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Search Results: 1 - 10 of 824 matches for " Masanobu Kawakami "
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Gross domestic product and dietary pattern among 49 western countries with a focus on polyamine intake  [PDF]
Phan Nguyen Thanh Binh, Kuniyasu Soda, Masanobu Kawakami
Health (Health) , 2010, DOI: 10.4236/health.2010.211198
Abstract: Socioeconomic status is known to affect dietary profile, and differences in food habits and choice may affect polyamine intake due to significant variations in the concentrations of the polyamines spermine, spermidine, and putrescine present in different foods. The relationship between gross domestic product (GDP) and dietary profile, with a focus on polyamine intake, was investigated for 49 different European and other Western countries. The data for food supply and GDP were collected from the database of the United Nations and the International Monetary Fund, respectively, and the amount of polyamine intake from food was estimated using polyamine concentrations listed in published sources. Countries were divided equally according to GDP values into two categories, higher and lower, and the amount and composition of food polyamines as well as dietary profile were compared. Higher GDP countries supply animal products and seafood in greater amounts than lower GDP countries; however, whole milk supply per calorie was higher in lower GDP than higher GDP countries. While crops supply was relatively higher in lower GDP countries, fruit supply was greater in higher GDP countries. Higher GDP was associated with increased amount of spermine and putrescine per total calorie, although spermidine amount per calorie was similar between higher and lower GDP countries. GDP, as an indicator of countries’ socioeconomic status, is associated with the amount and the composition of polyamines as well as dietary pattern.
Relationship between food polyamines and gross domestic product in association with longevity in Asian countries  [PDF]
Phan Nguyen Thanh Binh, Kuniyasu Soda, Chizuko Maruyama, Masanobu Kawakami
Health (Health) , 2010, DOI: 10.4236/health.2010.212206
Abstract: The relationship between gross domestic pro- duct (GDP) and dietary profile, with a focus on polyamine intake, was investigated in 35 Asian countries. Data on food supply, GDP, and health condition were collected from databases of the United Nations, the International Monetary Fund, and the World Health Organization, respectively. The amount of polyamine intake from food was estimated using polyamine concentrations listed in published sources. The amounts of putrescine, spermidine, spermine, and total polyamines in 1000 kcal of food in Asian countries were 39.07 ± 17.98, 33.74 ± 14.35, 14.05 ± 6.60 and 86.85 ± 33.96 μmol/1000 kcal, respectively. Putrescine, spermidine, and spermine constituted 44, 39, and 17% of total polyamine, respectively. Vegetables contributed the largest amount of both putrescine and spermidine and the second largest amount of spermine (45.5%, 62.2% and 27.2% of total putrescine, spermidine, and spermine, respectively). Meat was the richest source of spermine and contributed the greatest amount (50%) of this polyamine. We showed a significant positive association between GDP and the amount of polyamine per 1000 kcal of food. Lifespan was associated with both GDP and the amount of polyamine per energy quotient of food. As several basic research studies have shown that polyamines help prolong longevity, it follows that polyamines may have a role in determining the lifespan of humans.
Mediterranean diet and polyamine intake: possible contribution of increased polyamine intake to inhibition of age-associated disease
Phan Nguyen Thanh Binh, Kuniyasu Soda, Masanobu Kawakami
Nutrition and Dietary Supplements , 2011, DOI: http://dx.doi.org/10.2147/NDS.S15349
Abstract: iterranean diet and polyamine intake: possible contribution of increased polyamine intake to inhibition of age-associated disease Original Research (4789) Total Article Views Authors: Phan Nguyen Thanh Binh, Kuniyasu Soda, Masanobu Kawakami Published Date December 2010 Volume 2011:3 Pages 1 - 7 DOI: http://dx.doi.org/10.2147/NDS.S15349 Phan Nguyen Thanh Binh1, Kuniyasu Soda2, Masanobu Kawakami3 1Department of Food and Nutrition, Japan Women’s University, Tokyo, Japan; 2Cardiovascular Research Institute, 3Department of Internal Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan Abstract: The Mediterranean diet is a dietary pattern associated with increased longevity, and has been shown to have anti-inflammatory properties. Based on the findings that natural polyamines are strong anti-inflammatory substances, we have found that continuous and increased polyamine intake prolongs murine lifespan. Because polyamines are contained in most foods in widely varying concentrations, we sought epidemiologic evidence that supports an association between the Mediterranean diet and increased polyamine intake. The amounts of food supply in 49 European and other Western countries in 2005 were collected from the United Nations database, and the amount of food polyamine was estimated using polyamine concentrations in foods from published sources. The Mediterranean diet pattern was characteristically observed in Mediterranean countries. For all 49 countries and for foods such as olive oil (Spearman r = 0.602), fruit (r = 0.804), fruit and vegetables (r = 0.611), seafood (r = 0.461), and cheese (r = 0.411), the ratios of the amounts of these foods to total calories consumed were all positively associated (P < 0.05) with the amount of polyamine per calorie. Legumes per calorie (r = 0.379), wine per calorie (r = 0.285), and the amount of seafood and poultry meat relative to red meat (r = 0.313) had a trend of positive association with the amount of polyamine per calorie (P < 0.05), while several foods in the non-Mediterranean diet group had a trend of no or negative association. Food polyamines are absorbed quickly from the intestinal lumen, and long-term increased polyamine intake increases blood polyamine concentration. The present findings, together with previous studies on polyamines, indicate a possible role for the food polyamines that are abundant in the Mediterranean diet in prolonging human life.
Nanostrucure of Hybrid Plasmonic-Potonic Crystal Formed on Gel-Immobilized Colloidal Crystal Observer by AFM after Drying
Sho Kawakami,Atsushi Mori,Ken Nagashima,Shuuichi Hashimoto,Masanobu Haraguchi
Physics , 2015,
Abstract: Aiming at fabrication of hybrid plasmonic-photonic crystals, gel-immobilized colloidal crystals made of a polystyrene colloidal suspension and an N-(Hydroxy methyl)acrylamid-based gel were immersed into an aqueous dispersion of gold nanoparticles. Atomic force microscope (AFM) observations have been performed for the gel-immobilized colloidal crystals with gold nanoparticles deposited on their surfaces. In the present study, the diameter of a colloidal sphere was c.a. 190 nm. The diameter of a gold nanoparticle was the same as in a preliminary study, c.a. 40 nm. Various immersion times up to two hours were tested. Surface of a sample of 2 hr immersion has been observed. Prior to the AFM observation, the sample was dried in a desiccator for 18 hrs. We have identified a face-centered cubic {111} structure of a colloidal crystal of nearly close packing. Nanoparticles isolated with one another have been observed on the surface of gel-immobilized crystal, which can be regarded as gold nanoparticles from their sizes.
Core and Networking in L2 Lexical Teaching in an Input-Poor Context  [PDF]
Masanobu Sato, Shigenori Tanaka
Open Journal of Modern Linguistics (OJML) , 2014, DOI: 10.4236/ojml.2014.45058
Abstract: This paper discusses problems in developing L2 lexical competence in an input-poor environment, and suggests what we can do so as to minimize the negative effects of those problems on L2 lexical learning. As an unavoidable problem, we discussed a learner strategy unequivocally used by Japanese students when learning the meaning of a new word. To enhance L2 lexical learning, we suggested that lexical core, combined with the notion of network building, has a lot of pedagogical potential. With two cases (the preposition on, and the basic verbs of communication), we demonstrated how the core schema of a lexical item(s) becomes a common thread that weaves both intra-lexical and inter-lexical networks.
Tbx2 and Tbx3 Regulate the Dynamics of Cell Proliferation during Heart Remodeling
Inês Ribeiro, Yasuhiko Kawakami, Dirk Büscher, ángel Raya, Joaquín Rodríguez-León, Masanobu Morita, Concepción Rodríguez Esteban, Juan Carlos Izpisúa Belmonte
PLOS ONE , 2007, DOI: 10.1371/journal.pone.0000398
Abstract: Background The heart forms from a linear tube that is subject to complex remodeling during embryonic development. Hallmarks of this remodeling are the looping of the heart tube and the regionalization into chamber and non-chamber myocardium. Cardiomyocytes in the future chamber myocardium acquire different cellular and physiological characteristics through activation of a chamber-specific genetic program, which is in part mediated by T-box genes. Methodology/Principal Finding We characterize two new zebrafish T-box transcription factors, tbx3b and tbx2a, and analyze their role during the development of the atrioventricular canal. Loss- and gain-of-function analyses demonstrate that tbx3b and tbx2a are necessary to repress the chamber-genetic program in the non-chamber myocardium. We also show that tbx3b and tbx2a are required to control cell proliferation in the atrioventricular canal and that misregulation of cell proliferation in the heart tube influences looping. Furthermore, we characterize the heart phenotype of a novel Tbx3 mutation in mice and show that both the control of cell proliferation and the repression of chamber-specific genetic program in the non-chamber myocardium are conserved roles of Tbx3 in this species. Conclusions/Significance Taken together, our results uncover an evolutionarily conserved role of Tbx2/3 transcription factors during remodeling of the heart myocardium and highlight the importance of controlling cell proliferation as a driving force of morphogenesis.
Latent associations of low serum amylase with decreased plasma insulin levels and insulin resistance in asymptomatic middle-aged adults
Toshitaka Muneyuki, Kei Nakajima, Atsushi Aoki, Masashi Yoshida, Hiroshi Fuchigami, Hiromi Munakata, San-e Ishikawa, Hitoshi Sugawara, Masanobu Kawakami, Shin-ichi Momomura, Masafumi Kakei
Cardiovascular Diabetology , 2012, DOI: 10.1186/1475-2840-11-80
Abstract: We measured serum amylase, plasma insulin, obesity-related parameters such as leptin, cardiometabolic risk factors, and anthropometric parameters in a cross-sectional study of 54 asymptomatic subjects (mean age 48.6?±?7.6?years) who were not being treated for diabetes.Body mass index (BMI) and plasma glucose at 120?min after a 75-g oral glucose tolerance test (OGTT) were significantly higher in subjects with low serum amylase (< 60?IU/l, n?=?21) than in those with normal-to-high serum amylase (n?=?33) (P?=?0.04 and P?=?0.004, respectively). In univariate correlation analysis, serum amylase was significantly correlated with BMI alone (r?=?–0.39, P?=?0.004). By contrast, multivariate logistic analysis showed that each 1-SD increase in quantitative insulin sensitivity check index, and each 1-SD decrease in plasma insulin OGTT at 0 and 60?min, homeostasis model assessment of insulin resistance (HOMA)-R, and HOMA-β were significantly associated with low serum amylase, particularly after adjusting for BMI. When subjects were divided into three groups according to HOMA-R, serum amylase levels were significantly lower in subjects with HOMA-R?>?2.5 (n?=?23) compared with subjects with HOMA-R 1.6–2.5 (n?=?10) (61.1?±?13.6?U/ml versus 76.9?±?20.5?U/ml, Bonferroni test, P?=?0.02), but not compared with subjects with HOMA-R<1.6 (n?=?21; 62.7?±?17.6?U/ml). Similar trends were observed when subjects were divided according to plasma leptin and fasting plasma insulin levels.These results suggest that after adjusting for BMI, low serum amylase is associated with decreased basal insulin levels and insulin secretion, as well as high insulin resistance. The nature of these associations remains to be elucidated in further studies.For many years, low serum amylase was thought to reflect diffuse pancreatic destruction secondary to advanced pancreatic diseases, such as chronic pancreatitis [1,2]. Recently, several large clinical studies have shown that low serum amylase is also associated w
Association of serum osteoprotegerin with vascular calcification in patients with type 2 diabetes
Atsushi Aoki, Miho Murata, Tomoko Asano, Aki Ikoma, Masami Sasaki, Tomoyuki Saito, Taeko Otani, Sachimi Jinbo, Nahoko Ikeda, Masanobu Kawakami, San-e Ishikawa
Cardiovascular Diabetology , 2013, DOI: 10.1186/1475-2840-12-11
Abstract: The subjects were 124 patients with type 2 diabetes mellitus, including 88 males and 36 females with a mean (± SD) age of 65.6 ± 8.2 years old. Serum levels of osteoprotegerin, osteocalcin, fibroblast growth factor 23 (FGF23), 25-hydroxyvitamin D3 and adiponectin were measured by ELISA. Vascular calcification in the cervical artery was examined by ultrasound sonography. The subjects were divided into 4 quartiles depending on serum osteoprotegerin levels.Vascular calcification was significantly higher in the 4th quartile and significantly lower in the 1st quartile of serum osteoprotegerin levels, compared to other quartiles. There were no differences in serum osteoprotegerin and vascular calcification among patients with different stages of diabetic nephropathy, but serum FGF23 levels were elevated in those with stage 4 diabetic nephropathy. Simple regression analysis showed that serum osteoprotegerin levels had significant positive correlations with age, systolic blood pressure and serum adiponectin levels, and significant negative correlations with BMI and serum 25-hydroxyvitamin D3.These findings suggest that elevated serum osteoprotegerin may be involved in vascular calcification independently of progression of diabetic nephropathy in patients with type 2 diabetes.Atherosclerosis, macroangiopathy and microangiopathy are major prognostic factors in diabetes. Vascular endothelial impairment is the initial pathological change and is profoundly involved in development of atherosclerosis [1-4]. Progression of diabetic nephropathy, including microalbuminuria, is a risk factor for atherosclerosis in type 2 diabetes mellitus [5,6] and diabetic patients with advanced nephropathy (particularly those on dialysis with end-stage kidney disease) often have vascular calcification [7-10]. However, the duration of diabetes mellitus is not closely related to the extent of vascular calcification, and this condition may be more strongly related to biochemical changes.The RANK/RANKL
First-Principle Analysis for Electromagnetic Eigen Modes in an Optical Metamaterial Slab
Masanobu Iwanaga
PIER , 2012, DOI: 10.2528/PIER12071202
Abstract: Electromagnetic (EM) eigen modes in a fishnet metamaterial (MM) slab have been comprehensively analyzed in an experimental configuration, based only on precise solutions of Maxwell equations. The EM eigen modes were directly detected from light-absorption peaks. Each mode was explicitly characterized by the dispersion diagram and EM field distributions. It was consequently found that the modes were classfied into either inner modes inside the slab or a mode at the interface with the surrounding media. The symmetric properties of the inner modes were clarified using group theory. The interface mode was found to come from surface plasmon polariton at flat metal/insulator interface. The present analysis procedure is generally applicable to MM slabs and enables to clarify the properties without models or assumptions, which have been usually used in MM studies.
A Concep o Vitalista da Salva o" no Brasil: As Novas Religi es Japonesas e o Pentecostalismo
Masanobu Yamada
REVER : Revista de Estudos da Religi?o , 2004,
Abstract: The Vitalistic Conception of Salvation has been pointed out as a distinctive character of Japanese new religions. It has not been discussed, however, how this conception would develop in a different cultural context. This article will investigate Brazilian converts to Japanese new religions (Seicho-no-ie, Perfect Liberty and Tenrikyo) and compare them with those to Pentecostalism (Charismatic Renewal Movement and Universal Church of Kingdom of God). Brazilians who converted to the Japanese new religions raise four points of the new religions as different from their former religions: a) novelty of ritual and pray; b) more kindness than Catholic Church; c) change of God’s image; d) liberation from sin. These points can be found in the cases of Pentecostalism as well, although they do not have the Vitalistic Conception of Salvation.
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