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Search Results: 1 - 10 of 216 matches for " Masazumi Nishimoto "
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Striking Similarity in the Gene Expression Levels of Individual Myc Module Members among ESCs, EpiSCs, and Partial iPSCs
Masataka Hirasaki, Keiko Hiraki-Kamon, Masayoshi Kamon, Ayumu Suzuki, Miyuki Katano, Masazumi Nishimoto, Akihiko Okuda
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0083769
Abstract: Predominant transcriptional subnetworks called Core, Myc, and PRC modules have been shown to participate in preservation of the pluripotency and self-renewality of embryonic stem cells (ESCs). Epiblast stem cells (EpiSCs) are another cell type that possesses pluripotency and self-renewality. However, the roles of these modules in EpiSCs have not been systematically examined to date. Here, we compared the average expression levels of Core, Myc, and PRC module genes between ESCs and EpiSCs. EpiSCs showed substantially higher and lower expression levels of PRC and Core module genes, respectively, compared with those in ESCs, while Myc module members showed almost equivalent levels of average gene expression. Subsequent analyses revealed that the similarity in gene expression levels of the Myc module between these two cell types was not just overall, but striking similarities were evident even when comparing the expression of individual genes. We also observed equivalent levels of similarity in the expression of individual Myc module genes between induced pluripotent stem cells (iPSCs) and partial iPSCs that are an unwanted byproduct generated during iPSC induction. Moreover, our data demonstrate that partial iPSCs depend on a high level of c-Myc expression for their self-renewal properties.
Osteoconductivity Control Based on the Chemical Properties of the Implant Surface  [PDF]
Kensuke Kuroda, Masazumi Okido
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2018, DOI: 10.4236/jbnb.2018.91003
Abstract: Metallic materials, such as Ti, Zr, Nb, Ta, and their alloys, and also stainless steels are widely attractive as osteoconductive materials in the dental and orthopedic fields. Ceramics and polymers are also commonly used as biomaterials. However, they do not have high osteoconductivity in their pure form, and surface coatings with bioactive substances, such as hydroxyapatite or TiO2, are needed before implantation into the bone. Many reports claim that the surface chemical properties of implants, in particular, hydrophilicity and hydrophobicity, strongly affect the biological reactions. However, the effect of surface properties on osteoconductivity is not clear. In this review, we focus on the relationship between the surface hydrophilicity of metallic implants and osteoconductivity using in vivo evaluation, and the control of the osteoconductivity is discussed from the viewpoint of protein adsorption in implants.
Direct derivation of "mirror" ABJ partition function
Masazumi Honda
Physics , 2013, DOI: 10.1007/JHEP12(2013)046
Abstract: We study the partition function of the three-dimensional N=6 U(N)_k x U(N+M)_{-k} superconformal Chern-Simons matter theory known as the ABJ theory. We prove that the ABJ partition function on S^3 is exactly the same as a formula recently proposed by Awata, Hirano and Shigemori. While this formula was previously obtained by an analytic continuation from the L(2,1) lens space matrix model, we directly derive this by using a generalization of the Cauchy determinant identity. We also give an interpretation for the formula from brane picture.
On Perturbation theory improved by Strong coupling expansion
Masazumi Honda
Physics , 2014, DOI: 10.1007/JHEP12(2014)019
Abstract: In theoretical physics, we sometimes have two perturbative expansions of physical quantity around different two points in parameter space. In terms of the two perturbative expansions, we introduce a new type of smooth interpolating function consistent with the both expansions, which includes the standard Pad\'e approximant and fractional power of polynomial method constructed by Sen as special cases. We point out that we can construct enormous number of such interpolating functions in principle while the "best" approximation for the exact answer of the physical quantity should be unique among the interpolating functions. We propose a criterion to determine the "best" interpolating function, which is applicable except some situations even if we do not know the exact answer. It turns out that our criterion works for various examples including specific heat in two-dimensional Ising model, average plaquette in four-dimensional SU(3) pure Yang-Mills theory on lattice and free energy in c=1 string theory at self-dual radius. We also mention possible applications of the interpolating functions to system with phase transition.
The Process of Support by Nursing Professionals for Families Having a Member with Borderline Personality Disorder  [PDF]
Yasuyo Nishimoto, Naohiro Hohashi
Open Journal of Nursing (OJN) , 2016, DOI: 10.4236/ojn.2016.61003
Abstract: The purpose of this study was to explore the process of family support provided by nurses to families with a borderline personality disorder (BPD) patient. Semi-structured interviews were conducted with 16 nurses who had provided care to BPD patients. Data obtained from the interviews were qualitatively analyzed using a modified grounded theory approach. As an overall core category of family support processes practiced by nurses for families with BPD patients, family support practiced without awareness that the nurses were supporting families was extracted. Through this process, nurses held perceptions that were premises for family support, which were formed through their individual nursing experiences and perspectives. Nurses also had diverse perceptions concerning the image of families. Through the integration of perceptions that were premises for family support and perceptions of an image of the family, nurses underwent a process of “determination and ambivalence about the need for family support.” Then, nurses provided “family support practice” when they acknowledged the need for family support. During the “family support practice,” nurses had difficulties in providing family support. When family support was not successfully provided, nurses provided “family support practice with seeking more effective ways through trial and error.” For cases in which nurses did not acknowledge the need for intervention, they intentionally chose “not to provide family support.” Furthermore, during the “family support practice,” nurses had contradictory perspectives of family support. Such family support processes ultimately led to an awareness of the same family support required for the future. Family support was provided with “family support practice” and “family support practice with seeking more effective ways through trial and error.” In some cases, however, the process ended in “not to provide family support intentionally.” Experiences and perspectives in providing family support are important factors in carrying out future family support. Developing the positive implications of these factors and reducing psychological strain on nurses may ensure smooth implementation of family support. Thus, nurses need to recognize that they are supporting the family, which is identified as a core category.
Hydroxyapatite Coating of Titanium Implants Using Hydroprocessing and Evaluation of Their Osteoconductivity
Kensuke Kuroda,Masazumi Okido
Bioinorganic Chemistry and Applications , 2012, DOI: 10.1155/2012/730693
Abstract: Many techniques for the surface modification of titanium and its alloys have been proposed from the viewpoint of improving bioactivity. This paper contains an overview of surface treatment methods, including coating with hydroxyapatite (HAp), an osteoconductive compound. There are two types of coating methods: pyroprocessing and hydroprocessing. In this paper, hydroprocessing for coating on the titanium substrate with HAp, carbonate apatite (CO3–Ap), a CO3–Ap/CaCO3 composite, HAp/collagen, and a HAp/gelatin composite is outlined. Moreover, evaluation by implantation of surface-modified samples in rat tibiae is described. 1. Introduction Titanium (Ti) and its alloys are used as artificial joints and teeth roots in orthopedic and dental settings because they have the advantage that their mechanical properties are closer to those of bone than are those of stainless steel or cobalt-chromium alloys. However, the difference in mechanical properties between Ti and natural bone leads to negative effects, such as stress shielding. To mitigate these effects, many new Ti alloys have been developed for hard tissue implants, with a focus on controlling the alloy element and its content, phase, and other characteristics. When implants do not undergo surface modification to enhance the osteoconductivity, it takes a relatively long time to fix the metallic implant to bone such that it is stable. There are many approaches for improving the osteoconductivity of Ti and its alloys. These approaches can be classified into the following two techniques: (1) bioactive compounds that accelerate bone formation are coated on metallic implants and (2) a rough surface at the macrolevel is formed on the metallic implants, and the ingrowth of bone results in anchorage of the implants. These techniques have achieved a certain level of success, and the surface-modified implants have been used clinically. However, there are still weaknesses with the coating that need resolution, as well as unclear points regarding the effect of the surface properties on the osteoconductivity. Since hydroprocessing can be used to prepare the coating on complex-shaped substrates with complex topography, which many implants have, we focus on the use of hydroprocessing in many techniques for coating the bioactive compound, especially hydroxyapatite (HAp), and expound on the characteristics of the techniques and issues. Moreover, we describe in detail the evaluation of the osteoconductivity of implants coated with HAp, using in vivo testing in rat tibiae. 2. HAp Coating HAp (Ca10(PO4)6(OH)2), which is the
Localization and Large N reduction on S^3 for the Planar and M-theory limit
Masazumi Honda,Yutaka Yoshida
Physics , 2012, DOI: 10.1016/j.nuclphysb.2012.07.022
Abstract: We show a large N reduction on S^3 in a BPS sector for a broad class of theories : N>=2 supersymmetric Chern-Simons theory with any number of adjoint and bi-fundamental chiral multiplets.We show that a localization method can be applied to the reduced model and the path integral can be written by a multi-contour integral. By taking a particular localization configuration, we also show that the large N equivalence between the original theory on S^3 and the reduced model holds for the free energy and the expectation value of BPS Wilson loops. It turns out that the large N reduction on S^3 holds also for the M-theory limit.
Generalization of Rashmi-Shah-Kumar Minimum-Storage-Regenerating Codes
Masazumi Kurihara,Hidenori Kuwakado
Computer Science , 2013,
Abstract: In this paper, we propose a generalized version of the Rashmi-Shah-Kumar Minimum-Storage-Regenerating(RSK-MSR) codes based on the product-matrix framework. For any $(n,k,d)$ such that $d \geq 2k-2$ and $d \leq n-1$, we can directly construct an $(n,k,d)$ MSR code without constructing a larger MSR code and shortening of the larger MSR code. As a result, the size of a finite field over which the proposed code is defined is smaller than or equal to the size of a finite field over which the RSK-MSR code is defined. In addition, the $\{\ell,\ell'\}$ secure codes based on the generalized RSK-MSR codes can be obtained by applying the construction method of $\{\ell,\ell'\}$ secure codes proposed by Shah, Rashmi and Kumar. Furthermore, the message matrix of the $(n,k,d)$ generalized RSK-MSR code is derived from that of the RSK-MSR code by using the construction method of the $\{\ell=k,\ell'=0\}$ secure code.
Tomonaga-Luttinger-liquid criticality: numerical entanglement entropy approach
Satoshi Nishimoto
Physics , 2011, DOI: 10.1103/PhysRevB.84.195108
Abstract: The von Neumann entanglement entropy is studied with the density-matrix renormalization group technique. We propose a simple approach to calculate the central charge using the entanglement entropy for one-dimensional (1D) quantum system. This approach is applied to a couple of quantum systems: (i) 1D frustrated spin model and (ii) 1D half-filled spinless fermions with nearest-neighbor repulsion; and, it is confirmed that the central charge is estimated very accurately for the both systems. Also, a new method to determine the critical point between TL-liquid and gapped (or ordered) phases from the proposed approach is suggested. Furthermore, we mention that the Tomonaga-Luttinger parameter can be obtained in a like manner as the central charge, using the charge-density fluctuation of a part of the 1D system.
On the linear independence of the special values of a Dirichlet series with periodic coefficients
Masaki Nishimoto
Mathematics , 2011,
Abstract: A lower bound for the dimension of the $\Q$-vector space spanned by special values of a Dirichlet series with periodic coefficients is given. As a corollary, it is deduced that both special values at even integers and at odd integers contain infinitely many irrational numbers. This result is proved by T.Rivoal if the function considered is the Riemann zeta function, and this paper gives its generalization to more general Dirichlet series.
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