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Search Results: 1 - 10 of 1068 matches for " Masayoshi Harada "
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Assessment of the Water Quality in the Ariake Sea Using Principal Component Analysis  [PDF]
Toshinori Tabata, Kazuaki Hiramatsu, Masayoshi Harada
Journal of Water Resource and Protection (JWARP) , 2015, DOI: 10.4236/jwarp.2015.71003
Abstract: The aim of this study is to investigate the condition of the Ariake Sea, Japan, which has been suffering from severe environmental issues for the past few decades. Water quality data have been generated from several points in this area for over 30 years by the Fukuoka, Saga, Kumamoto, and Nagasaki prefectures. In order to understand the characteristics of this sea, principal component analysis (PCA) was utilized using 11 water quality parameters; transparency, temperature, salinity, dissolved oxygen (DO), chemical oxygen demand (COD), dissolved inorganic nitrogen (DIN), ammonium-nitrogen (NH4+-N), nitrate-nitrogen (NO3--N), nitrite-nitrogen (NO2--N), phosphate-phosphorus, (PO43--P) and silica. PCA conveyed the amount of nutrients originating from the river, the organic pollution level, and seasonal changes. Subsequently, principal component scores were calculated for each point. It was concluded that the Ariake Sea environment has been affected by two main factors, which are the nutrients from the Chikugo River and anticlockwise tidal residual flow. These two factors must be considered for the environmental restoration of the Ariake Sea.
Detection of Lymph Node Metastases in Human Colorectal Cancer by Using 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence with Spectral Unmixing
Kenichi Harada,Yoshinori Harada,Masatomo Beika,Noriaki Koizumi,Koji Inoue,Yasutoshi Murayama,Yoshiaki Kuriu,Masayoshi Nakanishi,Takeo Minamikawa,Yoshihisa Yamaoka,Ping Dai,Akio Yanagisawa,Eigo Otsuji,Tetsuro Takamatsu
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms141123140
Abstract: Accurate evaluation of metastatic lymph nodes (LNs) is indispensable for adequate treatment of colorectal cancer (CRC) patients. Here, we demonstrate detection of metastases of human CRC in removed fresh LNs using 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) fluorescence. A spectral unmixing method was employed to reduce the overlap of collagen autofluorescence on PpIX fluorescence. A total of 17 surgery patients with advanced CRC were included in this study. After 5-ALA at a dose of 15 mg/kg of body weight was applied orally 2 h prior to surgery, 87 LNs were subjected to spectral fluorescence imaging and histopathological diagnosis, and statistical analysis was performed. No apparent side effect was observed to be associated with 5-ALA administration. The spectral unmixing fluorescence intensity of PpIX in metastatic LNs was 10.2-fold greater than that in nonmetastaic LNs. The receiver-operating-characteristic (ROC) analysis showed that the area under the curve (AUC) was calculated as 0.95. Our results show the potential of 5-ALA-induced PpIX fluorescence processed by spectral unmixing for detecting metastases in excised fresh LNs from patients with CRC, suggesting that this rapid and feasible method is applicable to gross evaluation of resected LN samples in pathology laboratories.
A User Proprietary Obfuscate System for Positions Sharing in Location-Aware Social Networks  [PDF]
Wei Cherng Cheng, Masayoshi Aritsugi
Journal of Computer and Communications (JCC) , 2015, DOI: 10.4236/jcc.2015.35002

A user’s trajectory can be maliciously monitored by adversaries when they share the positions in location-aware social networking applications which require users to update their own locations continuously. An adversary infers user’s locations from the trajectories, and gleans user’s private information through them via location-aware social networking applications and public available geographic data. In this paper, we propose a user proprietary obfuscate system to suit situations for position sharing and location privacy preserving in location-aware social network. Users transform the public available geographic data into personal obfuscate region maps with pre-defined profile to prevent the location leaking in stationary status. Our obfuscation with size restricted regions method tunes user’s transformed locations fitting into natural movement and prevents unreasonable snapshot locations been recorded in the trajectory.

Role of carotenoid β-cryptoxanthin in bone homeostasis
Masayoshi Yamaguchi
Journal of Biomedical Science , 2012, DOI: 10.1186/1423-0127-19-36
Abstract: Bone is a dynamic tissue that preserves skeletal size, shape, and structural integrity and to regulate mineral homeostasis. Bone homeostasis is maintained through a balance between osteoblastic bone formation and osteoclastic bone resorption. Aging and numerous pathological processes induce decrease in bone formation and increase in bone resorption, leading to osteoporosis, a devastating bone disease [1]. Osteoporosis, which is induced with decrease in bone mass, is widely recognized as a major public health problem [1]. The most dramatic expression of the disease is represented by fractures of the proximal femur for which the number increases as the population ages [2].Nutritional factors may have the potential effect to prevent bone loss with increasing age. There is growing evidence that the supplementation of nutritional and food factors may have the preventive effect on bone loss that is induced in animal model of osteoporosis and in human subjects [3-6]. Chemical compounds in food and plants, which regulate on bone homeostasis, have been to be worthy of notice in maintaining of bone health and prevention of bone loss with increasing age [7-13].Carotenoids (carotene and xanthophyll) are present in fruit and vegetables. Carotenoids, which are a provitamin A, may have an anabolic effect on bone metabolism. Vitamin A (retinol, retinal, and retinoic acid), which is formed from carotenoids in animal and human, has been shown to have a role in the regulation of bone cells and it may have an anabolic effect on bone [14-16]. However, vitamin A is also known to have a detrimental effect on bone at high doses [17-20]. In laboratory animals, high levels of vitamin A lead to accelerated bone resorption, bone fractures, and osteoporotic bone lesions [17].Beta (β)-cryptoxanthin, a kind of xanthophyll, is abundant in Satsuma mandarin orange (Citrus unshiu MARC.). Of various carotenoids, β-cryptoxanthin has been found to have a potential-anabolic effect on bone due to stimulat
Biological implications of coeruleospinal inhibition of nociceptive processing in the spinal cord
Masayoshi Tsuruoka
Frontiers in Integrative Neuroscience , 2012, DOI: 10.3389/fnint.2012.00087
Abstract: The coeruleospinal inhibitory pathway (CSIP), the descending pathway from the nucleus locus coeruleus (LC) and the nucleus subcoeruleus (SC), is one of the centrifugal pain control systems. This review answers two questions regarding the role coeruleospinal inhibition plays in the mammalian brain. First is related to an abnormal pain state, such as inflammation. Peripheral inflammation activated the CSIP, and activation of this pathway resulted in a decrease in the extent of the development of inflammatory hyperalgesia. During inflammation, the responses of the dorsal horn neurons to graded heat stimuli in the LC/SC-lesioned rats did not produce a further increase with the increase of stimulus intensity in the higher range temperatures. These results suggest that the function of CSIP is to maintain the accuracy of intensity coding in the dorsal horn because the plateauing of the heat-evoked response in the LC/SC-lesioned rats during inflammation is due to a response saturation that results from the lack of coeruleospinal inhibition. The second concerns attention and vigilance. During freezing behavior induced by air-puff stimulation, nociceptive signals were inhibited by the CSIP. The result implies that the CSIP suppresses pain system to extract other sensory information that is essential for circumstantial judgment.
Capturing the Two Dimensions of Residential Segregation at the Neighborhood Level for Health Research
Masayoshi Oka
Frontiers in Public Health , 2014, DOI: 10.3389/fpubh.2014.00118
Abstract: Two conceptual and methodological foundations of segregation studies are that (i) segregation involves more than one group, and (ii) segregation measures need to quantify how different population groups are distributed across space. Therefore, percentage of population belonging to a group is not an appropriate measure of segregation because it does not describe how populations are spread across different areal units or neighborhoods. In principle, evenness and isolation are the two distinct dimensions of segregation that capture the spatial patterns of population groups. To portray people’s daily environment more accurately, segregation measures need to account for the spatial relationships between areal units and to reflect the situations at the neighborhood scale. For these reasons, the use of local spatial entropy-based diversity index (SHi) and local spatial isolation index (Si) to capture the evenness and isolation dimensions of segregation, respectively, are preferable. However, these two local spatial segregation indexes have rarely been incorporated into health research. Rather ineffective and insufficient segregation measures have been used in previous studies. Hence, this paper empirically demonstrates how the two measures can reflect the two distinct dimensions of segregation at the neighborhood level, and argues conceptually and set the stage for their future use to effectively and meaningfully examine the relationships between residential segregation and health.
Concentration of measure via approximated Brunn--Minkowski inequalities
Masayoshi Watanabe
Mathematics , 2008,
Abstract: We prove that an approximated version of the Brunn--Minkowski inequality with volume distortion coefficient implies a Gaussian concentration-of-measure phenomenon. Our main theorem is applicable to discrete spaces.
Two remarks on the Collatz cycle conjecture
Masayoshi Kaneda
Mathematics , 2010,
Abstract: We give a short proof of Belaga's result on bounds to perigees of $(3x+d)$-cycles of a given oddlength. We also reformulate the Collatz cycle conjecture which is rather a algorithmic problem into a purely arithmetic problem.
Local cut points and metric measure spaces with Ricci curvature bounded below
Masayoshi Watanabe
Mathematics , 2006,
Abstract: A local cut point is by definition a point that disconnectes its sufficiently small neighborhood. We show that there exists an upper bound for the degree of a local cut point in a metric measure space satisfying the generalized Bishop--Gromov inequality. As a corollary, we obtain an upper bound for the number of ends of such a space. We also obtain some obstruction conditions for the existence of a local cut point in a metric measure space satisfying the Bishop--Gromov inequality or the Poincar\'{e} inequality. For example, the measured Gromov--Hausdorff limits of Riemannian manifolds with a lower Ricci curvature bound satisfy these two inequalities.
A characterization of amenability of group actions on $C^\ast$-algebras
Masayoshi Matsumura
Mathematics , 2012,
Abstract: We show that coincidence of the full and reduced crossed product $C^\ast$-algebras of a group action on a unital commutative $C^\ast$-algebra implies amenability of the action whenever the group is exact. This is a partial answer to a problem posed by C. Anantharaman-Delaroche in 1987.
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