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Search Results: 1 - 10 of 67 matches for " Masazumi Tsuneyoshi "
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Mutation analysis of the Gadd45 gene at exon 4 in atypical fibroxanthoma
Akio Sakamoto, Shizuka Akieda, Yoshinao Oda, Yukihide Iwamoto, Masazumi Tsuneyoshi
BMC Dermatology , 2009, DOI: 10.1186/1471-5945-9-1
Abstract: Immunohistochemical expression of Bax was analyzed in 7 cases of AFX, and in 7 cases of benign fibrous histiocytoma (BFH) used as a comparison. The expression pattern of Bax was compared to previously reported p53 and Gadd45 expressions in a correspondent series. Mutation of the Gadd45 gene at exon 4 was also analyzed in AFX.AFX and BFH showed immunoreactivities respectively for Bax (3/7, 0/7), Gadd45 (4/7, 1/7) and p53 (2/7, 0/7). There was no exact correlation between p53 expression and Bax or Gadd45 expression. However, the pattern of expression between Bax and Gadd45 was also the same, with the exception of one case. No mutation of the Gadd45 gene at exon 4 was observed in a series of 6 AFX cases where DNA was available (0/6).These results suggest a possible association between Bax and Gadd45 in AFX, and may refute any possibility of dysfunction of Gadd45 in terms of gene mutation, at least at exon 4 of the Gadd45 gene.Atypical fibroxanthoma (AFX) is a nodular ulcerative lesion arising from the sun-exposed skin of the head and neck, typically in the elderly [1,2]. Solar elastosis associated with UV-radiation has been commonly observed in AFX cases [3]. Association between AFX and ultraviolet (UV) radiation has been suspected. On the other hand, in its less common forms with weakened association with UV, AFX occurs on the extremities and the trunk [1,2]. AFX is composed of spindle, plump, epithelioid and bizarre cells, in various proportions, arranged in haphazard, vaguely fascicular or storiform patterns. These histological features of AFX mimic those of high-grade sarcoma, such as malignant fibrous histiocytoma or leiomyosarcoma [2,4], which occurs deep within soft tissue.The tumor-suppressor protein p53 is a transcriptional activator which is involved in cell-cycle control, DNA repair, apoptosis and chromosome/genome instability. UV-induced p53 gene mutations occurring at dipyrimidine sites have been demonstrated in AFX, suggesting a central role for UV radiat
Dedifferentiated chondrosarcoma with leukocytosis and elevation of serum G-CSF. A case report
Akio Sakamoto, Hidetaka Yamamoto, Kazuhiro Tanaka, Shuichi Matsuda, Katsumi Harimaya, Yoshinao Oda, Masazumi Tsuneyoshi, Yukihide Iwamoto
World Journal of Surgical Oncology , 2006, DOI: 10.1186/1477-7819-4-37
Abstract: We report the case of a 72-year-old man with dedifferentiated chondrosarcoma characterized by dedifferentiated components of malignant fibrous histiocytoma- or osteosarcoma-like features in addition to conventional chondrosarcoma, arising from his pelvic bone. After hemipelvectomy, when local recurrence and metastasis were identified, leukocytosis appeared and an elevated level of serum granulocyte-colony-stimulating factor (G-CSF) was also recognized. The patient died of multiple organ failure 2 months after surgery. Autopsy specimens showed that the histological specimens of the recurrence and metastasis were dedifferentiated components, without any conventional chondrosarcoma components. G-CSF was expressed only in the dedifferentiated components, not in the chondrosarcoma components, immunohistochemically.This is the first report of chondrosarcoma, or any other primary bone tumor, with leukocytosis, probably stimulated by tumor-produced G-CSF from the dedifferentiated components.Granulocyte-colony stimulating factor (G-CSF) enhances differentiation along the neutrophil lineage, and accelerates maturation of metamyelocytes into mature neutrophils. G-CSF also prolongs the survival of neutrophils and their precursors, including stem cells[1]. Consequently, G-CSF is known to function as a hematopoietic growth factor and it is known to be responsible for leukocytosis. Normally, the serum G-CSF level is very low [2]. Production of granulocyte colony-stimulating factor (G-CSF) by tumor cells was first identified in lung carcinoma in 1977 [3]. G-CSF-producing tumors associated with leukocytosis include various types of malignancies, including lung caner [4,5], colon cancer [4], stomach cancer [4], thyroid caner [6], cervical cancer [7], malignant fibrous histiocytoma of soft tissue [8].Dedifferentiated chondrosarcoma accounts for approximately 10% of all chondrosarcomas [9]. Dedifferentiated chondrosarcoma shows both a rapid growth rate and metastatic spread, and it has
Osteoconductivity Control Based on the Chemical Properties of the Implant Surface  [PDF]
Kensuke Kuroda, Masazumi Okido
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2018, DOI: 10.4236/jbnb.2018.91003
Abstract: Metallic materials, such as Ti, Zr, Nb, Ta, and their alloys, and also stainless steels are widely attractive as osteoconductive materials in the dental and orthopedic fields. Ceramics and polymers are also commonly used as biomaterials. However, they do not have high osteoconductivity in their pure form, and surface coatings with bioactive substances, such as hydroxyapatite or TiO2, are needed before implantation into the bone. Many reports claim that the surface chemical properties of implants, in particular, hydrophilicity and hydrophobicity, strongly affect the biological reactions. However, the effect of surface properties on osteoconductivity is not clear. In this review, we focus on the relationship between the surface hydrophilicity of metallic implants and osteoconductivity using in vivo evaluation, and the control of the osteoconductivity is discussed from the viewpoint of protein adsorption in implants.
Direct derivation of "mirror" ABJ partition function
Masazumi Honda
Physics , 2013, DOI: 10.1007/JHEP12(2013)046
Abstract: We study the partition function of the three-dimensional N=6 U(N)_k x U(N+M)_{-k} superconformal Chern-Simons matter theory known as the ABJ theory. We prove that the ABJ partition function on S^3 is exactly the same as a formula recently proposed by Awata, Hirano and Shigemori. While this formula was previously obtained by an analytic continuation from the L(2,1) lens space matrix model, we directly derive this by using a generalization of the Cauchy determinant identity. We also give an interpretation for the formula from brane picture.
On Perturbation theory improved by Strong coupling expansion
Masazumi Honda
Physics , 2014, DOI: 10.1007/JHEP12(2014)019
Abstract: In theoretical physics, we sometimes have two perturbative expansions of physical quantity around different two points in parameter space. In terms of the two perturbative expansions, we introduce a new type of smooth interpolating function consistent with the both expansions, which includes the standard Pad\'e approximant and fractional power of polynomial method constructed by Sen as special cases. We point out that we can construct enormous number of such interpolating functions in principle while the "best" approximation for the exact answer of the physical quantity should be unique among the interpolating functions. We propose a criterion to determine the "best" interpolating function, which is applicable except some situations even if we do not know the exact answer. It turns out that our criterion works for various examples including specific heat in two-dimensional Ising model, average plaquette in four-dimensional SU(3) pure Yang-Mills theory on lattice and free energy in c=1 string theory at self-dual radius. We also mention possible applications of the interpolating functions to system with phase transition.
Orienting coupled quantum rotors by ultrashort laser pulses
Hiroyuki Shima,Tsuneyoshi Nakayama
Physics , 2004, DOI: 10.1103/PhysRevA.70.013401
Abstract: We point out that the non-adiabatic orientation of quantum rotors, produced by ultrashort laser pulses, is remarkably enhanced by introducing dipolar interaction between the rotors. This enhanced orientation of quantum rotors is in contrast with the behavior of classical paired rotors, in which dipolar interactions prevent the orientation of the rotors. We demonstrate also that a specially designed sequence of pulses can most efficiently enhances the orientation of quantum paired rotors.
Interacting Dipoles in Type-I Clathrates: Why Glass-like though Crystal?
Tsuneyoshi Nakayama,Eiji Kaneshita
Physics , 2008, DOI: 10.1209/0295-5075/84/66001
Abstract: Almost identical thermal properties of type-I clathrate compounds to those of glasses follow naturally from the consideration that off-centered guest ions possess electric dipole moments. Local fields from neighbor dipoles create many potential minima in the configuration space. A theoretical analysis based on two-level tunneling states demonstrates that interacting dipoles are a key to quantitatively explain the glass-like behaviors of low-temperature thermal properties of type-I clathrate compounds with off-centered guest ions.From this analysis, we predict the existence of a glass transition.
Glass-like Thermal-Transport in Symmetry-Broken Clathrates
Eiji Kaneshita,Tsuneyoshi Nakayama
Physics , 2009, DOI: 10.1209/0295-5075/86/56004
Abstract: We present the quantitative interpretation for the glass-like behavior of thermal conductivities $\kappa(T)$ for type-I clathrate compounds involving off-centered guest ions. It is shown that the dipole-dipole interaction generated in cage/guest-ion systems is crucial to reproduce the characteristics of thermal conductivities for these symmetry-broken clathrates. The above scenario also explains well the difference of $\kappa(T)$ between the $p$-type and the $n$-type $\beta$-BGS found recently by K. Suekuni et al. [Phys. Rev. B, 77 (2008) 235119.]
Dielectric anomaly in coupled rotor systems
Hiroyuki Shima,Tsuneyoshi Nakayama
Physics , 2004, DOI: 10.1103/PhysRevB.69.035202
Abstract: The correlated dynamics of coupled quantum rotors carrying electric dipole moment is theoretically investigated. The energy spectra of coupled rotors as a function of dipolar interaction energy is analytically solved. The calculated dielectric susceptibilities of the system show the peculiar temperature dependence different from that of isolated rotors.
Significance of Off-Center Rattling for Emerging Low-lying THz Modes in type-I Clathrates
Tsuneyoshi Nakayama,Eiji Kaneshita
Physics , 2011, DOI: 10.1143/JPSJ.80.104604
Abstract: We show that the distinct differences of low-lying THz-frequency dynamics between type-I clathrates with on-center and off-center guest ions naturally follow from a theoretical model taking into account essential features of the dynamics of rattling guest ions. Our model analysis demonstrates the drastic change from the conventional dynamics shown by on-center systems to the peculiar dynamics of off-center systems in a unified manner. We claim that glass-like plateau thermal conductivities observed for off-center systems stem from the flattening of acoustic phonon dispersion in the regime |k|<|G|/4. The mechanism is applicable to other systems such as glasses or relaxers.
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