10 of 210699 matches for " Mason L. Yeh "
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Complement Inhibition Promotes Endogenous Neurogenesis and Sustained Anti-Inflammatory Neuroprotection following Reperfused Stroke
Andrew F. Ducruet, Brad E. Zacharia, Sergey A. Sosunov, Paul R. Gigante, Mason L. Yeh, Justin W. Gorski, Marc L. Otten, Richard Y. Hwang, Peter A. DeRosa, Zachary L. Hickman, Paulina Sergot, E. Sander Connolly
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0038664
Abstract: Background and Purpose The restoration of blood-flow following cerebral ischemia incites a series of deleterious cascades that exacerbate neuronal injury. Pharmacologic inhibition of the C3a-receptor ameliorates cerebral injury by attenuating post-ischemic inflammation. Recent reports also implicate C3a in the modulation of tissue repair, suggesting that complement may influence both injury and recovery at later post-ischemic time-points. Methods To evaluate the effect of C3a-receptor antagonism on post-ischemic neurogenesis and neurological outcome in the subacute period of stroke, transient focal cerebral ischemia was induced in adult male C57BL/6 mice treated with multiple regimens of a C3a receptor antagonist (C3aRA). Results Low-dose C3aRA administration during the acute phase of stroke promotes neuroblast proliferation in the subventricular zone at 7 days. Additionally, the C3a receptor is expressed on T-lymphocytes within the ischemic territory at 7 days, and this cellular infiltrate is abrogated by C3aRA administration. Finally, C3aRA treatment confers robust histologic and functional neuroprotection at this delayed time-point. Conclusions Targeted complement inhibition through low-dose antagonism of the C3a receptor promotes post-ischemic neuroblast proliferation in the SVZ. Furthermore, C3aRA administration suppresses T-lymphocyte infiltration and improves delayed functional and histologic outcome following reperfused stroke. Post-ischemic complement activation may be pharmacologically manipulated to yield an effective therapy for stroke.
Palaeolithic-Mesolithic Day Meeting, British Museum, 17th March 1995
Sarah L. R. Mason
Papers from the Institute of Archaeology , 1995, DOI: 10.5334/pia.71
Abstract:
Neolithic Studies Group Autumn Meeting: Domestic Settlement and the Landscape, British Museum, 14th November 1994
Sarah L. R. Mason
Papers from the Institute of Archaeology , 1995, DOI: 10.5334/pia.75
Abstract:
AT THE INTERSECTION OF ECONOMICS AND CULTURE: THE THRIFT INDUSTRY AND PROGRESSIVE ERA SOCIAL REFORM
David L. Mason
Essays in Economic & Business History , 2000,
Abstract: Although America’s thrift industry originated in 1831, it did not truly grow until the 1880s when the country was entering the Second Industrial Revolution. By then thrifts were becoming an important source of home finance for the urban working class, who were attracted to it by promoters who emphasized the practical benefits of home ownership. These same industry promoters, however, also gained the support of Progressive Era elites by positioning the industry as a solution to urban problems created by industrialization. The success of these efforts is seen quantitatively in terms of industry growth, and qualitatively in the diversity of support in terms of race, gender and ethnicity.
Global anti-self-dual Yang-Mills fields in split signature and their scattering
L. J. Mason
Physics , 2005,
Abstract: We consider solutions to the anti-self-dual Yang Mills (ASDYM) equations in split signature that are global on the double cover of the appropriate conformally compactified Minkowski space $\widetilde\M$. Ward's ASDYM twistor construction is adapted to this geometry by using a correspondence between points of $\widetilde\M$ and holomorphic discs in $\CP^3$, twistor space, with boundary on the real slice $\RP^3$. A 1-1 correspondence is obtained between smooth global $\U(n)$ solutions to the ASDYM equations on $\widetilde\M$ and pairs consisting of an arbitrary holomorphic vector bundle $E$ over $\CP^3$ together with a smooth positive definite hermitian metric $H$ on $E|_{\RP^3}$. There are no topological or other restrictions on the bundle $E$. The description generalises the result of the scattering transform for 1+1 dimensional integrable systems in which solutions are encoded into a combination of algebraic data, here $E$, and a reflection coefficient, here $H:\RP^3\to E\otimes\bar E$. For trivial $E$, the twistor data consists of the smooth Hermitian matrix function $H$ on $\RP^3$ up to constants; the correspondence then provides a nonlinear generalisation of the X-ray transform. Explicit examples are given with different topologies of $E$. A scattering problem for ASDYM fields in split signature is set up and it is shown that sufficiently small data at past infinity uniquely determines data at future infinity by taking a family of holonomies followed by a sequence of two Birkhoff factorizations. The scattering map is simple on the holonomies, but non-trivial at the level of the connection in the non-abelian case.
Twistor actions for non-self-dual fields; a new foundation for twistor-string theory
L. J. Mason
Mathematics , 2005, DOI: 10.1088/1126-6708/2005/10/009
Abstract: Twistor space constructions and actions are given for full Yang-Mills and conformal gravity using almost complex structures that are not, in general, integrable. These are used as the basis of a derivation of the twistor-string generating functionals for tree level perturbative scattering amplitudes of Yang-Mills and conformal gravity. The derivation follows by expanding and resumming the classical approximation to the path integral obtained from the twistor action. It provides a basis for exploring whether the equivalence can be made to extend beyond tree level and allows one to disentangle conformal supergravity modes from the Yang-Mills modes.
Discussion of a Failure Hot-Spot Endurance Testing Case for CIGS Thin-Film Photovoltaic Module  [PDF]
Azen Y. Liu, S. L. Lai, Jimmy Yeh
Energy and Power Engineering (EPE) , 2013, DOI: 10.4236/epe.2013.54B036
Abstract: This paper describes the use of steady-state solar simulator for CIGS thin-film photovoltaic module hot-spot endurance test. In the study, not only are test procedures of hot-spot endurance test in IEC 61646 discussed, but also how to evaluate the performance of steady-state solar simulator by IEC 60904-9 is presented. Three CIGS thin-film PV modules with the same types are used for hot-spot endurance test in case study. It is found that some of the cell damages and visual defects on tested PV modules are clearly observed.
Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparum
Ellen Yeh,Joseph L. DeRisi
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.1001138
Abstract: Plasmodium spp parasites harbor an unusual plastid organelle called the apicoplast. Due to its prokaryotic origin and essential function, the apicoplast is a key target for development of new anti-malarials. Over 500 proteins are predicted to localize to this organelle and several prokaryotic biochemical pathways have been annotated, yet the essential role of the apicoplast during human infection remains a mystery. Previous work showed that treatment with fosmidomycin, an inhibitor of non-mevalonate isoprenoid precursor biosynthesis in the apicoplast, inhibits the growth of blood-stage P. falciparum. Herein, we demonstrate that fosmidomycin inhibition can be chemically rescued by supplementation with isopentenyl pyrophosphate (IPP), the pathway product. Surprisingly, IPP supplementation also completely reverses death following treatment with antibiotics that cause loss of the apicoplast. We show that antibiotic-treated parasites rescued with IPP over multiple cycles specifically lose their apicoplast genome and fail to process or localize organelle proteins, rendering them functionally apicoplast-minus. Despite the loss of this essential organelle, these apicoplast-minus auxotrophs can be grown indefinitely in asexual blood stage culture but are entirely dependent on exogenous IPP for survival. These findings indicate that isoprenoid precursor biosynthesis is the only essential function of the apicoplast during blood-stage growth. Moreover, apicoplast-minus P. falciparum strains will be a powerful tool for further investigation of apicoplast biology as well as drug and vaccine development.
Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparum
Ellen Yeh ,Joseph L. DeRisi
PLOS Biology , 2011, DOI: 10.1371/journal.pbio.1001138
Abstract: Plasmodium spp parasites harbor an unusual plastid organelle called the apicoplast. Due to its prokaryotic origin and essential function, the apicoplast is a key target for development of new anti-malarials. Over 500 proteins are predicted to localize to this organelle and several prokaryotic biochemical pathways have been annotated, yet the essential role of the apicoplast during human infection remains a mystery. Previous work showed that treatment with fosmidomycin, an inhibitor of non-mevalonate isoprenoid precursor biosynthesis in the apicoplast, inhibits the growth of blood-stage P. falciparum. Herein, we demonstrate that fosmidomycin inhibition can be chemically rescued by supplementation with isopentenyl pyrophosphate (IPP), the pathway product. Surprisingly, IPP supplementation also completely reverses death following treatment with antibiotics that cause loss of the apicoplast. We show that antibiotic-treated parasites rescued with IPP over multiple cycles specifically lose their apicoplast genome and fail to process or localize organelle proteins, rendering them functionally apicoplast-minus. Despite the loss of this essential organelle, these apicoplast-minus auxotrophs can be grown indefinitely in asexual blood stage culture but are entirely dependent on exogenous IPP for survival. These findings indicate that isoprenoid precursor biosynthesis is the only essential function of the apicoplast during blood-stage growth. Moreover, apicoplast-minus P. falciparum strains will be a powerful tool for further investigation of apicoplast biology as well as drug and vaccine development.
OnTectonicHistoryinRegionsEastoftheTibetanPlateaufromKansutoYunnan
L.T.YEH
地质学报 , 1944,
Abstract: With2PlatesDuringtherecentfiveyearsIhavejoinedseveralfieldpartiesinthecarryingoutofgeologicalreconnaissancesinregionsbetweenthevalleyoftheHuanghoandoftheYangtzeandintheSino-Tibetanborderland.Thisvastterritorycanbedividedintosixmajorgeologicalunits,e
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