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Search Results: 1 - 10 of 308 matches for " Masayoshi Kamon "
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(–)-Epigallocatechingallate Interferes RANKL/RANK Signal Pathway and Induces Apoptosis during Osteoclastogenesis in RAW264 Cell  [PDF]
Ran Zhao, Masayoshi Kamon, Kazuichi Sakamoto
Food and Nutrition Sciences (FNS) , 2014, DOI: 10.4236/fns.2014.52014
Abstract:

Green tea catechin, (–)-epigallocatechin-3-gallate [(–)-EGCG], was found to increase osteogenic functioning in mesenchymal stem cells. This study qualified EGCG, the strongest inhibitory efficiency for receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL)-activated osteoclastogenesis among other green tea catechins for RAW264, a murine preosteoclast cell line. Moreover, EGCG inhibited tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cell formation dose dependently in both single culture and co-culture systems, the expression of transcription factor, nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) and some osteoclastic genes. Especially, EGCG exhibited a strong inhibitory effect on the expression levels of RANK, the receptor of RANKL, and OSCAR, a key co-stimulator of the RANKL/RANK signal. Simultaneously, apoptotic genes expression and Hoechst staining revealed that EGCG induced apoptosis in RAW264. Taken together, these data suggest that the inhibitory effect of EGCG to osteoclastogenesis is associated with a down regulation of RANKL/RANK signal, and increased apoptosis of preosteoclasts.

Striking Similarity in the Gene Expression Levels of Individual Myc Module Members among ESCs, EpiSCs, and Partial iPSCs
Masataka Hirasaki, Keiko Hiraki-Kamon, Masayoshi Kamon, Ayumu Suzuki, Miyuki Katano, Masazumi Nishimoto, Akihiko Okuda
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0083769
Abstract: Predominant transcriptional subnetworks called Core, Myc, and PRC modules have been shown to participate in preservation of the pluripotency and self-renewality of embryonic stem cells (ESCs). Epiblast stem cells (EpiSCs) are another cell type that possesses pluripotency and self-renewality. However, the roles of these modules in EpiSCs have not been systematically examined to date. Here, we compared the average expression levels of Core, Myc, and PRC module genes between ESCs and EpiSCs. EpiSCs showed substantially higher and lower expression levels of PRC and Core module genes, respectively, compared with those in ESCs, while Myc module members showed almost equivalent levels of average gene expression. Subsequent analyses revealed that the similarity in gene expression levels of the Myc module between these two cell types was not just overall, but striking similarities were evident even when comparing the expression of individual genes. We also observed equivalent levels of similarity in the expression of individual Myc module genes between induced pluripotent stem cells (iPSCs) and partial iPSCs that are an unwanted byproduct generated during iPSC induction. Moreover, our data demonstrate that partial iPSCs depend on a high level of c-Myc expression for their self-renewal properties.
New Particle Searches at Tevatron (II)
Teruki Kamon
Physics , 1996,
Abstract: Various recent results of new particle searches at the Fermilab Tevatron are presented. No evidence is found for supersymmetric particles (chargino, gluino), leptoquark bosons and heavy gauge bosons in p-pbar collisions at sqrt{s} = 1.8 TeV. Excluded mass regions for each particle are determined.
Prospects of Discovery for Supersymmetry at the Tevatron
T. Kamon
Physics , 2003,
Abstract: We summarize a discovery potential for supersymmetric particles at the \ppbar collider of Tevatron with center-of-mass energy \sqrt{s} = 2 TeV and integrated luminosity $\intlum$ = 15-30 \invfb. Any direct search is kinematically limited to below 450 \mgev. We, however, have a unique opportunity to test various supersymmetric scenarios by a measurement of the branching ratio for the rare decay mode \bsmumu. Using the background estimate in the CDF analysis of \bsmumu in Run I, we investigate the prospects for studying this mode in Run II. CDF would be sensitive to this decay for a branching ratio > 1.2 \times 10^{-8} with 15 \invfb (or, if a similar analysis holds for \Dzero, >6.5\times 10^{-9} for the combined data). For \tanb > 30, the \bsmumu search can probe the SUSY parameter space that cannot be probed by direct production of SUSY particles at Run II. An observation of \bsmumu with a large branching ratio > 7(14) \times 10^{-8} (feasible with only 2 \invfb) would be sufficient to exclude the mSUGRA model for \tan\beta \leq 50 (55) including other experimental constraints. For some models, the branching ratio can be large enough to be detected even for small $\tan\beta$ and large \mhalf.
Antioxidant as an anticancer: consideration
Viroj Wiwanitkit, Kamon Chaiyasit
DARU Journal of Pharmaceutical Sciences , 2012, DOI: 10.1186/2008-2231-20-96
Abstract: Indeed, there is still no conclusive evidence for antioxidant use in cancer treatment although it might be useful in cancer prevention [2]. Therefore, the use of antioxidant in therapeutic process of cancer is a topic to be further studied. Indeed, if it is believed that the “scavenging free radical” is the main mechanism of antioxidant, the consideration should be on the pharmacodynamics of both antioxidant and standard antineoplastic drug. In case that induction of free radical is the main pharmacological process of antineoplastic drug (such as in quinine-based compound [3]), the use of antioxidant can be useless and should be avoided. However, in case that no drug interaction can be expected, the use of antioxidant can be allowed. Focusing on the specific advantage of antioxidant in cancer therapy, the antioxidant might be useful in the cancerous patients with cachexia who usually got the problems of redox dysequilibrium [4]. In this scenario, the antioxidant can help prevent Fenton reaction or reverse Warburg effect that can lead to chemotherapy resistance [5]. Hence, use of antioxidant supplementation in cancerous cachexic patient can be useful.The authors declare that they have no competing interest.VW - concept, draft, final check (90%), KC - concept (10%). Both authors read and approved the final manuscript.
A User Proprietary Obfuscate System for Positions Sharing in Location-Aware Social Networks  [PDF]
Wei Cherng Cheng, Masayoshi Aritsugi
Journal of Computer and Communications (JCC) , 2015, DOI: 10.4236/jcc.2015.35002
Abstract:

A user’s trajectory can be maliciously monitored by adversaries when they share the positions in location-aware social networking applications which require users to update their own locations continuously. An adversary infers user’s locations from the trajectories, and gleans user’s private information through them via location-aware social networking applications and public available geographic data. In this paper, we propose a user proprietary obfuscate system to suit situations for position sharing and location privacy preserving in location-aware social network. Users transform the public available geographic data into personal obfuscate region maps with pre-defined profile to prevent the location leaking in stationary status. Our obfuscation with size restricted regions method tunes user’s transformed locations fitting into natural movement and prevents unreasonable snapshot locations been recorded in the trajectory.

Role of carotenoid β-cryptoxanthin in bone homeostasis
Masayoshi Yamaguchi
Journal of Biomedical Science , 2012, DOI: 10.1186/1423-0127-19-36
Abstract: Bone is a dynamic tissue that preserves skeletal size, shape, and structural integrity and to regulate mineral homeostasis. Bone homeostasis is maintained through a balance between osteoblastic bone formation and osteoclastic bone resorption. Aging and numerous pathological processes induce decrease in bone formation and increase in bone resorption, leading to osteoporosis, a devastating bone disease [1]. Osteoporosis, which is induced with decrease in bone mass, is widely recognized as a major public health problem [1]. The most dramatic expression of the disease is represented by fractures of the proximal femur for which the number increases as the population ages [2].Nutritional factors may have the potential effect to prevent bone loss with increasing age. There is growing evidence that the supplementation of nutritional and food factors may have the preventive effect on bone loss that is induced in animal model of osteoporosis and in human subjects [3-6]. Chemical compounds in food and plants, which regulate on bone homeostasis, have been to be worthy of notice in maintaining of bone health and prevention of bone loss with increasing age [7-13].Carotenoids (carotene and xanthophyll) are present in fruit and vegetables. Carotenoids, which are a provitamin A, may have an anabolic effect on bone metabolism. Vitamin A (retinol, retinal, and retinoic acid), which is formed from carotenoids in animal and human, has been shown to have a role in the regulation of bone cells and it may have an anabolic effect on bone [14-16]. However, vitamin A is also known to have a detrimental effect on bone at high doses [17-20]. In laboratory animals, high levels of vitamin A lead to accelerated bone resorption, bone fractures, and osteoporotic bone lesions [17].Beta (β)-cryptoxanthin, a kind of xanthophyll, is abundant in Satsuma mandarin orange (Citrus unshiu MARC.). Of various carotenoids, β-cryptoxanthin has been found to have a potential-anabolic effect on bone due to stimulat
Biological implications of coeruleospinal inhibition of nociceptive processing in the spinal cord
Masayoshi Tsuruoka
Frontiers in Integrative Neuroscience , 2012, DOI: 10.3389/fnint.2012.00087
Abstract: The coeruleospinal inhibitory pathway (CSIP), the descending pathway from the nucleus locus coeruleus (LC) and the nucleus subcoeruleus (SC), is one of the centrifugal pain control systems. This review answers two questions regarding the role coeruleospinal inhibition plays in the mammalian brain. First is related to an abnormal pain state, such as inflammation. Peripheral inflammation activated the CSIP, and activation of this pathway resulted in a decrease in the extent of the development of inflammatory hyperalgesia. During inflammation, the responses of the dorsal horn neurons to graded heat stimuli in the LC/SC-lesioned rats did not produce a further increase with the increase of stimulus intensity in the higher range temperatures. These results suggest that the function of CSIP is to maintain the accuracy of intensity coding in the dorsal horn because the plateauing of the heat-evoked response in the LC/SC-lesioned rats during inflammation is due to a response saturation that results from the lack of coeruleospinal inhibition. The second concerns attention and vigilance. During freezing behavior induced by air-puff stimulation, nociceptive signals were inhibited by the CSIP. The result implies that the CSIP suppresses pain system to extract other sensory information that is essential for circumstantial judgment.
Capturing the Two Dimensions of Residential Segregation at the Neighborhood Level for Health Research
Masayoshi Oka
Frontiers in Public Health , 2014, DOI: 10.3389/fpubh.2014.00118
Abstract: Two conceptual and methodological foundations of segregation studies are that (i) segregation involves more than one group, and (ii) segregation measures need to quantify how different population groups are distributed across space. Therefore, percentage of population belonging to a group is not an appropriate measure of segregation because it does not describe how populations are spread across different areal units or neighborhoods. In principle, evenness and isolation are the two distinct dimensions of segregation that capture the spatial patterns of population groups. To portray people’s daily environment more accurately, segregation measures need to account for the spatial relationships between areal units and to reflect the situations at the neighborhood scale. For these reasons, the use of local spatial entropy-based diversity index (SHi) and local spatial isolation index (Si) to capture the evenness and isolation dimensions of segregation, respectively, are preferable. However, these two local spatial segregation indexes have rarely been incorporated into health research. Rather ineffective and insufficient segregation measures have been used in previous studies. Hence, this paper empirically demonstrates how the two measures can reflect the two distinct dimensions of segregation at the neighborhood level, and argues conceptually and set the stage for their future use to effectively and meaningfully examine the relationships between residential segregation and health.
Concentration of measure via approximated Brunn--Minkowski inequalities
Masayoshi Watanabe
Mathematics , 2008,
Abstract: We prove that an approximated version of the Brunn--Minkowski inequality with volume distortion coefficient implies a Gaussian concentration-of-measure phenomenon. Our main theorem is applicable to discrete spaces.
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