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Search Results: 1 - 10 of 961 matches for " Masanori "
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Pronuclear microinjection is not suitable for RNA polymerase III promoter driven constitutive RNAi transgenesis in mice for XY male-to-female sex reversal by Sry gene knockdown  [PDF]
Masanori Ito
Open Journal of Genetics (OJGen) , 2012, DOI: 10.4236/ojgen.2012.21008
Abstract: Silencing of gene expression by RNA interference (RNAi) has become a widely used tool. For the study of mammalian gene function expression vectors for short hairpin RNA (shRNA) were developed. However the standard methods of shRNA transgenic (Tg) mice production have not been established. Sry (sex-determining region on the Y chromosome) is a mammalian sex-determining gene on the Y chromosome. In mice, the transient expression of Sry in supporting cell precursor cells between 10.5 and 12.5 days post-coitus (dpc) triggers the differentiation of Sertoli cells from granulosa cells. Then high efficiency of Sry gene silencing in Tg mice should induce XY male-to-female sex reversal. An shRNA Tg mouse targeting Sry gene was attempted to be generated by pronuclear microinjection. A low rate (Tg pups/all pups born after microinjection = 2/154 to 7/178) of Tg pups was observed. These Tg mice showed no XY male-to-female sex reversal. The results suggest that exogenous expression of small RNA might exert a negative effect on embryonic development and another approach should be needed for RNAi transgenesis in mice.
A Note on Approximation of Likelihood Ratio Statistic in Exploratory Factor Analysis  [PDF]
Masanori Ichikawa
Open Journal of Statistics (OJS) , 2015, DOI: 10.4236/ojs.2015.56061

In normal theory exploratory factor analysis, likelihood ratio (LR) statistic plays an important role in evaluating the goodness-of-fit of the model. In this paper, we derive an approximation of the LR statistic. The approximation is then used to show explicitly that the expectation of the LR statistic agrees with the degrees of freedom of the asymptotic chi-square distribution.

Non-Neutral Technological Progress and Income Distribution—Piketty’s Fundamental Laws in a Neoclassical Two-Sector Model  [PDF]
Masanori Morita
Theoretical Economics Letters (TEL) , 2016, DOI: 10.4236/tel.2016.66119
Abstract: This paper discusses the theoretical validity of Thomas Piketty’s fundamental laws about income distribution in the context of a standard neoclassical growth model. We take Uzawa’s two-sector growth model as the platform of our analysis, as it allows us to make a distinction between the technological elasticity of factor substitution of the production function and the aggregate distributive elasticity of substitution. We examine the properties of the non-steady growth path through both analytical and numerical investigations. We conclude that some of the numerical simulations corroborate Piketty’s theory without assuming that the economy is on a steady growth path. However, if the elasticities of factor substitution in the individual sectors are less than one as many empirical studies show, then the economy approaches the state where all products are completely distributed to workers. This contradicts Piketty’s diagnosis about the current distributional inequality. In addition, the aggregate income distribution is stable for a relatively long time, and differences in the initial conditions are preserved during this period. This means that the comparative statics of the steady states might not present an adequate description of the economy’s behavior in a period of time that is practical. Our final evaluation of Piketty’s proposition is that it is better understood as a theory inferred from historical data and not one necessarily deduced from standard neoclassical growth theory.
Revisiting the J-Curve for Japan  [PDF]
Masanori Ono, SaangJoon Baak
Modern Economy (ME) , 2014, DOI: 10.4236/me.2014.51005

This paper investigates Japanese trade to see whether the J/S-curve phenomenon between net exports and the terms of trade is observed in the data from 1980Q1 to 2008Q3. Based on the results of a VAR stability test, the aggregate trade data are endogenously split into three sub-period data sets, with the J/S-curve present in the last two. The J/S-curve may stem from the increasing share of China and the oil-exporting countries in Japanese trade. In fact, the J/S-curve is observed in the bilateral trade data with those countries but not in the data with Korea or the United States.

Sensitivity Numerical Analysis of Human Body Exergy Balance under an Unsteady-State Thermal Environment
—Behavioral Adaptation Induced by Undesirable Cold Storage by Building Envelope in Winter

Koichi Isawa, Masanori Shukuya
Health (Health) , 2016, DOI: 10.4236/health.2016.88077
Abstract: We analyzed the relationships between the human body exergy balance and behavioral adaptations induced by undesirable cold storage by a building envelope under an unsteady-state thermal environment in winter. The complex interaction of the warm exergy production by shivering, lifting of the shell ratio, and reduction of the blood flow rate was considered to constitute the physiological adaptation necessary for maintaining the constant core temperature, which was an important aspect in living organisms. In the case of intermittent use room, it was suggested that better thermal comfort and desirable behavioral adaptations, which decreased the consumption of fossil fuels, could be achieved if interior wooden cladding was used in constructions with building envelopes that had a comparatively large heat capacity, or in cases of wooden constructions in which the building envelope heat capacity was comparatively small.
Estimate of Uniaxial Compressive Strength of Hydrothermally Altered Soft Rocks Based on Strength Index Tests  [PDF]
Masanori Kohno, Hiroyuki Maeda
Geomaterials (GM) , 2018, DOI: 10.4236/gm.2018.82002
Abstract: The purpose of this study was to clarify the relationships between results of index tests and uniaxial compressive strength (UCS) in hydrothermally altered soft rocks of the Upper Miocene, which are typical of the soft rock found in northeastern Hokkaido, Japan. Index tests were performed using point load testing machine and needle penetrometer with irregular lump specimens under forced-dry, forced-wet, and natural-moist states. The relationships between irregular lump point load strength (IPLS) index and UCS, and needle penetration (NP) index and UCS were “UCS = approximately 19 IPLS index” and “UCS = 0.848 (NP index)0.619”, respectively, in soft rocks with a UCS below 25 MPa. These relationships could be applied to on-site tests of rocks with natural moisture content. The UCS could be calculated from IPLS and NP tests on soft rocks only when UCS was below 25 MPa, using the equations obtained as a result of this study.
Toward an Understanding of the Madden-Julian Oscillation: With a Mesoscale-Convection-Resolving Model of 0.2 Degree Grid
Masanori Yamasaki
Advances in Meteorology , 2011, DOI: 10.1155/2011/296914
Abstract: This paper describes results from numerical experiments which have been performed as the author's first step toward a better understanding of the Madden-Julian oscillation (MJO). This study uses the author's mesoscale-convection-resolving model that was developed in the 1980s to improve parametrization schemes of moist convection. Results from numerical experiments by changing the SST anomaly in the warm pool area indicate that the period of the MJO does not monotonously change with increasing SST anomaly. Between the two extreme cases (no anomaly and strong anomaly), there is a regime in which the period varies in a wide range from 20 to 60 days. In the case of no warm pool, eastward-propagating Kelvin waves are dominant, whereas in the case of a strong warm pool, it produces a quasi-stationary convective system (with pronounced time variation). In a certain regime between the two extreme cases, convective activities with two different properties are strongly interacted, and the period of oscillations becomes complicated. The properties and behaviors of large-scale convective system (LCS), synoptic-scale convective system (SCS), mesoscale convective system (MCS), and mesoscale convection (MC), which constitute the hierarchical structure of the MJO, are also examined. It is also shown that cloud clusters, which constitute the SCS (such as super cloud cluster SCC), consist of a few MCS, and a new MCS forms to the west of the existing MCS. The northwesterly and southwesterly low-level flows contribute to this feature. In view of recent emphasis of the importance of the relative humidity above the boundary layer, it is shown that the model can simulate convective processes that moisten the atmosphere, and the importance of latent instability (positive CAPE), which is a necessary condition for the wave-CISK, is emphasized.
Gene Regulation System of Vasopressin and Corticotoropin-Releasing Hormone
Masanori Yoshida
Gene Regulation and Systems Biology , 2008,
Abstract: The neurohypophyseal hormones, arginine vasopressin and corticotropin-releasing hormone (CRH), play a crucial role in the physiological and behavioral response to various kinds of stresses. Both neuropeptides activate the hypophysialpituitary-adrenal (HPA) axis, which is a central mediator of the stress response in the body. Conversely, they receive the negative regulation by glucocorticoid, which is an end product of the HPA axis. Vasopressin and CRH are closely linked to immune response; they also interact with pro-inflammatory cytokines. Moreover, as for vasopressin, it has another important role, which is the regulation of water balance through its potent antidiuretic effect. Hence, it is conceivable that vasopressin and CRH mediate the homeostatic responses for survival and protect organisms from the external world. A tight and elaborate regulation system of the vasopressin and CRH gene is required for the rapid and flexible response to the alteration of the surrounding environments. Several important regulatory elements have been identified in the proximal promoter region in the vasopressin and CRH gene. Many transcription factors and intracellular signaling cascades are involved in the complicated gene regulation system. This review focuses on the current status of the basic research of vasopressin and CRH. In addition to the numerous known facts about their divergent physiological roles, the recent topics of promoter analyses will be discussed.
Vino y turismo del municipio de Cangas del Narcea (Asturias, Espa a)
Hatanaka, Masanori
PASOS : Revista de Turismo y Patrimonio Cultural , 2008,
Abstract: The objective of this work is to reconstruct the process of decline and the present hope of the wine sector of the municipality of Cangas del Narcea in the southwest of Asturias region in Spain, with attention to its relation with tourism. The stagnation of its wine sector commenced from a mid twentieth centuries by the several technical, economic and social problems. Some local actors with preoccupations react against the decay since 1990s. The attempt of recovery at wine works is parallel with several tourist initiatives. They are a wine museum, visit to wine caves, and some events related with the wine culture. These initiatives are also interesting to combine with other projects like the tourism and cultural interchange.
The Role of Foot Structure in Teaching Vowel Length Distinctions in Japanese
Masanori Deguchi
Theory and Practice in Language Studies , 2011, DOI: 10.4304/tpls.1.6.567-571
Abstract: The present study explores the possibility of using foot structure as a cue to teach vowel length distinctions in Japanese. While it has been said that the primary cue to such distinctions is duration (Fujisaki et al, 1975), Hirata (2004) has found that the duration of short vowels and that of long vowels overlap significantly across various speaking rates, implying that duration does not provide a reliable cue. The present study first demonstrates that different vowel lengths in minimal pairs correlate with different foot structures, and suggests that we use the difference in foot structure in order to correct learners’ pronunciation errors. This approach is then applied to words that are not in minimal pairs.
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