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Search Results: 1 - 10 of 1581 matches for " Masayuki Kohno "
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Intermittent Fasting Ameliorates Delayed-Type Hypersensitivity in NC/Nga Mice  [PDF]
Hirao Kohno, Katsuyasu Kouda, Hiroyasu Ishihara, Nobuhiro Nishio, Yutaka Sasaki, Harunobu Nakamura, Masayuki Iki, Yoshiaki Sonoda
Food and Nutrition Sciences (FNS) , 2011, DOI: 10.4236/fns.2011.24041
Abstract: It is well documented that dietary restriction can prevent many different diseases and extend the life spans of different rodent species. In the previous study, we reported that intermittent fasting (IF) as well as moderate dietary restriction ameliorated the allergic dermatitis in ICR mice. In the present study, we demonstrated the ameliorative effects of IF on allergic dermatitis in NC/Nga mice, a strain known as a model for atopic dermatitis. Interestingly, the total number of CD4+CD8+ double positive thymocyte in mice after IF significantly decreased in comparison to that in mice fed ad libitum. Although it was reported that an immunosuppressive compound inhibited the contact allergic response by inducing the CD4+CD25+ regulatory T-cells, IF did not affect regulatory T cells in the present study. These results suggested that CD4+CD8+ double positive thymocytes play an important role in the regulation of allergy by IF in NC/Nga mice.
Low-temperature properties of the spin-1 antiferromagnetic Heisenberg chain with bond-alternation
Masanori Kohno,Minoru Takahashi,Masayuki Hagiwara
Physics , 1997, DOI: 10.1103/PhysRevB.57.1046
Abstract: We investigate the low-temperature properties of the spin-1 antiferromagnetic Heisenberg chain with bond-alternation by the quantum Monte Carlo method (loop algorithm). The strength of bond-alternation at the gapless point is estimated as $\delta_{c}=0.2595\pm0.0005$. We confirm numerically that the low-temperature properties at the gapless point are consistent with field theoretical predictions. The numerical results are compared with those of the spin-1/2 antiferromagnetic Heisenberg chain and recent experimental results for [\{Ni(333-tet)($\mu$-N$_3$)\}$_n$](ClO$_4$)$_n$ (333-tet=tetraamine $N,N^{\prime}$-bis(3-aminopropyl)-1,3-propanediamine).
Shear viscosity to relaxation time ratio in SU(3) lattice gauge theory
Yasuhiro Kohno,Masayuki Asakawa,Masakiyo Kitazawa
Physics , 2011,
Abstract: We evaluate the ratio of the shear viscosity to the relaxation time of the shear flux above but near the critical temperature $T_c$ in SU(3) gauge theory on the lattice. The ratio is related to Kubo's canonical correlation of the energy-momentum tensor in Euclidean space with the relaxation time approximation and an appropriate regularization. Using this relation, the ratio is evaluated by direct measurements of the Euclidean observables on the lattice. We obtained the ratio with reasonable statistics for the range of temperature $1.3T_c \lesssim T \lesssim 4T_c$. We also found that the characteristic speed of the transverse plane wave in gluon media is almost constant, $v \simeq 0.5$, for $T \gtrsim 1.5T_c$, which is compatible with the causality in the second order dissipative hydrodynamics.
A novel transferrin receptor-targeted hybrid peptide disintegrates cancer cell membrane to induce rapid killing of cancer cells
Megumi Kawamoto, Tomohisa Horibe, Masayuki Kohno, Koji Kawakami
BMC Cancer , 2011, DOI: 10.1186/1471-2407-11-359
Abstract: In vitro: We assessed the cytotoxicity of TfR-lytic hybrid peptide for 12 cancer and 2 normal cell lines. The specificity for TfR is demonstrated by competitive assay using TfR antibody and siRNA. In addition, we performed analysis of confocal fluorescence microscopy and apoptosis assay by Annexin-V binding, caspase activity, and JC-1 staining to assess the change in mitochondria membrane potential. In vivo: TfR-lytic was administered intravenously in an athymic mice model with MDA-MB-231 cells. After three weeks tumor sections were histologically analyzed.The TfR-lytic hybrid peptide showed cytotoxic activity in 12 cancer cell lines, with IC50 values as low as 4.0-9.3 μM. Normal cells were less sensitive to this molecule, with IC50 values > 50 μM. Competition assay using TfR antibody and knockdown of this receptor by siRNA confirmed the specificity of the TfR-lytic hybrid peptide. In addition, it was revealed that this molecule can disintegrate the cell membrane of T47D cancer cells just in 10 min, to effectively kill these cells and induce approximately 80% apoptotic cell death but not in normal cells. The intravenous administration of TfR-lytic peptide in the athymic mice model significantly inhibited tumor progression.TfR-lytic peptide might provide a potent and selective anticancer therapy for patients.The transferrin receptor (TfR) is a cell-membrane-associated glycoprotein involved in the cellular uptake of iron and the regulation of cell growth [1]. Iron is a required cofactor of heme and nonheme proteins involved in a variety of cellular processes including metabolism and DNA synthesis [2,3]. Therefore, various studies have shown elevated levels of TfR expression on cancer cells when compared with their normal counterparts [4-13]. Bladder-transitional cell carcinomas, breast cancer, glioma, lung adenocarcinoma, chronic lymphocytic leukemia, and non-Hodgkin's lymphoma also showed increased TfR expression that correlated with tumor grade and stage or prognosi
Designed hybrid TPR peptide targeting Hsp90 as a novel anticancer agent
Tomohisa Horibe, Masayuki Kohno, Mari Haramoto, Koji Ohara, Koji Kawakami
Journal of Translational Medicine , 2011, DOI: 10.1186/1479-5876-9-8
Abstract: We focused on the interaction of Hsp90 with its cofactor protein p60/Hop, and engineered a cell-permeable peptidomimetic, termed "hybrid Antp-TPR peptide", modeled on the binding interface between the molecular chaperone Hsp90 and the TPR2A domain of Hop.It was demonstrated that this designed hybrid Antp-TPR peptide inhibited the interaction of Hsp90 with the TPR2A domain, inducing cell death of breast, pancreatic, renal, lung, prostate, and gastric cancer cell lines in vitro. In contrast, Antp-TPR peptide did not affect the viability of normal cells. Moreover, analysis in vivo revealed that Antp-TPR peptide displayed a significant antitumor activity in a xenograft model of human pancreatic cancer in mice.These results indicate that Antp-TPR peptide would provide a potent and selective anticancer therapy to cancer patients.Heat-shock protein 90 (Hsp90) is a molecular chaperone [1] that participates in the quality control of protein folding. The mechanism of action of Hsp90 includes sequential ATPase cycles and the stepwise recruitment of cochaperones, including Hsp70, CDC37, p60/Hsp-organizing protein (Hop), and p23 [2,3]. In particular, Hsp90 and Hsp70 interact with numerous cofactors containing so-called tetratricopeptide repeat (TPR) domains. TPR domains are composed of loosely conserved 34-amino acid sequence motifs that are repeated between one and 16 times per domain. Originally identified in components of the anaphase-promoting complex [4,5], TPR domains are now known to mediate specific protein interactions in numerous cellular contexts [6-8]. Moreover, apart from serving mere anchoring functions, TPR domains of the chaperone cofactors Hip and p60/Hop also are able to regulate the ATPase activities of Hsp70 and Hsp90, respectively [9,10]. Each 34-amino acid motif forms a pair of antiparallel α-helices. These motifs are arranged in a tandem array into a superhelical structure that encloses a central groove. The TPR-domain-containing cofactors of the Hsp70/Hsp
Molecular mechanism of cytotoxicity induced by Hsp90-targeted Antp-TPR hybrid peptide in glioblastoma cells
Horibe Tomohisa,Torisawa Aya,Kohno Masayuki,Kawakami Koji
Molecular Cancer , 2012, DOI: 10.1186/1476-4598-11-59
Abstract: Background Heat-shock protein 90 (Hsp90) is vital to cell survival under conditions of stress, and binds client proteins to assist in protein stabilization, translocation of polypeptides across cell membranes, and recovery of proteins from aggregates. Therefore, Hsp90 has emerged as an important target for the treatment of cancer. We previously reported that novel Antp-TPR hybrid peptide, which can inhibit the interaction of Hsp90 with the TPR2A domain of Hop, induces selective cytotoxic activity to discriminate between normal and cancer cells both in vitro and in vivo. Results In this study, we investigated the functional cancer-cell killing mechanism of Antp-TPR hybrid peptide in glioblastoma (GB) cell lines. It was demonstrated that Antp-TPR peptide induced effective cytotoxic activity in GB cells through the loss of Hsp90 client proteins such as p53, Akt, CDK4, and cRaf. Antp-TPR also did not induce the up-regulation of Hsp70 and Hsp90 proteins, although a small-molecule inhibitor of Hsp90, 17-AAG, induced the up-regulation of these proteins. It was also found that Antp-TPR peptide increased the endoplasmic reticulum unfolded protein response, and the cytotoxic activity of this hybrid peptide to GB cells in the endoplasmic reticulum stress condition. Conclusion These results show that targeting of Hsp90 by Antp-TPR could be an attractive approach to selective cancer-cell killing because no other Hsp90-targeted compounds show selective cytotoxic activity. Antp-TPR might provide potent and selective therapeutic options for the treatment of cancer.
Evaluation of Israel-Stewart parameters in lattice gauge theory
Yasuhiro Kohno,Masayuki Asakawa,Masakiyo Kitazawa,Chiho Nonaka
Physics , 2009,
Abstract: Navier-Stokes equations are known as hydrodynamic equations which take account of effects of dissipations. There are, however, problems in the relativistic Navier-Stokes equations, i.e. the equations violate causality. Israel-Stewart equations, which evade the problems of Navier-Stokes equations by introducing new parameters, such as the relaxation times, have recently been used in describing the space-time evolution of the quark-gluon plasma produced in high energy heavy ion collisions. The viscosities and the relaxation times are related to each other by imposing entropy constraints on the system. According to Boltzmann-Einstein principle, the probability distribution of the fluctuation in the energy-momentum tensor is related to the entropy of the system. Applying this principle to the entropy in Israel-Stewart theory, one can obtain the ratios of the viscosities to the relaxation times. We evaluate the ratios of the viscosities to the relaxation times in SU(3) lattice gauge theory.
Evidence for the singlet-dimer ground state in an S = 1 antiferromag netic bond alternating chain
Yasuo Narumi,Masayuki Hagiwara,Masanori Kohno,Koichi Kindo
Physics , 2000, DOI: 10.1103/PhysRevLett.86.324
Abstract: Susceptibility, ESR and magnetization measurements have been performed on si ngle crystals of an S=1 bond alternating chain compound: [Ni(333-tet)(\mu-NO _2)](ClO_4) (333-tet = N,N'-bis(3-aminopropyl)propane-1,3-diamine) and the c ompound doped with a small amount of Zn. We observed an anomalous angular de pendence in the Zn-doped sample. These behaviors are well explained by the m odel based on the VBS picture for the singlet-dimer phase. The picture impli es that the free spins of S=1 with a positive single-ion anisotropy are indu ced at the edges of the chains without forming the singlet-dimer.
Preconditioned Iterative Method for Regular Splitting  [PDF]
Toshiyuki Kohno
Advances in Pure Mathematics (APM) , 2017, DOI: 10.4236/apm.2017.72009
Abstract: Several preconditioners are proposed for improving the convergence rate of the iterative method derived from splitting. In this paper, the comparison theorem of preconditioned iterative method for regular splitting is proved. And the convergence and comparison theorem for any preconditioner are indicated. This comparison theorem indicates the possibility of finding new preconditioner and splitting. The purpose of this paper is to show that the preconditioned iterative method yields a new splitting satisfying the regular or weak regular splitting. And new combination preconditioners are proposed. In order to denote the validity of the comparison theorem, some numerical examples are shown.
Targeting Interleukin-4 Receptor Alpha by Hybrid Peptide for Novel Biliary Tract Cancer Therapy
Kahori Seto,Junichi Shoda,Tomohisa Horibe,Eiji Warabi,Masayuki Kohno,Toru Yanagawa,Hiroki Bukawa,Yasuni Nakanuma,Koji Kawakami
International Journal of Hepatology , 2014, DOI: 10.1155/2014/584650
Abstract: It is known that the interleukin-4 receptor α (IL-4Rα) is highly expressed on the surface of various human solid tumors. We previously designed novel IL-4Rα-lytic hybrid peptide composed of binding peptide to IL-4Rα and cell-lytic peptide and reported that the designed IL-4Rα-lytic hybrid peptide exhibited cytotoxic and antitumor activity both in vitro and in vivo against the human pancreatic cancer cells expressing IL-4Rα. Here, we evaluated the antitumor activity of the IL-4Rα-lytic hybrid peptide as a novel molecular targeted therapy for human biliary tract cancer (BTC). The IL-4Rα-lytic hybrid peptide showed cytotoxic activity in six BTC cell lines with a concentration that killed 50% of all cells (IC50) as low as 5?μM. We also showed that IL-4Rα-lytic hybrid peptide in combination with gemcitabine exhibited synergistic cytotoxic activity in vitro. In addition, intravenous administration of IL-4Rα-lytic hybrid peptide significantly inhibited tumor growth in a xenograft model of human BTC in vivo. Taken together, these results indicated that the IL-4Rα-lytic hybrid peptide is a potent agent that might provide a novel therapy for patients with BTC. 1. Introduction Biliary tract cancer such as gallbladder cancer and extrahepatic bile duct cancer as well as intrahepatic bile duct cancer (one of the primary liver cancers) is likely to undergo metastasis to the peritoneum (peritoneal dissemination) or the liver at early stages and is often resistant to conventional chemotherapy and radiotherapy. These cancers have been thus viewed as intractable cancers unlikely to be cured completely. In Japan, the incidence of biliary tract cancer and intrahepatic bile duct cancer is about 10 out of every 100,000 people [1]. As for intrahepatic bile duct cancer, both the incidence and death rate have been rising in Japan in recent years, resembling the trend observed in western countries [2, 3]. In Japan, gemcitabine and S-1 have recently begun to be used for anticancer chemotherapy, and these drugs are expected to prolong the survival period of patients as compared to existing anticancer drugs [4]. However, because of frequent adverse events of the hematological system arising from these drugs and because of compromised hepatic function often noted in patients with intrahepatic bile duct cancer due to accompanying liver cirrhosis and in those with extrahepatic bile duct cancer or gallbladder cancer due to accompanying obstructive cholestasis, treatment with these drugs has to be discontinued or stopped. To improve the outcome of treatment of these cancers, it is very
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